scholarly journals Refractory bronchorrhea and mucinous pleural effusion caused by lung metastasis of pancreatic cancer

2021 ◽  
Author(s):  
Taro Yoneda ◽  
Hayato Koba ◽  
Tsukasa Ueda ◽  
Chihoka Nakai ◽  
Hiroko Morita ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pleural Effusion ◽  
Bronchial Asthma ◽  
Lung Metastasis ◽  
Malignant Disease

Our case indicates that when bronchorrhea and mucinous pleural effusion with pancreatic cancer are observed, bronchorrhea due to malignant disease should be taken into consideration and, bronchorrhea derived from not bronchial asthma but lung metastasis of pancreatic cancer could lead to be refractory.

scholarly journals An update of the long-term outcome of patients with nonspecific pleurisy at medical thoracoscopy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yan-Xia Yu ◽  
Yuan Yang ◽  
Yan-Bing Wu ◽  
Xiao-Juan Wang ◽  
Li-Li Xu ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Disease ◽  
Long Term Outcomes ◽  
Benign Diseases ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Medical Thoracoscopy ◽  
One Year

Abstract Background Medical thoracoscopy (MT) is recommended in patients with undiagnosed exudative pleural effusion and offers a degree of diagnostic sensitivity for pleural malignancy. However, not all patients who undergo MT receive an exact diagnosis. Our previous investigation from 2014 summarized the long-term outcomes of these patients with nonspecific pleurisy (NSP); now, we offer updated data with the goal of refining our conclusions. Methods Between July 2005 and August 2018, MT with pleural biopsies were performed in a total of 1,254 patients with undiagnosed pleural effusions. One hundred fifty-four patients diagnosed with NSP with available follow-up data were included in the present study, and their medical records were reviewed. Results A total of 154 patients were included in this study with a mean follow-up duration of 61.5 ± 43.7 months (range: 1–180 months). No specific diagnosis was established in 67 (43.5%) of the patients. Nineteen patients (12.3%) were subsequently diagnosed with pleural malignancies. Sixty-eight patients (44.2%) were diagnosed with benign diseases. Findings of pleural nodules or plaques during MT and the recurrence of pleural effusion were associated with malignant disease. Conclusions Although most NSP patients received a diagnosis of a benign disease, malignant disease was still a possibility, especially in those patients with nodules or plaques as noted on the MT and a recurrence of pleural effusion. One year of clinical follow-up for NSP patients is likely sufficient. These updated results further confirm our previous study’s conclusions.

scholarly journals Histiocytic pleural effusion: The strong clue to malignancy

2021 ◽  
Author(s):  
Ganghee Chae ◽  
Jae-Bum Jun ◽  
Hwa Sik Jung ◽  
Chui Yong Park ◽  
Jin Hyoung Kim ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Pleural Fluid ◽  
Malignant Pleural Effusion ◽  
Clinical Characteristics ◽  
Malignant Disease ◽  
White Blood Cells ◽  
University Hospital ◽  
Lung Cancers ◽  
Fluid Analysis ◽  
Tuberculous Pleurisy

Abstract Background There have been many studies on the clinical characteristics of neutrophilic, lymphocytic, and/or eosinophilic pleural effusion. While caring for patients with pleural effusion, we found that histiocytic pleural effusion (HisPE) was not uncommon. However, few studies have explored HisPE. The purpose of the present study was to determine the clinical characteristics and etiologies of HisPE. Methods In this retrospective study, HisPE was defined as pleural fluid white blood cells comprised of ≥ 50% histiocytes. Using a clinical data warehouse, patients with HisPE among all patients aged > 18 years who underwent thoracentesis and pleural fluid analysis between January 2010 and December 2019 at Ulsan University Hospital were enrolled. A total of 295 (9.0%) of 3279 patients who underwent thoracentesis were identified as HisPE patients. Among them, 201 with exudative HisPE were included. Clinical characteristics and etiologies were extracted from medical records and analyzed. Results Among the 201 patients with exudative HisPE, the major causes were malignant pleural effusion (n = 102 [50.7%]), parapneumonic effusion (n = 9 [4.5%]), and tuberculous pleurisy (n = 9 [4.5%]). In the 102 patients with malignant pleural effusion, the main types of cancer were lung (n = 42 [41.2%]), breast (n = 16 [15.7%]), and stomach cancer (n = 11 [10.8%]). Among lung cancers, adenocarcinoma (n = 34 [81.0%]) was the most common histology. Conclusions The leading cause of exudative HisPE was malignancy, particularly lung cancer. Physicians should consider the possibility of malignant disease if histiocytes are predominantly present in pleural effusion.

Characteristics of Lung Metastasis as an Initial Recurrence Pattern After Curative Resection of Pancreatic Cancer

Pancreas ◽  
2020 ◽  
Vol 49 (5) ◽  
pp. 699-705
Author(s):  
Daishi Morimoto ◽  
Suguru Yamada ◽  
Fuminori Sonohara ◽  
Hideki Takami ◽  
Masamichi Hayashi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lung Metastasis ◽  
Curative Resection ◽  
Recurrence Pattern ◽  
Initial Recurrence

scholarly journals A case report of resection for postoperative lung metastasis of pancreatic cancer after systemic chemotherapy

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S543
Author(s):  
S. Takamatsu ◽  
T. Irie ◽  
S. Kato ◽  
H. Nagano ◽  
S. Ootsukasa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Case Report ◽  
Lung Metastasis ◽  
Systemic Chemotherapy

Lumen-apposing metal stent for treatment of malignant biliary obstruction, placed through an uncovered duodenal self-expanding metal stent

2021 ◽  
Vol 14 (4) ◽  
pp. e238599
Author(s):  
Rasmus Due-Petersson ◽  
Lasse Bremholm Hansen
Keyword(s):  
Pancreatic Cancer ◽  
Biliary Obstruction ◽  
Malignant Disease ◽  
Oral Intake ◽  
Malignant Biliary Obstruction ◽  
Metal Stents ◽  
Endoscopic Stenting ◽  
Duodenal Stenosis ◽  
Metal Stent ◽  
Duodenal Stent

The development and refinement of endoscopic stenting techniques in recent years have made endoscopic treatment an important part of palliative care for irresectable malignant disease in the gastrointestinal tract. We present the case of a 82-year-old man with biliary obstruction and duodenal stenosis on the basis of disseminated pancreatic cancer. He was bothered by jaundice and reduced oral intake. This is typically alleviated using stents; however, the placement of a duodenal stent can limit the possibility of subsequent placement of a biliary stent. This therapeutic challenge was solved using a combination of lumen-apposing metal stents (LAMS) and self-expanding uncovered metal stents (SEMS). LAMS is a relatively novel type of stent intended for endoscopic ultrasonography-guided placement. First, we placed a SEMS in the duodenum, a LAMS was subsequently placed through the mesh of the duodenal SEMS, alleviating the biliary system. The patient was able to resume oral intake and his jaundice subsided.

scholarly journals Incidence, aetiology and clinical features of eosinophilic pleural effusion: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Minfang Li ◽  
Yunxiang Zeng ◽  
Yaqing Li ◽  
Dan Jia ◽  
Sheng Chen ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Pleural Effusion ◽  
Peripheral Blood ◽  
Malignant Disease ◽  
Prognostic Significance ◽  
High Incidence ◽  
Wbc Count ◽  
Underlying Diseases ◽  
The Relationship ◽  
Eosinophilic Pleural Effusion

Abstract Background Eosinophilic pleural effusion (EPE) is a distinct entity among pleural effusions, but its diagnostic and prognostic significance is still controversial. This study aimed to evaluate the incidence and aetiological distribution of EPE in our institution and to assess the relationship between EPE and malignancy and other underlying diseases and the relevance of the percentage of eosinophils and other laboratory parameters. Methods A retrospective study was conducted by reviewing the medical records of 252 patients with PE from September 2017 to January 2021. Results EPE was found in 34 (13.49%) out of 252 patients. There were 20 (58.82%) males and 14 (41.18%) females in the EPE group. The mean percentage of eosinophils in EPE (21.7%, range (10.0–67.5%)) was significantly higher than the percentage of eosinophils in peripheral blood (5.65%, range (0–34.60%); p < 0.05). The most common cause of EPE was malignant disease (52.94%), followed by idiopathy (14.71%), parasites (8.82%), pneumonia (8.82%) and others (14.71%). Comparative analysis of patients with malignant versus nonmalignant EPE showed that patients with malignant EPE were significantly older, and had a lower white blood cell (WBC) count in the pleural fluid (1.8 vs 4.7 cells × 109/L, p < 0.05). However, the percentage of eosinophils in PE was not significantly different between malignant EPE and nonmalignant EPE (p = 0.66). There was no correlation between the percentage of eosinophils in PE and peripheral blood (r = 0.29; p = 0.09). Conclusions Malignant disease ranks as the leading cause of EPE. The presence of EPE should not be considered as a predictive factor of benign conditions. Pleural parasitic infestation (PPI) should be emphasized in areas with a high incidence of parasitic disease.

CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
D Saur ◽  
B Seidler ◽  
G Schneider ◽  
H Algül ◽  
RM Schmid
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Lung Metastasis ◽  
Cxcr4 Expression
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