Evaluation of Haemodynamics and Morphology of Carotid Artery in Nonarteritic Anterior Ischaemic Optic Neuropathy

Abstract Purpose To compare haemodynamics and morphological changes of carotid artery in patients with unilateral non-arteritic anterior ischaemic optic neuropathy (NAION) with their contralateral side. Methods Twenty-six patients with unilateral NAION were included in this retrospective study. Colour Doppler imaging (CDI) was used to measure the haemodynamics and morphological changes of carotid artery, including blood flow velocities of common carotid artery (CCA) as well as the diameter of CCA, internal carotid artery (ICA), external carotid artery (ECA) and the thickness of carotid artery plaque. A paired-sample t test was performed to analyze those carotid artery hemodynamics and morphological changes between the affected eye and the unaffected contralateral eye. Subgroup analysis of the blood flow velocities of CCA was performed by dividing patients into two groups according to the presence/ absence of diabetes mellitus, hypertension or hyperlipidaemia. Results The average blood flow velocity of CCA in the affected eyes was 0.45 ± 0.13m/s, greater than that in the unaffected eyes (0.41 ± 0.15m/s) (p = 0.003; t=-3.321). Subgroup analysis found this significant bilateral difference was still existed in groups of diabetes mellitus, non-diabetes mellitus, and hypertension except for groups of non-hypertension, hyperlipidamemia, and non-hyperlipidaemia. The thickness of carotid artery plaque was 0.75 ± 1.33mm in the affected eyes, insignificantly differed from that in the unaffected eyes (0.55 ± 0.77mm) (p = 0.4). There were no difference in the diameters of the CCA, ICA, and ECA between the affected and unaffected eyes (p = 0.862, 0.758, and 0.72, respectively). Conclusions Increased CCA blood flow velocity might be associated with the development of NAION. Further study on larger scale are needed to confirm our findings.

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Diameter and haemodynamics of internal carotid artery siphon and ophthalmic artery in patients with non-arteritic anterior ischaemic optic neuropathy

10.21203/rs.2.14175/v1 ◽

2019 ◽

Author(s):

Zhiyong Fu ◽

Hongyang Li ◽

Yanling Wang

Keyword(s):

Blood Flow ◽

Carotid Artery ◽

Internal Carotid Artery ◽

Blood Flow Velocity ◽

Ophthalmic Artery ◽

Internal Carotid ◽

Flow Volume ◽

Blood Flow Volume ◽

Ischaemic Optic Neuropathy ◽

Anterior Ischaemic Optic Neuropathy

Abstract Purpose To compare the diameter and the haemodynamics of internal carotid artery siphon(ICAS) and ophthalmic artery (OA) in patients with unilateral non-arteritic anterior ischaemic optic neuropathy (NAION) with their contralateral sides and age-matched controls. Methods 30 patients clinically diagnosed with NAION (unilateral affected) and 30 age-matched controls participated in this study. By CTA, the diameter of ICAS and OA in both eyes were measured. By CDI, the blood flow velocity (Vm) and the blood flow volume of ICAS and OA in both eyes were measured or calculated. Measurements on the affected side of the patients were compared to the contralateral healthy side and the controls. Results Compared between the affected sides and the controls, the Vm, the diameter, and the blood flow volume in the ICAS were all significantly decreased (p<0.05), the Vm and the blood flow volume in the OA tended to be reduced (p=0.062, 0.055 respectively), while the difference of the diameter in the OA was insignificant (p=0.116). Compared between the affected sides and the unaffected healthy sides, the Vm, the diameter, and the blood flow volume in the ICAS were also significantly decreased (p<0.05), while no marked differences were detected in the OA, neither for the Vm, the diameter, or the blood flow volume(p=0.178, 0.151,0.173 respectively). Conclusion NAION may be associated with decreased blood flow velocity and diameter in the ICAS . These findings might be potentially useful in the monitoring of NAION.

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Imageology of internal carotid artery siphon in non-arteritic anterior ischaemic optic neuropathy

International Journal of Ophthalmology ◽

10.18240/ijo.2020.12.15 ◽

2020 ◽

Vol 13 (12) ◽

pp. 1941-1947

Author(s):

Zhi-Yong Fu ◽

Yan-Ling Wang

Keyword(s):

Blood Flow ◽

Carotid Artery ◽

Internal Carotid Artery ◽

Optic Neuropathy ◽

Internal Carotid ◽

Resistance Index ◽

Unaffected Side ◽

Significant Difference ◽

Ischaemic Optic Neuropathy ◽

Anterior Ischaemic Optic Neuropathy

AIM: To evaluate whether narrowing of internal carotid artery siphon (ICAS) may increase the risk of developing non-arteritic anterior ischaemic optic neuropathy (NAION). METHODS: Totally 30 consecutive patients who had unilateral NAION and 30 gender-matched control subjects were recruited in the present study. The diameter of ICAS of all the participants were measured using head-and-neck computed tomographic angiography (CTA). Color doppler flow imaging (CDI) was used to measure the haemodynamics parameters of ICAS and short posterior ciliary arteries (SPCAs) in all subjects. Comparison of parameters between the NAION patients and controls as well as between the two sides within the patients were performed. The correlation between the diameter of ICAS and NAION was analyzed. RESULTS: A comparison of parameters between the affected side of the NAION patients and the controls, including the diameter of ICAS, the resistance index (RI) of ICAS, the blood flow velocities of SPCAs and RI of SPCAs, showed significantly difference (P<0.01), while there was no significant difference in terms of the mean blood flow velocity (Vm) of ICAS; Similar results were found while comparing all the measurements of the affected and unaffected side of patients (P for RI of SPCAs <0.05). No marked difference was detected in nearly all parameters except for RI of ICAS and SPCAs between the unaffected side of the NAION patients and the controls (P<0.05). The diameter of ICAS were significantly positive correlated with both peak systolic velocity (PSV) of SPCAs and end diastolic velocity (EDV) of SPCAs in patients with NAION (r=0.514, P<0.01 and r=0.418, P<0.05, respectively). CONCLUSION: Narrowing of ICAS may increase the risk of developing NAION.

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Spontaneous oscillations in cerebral blood flow velocity in normal humans and in patients with carotid artery disease

Neuroscience Letters ◽

10.1016/0304-3940(91)90880-3 ◽

1991 ◽

Vol 127 (1) ◽

pp. 5-8 ◽

Cited By ~ 62

Author(s):

Rolf R. Diehl ◽

Beate Diehl ◽

Matthias Sitzer ◽

Michael Hennerici

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Carotid Artery ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Cerebral Blood Flow Velocity ◽

Carotid Artery Disease ◽

Normal Humans ◽

Spontaneous Oscillations ◽

Artery Disease

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Nailfold capillaroscopy in non-insulin dependent diabetes mellitus: blood flow velocity during rest and post-occlusive reactive hyperaemia

Clinical Physiology ◽

10.1111/j.1475-097x.1990.tb00825.x ◽

1990 ◽

Vol 10 (5) ◽

pp. 451-461 ◽

Cited By ~ 13

Author(s):

C. C. Pazos-Moura ◽

E. G. Moura ◽

E. Bouskela ◽

I. P. Torres Filho ◽

M. M. D. Breitenbach

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Nailfold Capillaroscopy ◽

Dependent Diabetes Mellitus ◽

Reactive Hyperaemia ◽

Insulin Dependent

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PECULIARITIES OF STATE OF PROTECTION AND AGGRESSION FACTORS IN PATIENTS WITH DIABETES MELLITUS TYPE II AND GASTROESOPHAGEAL REFLUX DISEASE

EUREKA Health Sciences ◽

10.21303/2504-5679.2020.001080 ◽

2020 ◽

Vol 1 ◽

pp. 27-34 ◽

Cited By ~ 1

Author(s):

Aleksey Oparin ◽

Anton Kudriavtsev ◽

Anatoliy Oparin

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Blood Flow Velocity ◽

Reflux Disease ◽

Diabetes Mellitus Type ◽

Type Ii ◽

Diabetes Mellitus Type Ii ◽

Patients With Diabetes

Diabetes mellitus is one of the most serious problems of the clinical medicine. This is determined by the fact that it is followed by multisystemic affects, as well as complications on the side of other organs and systems, among which a special place is occupied by gastroesophageal reflux disease. As for the combination and mutual influence of diabetes mellitus and gastroesophageal reflux disease, this issue has not been studied yet, the data of modern literature are not complete and quite contradictory. The aim of the study: to investigate the state of the factors of aggression and protection of the oesophageal mucosa in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease without associated pathology. Method. There were two groups of patients under observation. The first group included 45 patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease (26 men and 19 women). The second group included 38 patients with gastroesophageal reflux disease without associated pathology – 20 men and 18 women. By sex, age, body weight, Helicobacter pylori infection, smoking and alcohol consumption, both groups were comparable. The surveillance program included determining the compensation ratio of carbohydrate metabolism and the state of the factor. The antioxidant protection factor was assessed by the level of catalase activity in the blood serum, as well as by the diameter of the celiac trunk and the blood flow velocity in it. Statistical processing of the obtained data was carried out with the aid of the program WINDOWS STATISTIKA 6.0. For all types of analysis, differences were considered statistically significant with p<0.05. Results. During the study, we found that in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease, as well as in patients with gastroesophageal reflux disease without associated pathology, the level of pH-metry was reduced, but with varying measures of confidence. At the same time, we found that patients with GERD without associated pathology had a decrease in the blood flow velocity in the celiac trunk. Concurrently, we ascertained that the decrease in the blood flow velocity in patients of both groups reduced the diameter of the celiac trunk. Conclusions. In patients with diabetes mellitus type II, concomitant gastroesophageal reflux disease has a subtle clinical presentation that is affected by a significant decline in mucosal sealing protection factors. In patients with GERD without associated pathology, typical clinical manifestations, accompanied by inflammation, acid regurgitation and dyspepsia, are more vivid.

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