Comparison of Serum Vitamin D and Interleukin-6 Levels in Patients with Preeclampsia and Healthy Pregnant Women

Objective To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Methods A prospective case-control study that recruited healthy pregnant women (control group) (n = 78) and women with GDM (GDM group) (n = 79), with no other comorbidities. Peripheral blood samples were collected in the 3rd trimester of gestation, and all of the pregnant women were followed-up until the end of the pregnancy and the postpartum period. Serum vitamin D concentrations were measured by high-performance liquid chromatography (HPLC). For genomic polymorphism analysis, the genomic DNA was extracted by the dodecyltrimethylammonium bromide/cetyltrimethylammonium bromide (DTAB/CTAB) method, and genotyping was performed by the polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) technique, using the restriction enzyme FokI. The Student-t, Mann-Whitney, chi-squared, and Fischer exact tests were used for the analysis of the results. Results There was no significant difference between the pregnant women in the control and GDM groups regarding serum vitamin D levels (17.60 ± 8.89 ng/mL versus 23.60 ± 10.68 ng/mL; p = 0.1). Also, no significant difference was detected between the FokI genotypic frequency when the 2 groups were compared with each other (p = 0.41). Conclusion There was no association between the FokI polymorphism and the development of GDM, nor was there any change in serum vitamin D levels in patients with GDM.

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LATE-BREAKING ABSTRACT: The association between serum vitamin D deficiency and allergic symptom in pregnant women

10.1183/13993003.congress-2015.pa4086 ◽

2015 ◽

Author(s):

Kumiko Kanatani ◽

Yuichi Adachi ◽

Kei Hamazaki ◽

Hidekuni Inadera ◽

Kazunari Onishi ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Allergic Symptom ◽

Serum Vitamin D

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VITAMIN D DEFICIENCY;

The Professional Medical Journal ◽

10.29309/tpmj/2012.19.02.2013 ◽

2012 ◽

Vol 19 (02) ◽

pp. 208-213

Author(s):

MUHAMMAD ASLAM ◽

ZAHID MASOOD ◽

Abdul SATTAR ◽

Maria Qudsia

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Sampling Technique ◽

Reproductive Age ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Vitamin D 3

Objective: To study the Prevalence of Vitamin D deficiency in pregnant women. Study Design: A Cross-sectional analyticalstudy through convenient sampling technique. Setting and duration: At a private Clinic located at East Canal Road Faisalabad, from March2011 to June 2011. Material and method: The study included consecutive 61 pregnant women of reproductive age and non-pregnant womenwere excluded. Blood samples were taken in morning i.e. overnight fasting samples, by venepuncture by disposable syringes sample weretaken and samples were stored at -20 degree centigrade till they were analyzed. Our interest was in age and serum Vitamin D 3 levels. Results:Out of 61 pregnant women results showed that 87.0% pregnant women were having Vitamin D deficiency, 10.0% were having Vitamin Dinsufficiency, 3.0% had Vitamin D sufficiency and none shows Vitamin D intoxication. Vitamin D deficiency was more prevalent in pregnantwomen of younger age group. Furthermore prevalence was higher among the pregnant mothers with high parity. Moreover, 65% women werenot exposed to sunlight properly, 60% women had muscle cramps and bony aches. 90% women never were tested for tested Vitamin D levelsbefore. Conclusions: Prevalence of Vitamin D deficiency is significant in pregnant women. It is also important for its effects on various organsand systems of body as well as on pregnancy and neonate. The different aspects of study led to conclusion to emphasize that Health educationbe imparted to pregnant women and their families in terms of diet, proper sunlight exposure and taking Vitamin D supplements in pregnancy. It isthus recommended to perform Vitamin D levels in every pregnant woman.

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Maternal Serum 25-Hydroxy Vitamin D Concentrations and Calcium Levels in Preeclamptic Women, Sindh, Pakistan

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i52b33619 ◽

2021 ◽

pp. 216-221

Author(s):

Khalil Ahmed Memon ◽

Hazoora Shaikh ◽

Rukhsana Soomoro ◽

Yasmeen Joyo ◽

Saira Parveen ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Multinomial Logistic Regression ◽

Serum Vitamin ◽

Maternal Serum ◽

Control Group ◽

Case Group ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

25 Hydroxyvitamin D

Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations in patients with pre-eclampsia, Hyderabad, Sindh, Pakistan. Methodology: Cross sectional study was conducted at the Gynaecology and Obstetrics Department, LUHS, Hyderabad during the period of January 2020 to June 2020. Total 150 pregnant women were selected according to predesign Proforma and divided into two groups. 50 females were normal normotensive pregnant women as a control group, 100 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken for the analysis of 25-hydroxyvitamin D or 25(OH)D and calcium levels. 25(OH)D were performed on chemiluminescence, While calcium concentration of Microlab 300. Data was analysed by using SPSS version 23. Student t-test was used for analysed of continuous variables. Results: The maternal serum vitamin D and calcium levels were significantly decreased as compared to patient with preeclampsia and normotensive healthy pregnant ladies. The blood pressure also declined in case group with P<0.001.Multinomial logistic regression showed significant odd ratio of Vitamin-D and Calcium deficiency in preeclampsia. Conclusion: The present study reveals that 25-hydroxyvitamin D, and Calcium levels declined significantly in preeclamptic women, and mighty be biomarker of this life threating disease.

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Vitamin D Levels in Pregnant Congolese Women and Their New-Borns, and the Association with Neonatal Outcomes – A Pilot Study

10.21203/rs.3.rs-40821/v1 ◽

2020 ◽

Author(s):

Gurpreet Dhillon ◽

Sunil Rai ◽

Harpreet Dhillon ◽

Shibu Sasidharan ◽

Costa Kimweri ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Preterm Births ◽

Maternal Serum ◽

Neonatal Outcomes ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Sufficient Vitamin

Abstract Background: This study was thus undertaken to study the estimation of vitamin D levels in pregnant women and their newborns in DRC and to study its association with various neonatal outcomes. Methods: Observational study done on 569 pregnant women and their newborn babies. Sample obtained from maternal serum and cord blood from the placental end during peripartum period. The data was analysed to estimate the prevalence of vitamin D levels in mothers and newborns and to identify association, if any, between maternal vitamin D levels and neonatal outcomes.Results: 464 mothers had sufficient vitamin D (VDS) levels (>30 ng/dL) and 105 had vitamin D deficiency (VDD) with mean maternal serum vitamin D level of 35.63ng/ml (SD 6.18, range 9.2-39.8). All the newborns (n=569) were vitamin D deficient (<30ng/ml). The percentage of LBW babies born to VDD mothers was 18.09%, which was very similar to the percentage of LBW babies born to VDS mothers (18.31%) (p=0.76456749). The incidence of caesarean section was 58.09% in the vitamin D deficient (VDD) group as compared to 19.61% in the sufficient (VDS) group (p<0.0005). The incidence of preterm births was 10.77% in the sufficient group (VDS) as compared to 17.14% in the vitamin D deficient (VDD) group (p=0.038). Conclusion: Our findings will help health professionals, policy makers, and the general public in Africa aware of the high prevalence of vitamin D deficiency and the associated health risks.

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High prevalence of vitamin D deficiency in pregnant women and its relationship with adverse pregnancy outcomes in Guizhou, China

Journal of International Medical Research ◽

10.1177/0300060518781477 ◽

2018 ◽

Vol 46 (11) ◽

pp. 4500-4505 ◽

Cited By ~ 4

Author(s):

Song Hong-Bi ◽

Xu Yin ◽

Yang Xiaowu ◽

Wang Ying ◽

Xu Yang ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Perinatal Outcomes ◽

Perinatal Period ◽

Maternal Outcomes ◽

Serum Vitamin D ◽

Adverse Perinatal Outcomes ◽

Adverse Pregnancy

Objective This study was performed to investigate the prevalence of vitamin D deficiency in pregnant women in Guizhou, China and its correlation with adverse infant and maternal outcomes during the perinatal period. Methods In total, 220 pregnant women who received perinatal care and delivered in the Affiliated Hospital of Guizhou Medical University from November 2014 to April 2015 were enrolled. Each woman’s serum vitamin D concentration was tested during early pregnancy, and its correlation with adverse infant and maternal outcomes in the perinatal period was analyzed. Results The mean serum vitamin D concentration was 29.5 ± 5.8 nmol/L. More than 90% of pregnant women had vitamin D insufficiency. Additionally, 38.4% of women with vitamin D deficiency and 22.2% with vitamin D inadequacy developed adverse perinatal outcomes. The vitamin D level was negatively correlated with adverse pregnancy outcomes. Conclusion Vitamin D deficiency is highly prevalent among pregnant women in Guizhou, China. The incidence of adverse perinatal outcomes was far higher in association with vitamin D deficiency than sufficiency. A negative correlation was found between the vitamin D level and the incidence of adverse perinatal outcomes in pregnant women. Therefore, targeted screening and proper supplementation are needed during early pregnancy.

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Comparison of Vitamin D Level among Vaccinated and Non Vaccinated Pregnant Women with Covid-19

10.53350/pjmhs2115103500 ◽

2021 ◽

Vol 15 (10) ◽

pp. 3500-3502

Author(s):

Saeeda Safi ◽

Umme habiba ◽

Shandana Mustafa Jadoon ◽

Umbreen Idrees ◽

Ayesha Aftab ◽

...

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Body Mass ◽

Gestational Age ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Group I ◽

Group Ii

Objective: The aim of this study is to compare the vitamin D level among vaccinated and non-vaccinated pregnant women with COVID-19. Study Design: Observational/comparative study Place and Duration: The study was conducted at the department of Gynae and Obs Quaid-e-Azam International Hospital, Islamabad and Qazi Hussain Ahmad Medical Complex, Nowshera for Duration of six months from October 2020 to March 2021. Methods: Total 120pregnant women had coronavirus disease were presented. Informed written consent was taken for details demographics age, gestational age, parity and body mass index. 18-45years was the women ages. Patients were categorized into 2-groups. Group I had 60 vaccinated patients and in group II 60 non-vaccinated pregnant women. Blood sample of all the patients were taken for the level of serum 25-hydroxy vitaminD3 [25 (OH) D3]. Vitamin D deficiency was calculated and compared among both groups. Sufficient serum vitamin D level was considered >30ng/ml. SPSS 23.0 version was used to analyze complete data. Results: In group I age was 28.4±8.55 years with mean BMI 24.08±1.18 kg/m2 and in group II age was 27.41±6.37 years with mean body mass index 23.12±4.42 kg/m2. Mean gestation age in group I was 33.12±9.42 weeks and in group II mean gestational age was 34.07±5.63 weeks. Mean parity in group I was 3.88±7.27 and in group II 4.01±4.14 was mean parity. We found 28 (46.7%) primigravida cases in I-group and 30 (50%) primigravida females in II-group. In group I 51(85%) patients had vitamin D deficiency and in group II 54 (90%) had deficiency of vitamin D. Among 51 deficient women of group I, number of severe deficiency (<10ng/ml) women were 8 (13.3%), deficiency (10-20ng/ml) were 13 (21.7%) and not-sufficient (20-30ng/ml) were 30 (50%) and in group II prevalence of severity (<10ng/ml) patients were 10 (16.7%), deficient cases (10-20ng/ml) were 15 (25%) and not-sufficient cases (20-30ng/ml) were 29 (48.3%). Deficient vitamin D serum levels were 15.01±1.22 in group I and 14.34±4.12 in group II. Conclusion: In this study we concluded that prevalence of vitamin D deficiency was highly among pregnant women and most probably in non-vaccinated pregnant patients but did not find any significantly difference among both groups. Keywords: Pregnancy, COVID-19, Vitamin D, Vaccination

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Association of serum vitamin D levels with gestational diabetes mellitus

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20212147 ◽

2021 ◽

Vol 10 (6) ◽

pp. 2198

Author(s):

Sharmeen Mahmood ◽

Hasna Hena Pervin ◽

Shereen Yousuf

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Serum Vitamin ◽

Maternal Serum ◽

Control Group ◽

Case Group ◽

Vitamin D Status ◽

Third Trimester ◽

Serum Vitamin D ◽

Vitamin D Levels

Background: This study was done to evaluate the association of serum vitamin D level with GDM (n=30) and without GDM (n=30). The age and body mass index of the participants along with their gestational age, gravidity and parity were harmonized. The serum vitamin D levels and blood glucose were investigated. The results revealed that, normal pregnant women had significantly higher vitamin D level than their GDM counterparts.Methods: This case-control study was conducted on healthy pregnant women attending routine antenatal care at Bangabandhu Sheikh Mujib medical university from January 2019 to December 2019 recruited at third trimester of gestation. We measured maternal serum vitamin D status (25[OH]D) in third trimester of pregnancy. GDM was diagnosed according to the American diabetes association. guidelines. Vitamin D status was defined as, vitamin D sufficiency (≥30 or ≥75 nmol/L), insufficiency (20-30 and 50-75 nmol/L), were used to categories participants according to their 25[OH]D concentrations. We calculated adjusted odds ratios and 95% confidence intervals (CIs) using logistic regression.Results: The mean serum vitamin D level was lower in case group case 23.4 (17.4±35.1) compared to that in control group 29.7 (15.4±39.8) and the difference between the 2 groups was statistically significant (p≤0.001). Sufficient level of vitamin D was more in control group (66.7%) than that of case group (26.1%). Insufficient level of vitamin D was higher in case (73.3%) group than that of control (33.3%) group. These findings were significant (p=0.021). Respondents with insufficient level of vitamin D have 3.1 times more chance to develop GDM.Conclusions: Serum vitamin D level is reduced in pregnant women having GDM.

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The relationship of serum vitamin D, calcium, and phosphorus levels of mothers with growth indices of their newborns in pregnant women admitted to Hajar hospital of Shahrekord in 2016

Journal of Shahrekord University of Medical Sciences ◽

10.34172/jsums.2019.41 ◽

2019 ◽

Vol 21 (5) ◽

pp. 237-243

Author(s):

Sheida Shabanian ◽

Neda Neyazi ◽

Abolfazl Khoshdel ◽

Soleyman Kheiri ◽

Mohammad Saleh Ghafari

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Analytical Study ◽

Phosphorus Deficiency ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Calcium And Phosphorus ◽

Relationship Of ◽

The Relationship ◽

Phosphorus Levels

Background and aims: Vitamin D deficiency is a known pandemic problem which has thousands of bad health outcomes. The aim of the current study was to investigate the effect of maternal vitamin D, Ca, and PO4 levels on growth indexes of newborns at birth and 1 month and 3 months after delivery in pregnant women admitted to Hajar hospital of Shahrekord, Iran in 2016. Materials and Methods: This descriptive-analytical study was conducted on 196 pregnant women admitted to the hospital. During pregnancy, 5 mL of mother’s blood and 5 mL of umbilical cord blood were taken. Serum calcium and phosphorus levels were determined immediately after sampling and then centrifuged. After collecting the samples, 25-OHD levels were measured by ELISA method. Neonatal growth indexes such as weight, height, and head circumference atbirth,1 month, and 3 months were measured. Data were analyzed using independent samples t test, ANOVA, and correlation coefficient by SPSS version 16.0. Results: Deficiency of vitamin D, phosphorus, and calcium was observed in 76%, 1%, and 25% of women, respectively. Moreover, deficiency of vitamin D, phosphorus, and calcium was reportedin56.1%, 15.8%, and 9.2% of newborns, respectively. There was a significant relationship between calcium level in newborns and their weight and height at birth, one month, and three months of age ( P<0.05). Levels of vitamin D, calcium and phosphorus of mother and newborns were significantly correlated ( P<0.05). Conclusion: More than two-thirds of mothers and more than half of the newborns were deficient in vitamin D. There was also a lack of calcium in one third of mothers and 9.2% of newborns, and phosphorus deficiency was observed only in 1% of mothers and 15.8% of newborns. Due to the low intake of these materials through nutrition, the supplementation of these substances, especially vitamin D and calcium, is required during pregnancy.

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