scholarly journals Heart geometry in climacteric syndrome on the background of type 1 diabetes mellitus

2021 ◽  
Vol 17 (4) ◽  
pp. 304-307
Author(s):  
O.A. Goncharova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Left Ventricle ◽  
Type 1 Diabetes Mellitus ◽  
Postmenopausal Women ◽  
Wall Thickness ◽  
Estrogen Deficiency ◽  
The Body ◽  
Perimenopausal Women

Background. The climacteric period in women with type 1 diabetes mellitus (DM1) initiates an additional damaging effect on the existing cardinal pathology associated with DM. The purpose was to establish the features of geometric remodeling of the left ventricle (LV) of the heart in women with DM1 during the climacteric period. Materials and methods. The study involved 60 women with type 1 diabetes at the age of 48.74 ± 0.65 years, inclu­ding 41 perimenopausal and 19 postmenopausal ones. The control group consisted of 20 women without diabetes mellitus at the age of 50.02 ± 0.71 years. According to echocardiography, taking into account the stage of menopause, the indicators of the end-diastolic volume (EDV) and size (EDS), the posterior wall thickness of the LV (LVPWT) and the interventricular septum (IVST) were analyzed. The frequency of various types of geometric remodeling of the left ventricle of the heart was analyzed using the Penn Convention formula; for this, the LV myocardial mass index (LVMI) was calculated according to the formulas LVMI = 1.04 [(EDS + LVPWT + IVST)3 – EDS3] – 13.6 (LVMI = ratio LVMI to the plane of the body surface (A) in m2; AM2 = 1 + Weight + Δh / 100, where Δh is the difference between the height of a woman and 160 cm) and the relative wall thickness of the LV (LVRWT) LVRWT = 2LVPWT / EDS. Based on these data, the frequency of various types of geometric remodeling was established: normal geometry, concentric remode­ling, concentric or eccentric LV hypertrophy. Results. The data obtained indicate that postmenopausal women present a significant decrease in the frequency of normal heart geometry compared to perimenopausal women (26.4 versus 75.6 %, p < 0.001) and the frequency of concentric LV remodeling 3.5 times increases (26.3 versus 7.3 %, respectively). Concentric hypertrophy and eccentric LV hypertrophy prevailed 2.5 times in postmenopausal women (31.6 versus 12.1 % and 12.7 versus 4.9 %). Conclusions. In perimenopausal women with type 1 diabetes mellitus, in almost a quarter of cases, geometric remodeling of the left ventricle of the heart takes place. In postmenopausal women with estrogen deficiency, the frequency of pathologi­cal forms of heart geometry exceeds 75 %. The strategy of therapy for cardiac pathology in menopausal women against the background of DM1 should take into account the pathogenetic mechanisms of pathology associated with impaired carbohydrate metabolism and atherogenic measurements against the background of estrogen deficiency as well as limit polypharmacy.

scholarly journals Correlation between echocardiographic parameters of left ventricle and glycosylated hemoglobin in children with type 1 Diabetes Mellitus

2022 ◽  
Vol 3 (1) ◽  
pp. 44-52
Author(s):  
Valeriu ESANU ◽  
Ina PALII
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Left Ventricle ◽  
Type 1 Diabetes Mellitus ◽  
Wall Thickness ◽  
Structural Parameters ◽  
Glycosylated Hemoglobin ◽  
Left Ventricular ◽  
Systolic Volume

Introduction. Deterioration of left ventricular (LV) parameters in Diabetes Mellitus (DM) can occur in the absence of other heart problems. An association between glycosylated hemoglobin (HbA1c) and changes of the LV parameters in DM has been reported. However, data regarding this association model in children with Type 1 Diabetes Mellitus (T1DM) are limited. The purpose of the work was to investigate the association between HbA1c and the LV parameters in pediatric patients. Material and methods. The study was conducted on 28 children with T1DM ((aged 10 - 18 years, gender M (15)/F (13), duration ≥5 years). The clinical (standard medical examination) and paraclinical (biochemical dosage – HbA1c, echocardiography – LV functional and structural parameters) data was carried out. Statistical analysis  used the SPSS version 20. Results. The correlational study between the HbA1c and the LV parameters revealed a statistically significant positive correlation coefficient with aortic root diameter (mm) (r=0.7**, p<0.001), left atrium (mm) (r=0.8**, p<0.001 LV diastolic diameter (mm) (r=0.7**, p<0.001), LV systolic diameter (mm) (r=0.7**, p<0.001), septal wall thickness (mm) (r=0.5*, p=0.036), posterior wall thickness (mm) (r=0.5*, p=0.032), LV diastolic volume (ml) (r=0.5*, p=0.025), LV systolic volume (ml) (r=0.6**, p=0.01), ejection fraction (%) (r=0.7**, p=0.001), fractional shortening (%) (r=0.6**, p=0.002). Conclusions. The results of the study show that in children with T1DM, the increase value of the HbA1c is associated with a consensual and proportional increase in the values of the parameters of the left ventricle.  

scholarly journals Control of Blood Glucose Level for Type 1 Diabetes Mellitus using Improved Hovorka Equations: Comparison between Clinical and In-Silico Works

2020 ◽  
Author(s):  
Nur’Amanina Mohd Sohadi ◽  
Ayub Md Som ◽  
Noor Shafina Mohd Nor ◽  
Nur Farhana Mohd Yusof ◽  
Sherif Abdulbari Ali ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Type 1 Diabetes Mellitus ◽  
Glucose Level ◽  
In Silico ◽  
Artificial Pancreas ◽  
The Body

AbstractBackgroundType 1 diabetes mellitus (T1DM) occurs due to inability of the body to produce sufficient amount of insulin to regulate blood glucose level (BGL) at normoglycemic range between 4.0 to 7.0 mmol/L. Thus, T1DM patients require to do self-monitoring blood glucose (SMBG) via finger pricks and depend on exogenous insulin injection to maintain their BGL which is very painful and exasperating. Ongoing works on artificial pancreas device nowadays focus primarily on a computer algorithm which is programmed into the controller device. This study aims to simulate so-called improved equations from the Hovorka model using actual patients’ data through in-silico works and compare its findings with the clinical works.MethodsThe study mainly focuses on computer simulation in MATLAB using improved Hovorka equations in order to control the BGL in T1DM. The improved equations can be found in three subsystems namely; glucose, insulin and insulin action subsystems. CHO intakes were varied during breakfast, lunch and dinner times for three consecutive days. Simulated data are compared with the actual patients’ data from the clinical works.ResultsResult revealed that when the patient took 36.0g CHO during breakfast and lunch, the insulin administered was 0.1U/min in order to maintain the blood glucose level (BGL) in the safe range after meal; while during dinner time, 0.083U/min to 0.1 U/min of insulins were administered in order to regulate 45.0g CHO taken during meal. The basal insulin was also injected at 0.066U/min upon waking up time in the early morning. The BGL was able to remain at normal range after each meal during in-silico works compared to clinical works.ConclusionsThis study proved that the improved Hovorka equations via in-silico works can be employed to model the effect of meal disruptions on T1DM patients, as it demonstrated better control as compared to the clinical works.

scholarly journals The influence of diabetic autonomous neuropathy on myocardial remodeling in type 1 diabetes mellitus

2011 ◽  
Vol 14 (2) ◽  
pp. 49-52
Author(s):  
Irina Arkad'evna Bondar' ◽  
Elena Anatol'evna Koroleva ◽  
Olga Grigor'evna Chudinova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Left Ventricle ◽  
Type 1 Diabetes Mellitus ◽  
Interventricular Septum ◽  
Posterior Wall ◽  
Left Ventricular ◽  
Myocardial Remodeling ◽  
Left Ventricular Myocardial Mass

Aim. To assess the influence of diabetic autonomous neuropathy (DAN) on left ventricular myocardial remodeling in type 1 diabetes mellitus. Materials and methods. The study included 78 patients (30 men and 48 women) with DM1 (mean age 28.9?8.3 years, DM1 duration9.7?7.5 years). DAN was diagnosed by standard ECG tests (Valsalva and breathing tests). The patients were examined using echocardiographywith the measurement of the thickness of interventricular septum (IVS) and left ventricle posterior wall (PW), end diastolic and systolic size (EDS and ESS) of the left ventricle, left ventricular myocardial mass (MM), MM index and relative wall thickness (RWT). LV hypertrophy(LVH) was diagnosed at MM index ?134 g/m2 in men and ?110 g/m2 in women; concentric and excentric types of LV hypertrophy wererecorded at RWT ?0.45 and

scholarly journals Analysis of literature data on the relationship between vitamin D deficiency and type 1 diabetes mellitus

2021 ◽  
pp. 28-32
Author(s):  
Victoriia Fylymonenko ◽  
Liubov Galuzinska ◽  
Tetiana Briukhanova ◽  
Olena Chumak ◽  
Olena Yatsenko
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Experimental Studies ◽  
The Body ◽  
The Status ◽  
The Relationship

Type 1 diabetes mellitus is a chronic autoimmune disease in which genetic predisposition and environmental factors play a major role. Vitamin D deficiency is becoming a pandemic in the world and is observed in type 1 diabetes mellitus. The aim. Analytical review of available literature data on the relationship of vitamin D deficiency with the development and course of type 1 diabetes mellitus. Materials and methods. Analysis of open sources of scientific literature. Results and discussion. Clinical observations and experimental studies show that vitamin D deficiency is one of the risk factors for the development of type 1 diabetes, and is a consequence of this disease. The status of vitamin D in the body is determined not only by the intake of vitamin from the outside, but also by the activity of tissue transport and metabolism systems, which have a high degree of polymorphism. Numerous studies show the positive effect of the use of vitamin D preparations in the prevention and treatment of type 1 diabetes mellitus. However, there are works in which there is no protective effect. Conclusions. Thus, the optimization of the status of vitamin D in the body is a promising measure to prevent the development of type 1 diabetes and facilitate its course, but requires further research.

Serum fibronectin content in the patients suffering from type 1 diabetes mellitus with microangiopathies since the childhood and in the subjects presenting with obesity

2015 ◽  
Vol 61 (1) ◽  
pp. 36-40
Author(s):  
L A Mogil’nitskaya
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
The Body ◽  
Important Condition ◽  
Diabetic Angiopathies ◽  
Pathological Conditions ◽  
Carbohydrate And Lipid Metabolism

Micro- and macroangiopathies are the main causes of disability and mortality among the patients suffering from diabetes mellitus. Endothelial dysfunction is the early and important condition preceding the development of diabetic angiopathies. The serum fibronectin content may be one of the markers of endothelial dysfunction. We have documented the enhanced serum fibronectin content in the patients suffering from type 1 diabetes mellitus with concomitant microangiopathies and in the subjects presenting with obesity. The rise in the serum fibronectin level correlated with the body mass index, parameters of carbohydrate and lipid metabolism. Alteration of these parameters discovered in the present study may be used as the markers of endothelial dysfunction associated with the above pathological conditions.

Emerging Aspects of the Body Composition, Bone Marrow Adipose Tissue and Skeletal Phenotypes in Type 1 Diabetes Mellitus

2019 ◽  
Vol 22 (3) ◽  
pp. 420-428 ◽  
Author(s):  
Adriana L. Carvalho ◽  
Bianca Massaro ◽  
Luciana T. P. e Silva ◽  
Carlos E.G. Salmon ◽  
Sandra Y. Fukada ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Marrow ◽  
Type 1 Diabetes ◽  
Body Composition ◽  
Adipose Tissue ◽  
Type 1 Diabetes Mellitus ◽  
The Body ◽  
Bone Marrow Adipose Tissue ◽  
Marrow Adipose Tissue
Sign in / Sign up

Export Citation Format

Share Document