scholarly journals Association of Vitamin D Status and Cardio-Metabolic Risk Factors in Children and Adolescents: The CASPIAN-V Study

2020 ◽  
Author(s):  
Mostafa Qorbani ◽  
Motahar Heidari-Beni ◽  
Hanieh-Sadat Ejtahed ◽  
Gita Shafiee ◽  
Farid Goodarzi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Communicable Disease ◽  
Pediatric Population ◽  
Surveillance Program ◽  
Cross Sectional ◽  
Low Hdl ◽  
25 Hydroxy Vitamin D ◽  
And Control

Abstract Background: Metabolic syndrome (MetS) starts from early life, and is one of the important underlying factors for non-communicable disease (NCDs) in adulthood. Controversial evidence exists on the role of vitamin D deficiency in increasing risk of pediatric MetS. Objective: This study aimed to assess the relationship between vitamin D level with MetS and its components in children and adolescents. Methods: This cross-sectional nationwide study was performed as part of a surveillance program in Iran. Participants were 2596 students, aged 7 to 18 years, living in 30 provinces. In addition to filling questionnaires, physical examination was conducted, and blood samples were collected. Serum concentration of 25-hydroxy vitamin D (25(OH)D) was measured using direct competitive immunoassay chemiluminescene method.Results: 2596 students with mean age of 12.2 y (55.1% boys) were recruited. Prevalence of vitamin D deficiency and insufficiency in participants was 10.6% (n=276), and 60.5% (n=1570), respectively. Prevalence of MetS was higher in vitamin D deficient group. Students with deficient vitamin D level had higher odds of MetS (OR: 4.25, 95%CI: 2.26-7.98), abdominal obesity (OR: 2.24, 95%CI: 1.61-3.12), low HDL-C (OR: 1.65, 95%CI: 1.18-2.30) and high fasting blood sugar (OR: 2.56, 95%CI: 1.43-4.57) in comparison to those with sufficient level of vitamin D.Conclusion: Vitamin D deficiency was associated with increased odds of MetS and its components in Iranian pediatric population. These findings underscore the importance of prevention and control of vitamin D deficiency in preventative programs against NCDs.

scholarly journals Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study

BMC Nutrition ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mostafa Qorbani ◽  
Motahar Heidari-Beni ◽  
Hanieh-Sadat Ejtahed ◽  
Gita Shafiee ◽  
Farid Goodarzi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Pediatric Population ◽  
Cross Sectional Study ◽  
Surveillance Program ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Low Hdl ◽  
25 Hydroxy Vitamin D

Abstract Background Metabolic syndrome (MetS) starts from early life and is one of the important underlying factors for non-communicable diseases (NCDs) in adulthood. Controversial evidence exists on the role of vitamin D deficiency in increasing the risk of pediatric MetS. Objective This study aimed to assess the relationship between vitamin D level with MetS and its components in children and adolescents. Methods This nationwide cross-sectional study was performed as part of a surveillance program in Iran. Participants were 2596 students, aged 7 to 18 years, living in 30 provinces. In addition to filling questionnaires, a physical examination was conducted, and blood samples were collected. The serum concentration of 25-hydroxy vitamin D (25(OH)D) was measured using the direct competitive immunoassay chemiluminescence method. Results 2596 students with a mean age of 12.2 y (55.1% boys) were recruited. Prevalence of vitamin D deficiency and insufficiency in participants was 10.6% (n = 276), and 60.5% (n = 1570), respectively. The prevalence of MetS was higher in the vitamin D deficient group. Students with deficient vitamin D levels had higher odds of MetS (OR: 4.25, 95%CI: 2.26–7.98), abdominal obesity (OR: 2.24, 95%CI: 1.61–3.12), low HDL-C (OR: 1.65, 95%CI: 1.18–2.30) and high fasting blood sugar (OR: 2.56, 95%CI: 1.43–4.57) in comparison to those with sufficient level of vitamin D. Conclusion Vitamin D deficiency was associated with increased odds of MetS and its components in the Iranian pediatric population. These findings underscore the importance of prevention and control of vitamin D deficiency in preventative programs against NCDs.

Genetic Variation in CYP2R1 and GC Genes Associated With Vitamin D Deficiency Status

2016 ◽  
Vol 30 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Nicole A. Slater ◽  
Michelle L. Rager ◽  
Dawn E. Havrda ◽  
Arthur F. Harralson
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Total Serum ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Variant Alleles

This cross-sectional study enrolled 180 patients at a private family practice in Virginia. Total serum vitamin D concentrations were obtained weekly from January 30, 2013, through March 30, 2013, in consecutive patients regularly scheduled for laboratory work at the practice. Patients were categorized into 2 groups and analyzed for variant alleles in vitamin D receptor ( VDR; rs2228570), cytochrome P450 2R1 ( CYP2R1; rs10741657), 7-dehydrocholesterol reductase ( DHCR7; rs12785878), and group-specific component ( GC; rs2282679) to determine whether variants of those alleles influenced total serum 25(OH)D concentrations. One-hundred and eighty patients were enrolled, with 40 (22%) being sufficient, 25-hydroxy vitamin D level 25(OH)D ≥ 30 ng/mL, and 140 (78%) being insufficient, 25(OH)D < 30 ng/mL. Of the 4 genes, 2 genes, CYP2R1 (rs10741657) and GC (rs2282679), demonstrated a significant association related to vitamin D status. Subjects with 1 or more variant alleles at rs10741657 were almost 3.7 (odds ratio [OR] 3.67; 95% confidence interval [CI]: 1.35-9.99) times more likely be insufficient in vitamin D and subjects with 1 or more variant alleles at rs2282679 were about half (OR 0.42; 95% CI: 0.18-0.93) as likely to be insufficient in vitamin D. Allelic variations in CYP2R1 (rs10741657) and GC (rs2282679) affect vitamin D levels, but variant alleles on VDR (rs2228570) and DHCR7 (rs12785878) were not correlated with vitamin D deficiency, 25(OH)D < 30 ng/mL.

scholarly journals Serum Levels of Vitamin D in Diabetic Patients With and Without Retinopathy

2020 ◽  
Author(s):  
Mehrdad Afarid ◽  
Naghme Ghattavi ◽  
Mohammad Karim Johari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Proliferative Retinopathy ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
25 Hydroxy Vitamin D

Purpose: To evaluate the levels of vitamin D in the serum of diabetic patients with and without diabetic retinopathy (DR). Methods: Thirty patients with DR and thirty diabetic patients without retinopathy were included in this cross-sectional study. Based on ophthalmic examination, patients with DR were categorized into having non-proliferative retinopathy (NPDR) and proliferative retinopathy (PDR). Patients were tested for fasting blood sugar (FBS), hemoglobin A1C (HbA1C), 25-hydroxy vitamin D (25 (OH) D), and creatinine levels in the serum, and for urine protein. Vitamin D deficiency was defined as a serum 25 (OH) D level < 20 ng/mL. Results: We found that all diabetic patients had mild vitamin D deficiency (serum 25 (OH) D level = 10–20 ng/mL). The mean serum 25 (OH) D concentration in patients with DR was lower than in those without DR (12.10 ± 14.62 ng/mL vs 15.61 ± 9.40 ng/mL, respectively, P = 0.012). Trace or more proteinuria was frequently present in patients with DR than in those without DR (56% in DR vs 30% in non-DR; P = 0.037). There were no significant differences in the FBS, HbA1C, and serum creatinine levels between patients with or without retinopathy. Conclusion: The present study demonstrated that patients with DR had lower levels of serum vitamin D compared with those without retinopathy.

scholarly journals A Comparative Study of Serum 25-Hydroxy Vitamin D Levels in Children with Seizures Receiving Monotherapy and Polytherapy

2021 ◽  
Vol 11 (01) ◽  
pp. e331-e337
Author(s):  
Nazeem Fathima A. ◽  
Radha Kumar ◽  
Dev Kumar V. ◽  
Devanand Gulab Chaudhary
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
Hospital Setting ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

AbstractThe association between serum 25-hydroxy vitamin D (25(OH)D) antiepileptic drugs (AEDs) and bone health in individuals with epilepsy has been recognized for more than 30 years. Several studies indicate an increased risk for bone loss in patients on antiepileptic medication as well as low levels of serum 25(OH)D. Patients on polytherapy AED are at a higher risk of adverse drug effects compared with those on monotherapy. The present study assessed serum 25(OH)D levels in children receiving AED and compares those children receiving monotherapy versus polytherapy. This is a prospective cross-sectional study conducted in a tertiary care hospital setting on children with seizures receiving AEDs for period of more than 6 months. Participants were enrolled in three groups: 25 children on monotherapy, 25 children on polytherapy, and 25 healthy controls. Serum 25(OH)D level was performed for all children and analyzed. Serum 25(OH)D levels were normal in 52%, insufficient levels in 43.3%, and deficient in 6.7% of children. Vitamin D level was insufficient in 40% of children receiving monotherapy and 52% receiving polytherapy AED. Vitamin D deficiency was present in 4% in monotherapy group and 16% in polytherapy group which was statistically significant (p-value 0.047). Vitamin D deficiency was higher in children receiving AED compared with normal controls. Vitamin D deficiency and insufficiency were higher in children on polytherapy. Our study emphasized the importance of monitoring vitamin D levels in children receiving AED to detect abnormalities in vitamin D levels.

scholarly journals Association of Vitamin D Status and Physical Activity with Lipid Profile in Korean Children and Adolescents: A Population-Based Study

Children ◽  
2020 ◽  
Vol 7 (11) ◽  
pp. 241
Author(s):  
Kyungchul Song ◽  
Gihong Park ◽  
Youngha Choi ◽  
Jun Suk Oh ◽  
Han Saem Choi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Lipid Profile ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Korean Children ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Low Hdl ◽  
25 Hydroxyvitamin D

Dyslipidemia is one of the important influencing factors of cardiovascular health in the youth, and thus, assessment of its etiology is important. We aimed to investigate the association of dyslipidemia with vitamin D and physical activity in Korean children and adolescents. Data of 3183 subjects aged 12–18 years in the Korea National Health and Nutrition Examination Survey were analyzed. Participants were divided into subgroups according to sex, body mass index, 25-hydroxyvitamin D levels, and lipid profile. The mean 25-hydroxyvitamin D level was 16.15 ng/mL, which was below normal. In total, 79.3% of the subjects had vitamin D deficiency. Females had lower vitamin D levels and a higher incidence of dyslipidemia compared to males. Vitamin D deficiency was significantly associated with high density lipoprotein cholesterol (HDL-C) levels. The low HDL-C group consisted of a higher proportion of subjects with vitamin D deficiency and low physical activity. This study suggests that vitamin D deficiency is prevalent in Korean children and adolescents. Vitamin D deficiency and low physical activity are related with low HDL-C levels. Maintaining sufficient vitamin D levels and physical activity may help prevent dyslipidemia.

scholarly journals Prevalence of vitamin D deficiency in postmenopausal women and its association with fasting blood sugar

2019 ◽  
Vol 8 (7) ◽  
pp. 2617
Author(s):  
Mridu Sinha ◽  
J. K. Goel ◽  
Shanti Sah ◽  
Akanshamani .
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Blood Sugar ◽  
Hypovitaminosis D ◽  
Fasting Blood Sugar ◽  
Reference Level ◽  
Cross Sectional ◽  
High Prevalence ◽  
25 Hydroxy Vitamin D

Background: Vitamin D is indispensable for human body as it caters for both skeletal as well as extra-skeletal needs, especially in postmenopausal women. Aim of this study was to know the prevalence of vitamin D deficiency among apparent healthy postmenopausal women and to find its association with fasting blood sugar.Methods: This was a cross-sectional observational study of postmenopausal women attending Gynae OPD of Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, over a period of six months. Apparently healthy postmenopausal women were selected after satisfying inclusion-exclusion criteria and were subjected to fasting blood sugar and serum 25-hydroxy-vitamin D level. They were categorized as vitamin D deficient, insufficient or sufficient according to corresponding levels of <20ng/ml, 20-30ng/ml or >30ng/ml respectively. Upper reference level for fasting blood sugar was taken as 110mg/dl. Statistical analysis was done to see the association between vitamin D deficiency and fasting blood sugar.Results: Mean age of study group was 56.9 years and the average age of attainment of menopause was 50.3 years. Prevalence of vitamin D deficiency (57.4%) including insufficiency (13%) among postmenopausal women was high 70.4%, but there was no association between hypovitaminosis D and fasting blood sugar (p=0.949).Conclusions: Despite high prevalence of vitamin D deficiency among Indian postmenopausal women, there is no correlation between it and fasting blood sugar.

scholarly journals Association between serum 25-hydroxy vitamin D level and menstrual cycle length and regularity: A cross-sectional observational study

2021 ◽  
Author(s):  
Vinita Singh ◽  
Neelam Tamar ◽  
Zamir Lone ◽  
Esha Das ◽  
Rajshree Sahu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Menstrual Cycle ◽  
Vitamin D Deficiency ◽  
Cycle Length ◽  
Menstrual Disorders ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Menstrual Irregularities ◽  
25 Hydroxy Vitamin D

Background: Research examining the role of vitamin D deficiency and the development of menstrual disorders in women is of widespread interest. Studies have been published showing that supplementation with high-dose vitamin D can lead to the restoration of the menstrual cycle. We lack adequate information regarding the effect of vitamin D levels on the physiology of menstruation and further on fertility in women of reproductive age due to the contradictory results reported by studies. Objective: To study the association of 25-hydroxy vitamin D with menstrual cycle characteristics including long and short cycle length and cycle irregularity. Materials and Methods: In this cross-sectional study, serum vitamin D levels of 166 women attending an outpatient department with menstrual irregularities after excluding all obvious causes of menstrual disorders (n = 83) between April-June 2019 were measured and were compared with women of similar profiles with complaints other than menstrual irregularities (n = 83). Results: A decreased level of vitamin D was associated with a 13.3 times odds of an irregular cycle (OR (95% CI): 13.30 (5.79-30.60), p < 0.001). 25-hydroxy vitamin D was not associated with age or body mass index. We found a significant difference (p < 0.001) in mean vitamin D levels among the females with irregular cycles vs. regular cycles. Conclusion: Vitamin D plays a role in the physiology of reproduction specific to the menstrual cycle and ovulation. Long-term prospective studies assessing the exact cutoff value and the exact dose of supplementation required are needed. Key words: Menstrual disturbances, Ovulation, Reproductive period, Vitamin D deficiency, Dietary supplements, Polycystic ovarian syndrome.

scholarly journals Vitamin D Toxicity in A Pediatric Toxicological Referral Center: A Cross-Sectional Study from Iran

2020 ◽  
Author(s):  
Fariba Farnaghi ◽  
Hossein Hassanian-Moghaddam ◽  
Nasim Zamani ◽  
Narges Gholami ◽  
Latif Gachkar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pediatric Population ◽  
Demographic Data ◽  
Essential Element ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Benign Condition ◽  
Significant Difference ◽  
Vitamin D Toxicity

Abstract Background: Vitamin D is an essential element for body health whose supplements are generally administered to prevent vitamin D deficiency. Since these supplements are available at homes, vitamin D toxicity may happen in children.Methods: All children younger than 12 years who presented to the pediatric emergency department of Loghman Hakim Hospital, Tehran, Iran with history of ingestion ofvitamin D supplements more than 1500 IU/day were enrolled. Patients’ demographic data, on-presentation signs and symptoms, laboratory findings, treatments given, and outcome were evaluated.Result: Fifteenpatients presented during the study period. Their mean age was 46.53 ±10.14 months and 12 (80%) were girls. All of them had unintentionally ingested vitamin D. Mean ingested dose was 406700.7±227400.1 IU. In eight patients (53.3%), 25 Hydroxyvitamin D level was more than 100 ng/mL. One patient experienced hypercalcemia while all of them were asymptomatic and discharged without complications. There was no significant difference between patients with and without high levels of 25 OH vitamin D regarding lab tests, toxicity course, and outcome.Conclusion: It seems that acute vitamin D toxicity is a benign condition in our pediatric population which may be due to high prevalence of vitamin D deficiency in Iran.

scholarly journals 25-Hydroxyl Vitamin D Deficiency in Nasal Polyposis

2019 ◽  
Vol 24 (03) ◽  
pp. e308-e312
Author(s):  
Ankur Kumar Chandrakar ◽  
Arun Alexander ◽  
Medha R. ◽  
Kalaiselvi Rajendiran ◽  
Karthikeyan Ramasamy
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Disease Severity ◽  
Nasal Polyposis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
The Mean ◽  
Hs Crp

Abstract Introduction Vitamin D is known to have immunomodulatory functions and has action on chronic inflammatory processes, such as nasal polyposis. Objective The present study assessed the levels of 25-hydroxy vitamin D and high-sensitivity C-reactive protein (hs-CRP) in patients with nasal polyposis, as compared with healthy control subjects, and identified their association with disease severity in nasal polyposis. It further assessed the levels of 25-hydroxyl vitamin D and hs-CRP in patients with nasal polyposis and atopy and compared it with patients with nasal polyposis without atopy. Methods This was a cross-sectional study involving 2 groups: 80 patients with nasal polyposis and 80 healthy subjects. In patients with nasal polyposis, the disease severity is assessed by the sino-nasal outcome test (SNOT20) and by the Lund & Mackay staging system. Levels of 25-hydroxy vitamin D and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA). Result The mean 25-hydroxyl vitamin D levels (ng/ml) was 12.01 ± 7.29 for cases and 22.87 ± 14.95 for controls, with p < 0.0001. The mean hs-CRP levels (mg/L) was 5.99 ± 2.74 in cases and 2.41 ± 1.95 in controls, with p < 0.0001. The severity of polyposis correlated negatively with serum levels of 25-hydroxy vitamin D and positively with hs-CRP. Conclusion The study has thus shown significant correlation between vitamin D deficiency and inflammation in patients with nasal polyps.

scholarly journals Vitamin D Deficiency in Pregnant Women and Their Neonates

2016 ◽  
Vol 8 (9) ◽  
pp. 83 ◽  
Author(s):  
Maryam Abbasian ◽  
Reza Chaman ◽  
Mohammad Amiri ◽  
Mohammad Esmaeil Ajami ◽  
Tohid Jafari-Koshki ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Bone Mineralization ◽  
Calcium Deficiency ◽  
Cross Sectional Study ◽  
Vitamin D Insufficiency ◽  
Maternal Serum ◽  
Cross Sectional ◽  
25 Hydroxy Vitamin D

<p><strong>BACKGROUND</strong> <strong>&amp; OBJECTIVE:</strong> Vitamin D deficiency during pregnancy is a worldwide problem. Studies have reported prevalence ranged 18-84% in pregnant women. Receiving adequate calcium and vitamin D during pregnancy period is necessary for calcium homeostasis, fetal growth and bone mineralization. This study was aimed to determine the prevalence of vitamin D deficiency in pregnant women and their neonates in Shahroud city in the northeast Iran.</p><p><strong>METHODS:</strong> In this cross-sectional study, 284 pregnant women and their neonates referred to Fatemiyeh Hospital of Shahroud were included. Blood samples of mothers and umbilical cords were collected during the delivery and were sent to laboratory in order to measure calcium and 25-hydroxy vitamin D.<strong></strong></p><p><strong>FINDINGS:</strong> Amounts of Vitamin D insufficiency (20-30 ng/mL) and deficiency (&lt;20 ng/mL) in (mothers, neonates) were found to be (60.2%, 48.9%) and (1.1%, 2.5%) respectively. Calcium deficiency (&lt;8.5 mg/dL) was present in 33.5% of mothers and 25% of neonates. There was a weak correlation between maternal serum and cord blood 25-hydroxy vitamin D (r=0.12, p=0.053).<strong></strong></p><p><strong>CONCLUSION:</strong> More than half of the mothers and their neonates had some degrees of vitamin D deficiency. It is recommended to evaluate the nutritional status of vitamin D in pregnant women along with public health interventions to be carried out.</p>

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