Relationships Between Serum α-Klotho Concentration and Inflammation-Related Cytokines in Hemodialysis Patients

2021 ◽  
Author(s):  
Katarzyna A. Lisowska ◽  
Hanna Storoniak ◽  
Monika Soroczyńska-Cybula ◽  
Mateusz Maziewski ◽  
Alicja Dębska-Ślizień
Keyword(s):  
Serum Concentration ◽  
Linear Regression Analysis ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Multivariable Linear Regression Analysis ◽  
Positive Correlations ◽  
The Relationship

Abstract We investigated the relationship between α-Klotho and cytokines related to inflammation in HD patients. We analyzed levels of α-Klotho with ELISA and inflammatory cytokines with CBA in the serum of HD patients. There was a significant negative correlation between the concentration of serum α-Klotho and patients’ age and the serum concentration of PTH. No correlation has been found between α-Klotho and Ca or Pi. HD time, creatynine or eGFR. However, there were significant positive correlations between the concentration of α-Klotho and the serum concentration of IL-12p70, IL-10, and IL-1β. Furthermore, the concentration of IL-10 and IL-1β was significantly lower in HD patients with low α-Klotho concentrations compared with HD patients with high α-Klotho. However, in a multivariable linear regression analysis, only patients’ age was associated independently with α-Klotho level. While these results draw our attention to potential relationships between α-Klotho proteins and inflammatory markers in HD patients, our cross-sectional study could not fully explain the pathogenic link between α-Klotho and inflammation in these patients. Therefore, further studies are necessary to clarify these relationships. However, this observation aligns with previous studies that confirm a significant relationship between Klotho concentration and human aging.

scholarly journals Association of Salivary Statherin, Calcium, and Proline-Rich Proteins on Oral Hygiene: A Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Deepak Gowda Sadashivappa Pateel ◽  
Shilpa Gunjal ◽  
Liew Fong Fong ◽  
Nur Sulwana Mohd Hanapi
Keyword(s):  
Oral Health ◽  
Negative Correlation ◽  
Oral Hygiene ◽  
Linear Regression Analysis ◽  
Rank Correlation ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

Background. Saliva, as a complex biofluid, plays a pivotal role in maintaining oral health and tooth integrity. There has been inconsistent data available on the relationship between salivary parameters and oral health. This study aims to investigate the association between salivary statherin, acidic proline-rich proteins (aPRP), and calcium with oral hygiene status. Methods. One hundred and eighty-eight healthy subjects aged between 18 and 50 years with varying oral hygiene status who gave consent to participate were included in this cross-sectional study. The subjects were recruited from primary oral health care of MAHSA University. Oral hygiene of all the participants was measured using Oral Hygiene Index–Simplified (OHI-S). Stimulated saliva collected using paraffin wax was analyzed for salivary statherin, aPRP, and calcium. The relationship between salivary statherin, aPRP, and calcium levels with OHI-S was assessed using Spearman’s Rank correlation coefficient; the strength of relationship was assessed by multiple linear regression analysis. Results. The study found a weak positive correlation (r = 0.179, p  = 0.014) between salivary statherin and OHI-S; weak negative correlation (r = −0.187, p  = 0.010) between salivary aPRP and OHI-S; and moderate negative correlation between salivary statherin and salivary aPRP levels (r = −0.50, p  < 0.001) which were statistically significant. Conclusion. Poor oral hygiene is associated with increased statherin and reduced aPRP levels in saliva. Thus, these salivary components may have a role in predicting oral hygiene status.

scholarly journals Bone responsiveness to parathyroid hormone is negatively associated with parathyroid hormone-lowering drug use in patients undergoing hemodialysis: a cross-sectional study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Naoto Tominaga ◽  
Tomoki Yonaha ◽  
Masayuki Yamanouchi ◽  
Hirofumi Sumi ◽  
Yasuhiro Taki ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tracp 5B

Abstract Background Parathyroid hormone (PTH) acts on bone to indirectly increase the number and activity of osteoclasts. Thus, PTH has a stimulatory effect on bone resorption and upregulates bone turnover. However, the responsiveness of bone to PTH varies widely among patients receiving dialysis. In fact, relative to the serum PTH level, the level of serum tartrate-resistant acid phosphatase-5b (TRACP-5b), a bone resorption marker derived from osteoclasts, varies as well. This study aimed to examine factors related to bone responsiveness to PTH in patients undergoing chronic hemodialysis (HD). Methods This study included patients receiving chronic HD in Kawasaki Municipal Tama Hospital (Kanagawa, Japan) and Yonaha Medical Clinic (Okinawa, Japan) and excluded patients who received HD for less than 6 months, those who received a combination of HD and peritoneal dialysis, and those who had cancer bone metastases or myeloma. The TRACP-5b/intact PTH (iPTH) ratio was created as an index of bone responsiveness to PTH, categorized into tertiles (low, medium, and high), and a cross-sectional study was conducted. P < 0.05 indicated statistically significant differences. Results One hundred and six patients were analyzed. Age (P = 0.010), body mass index (BMI) (P = 0.003), use of calcium-sensing receptor (CaSR) agonists (P = 0.008), use of vitamin D receptor activators (VDRAs) (P = 0.012), plasma iPTH level (P < 0.001), serum 1,25(OH)2D level (P = 0.003), and serum TRACP-5b level (P < 0.001) were significantly different among the three categories. In the single linear regression analysis, age (P = 0.016), corrected serum calcium level (P = 0.007), and ln [1,25(OH)2D] (P = 0.044) showed a significant positive correlation with ln [TRACP-5b/iPTH], whereas BMI (P = 0.026), use of CaSR agonists (P = 0.001), use of VDRAs (P = 0.009), and serum phosphorus level (P = 0.018) showed a significant negative correlation. Upon conducting multiple linear regression analysis incorporating significant variables in the single linear regression analysis, a significant negative correlation was observed between the TRACP-5b/iPTH ratio and intravenous administration of a CaSR agonist (etelcalcetide) and/or a VDRA (calcitriol or maxacalcitol) in all the adjusted models. Conclusions Bone responsiveness to PTH is negatively correlated with the intravenous administration of a CaSR agonist and/or a VDRA in patients undergoing chronic HD.

scholarly journals Influence of dietary habits on depression among patients with rheumatoid arthritis: A cross-sectional study using KURAMA cohort database

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255526
Author(s):  
Hiroto Minamino ◽  
Masao Katsushima ◽  
Motomu Hashimoto ◽  
Yoshihito Fujita ◽  
Mie Torii ◽  
...  
Keyword(s):  
Mental Disorder ◽  
Disease Activity ◽  
Dietary Habits ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Depression Score ◽  
Fish Intake ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship

Objective Although mental disorder is one of the most common comorbidities of rheumatoid arthritis (RA) and is known as a critical influence on RA remission rates, there is little knowledge regarding a possible therapeutic strategy for depression or anxiety in a RA population. Most recently, clinical evidence of dietary improvement for depression has emerged in a general population, but the relationship between dietary habits and mental disorder has not been investigated in RA. The purpose of this study is to elucidate clinical associations between mental disorder (depression/anxiety), dietary habits and disease activity/physical function in patients with RA. Methods A cross-sectional study was performed with 267 female outpatients from the KURAMA database. Using the Hospital Anxiety and Depression Scale (HADS), we classified the participants into three groups by depression state, and their characteristics were compared. Using the 20-items on the self-reported food frequency questionnaire, we investigated the relationship between dietary habits and depression or anxiety, adopting a trend test and a multivariate standardized linear regression analysis for the HADS score of depression or that of anxiety as a dependent variable. Results According to the classified stage of depression, current disease activity (DAS28-CRP: 28-Joint RA Disease Activity Score-C-reactive protein) and the health assessment questionnaire disability Index (HAQ-DI) were significantly increased. Trend analyses revealed that the depression score was inversely associated with the consumption of three food (fish, vegetables and fruit) out of twenty as was the anxiety score with only fish intake. Furthermore, multiple linear regression analysis revealed that the depression score was negatively associated with frequent fish intake (≥ 3 times per week) (Estimate -0.53, p = 0.033), HAQ-DI score within normal range (Estimate -0.88, p ≤ 0.001) and MTX use (Estimate -0.60, p ≤ 0.023). For the anxiety score, multivariate analysis showed similar but not significant associations with variables except for HAQ-DI score. Conclusions In a RA population, both depression and anxiety had a significant and negative association with HAQ-DI score, and depression rather than anxiety had negative association with frequent fish intake. Modification of dietary habits such as increased fish consumption may have a beneficial effect on the depression state in RA patients.

scholarly journals The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Song Li ◽  
Chu-Jin Zhao ◽  
Hong-Li Hua ◽  
Yu-Qin Deng ◽  
Ze-Zhang Tao
Keyword(s):  
Linear Regression Analysis ◽  
Specific Ige ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Chi Square Test ◽  
Serum Total Ige ◽  
The Relationship

Abstract Background The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, several others reported the lack of any existing association. This study aimed to investigate the relationship between allergy and sinusitis. Methods We conducted a cross-sectional study using a representative sample of the US population from the National Health and Nutrition Examination Survey 2005‒2006 (n  = 7244). A self-reported allergy questionnaire and total and allergen-specific IgE levels were used for analysis. Participants were divided into positive and negative allergy symptoms groups (PAS, NAS, respectively) to eliminate the influence of allergy symptoms on the apparent incidence of sinusitis. Pearson’s chi-square test and the linear regression analysis using Durbin Watson test were used for statistical analysis. Results Sinusitis incidence in the PAS group (22.4%; 521/2327) was significantly higher than that in the NAS group (7.1%; 348/4917) [odds ratios (OR)  = 3.788, 95% confidence interval (CI) 3.272‒4.384, P  < 0.001]. sinusitis incidence in non-sensitized and sensitized groups was not statistically different. After controlling for allergy symptoms, there was a negative correlation between sensitization status and the occurrence of sinusitis in the PAS group (OR  = 1.407, 95% CI 1.156‒1.711, P  < 0.01). Increase in serum total IgE levels correlated with decrease in incidence of sinusitis in both PAS and NAS groups. sinusitis incidence was significantly reduced in the PAS group in participants sensitized to allergens such as cockroaches, ragweed, ryegrass, Bermuda grass, oak, birch, and thistle. Conclusion Allergy is related to sinusitis incidence. It is likely that sensitization status could reduce the incidence of sinusitis, albeit in an antigen-specific manner.

The Relationship Between Anxiety and Intolerance of Uncertainty Levels in Individuals Who Received Liver Transplant: A Descriptive Cross-Sectional Study

2020 ◽  
pp. 105477382096291
Author(s):  
Erman Yıldız
Keyword(s):  
State Anxiety ◽  
Linear Regression Analysis ◽  
Intolerance Of Uncertainty ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Convenience Sample ◽  
The Mean ◽  
The Relationship

Studies have revealed that anxiety is associated with intolerance of uncertainty (IU); however, no study has examined the predictive effect of IU on anxiety in individuals with liver transplantation (LT). Therefore, this study aimed to identify the relationship between anxiety and IU levels in individuals who received LT. A descriptive cross-sectional study with a convenience sample ( N = 118) was conducted at a center in eastern Turkey. The data were analyzed using descriptive statistics, correlation, and hierarchical linear regression analysis. The mean scores for the dimensions of IU, state anxiety and trait anxiety were 34.42 ± 8.35, 40.38 ± 10.07, and 41.88 ± 7.53, respectively. IU and anxiety in individuals with LT were identified as related dynamics. Present findings suggest that uncertainty and IU can be considered in the conceptualization and treatment of anxiety and related pathologies. Nurses may seriously consider these results in order to increase the quality of the treatment and care provided to patients.

scholarly journals Relationship Between Social Activity and Frailty in Japanese Older Women During Restriction on Outings due to COVID-19

2021 ◽  
Vol 24 (4) ◽  
pp. 320-324
Author(s):  
Michiko Akita ◽  
Naoto Otaki ◽  
Miyuki Yokoro ◽  
Megumu Yano ◽  
Norikazu Tanino ◽  
...  
Keyword(s):  
Older Women ◽  
Linear Regression Analysis ◽  
Social Activity ◽  
Mail Survey ◽  
Cross Sectional Study ◽  
Multivariate Linear Regression Analysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship ◽  
Study Setting

Background  This study investigated the relationship between social activities and frailty during the restriction on outings due to COVID-19.  Design  A cross-sectional study.  Setting and Subjects  This study was conducted in City Nishinomiya of Prefecture Hyogo, in Japan. A mail survey was carried out among women aged 65 years or older in May 2020. A population of 293 women aged 65 years or older living in the community was recruited for the study and 213 of them were analyzed.  Measurements  The survey included questions on sex, age, height, weight, and social activity. Social activity consisted of participation in social organizations and their frequency, as well as frequency of interaction with family and friends. The survey also asked if regular social activity had been impeded by COVID-19.  Results  A significant association was found between frailty and hindered interaction with friends (β: 0.176, p = .014). Multivariate linear regression analysis confirmed that this association was also significant in Model 1 (β: 0.158, p = .025), and Model 2 (β: 0.148, p = .034).  Conclusions  No association between being hindered in social activity and frailty was found in older women living in the community during the restriction on outings due to COVID-19. 

scholarly journals The relationship between 25-hydroxyvitamin D concentration and liver enzymes in healthy adults: A Cross-sectional Study

2020 ◽  
Author(s):  
Ji-nian Wang ◽  
Li Li ◽  
Liang-yun Li ◽  
Qi Yan ◽  
Pan-pan Lian ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Diseases ◽  
Liver Enzymes ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Abstract Background: Studies have shown that serum 25-hydroxyvitamin D (25(OH)D), a product of exogenous vitamin D, plays an influential role in calcium and phosphorus balance, anti-inflammation, and cardiovascular protection. There were long-standing interests in the potential benefits of vitamin D for preventing liver diseases. Investigations showed that 25(OH)D was increased in adolescents with abnormal liver function. Yet data about the relationship of 25(OH)D concentration and liver enzymes from prospective cross-sectional study was limited. The present study is undertaken to examine whether serum 25-hydroxyvitamin D and alanine aminotransferase (ALT) ，glutamyl transferase (GGT) and alkaline phosphatase (ALP) were closely related. Methods: The cross-sectional study of 368 healthy volunteers with no history of liver diseases was used to examine risk factors. The associations between ALT, G and ALP and 25(OH)D were assessed by Pearson correlation and Spearman correlation, respectively. Linear regression analysis was carried out in different models with ALT, GGT and ALP as dependent variables. Results: The results found no significant difference between ALT and ALP in different vitamin D groups (25(OH)D < 25 nmol/L、25-50 nmol/L and > 50 nmol/L) ( Kruskal-Wallis test, all p > 0.05 ). Multiple linear regression analysis revealed that there were no significant association between ALT, GGT and ALP levels and 25(OH)D concentration, respectively, after adjusting covariates including age, BMI, sex, BuN, Cr, UA, AST, Ghb, ALB, WBC, cholesterol, HDL, LDL, cholesterol, and total protein. (All p > 0.1). Conclusion: This study suggested that there was no association between the 25(OH)D concentration and the levels of ALT, GGT or ALP in normal population.

scholarly journals Anxious temperament and cyberchondria as mediated by fear of COVID-19 infection: A cross-sectional study

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255750
Author(s):  
Włodzimierz Oniszczenko
Keyword(s):  
Rating Scale ◽  
Numerical Rating Scale ◽  
Linear Regression Analysis ◽  
Correlation Coefficients ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Severity Scale ◽  
Cross Sectional ◽  
Numerical Rating ◽  
Positive Correlations

This study’s main goal was to evaluate the association between anxious temperament and the fear of COVID-19-related self-infection and infection in loved ones (family members, friends, relatives) and cyberchondria. The sample consisted of 499 men and women aged between 18 and 72 who were gathered from the general population via an online recruitment platform. A numerical rating scale comprising 11 degrees of fear was used to assess participants’ COVID-19-related fear, and affective temperaments were evaluated using Akiskal’s Temperament Evaluation of the Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A) scales. Cyberchondria was assessed using McElroy and Shevlin’s Cyberchondria Severity Scale (CSS). Small to medium positive correlations were found between depressive, cyclothymic, irritable and anxious temperaments and cyberchondria and between depressive and anxious temperaments and COVID-19 fears. However, no correlation was observed between the hyperthymic temperament and cyberchondria. Cyberchondria positively correlated with both COVID-19 fears scales, though the correlation coefficients were medium. Based on the results of linear regression analysis, only anxious temperament and COVID-19 fear of self-infection were significant predictors of cyberchondria. The analysis also revealed a significant indirect effect of anxious temperament on cyberchondria through fear of COVID-19 self-infection as a mediator between anxious temperament and cyberchondria.

scholarly journals Influence of Dietary Habits on Depression Among Patients With Rheumatoid Arthritis: A Cross-Sectional Study Using KURAMA Cohort Database

2021 ◽  
Author(s):  
Hiroto Minamino ◽  
Masao Katsushima ◽  
Motomu Hashimoto ◽  
Yoshihito Fujita ◽  
Mie Torii ◽  
...  
Keyword(s):  
Disease Activity ◽  
Dietary Habits ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Depression Score ◽  
Fish Intake ◽  
Sectional Study ◽  
Cross Sectional ◽  
Physical Dysfunction ◽  
The Relationship

Abstract BackgroundAlthough depression is one of the most common comorbidities of rheumatoid arthritis (RA) and is known as a critical influence on RA remission rates, there is little knowledge regarding a possible therapeutic strategy for depression in a RA population. Most recently, clinical evidence of dietary improvement for depression has emerged in a general population, but the relationship between dietary habits and depression has not been investigated in RA. The purpose of this study is to elucidate clinical associations between depression, dietary habits and disease activity/physical function in patients with RA.MethodsA cross-sectional study was performed with 267 female outpatients from the KURAMA database. Using the Hospital Anxiety and Depression Scale (HADS), we classified the participants into three groups by depression state, and their characteristics were compared. Using the 20-items on the self-reported food frequency questionnaire, we investigated the relationship between dietary habits and depression or anxiety, adopting a trend test and a multivariate standardized linear regression analysis for the HADS score as a dependent variable.ResultsClassification of the depressive state revealed that current disease activity and physical dysfunction (28-Joint RA Disease Activity Score-C-reactive protein (DAS28-CRP) as well as the health assessment questionnaire disability Index (HAQ)) were significantly increased according to the stage of depression. Trend analysis identified three of 20 foods, i.e., fish, vegetables and fruit, the consumption of which was inversely associated with the depression score. Furthermore, multiple linear regression analysis revealed that the depression score was negatively associated with frequent fish intake (> 3 times per week) (Estimate -0.53, p = 0.033) as well as remission of HAQ (Estimate -0.88, p ≤ 0.001). For the anxiety score, none of the dietary habits showed any correlation in the multiple regression analysis.ConclusionDepression state assessed by HADS score was significantly and independently associated with both fish intake frequency and remission of physical dysfunction in an RA population. Modification of dietary habits, such as that by increased fish consumption, may have a beneficial effect on the depression state in RA patients.

Sign in / Sign up

Export Citation Format

Share Document