scholarly journals Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

2021 ◽  
Author(s):  
Nikita J. Patel ◽  
Milan P. Dhaduk ◽  
Ravi A. Dabhi ◽  
Bhupesh S. Bhatt ◽  
Vaibhav D. Bhatt ◽  
...  
Keyword(s):  
Biological Activities ◽  
Conductivity Measurement ◽  
Binding Mode ◽  
Docking Studies ◽  
Antibacterial Study ◽  
H Nmr ◽  
Biological Studies ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
Mcf 7

Abstract A series of trisubstituted pyrazole-based ligands (L1-L6) and corresponding palladium(II) complexes were synthesized and characterized by conductivity measurement, 1H NMR, 13C NMR, Fourier Transform infrared (FT-IR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Synthesized compounds were screened for various biological activities. UV-Vis spectroscopy, viscosity measurement, fluorescence spectroscopy and molecular docking studies were used to determine the binding mode between HS-DNA and complexes, which suggest intercalation mode of binding. The protein binding study of complexes was evaluated by UV-visible spectroscopy. Antibacterial study of the complexes was screened against two Gram (+ve) and three Gram (-ve) bacteria and results show that all complexes are more effective against microorganisms than their respective ligands. The cytotoxicity of the synthesized compounds was tested against brine shrimp and MCF-7 Cells. The LC50 values of the ligand and complexes were found in the range of 9.24-4.12 µg/mL and 5.68-7.94 µg/mL, respectively.

scholarly journals Synthesis and characterization of VO(II), Cr(III),Mn(II), Fe(II),Zn(II),Cd(II),Hg(II) and UO2(VI) complexes with ligands containing (ONO) and (ON) donor set atoms

2008 ◽  
Vol 5 (2) ◽  
pp. 285-296
Author(s):  
Baghdad Science Journal
Keyword(s):  
Conductivity Measurement ◽  
Molar Ratio ◽  
Ratio Measurement ◽  
Mixed Ligands ◽  
Flame Atomic Absorption ◽  
State Study ◽  
Vis Spectroscopy ◽  
Atomic Absorption Technique ◽  
Ft Ir ◽  
Hydroxy Quinoline

A new Schiff base o-hydroxybenzylidene-1-phenyl-2,3-dimethyl-4-amino-3-pyrazolin-5-on (HL) ,have been prepared and characterization.(HL) has been used as a chelating ligand to prepare a number of metal complexes VO(II) ,Cr(III) ,Mn(II),Fe(II),Hg(II) and UO2(II) .and mixed ligands complexes have been prepared between o-hydroxybenzylidene-1-phenyl-2,3-dimethyl-4-amino-3-pyrazolin-5-on and 8- hydroxy quinoline with VO(II),Zn(II),Cd(II), Hg(II) and UO2(II) the prepared complexes were isolated and characterized by (FT-IR)and (UV-Vis) spectroscopy. Elemental analysis (C.H.N) Chloride contents, Flame atomic absorption technique. in addition to magnetic susceptibility and conductivity measurement. Molar ratio measurement in solution gave comparable results with those obtained from solid state study.

Structural, spectral and docking studies of a coordination polymer of zinc(II) formed by a pyridine-derived linker

2018 ◽  
Vol 73 (6) ◽  
pp. 369-375 ◽  
Author(s):  
Farzin Marandi ◽  
Keyvan Moeini ◽  
Fereshteh Alizadeh ◽  
Zahra Mardani ◽  
Ching Kheng Quah ◽  
...  
Keyword(s):  
Coordination Polymer ◽  
Docking Studies ◽  
Stacking Interactions ◽  
X Ray Diffraction ◽  
X Ray ◽  
H Nmr ◽  
Docking Calculations ◽  
Ft Ir ◽  
Zinc Coordination ◽  
Linear Coordination

AbstractA mixed ligand zinc coordination polymer, {Zn(μ-DPE)(DBM)2}n (1) (HDBM: dibenzoylmethane and DPE: (E)-1,2-di(pyridin-4-yl)ethene), was prepared and identified by elemental analysis, FT-IR, 1H NMR spectroscopy and single-crystal X-ray diffraction. In the 1D linear coordination polymer of 1, the zinc atom has a ZnN2O4 environment with octahedral geometry. These complex units are linked by the bridging of the planar N2 donor DPE ligands. In the coordination network of complex 1, in addition to the hydrogen bonds, the network is more stabilized by π–π stacking interactions between pyridine and β-diketone moieties of the ligands. These interactions increase the ability of the compound to interact with biomacromolecules (BRAF kinase, CatB, DNA gyrase, HDAC7, rHA, RNR, TrxR, TS and Top II) as investigated by docking calculations.

Study on Host-Guest Inclusion Complexation of a Drug in Cucurbit [6]uril

2018 ◽  
Vol 232 (2) ◽  
pp. 281-293 ◽  
Author(s):  
Kanak Roy ◽  
Subhadeep Saha ◽  
Biswajit Datta ◽  
Lovely Sarkar ◽  
Mahendra Nath Roy
Keyword(s):  
Surface Tension ◽  
Specific Conductivity ◽  
Inclusion Complexation ◽  
Conductivity Measurements ◽  
Saline Environment ◽  
H Nmr ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
The Stability ◽  
Ft Ir Spectroscopy

AbstractAssembly of pyridine-2-aldoxime drug with cucurbit [6]uril (CB[6]) has been investigated by1H-NMR and 2D-ROESY NMR, UV-Vis spectroscopy, FT-IR spectroscopy, surface tension and conductivity measurements in aqueous saline environment. The distinct cationic receptor feature and the cavity dimension of the CB[6] emphasize that the macro-cyclic host molecule remain as complex with the nerve stimulus drug molecule. The results obtained from surface tension and specific conductivity measurements suggest 1:1 inclusion complex formation between drug and CB[6]. The stability constant evaluated by UV-Vis spectroscopic approach is 2.21×105M−1at 298.15 K, which indicates that the complex is sufficiently stable at physiological temperature.

Lyotropic liquid crystalline phthalocyanines containing 4-((S)-3,7-dimethyloctyloxy)phenoxy moieties

2017 ◽  
Vol 21 (01) ◽  
pp. 16-23 ◽  
Author(s):  
Sibel Eken Korkut ◽  
Hale Ocak ◽  
Belkıs Bilgin-Eran ◽  
Dilek Güzeller ◽  
M. Kasım Şener
Keyword(s):  
Liquid Crystalline ◽  
Spectroscopic Properties ◽  
The Novel ◽  
H Nmr ◽  
Vis Spectroscopy ◽  
Wide Range ◽  
Ft Ir ◽  
Aggregation Behaviors ◽  
Mesomorphic Properties ◽  
Thermotropic Liquid Crystalline Behavior

The novel metal free phthalocyanine and its copper complex which are octa-substituted at the peripheral positions with 4-(([Formula: see text]-3,7-dimethlyoctyloxy)phenoxy moieties were synthesized and characterized by FT-IR, 1H NMR and mass spectroscopy. Their mesomorphic properties were studied by polarizing optical microscopy. The spectroscopic properties and aggregation behaviors of the novel phthalocyanines were also investigated by UV-vis spectroscopy in different solvents with same concentration as well as in a wide range of concentrations of chloroform. Both compounds with chloroform and [Formula: see text]-dodecane clearly show the lyotropic columnar mesophase in a wide temperature range whereas thermotropic liquid crystalline behavior for both compounds is not observed. Both of these novel compounds show no aggregation in toluene, tetrahydrofuran, dichloromethane and chloroform.

Synthesis, in vitro inhibition effect of novel phthalocyanine complexes as carbonic anhydrase and paraoxonase enzyme inhibitors

2020 ◽  
Vol 24 (08) ◽  
pp. 1047-1053
Author(s):  
Emre Güzel ◽  
Barış Seçkin Arslan ◽  
Kübra Çıkrıkçı ◽  
Adem Ergün ◽  
Nahit Gençer ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Enzyme Inhibitors ◽  
Inhibition Effect ◽  
H Nmr ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
First Time ◽  
Ft Ir Spectroscopy ◽  
C Nmr

The preparation and assessment of carbonic anhydrase and paraoxonase enzyme inhibition properties of 3-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)ethoxy)phthalonitrile (2) and its nitrogen-containing non-peripheral phthalocyanine derivatives (3 and 4) are reported for the first time. The new phthalonitrile and its phthalocyanine derivatives have been elucidated by FT-IR spectroscopy, 1H-NMR, [Formula: see text]C-NMR, mass and UV-vis spectroscopy. The results demonstrated that all synthesized compounds moderately inhibited carbonic anhydrase and paraoxonase enzymes. Among the compounds, the most active ones were found to be compound 4 for PON (Ki : 0.14 [Formula: see text]M), compound 3 for hCA I (Ki : 22.52 [Formula: see text]M) and compound 1 for hCA II (Ki : 13.62 [Formula: see text]M).

Reaction of 2-[(2-aminoethyl)amino]ethanol with pyridine-2-carbaldehyde and complexation of the products with CuII and CdII along with docking studies

2019 ◽  
Vol 75 (7) ◽  
pp. 951-959 ◽  
Author(s):  
Zahra Mardani ◽  
Mohammad Hakimi ◽  
Keyvan Moeini ◽  
Fabian Mohr
Keyword(s):  
Crystal Packing ◽  
Docking Studies ◽  
Molar Ratio ◽  
Distorted Octahedral Geometry ◽  
X Ray Diffraction ◽  
Donor Ligand ◽  
X Ray ◽  
H Nmr ◽  
Distorted Octahedral ◽  
Ft Ir

The reaction between 2-[2-(aminoethyl)amino]ethanol and pyridine-2-carbaldehyde in a 1:2 molar ratio affords a mixture containing 2-({2-[(pyridin-2-ylmethylidene)amino]ethyl}amino)ethanol (PMAE) and 2-[2-(pyridin-2-yl)oxazolidin-3-yl]-N-(pyridin-2-ylmethylidene)ethanamine (POPME). Treatment of this mixture with copper(II) chloride or cadmium(II) chloride gave trichlorido[(2-hydroxyethyl)({2-[(pyridin-2-ylmethylidene)amino]ethyl})azanium]copper(II) monohydrate, [Cu(C10H16N3O)Cl3]·H2O or [Cu(HPMAE)Cl3]·H2O, 1, and dichlorido{2-[2-(pyridin-2-yl)oxazolidin-3-yl]-N-(pyridin-2-ylmethylidene)ethanamine}cadmium(II), [CdCl2(C16H18N4O)] or [CdCl2(POPME)], 2, which were characterized by elemental analysis, FT–IR, Raman and 1H NMR spectroscopy and single-crystal X-ray diffraction. PMAE is potentially a tetradentate N3O-donor ligand but coordinates to copper here as an N2 donor. In the structure of 1, the geometry around the Cu atom is distorted square pyramidal. In 2, the Cd atom has a distorted octahedral geometry. In addition to the hydrogen bonds, there are π–π stacking interactions between the pyridine rings in the crystal packing of 1 and 2. The ability of PMAE, POPME and 1 to interact with ten selected biomolecules (BRAF kinase, CatB, DNA gyrase, HDAC7, rHA, RNR, TrxR, TS, Top II and B-DNA) was investigated by docking studies and compared with doxorubicin.

Influence of PCBM on the Glass Transition Temperature (Tg) of Poly(N-Vinylcarbazole)-Based Photorefractive Composite

2017 ◽  
Vol 896 ◽  
pp. 62-71 ◽  
Author(s):  
Bai Li Chen ◽  
Chuan Qun Huang ◽  
Rui Zhuang Yang ◽  
Yu Fang ◽  
Qing Jun Zhang ◽  
...  
Keyword(s):  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Acid Methyl Ester ◽  
Differential Scanning Calorimetric ◽  
H Nmr ◽  
Composite Polymers ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
Dsc Method

2,5-dimethyl-(4-p-nitrophenylazo) phenetole (DMNPAPE) was synthesized. And its structure was confirmed with ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared (FT-IR) spectra and 1H Nuclear Magnetic Resonance (1H NMR) spectroscopy. The photorefractive composite consist of 33 wt % poly (N-vinycarbazole) (PVK), 50 wt % 2, 5-dimethyl-(4-p-nitrophenylazo) phenetole (DMNPAPE) and 16 wt % ethyl carbazole (ECZ) doped with x wt % (≤1 wt%) [6, 6]-phenyl C61 butyric acid methyl ester (PCBM) was fabricated. The influence of PCBM on the glass transition temperature (Tg) of the photorefractive composite was studied using a differential scanning calorimetric (DSC) method. The active energy of glass transition (Eg) was evaluated by Kissinger’s and Moynihan’s relation. The analysis results indicate that the transition region shifts to higher temperatures with the increasing heating rate, and PCBM content (≤1.0 wt %) can influence Tg of PVK - based PR composite polymers. The Tg first increase and then went down with the PCBM content (below 1.0 wt %) increasing. The possible cause of the influence of PCBM on Tg was proposed.

scholarly journals SYNTHESIS OF INDOLE, COUMARINYL AND PYRIDINYL DERIVATIVES OF ISONIAZID AS POTENT ANTITUBERCULAR AND ANTIMICROBIAL AGENTS AND THEIR MOLECULAR DOCKING STUDIES

2017 ◽  
Vol 9 (12) ◽  
pp. 233 ◽  
Author(s):  
Anil S. Rathod ◽  
Shivakumar S. Godipurge ◽  
Jaiprakash S. Biradar
Keyword(s):  
Molecular Docking ◽  
Mode Of Action ◽  
Antimicrobial Agents ◽  
Antioxidant Activities ◽  
Docking Studies ◽  
Spectroscopic Methods ◽  
Biological Studies ◽  
H37rv Strain ◽  
Ft Ir ◽  
Derivatives Of

Objective: The aim of this study was to the synthesis of indole, coumarinyl and pyridinyl derivatives of isoniazid as potent anti-TB and antimicrobial agents and their molecular docking studies.Methods: The structures of the newly synthesized compounds were confirmed by FT-IR, 1HNMR, and Mass spectroscopic methods and to evaluate the biological studies like anti-TB, antimicrobial and antioxidant activities. The mode of action of these active compounds was carried out by molecular docking studies.Results: Among all the synthesized compounds tested 5d was found to be the most active with M. tuberculosis H37Rv strain at 12.5µg/ml, 5b at 25µg/ml, 4d was found to be the most active with S. typhi, S. aureus and A. Nizer, 5a with A. Oryzae, 5c with A. terrous and A. Flavous and 5d with Shegella at 100µg/ml and some of the compounds like 4d, 5a, 5b and 5d have shown promising antioxidant properties.Conclusion: All the synthesized compounds have exhibited promising anti-TB, antimicrobial and antioxidant activities. 

scholarly journals Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids

2009 ◽  
Vol 2009 ◽  
pp. 1-12 ◽  
Author(s):  
Mohamed A. Abdellah ◽  
Sotiris K. Hadjikakou ◽  
Nick Hadjiliadis ◽  
Maciej Kubicki ◽  
Thomas Bakas ◽  
...  
Keyword(s):  
Wistar Rat ◽  
In Vitro Cytotoxicity ◽  
X Ray ◽  
Biological Studies ◽  
Vis Spectroscopy ◽  
Hydroxybenzoic Acids ◽  
Ft Ir ◽  
Hydroperoxylinoleic Acid ◽  
Ft Raman

Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZAor p-H2BZA) of formulae[R2Sn(HL)2](whereH2L= o-H2BZAand R = Me- (1),n-Bu- (2));[R3Sn(HL)](whereH2L= o-H2BZAand R =n-Bu- (3), Ph- (4) orH2L= p-H2BZAand R =n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZAor p-H2BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy,H1,S119n-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes1and2have also been determined. Finally, the influence of these complexes1–6upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex6has the lowestIC50value. Also complexes1–6were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex4to be the most active one.

scholarly journals Antimicrobial and In Vitro Cytotoxic Efficacy of Biogenic Silver Nanoparticles (Ag-NPs) Fabricated by Callus Extract of Solanum incanum L.

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 341
Author(s):  
Islam Lashin ◽  
Amr Fouda ◽  
Adil A. Gobouri ◽  
Ehab Azab ◽  
Zuhair M. Mohammedsaleh ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Biological Activities ◽  
Leaf Explants ◽  
Pythium Ultimum ◽  
Phytopathogenic Fungi ◽  
Ag Nps ◽  
Solanum Incanum ◽  
Vis Spectroscopy ◽  
Ft Ir

The in vitro callus induction of Solanum incanum L. was executed on MS medium supplemented with different concentrations of auxin and cytokinin utilizing petioles and explants of leaves. The highest significant fresh weights from petioles and leaf explants were 4.68 and 5.13 g/jar for the medium supplemented with1.0 mg L−1 BA and 1.0 mg L−1 2,4-D. The callus extract of the leaves was used for the green synthesis of silver nanoparticles (Ag-NPs). Analytical methods used for Ag-NPs characterization were UV-vis spectroscopy, Fourier Transform Infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and Transmission Electron Microscopy (TEM). Spherical, crystallographic Ag-NPs with sizes ranging from 15 to 60nm were successfully formed. The FT-IR spectra exhibited the role of the metabolites involved in callus extract in reducing and capping Ag-NPs. The biological activities of Ag-NPs were dose-dependent. The MIC value for Staphylococcus aureus, Bacillus subtilis, and Escherichia coli was 12.5 µg mL−1, while it was 6.25 µg mL−1 for Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans. The highest inhibition of phytopathogenic fungi Alternaria alternata, Fusarium oxysporum, Aspergillus niger, and Pythium ultimum was 76.3 ± 3.7, 88.9 ± 4.1, 67.8 ± 2.1, and 76.4 ± 1.0%, respectively at 200 µg mL−1. Moreover, green synthesized Ag-NPs showed cytotoxic efficacy against cancerous cell lines HepG2, MCF-7 and normal Vero cell line with IC50 values of 21.76 ± 0.56, 50.19 ± 1.71, and 129.9 ± 0.94 µg mL−1, respectively.

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