scholarly journals Changes in weight and body composition after initiating insulin therapy and their relationship with metabolic control during the first year of type 1 diabetes in adults. InLipoDiab1 Study

2021 ◽  
pp. e531
Author(s):  
Maja Miętkiewska ◽  
Aleksandra Uruska

Introduction. As in the general population, an increase in the incidence of overweight has been observed in individuals with type 1 diabetes (T1DM). Nevertheless, weight gain in this group may contribute to the deterioration of the metabolic management. The aim of this study was to evaluate changes in the body weight and body composition after initiating insulin therapy and to assess their relationship with the metabolic management during the first year of T1DM in adults.Material and Methods. The prospective analysis included 139 adults patients with newly diagnosed T1DM, treated with Intensive functional insulin therapy (IFI) from the onset of the disease (age 26.3 ± 5.9 years). Patients were assessed at the time of the diagnosis and after 12 months. Metabolic parameters, including the HbA1c and lipid profile were investigated. The group was divided according to weight gain during the follow-up period.Results. Weight gain was observed in 68.3% of participants (n = 95). In most cases an increase in body fat was found (41% vs 59% p = 0.01). Changes in the body weight corresponded to significant changes in body composition. Conversely, HbA1c decreased during the follow-up in all groups. The highest reduction was observed in a group with “excessive weight gain”. Additionally, a significant increase in high density lipoproteins was observed in each group. However, weight gain was not accompanied by a deterioration of the lipid profile.Conclusions. Weight gain is a considerable problem among adults with newly diagnosed T1DM and is connected mainly with an increase of adipose tissue above the normal range. Changes in the body weight, associated with body composition changes, did not result in the dysfunctions of the metabolic management.

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1371
Author(s):  
Kelly Giudici ◽  
Sophie Guyonnet ◽  
Yves Rolland ◽  
Bruno Vellas ◽  
Philipe de Souto Barreto ◽  
...  

This study aimed to analyze associations between weight variation patterns and changes in cognitive function and hippocampal volume among non-demented, community-dwelling elderly. Sample was formed of 1394 adults >70 years (63.9% female), all volunteers from the Multidomain Alzheimer Preventive Trial (MAPT). Weight loss was defined as ≥5% of body weight decrease in the first year of follow-up; weight gain as ≥5% of weight increase; and stability if <5% weight variation. Cognition was examined by a Z-score combining four tests. Measures were assessed at baseline, 6, 12, 24, 36, 48, and 60 months of follow-up. Hippocampal volume was evaluated with magnetic resonance imaging in 349 subjects in the first year and at 36 months. Mixed models were performed. From the 1394 participants, 5.5% (n = 76) presented weight loss, and 9.0% (n = 125) presented weight gain. Cognitive Z-score decreased among all groups after 5 years, but decline was more pronounced among those who presented weight loss (adjusted between-group mean difference vs. stable: −0.24, 95%CI: −0.41 to −0.07; p = 0.006). After 3 years, hippocampal atrophy was observed among all groups, but no between-group differences were found. In conclusion, weight loss ≥5% in the first year predicted higher cognitive decline over a 5 year follow-up among community-dwelling elderly, independently of body mass index.


1997 ◽  
Vol 92 (5) ◽  
pp. 481-486 ◽  
Author(s):  
A. C. Hackney ◽  
W. Hezier ◽  
T. P. Gulledge ◽  
S. Jones ◽  
D. Strayhorn ◽  
...  

1. As an ancillary study carried out during the recently completed Multicenter Study of Hydroxyurea, we examined the effect of hydroxyurea on the body weight, body composition and exercise capacity of adult patients with sickle-cell anaemia. 2. The subjects received either hydroxyurea (six males and four females) or placebo (eight males and six females). Data for each subject were generated during four separate 24 h admissions to the General Clinical Research Center. These admissions occurred at baseline and then at 6, 12 and 18 months after the start of study drug (hydroxyurea or placebo) administration. During each admission, body composition was measured by using a dual X-ray absorptiometer, and exercise testing was performed by cycle ergometry. Anaerobic performance was assessed according to a ‘Wingate’ protocol (20 s at maximal intensity against a cycling resistance of 7.5% body weight). Aerobic performance was examined using a steady state submaximal exercise protocol (10 min cycling time). 3. At baseline, no significant difference in any parameter was found between the hydroxyurea- and placebo-treated groups. At 18 months, the hydroxy-urea-treated subjects exhibited an average weight gain of 3.16 kg. The mean weight gain in the placebo-treated subjects was 1.82 kg. Body composition analysis showed that the additional weight in both groups involved both lean and fat body mass components. In anaerobic performance, the subjects given hydroxyurea showed an increase in peak muscle power of 104.9 W. The placebo group also showed an increase, but theirs was a more modest gain of 57.7 W. The most marked improvement in anaerobic performance was observed in the hydroxyurea-treated men (P < 0.05). In aerobic performance, the hydroxyurea-treated subjects exhibited a decrease in peak heart rate response to a standardized workload of 15.2 beats/min, as compared with a decrease of only 4.3 beats/min in the placebo-treated patients. 4. Taken together, the overall weight gain, combined with increases in both anaerobic muscular performance and aerobic cardiovascular efficiency, provides objective data to support the subjective impression that hydroxyurea administration produces an improvement in the physical capacity of patients with sickle-cell anaemia.


2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Bruce W. Bailey ◽  
Ciera L. Bartholomew ◽  
Caleb Summerhays ◽  
Landon Deru ◽  
Sharla Compton ◽  
...  

Purpose. Transitioning from high school to college generally results in reduced physical activity and weight gain at a rate that is higher than the general population. The purpose of this study was to examine the effects of three progressively higher step recommendations over 24 weeks on changes in body weight and body composition. Methods. Ninety-two freshmen college women wore a multifunction pedometer for 24 weeks after being randomly assigned to a daily step level: 10,000, 12,500, or 15,000. Pedometer data were downloaded every two weeks and participants were counseled on meeting their step recommendation. Body weight and body composition were assessed at baseline and 24 weeks. Body composition was assessed by dual X-ray absorptiometry. Results. On average, women took 10,786 ± 1501, 12,650 ± 2001, and 13,762 ± 2098 steps per day for the 10,000-, 12,500-, and 15,000-step groups, respectively (F = 15.48, P<0.0001). Participants gained 1.4 ± 2.6, 1.8 ± 2.1, and 1.4 ± 2.1 kg for the 10,000-, 12,500-, and 15,000-step groups, respectively (F = 37.74, P<0.0001). Weight gain was not significantly different between groups (F = 0.18, P=0.8385). There was also no difference in fat weight gain (F = 0.41, P=0.7954). Discussion. A step recommendation beyond 10,000 does not prevent weight or fat gain over the first year of college. Future research should focus on either intensity of physical activity or the addition of dietary interventions to prevent weight gain during the first year of college.


2002 ◽  
Vol 19 (5) ◽  
pp. 417-423 ◽  
Author(s):  
A. M. Rosenfalck ◽  
T. Almdal ◽  
J. Hilsted ◽  
S. Madsbad

2000 ◽  
Vol 50 ◽  
pp. 79
Author(s):  
AnneMette Rosenfalck ◽  
Thomas Almdal ◽  
Jannik Hilsted ◽  
Sten Madsbad

2011 ◽  
Vol 40 (4) ◽  
pp. 912-921 ◽  
Author(s):  
N.F. Sant´Ana ◽  
C.A.A. Fontes ◽  
R.S.T. Silva ◽  
C.S. Garcia ◽  
R.A.M. Vieira ◽  
...  

The objective of this work was to evaluate body composition and net requirements of protein and energy for weight gain of Nellore and crossbred F1 Limousin-Nellore steers finished on Mombasa grass pastures. Mombasa grass (Panicum maximum) pastures were managed under intermitent stocking during the rainy season, with a forage offer of 8% of the body weight (BW) based on the dry matter of green leaves. Twenty-four steers were used: 12 were Nellore (386 kg SBW) and 12 were F1 Limousin-Nellore (397 kg SBW). Changes in body composition in a 104-day experimental period were evaluated according to the comparative slaughter method. After slaughter, all body components were weighed and representative samples of carcass (HH section) and non-carcass tissues were collected, processed and chemically analyzed to determine body contents of protein, fat and energy in each animal. Linearized allometric equations were fitted to describe the pattern of growth of body components as a function of empty body weight of the animals. The obtained equations were derived to predict net requirements of protein and energy for weight gain. There were no differences between Nellore and crossbreed steers regarding to protein deposition. Nellore animals tended to a greater deposition of energy on weight compared to crossbred animals. It is possible to obtain well finished carcass in Nellore and crossbred steers with a greater weight on tropical pastures with an adequate supply of leaves.


2009 ◽  
Vol 38 (4) ◽  
pp. 746-751 ◽  
Author(s):  
Dulciene Karla Bezerra de Andrade ◽  
Antonia Sherlânea Chaves Véras ◽  
Marcelo de Andrade Ferreira ◽  
Mércia Virginia Ferreira dos Santos ◽  
Wellington Samay de Melo ◽  
...  

The body composition and net protein and energy requirements for weight gain of 5/8 Hostein-Zebu crossbred cattle raised in Brachiaria decumbens Spaft pasture were evaluated. In total, 16 bulls with 10 months of age and body weight (BW) of 180 ± 19.95 kg were used. The animals were kept with free access to pasture or with restricted grazing (from 6 to 10 h). Four animals were slaughtered at the beginning of the experimental period to estimate the empty body weight (EBW) and the initial body composition of the remaining animals. The other animals were slaughtered at the end of the 84-day trial period. The logarithm equations of the protein and energy body content were adjusted according to the logarithm of the empty body weight EBW. From these equations, the net protein and energy requirements for weight gain were estimated. There was an increase in fat (from 37.17 to 59.08 g/kg EBW) and energy (from 1.68 to 1.94 Mcal/kg EBW) concentrations, with increase in body weight from 150 to 250 kg. The protein and energy requirements for gaining 1 kg of EBW increased with the increase in body weight or empty body weight. The relationship between fat concentration in gain and protein requirements also increased, indicating that as the BW or EBW increase, more fat deposition in the gain is observed.


2018 ◽  
Vol 16 (2) ◽  
pp. 201-210
Author(s):  
Muryanto Muryanto ◽  
Pita Sudrajad ◽  
Amrih Prasetyo

The aim of the study was to determine the development of ramie plants (Boehmeria nivea L. Gaud) and the effect of using ramie leaves on feed on the body weight gain of Wonosobo Sheep (Dombos). Research on the development of ramie plants using survey methods in the area of ramie plant development in Wonosobo Regency. While the research on the use of ramie leaves for fattening was carried out in Butuh Village, Kalikajar District, Wonosobo Regency in 2018. 21 male Dombos were divided into 3 feed treatments with forage proportions of 70%, 50% and 30 ramie leaves respectively. %. The results showed that currently ramie plants were being developed in Wonosobo Regency by CV. Ramindo Berkah Persada Sejahtera in Gandok Village, Kalikajar District, Wonosobo Regency, Central Java. Until now the area of the crop has reached 13 ha. Of this area will produce ramie leaves 195,000 kg / year. If one sheep needs 4 kg of ramie / tail / day leaves, then the potential capacity of sheep is 135 heads / year, if the given one is 50% then the Jurnal Litbang Provinsi Jawa Tengah, Volume 16 202 Nomor 2 – Desember 2018potential capacity is 270 heads / year and if it is reduced again to 25% of ramie leaves then the potential capacity 440 heads / year. The use of ramie leaves as a feed for Wonosobo Sheep fattening can be given as much as 30% in fresh form.


Author(s):  
P. M, Lunagariya ◽  
R. S. Gupta ◽  
S. V. Shah ◽  
Y. G. Patel

The study was planned to evaluate the effect of exogenous fibrolytic enzymes (EFE) supplementation for 56 days @ 240 mg/kg total mixed ration (TMR) on digestibility of dry matter and nutrients in dairy cows. Six dry non-pregnant cows were assigned in each treatment with and without EFE. The digestibility trial of seven days was conducted after 49 days of feeding. Dry matter and nutrients intake of cows was not influenced by EFE. The supplementation of EFE had improved digestibility of dry matter, organic matter, crude fiber, neutral detergent fiber, cellulose (p less than 0.01), as well as digestibility of nitrogen-free extract and acid detergent fiber, was also higher (pless than 0.05). The body weight gain of cows was higher on the supplementation of EFE in TMR. The study concluded that feeding exogenous fibrolytic enzymes (240 mg/kg) supplemented TMR improved digestibility of dry matter and nutrients, which was reflected as higher body weight gain in dry non-pregnant Gir and crossbred dairy cows.


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