scholarly journals Tailormade Drug Delivery System: A Novel Trio Concept of 3DP+ Hydrogel+ SLA

2019 ◽  
Vol 9 (4-s) ◽  
pp. 861-866 ◽  
Author(s):  
Lalita Devi ◽  
Punam Gaba ◽  
Hitesh Chopra
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery System ◽  
Delivery System ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
System A ◽  
Hydrogel Formation ◽  
Organic Fluids ◽  
Dimensional Printing

Hydrogels possess three-dimensional polymeric network structure and equipped for retaining extensive measure of water or organic fluids. This quality makes them as exceptional candidate for the simulation of extra cellular matrixes. For this the three dimensional printing (3DP) has evolved as the technique for the formation of the digital models. The 3DP is capable for processing the prescriptions and the therapeutic gadgets. One of the technique known as stereolithographic (SLA) printing has shown promising results in formulating the hydrogel based system for fabrication. The SLA acts by cross connecting the saps to shape the polymer matrices. Due to water captured in the gels it is conceivable to create the pre- wetted, medicate hydrogels and gadgets. The 3DP helps in formation of tailor made drug delivery system as per needs of patients. Many of Bioinks has been tried up for the hydrogel formation such as collagen, gelatin, hyaluronan, silk, alginate, and nanocellulose etc. Keywords: 3D Printing, Hydrogel, Steriolithography

scholarly journals 3D Printing Technology in Pharmaceutical Drug Delivery

2021 ◽  
Vol 68 (1) ◽  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Computer Aided Design ◽  
Three Dimensional ◽  
Pharmaceutical Manufacturing ◽  
Three Dimensional Printing ◽  
Pharmaceutical Drug ◽  
Pharmaceutical Technology ◽  
Aided Design ◽  
Dimensional Printing

Three dimensional printing (3DP) enables the development of diverse geometries through computer aided design using different techniques and materials for desired applications such as pharmaceutical drug delivery system. The process of 3D printing was patented in 1986; however, the research in the field of 3DP did not become popular until the last decade. There has been an increasing research into the areas of 3DP for medical applications for fabricating prosthetics, bioprinting and pharmaceutics. It becomes one of the most innovatory and influential tools serving as a technology of precise manufacturing of developed dosage forms, tissue engineering and disease modelling. It is a valuable strategy to overcome some challenges of conventional pharmaceutical process. This technology will reform the pharmaceutical manufacturing style and formulation techniques. The present review focused on various techniques, applications of 3D printing in pharmaceutical technology.

scholarly journals Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization

2022 ◽  
Vol 15 (1) ◽  
pp. 68
Author(s):  
Tarek A. Ahmed ◽  
Hanadi A. Alotaibi ◽  
Waleed S. Alharbi ◽  
Martin K. Safo ◽  
Khalid M. El-Say
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Seed Oil ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Black Seed Oil ◽  
Compression Characteristics ◽  
Dimensional Printing

Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study their quality attributes and pharmacokinetics behavior. Black seed oil based self-nanoemulsifying drug delivery system (SNEDDS) formulation was developed and characterized. Glimepiride liquisolid and directly compressed tablets were prepared and their pre-compression and post-compression characteristics were evaluated. Semi-solid pastes loaded with SNEDDS were prepared and used to develop three-dimensional printing tablets utilizing the extrusion technique. In vivo comparative pharmacokinetics study was conducted on Male Wistar rats using a single dose one-period parallel design. The developed SNEDDS formulation showed a particle size of 45.607 ± 4.404 nm, and a glimepiride solubility of 25.002 ± 0.273 mg/mL. All the studied tablet formulations showed acceptable pre-compression and post-compression characteristics and a difference in their in vitro drug release behavior. The surface of the liquisolid and directly compressed tablets was smooth and non-porous, while the three-dimensional printing tablets showed a few porous surfaces. The inner structure of the liquisolid tablets showed some cracks and voids between the incorporated tablet ingredients while that of the three-dimensional printing tablets displayed some tortuosity and a gel porous-like structure. Most of the computed pharmacokinetic parameters improved with the liquisolid and three-dimensional printed tablets. The relative bioavailabilities of the three-dimensional printed and liquisolid tablets compared to commercial product were 121.68% and 113.86%, respectively. Therefore, the liquisolid and three-dimensional printed tablets are promising techniques for modifying glimepiride release and improving in vivo performance but more clinical investigations are required.

An Update on Recent Advances in Cubosome: A Novel Drug Delivery System

2021 ◽  
Vol 21 ◽  
Author(s):  
Madhukar Garg ◽  
Anju Goyal ◽  
Sapna Kumari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Lipid Bilayers ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Three Dimensional ◽  
Biologically Active ◽  
Potential Applications ◽  
Health Related ◽  
Novel Drug

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

Recent Applications of Nanoemulsion Based Drug Delivery System: A Review

2021 ◽  
pp. 2852-2858
Author(s):  
Asif Eqbal ◽  
Vaseem Ahamad Ansari ◽  
Abdul Hafeez ◽  
Farogh Ahsan ◽  
Mohd Imran ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Therapeutic Agents ◽  
Topical Drug Delivery ◽  
Transdermal Drug Delivery System ◽  
Small Droplet ◽  
Pharmaceutical Application ◽  
System A

Nanoemulsions are drug transporters for the delivery of therapeutic agents. They possess the small droplet size having the range of 20×10-9-200×10-9m. The main purpose of using Nanoemulsion is to enhance the drug bio- availability of transdermal drug delivery system. With the help of phase diagram, we can select the components of nanoemulsion depending upon formulas ratio of oil phase, surfactant/co-surfactant and water phase. Nanoemulsion directly used as a topical drug delivery in skin organs. The most useable pharmaceutical application has been developed till date to provide systemic effects to penetrating the full thickness of skin organ layer nanoemulsions can be administered through variety of routes such as percutaneous, perioral, topical, transdermal, ocular and parental administration of medicaments. Nanoemulsions are transparent and slightly opalescent. Nanoemulsion can be prepared through various methods. Nanoemulsions are transparent and slightly opalescent. Factor affecting nanoemulsions are surfactant, viscosity, lipophilic, drug content, pH, concentration of each component, and methodology of formulation. It is unfeasible to test all factors at the various levels. Design of formulation when it comes to experimental design it gives an excellent approach through reducing the time and money.

Recent Advancement and Technological Aspects of Pulsatile Drug Delivery System - A Laconic Review

2017 ◽  
Vol 18 (10) ◽  
Author(s):  
Vinay Pandit ◽  
Ajay Kumar ◽  
Mahendra S. Ashawat ◽  
Chander P. Verma ◽  
Pravin Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
System A ◽  
Recent Advancement ◽  
Pulsatile Drug Delivery

scholarly journals Colon Targeted Drug Delivery System – A Review.

2018 ◽  
Vol 9 (1) ◽  
pp. 2604-2635
Author(s):  
Ankit Dugad . ◽  
Pravin Nalawade . ◽  
Ravindra Thakhre . ◽  
Sujit Kakade .
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
System A ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

scholarly journals BIOADHESIVE MULTIPARTICULATE (MICROSPHERS) DRUG DELIVERY SYSTEM: A REVIEW

2013 ◽  
Vol 3 (2) ◽  
Author(s):  
Ravindra B Borade ◽  
Yogesh Y Mahajan ◽  
Nilesh P Jadhav ◽  
Jaiprakash V Kokane ◽  
Md. Rageeb Md. Usman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
System A
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