scholarly journals Agreement of the Point of Care Test (POCT) Boditech iCHROMA™ Covid-19 IgG Antibody Assay with the Abbott Architect SARSCoV- 2 IgG Antibody Assay

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
John Bolodeoku
Keyword(s):  
Point Of Care ◽  
Antibody Assay ◽  
Igg Antibody ◽  
Point Of Care Test ◽  
Abbott Architect

scholarly journals Kinetics and performance of the Abbott Architect SARS-CoV-2 IgG antibody assay

2020 ◽  
Author(s):  
Fergus Hamilton ◽  
Peter Muir ◽  
Marie Attwood ◽  
Alan Noel ◽  
Barry Vipond ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Clinical Settings ◽  
Antibody Testing ◽  
Antibody Assay ◽  
Igg Antibody ◽  
Negative Results ◽  
Hospitalised Patients ◽  
And Performance ◽  
Negative Controls ◽  
Abbott Architect

ObjectivesTo assess the performance (sensitivity and specificity) of the Abbott Architect SARS-CoV-2 IgG antibody assay across three clinical settings.MethodsAntibody testing was performed on three clinical cohorts of COVID-19 disease: hospitalised patients with PCR confirmation, hospitalized patients with a clinical diagnosis but negative PCR, and symptomatic healthcare workers (HCW’s). Pre-pandemic respiratory infection sera were tested as negative controls. The sensitivity of the assay was calculated at different time points (<5 days, 5-9 days, 10-14 days, 15-19 days, >20 days, >42 days), and compared between cohorts.ResultsPerformance of the Abbot Architect SARS-CoV-2 assay varied significantly between cohorts. For PCR confirmed hospitalised patients (n = 114), early sensitivity was low: <5 days: 44.4% (95%CI: 18.9%-73.3%), 5-9 days: 32.6% (95%CI, 20.5%-47.5%), 10-14 days: 65.2% (95% CI 44.9%-81.2%), 15-20 days: 66.7% (95% CI: 39.1%-86.2%) but by day 20, sensitivity was 100% (95%CI, 86.2-100%).In contrast, 17 out of 114 symptomatic healthcare workers tested at >20 days had negative results, generating a sensitivity of 85.1% (95%CI, 77.4% - 90.5%). All pre-pandemic sera were negative, a specificity of 100%. Seroconversion rates were similar for PCR positive and PCR negative hospitalised cases.ConclusionsThe sensitivity of the Abbot Architect SARS-CoV-2 IgG assay increases over time, with sensitivity not peaking until 20 days post symptoms. Performance varied markedly by setting, with sensitivity significantly worse in symptomatic healthcare workers than in the hospitalised cohort. Clinicians, policymakers, and patients should be aware of the reduced sensitivity in this setting.

scholarly journals Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19

2020 ◽  
Author(s):  
Mina Psichogiou ◽  
Andreas Karabinis ◽  
Ioanna D. Pavlopoulou ◽  
Dimitrios Basoulis ◽  
Konstantinos Petsios ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Attack Rate ◽  
Point Of Care ◽  
Igg Antibody ◽  
Point Of Care Test ◽  
Care Workers ◽  
Potential Risk Factors ◽  
Second Wave ◽  
Weighted Prevalence

AbstractGreece is a country with limited spread of SARS-CoV-2 and cumulative infection attack rate of 0.12% (95%CI 0.06%-0.26%). Health care workers (HCWs) are a well-recognized risk group for COVID-19. The study aimed to estimate the seroprevalence of antibodies to SARS-CoV-2 in two hospitals and assess potential risk factors. Hospital-1 was involved in the care of COVID-19 patients while hospital-2 was not. A validated, rapid, IgM/IgG antibody point-of care test was used. 1,495 individuals consented to participate (response rate 77%). The anti-SARS-CoV-2 weighted prevalence was 1.07% (95%CI 0.37-1.78) overall and 0.44% (95%CI 0.12-1.13) and 2.4% (95%CI 0.51-8.19) in hospital-1 and hospital-2, respectively. The overall, hospital-1, and hospital-2 seroprevalence was 9, 3 and 20 times higher than the estimated infection attack rate in general population, respectively. Suboptimal use of personal protective equipment was noted in both hospitals. These data have implications for the preparedness of a second wave of COVID-19 epidemic.

scholarly journals Preliminary Results of Seroprevalence of SARS-CoV-2 at Community Clinics in Tokyo

2020 ◽  
Author(s):  
Morihito Takita ◽  
Tomoko Matsumura ◽  
Kana Yamamoto ◽  
Erika Yamashita ◽  
Kazutaka Hosoda ◽  
...  
Keyword(s):  
Point Of Care ◽  
Cross Reactivity ◽  
Igg Antibody ◽  
Community Clinics ◽  
Diagnostic Pcr ◽  
Point Of Care Test ◽  
Positive Rate ◽  
Specific Igg ◽  
Novel Coronavirus ◽  
Low Sensitivity

AbstractSerological evaluation with SARS-CoV-2 specific IgG antibody will be an alternative way to know the pandemic of novel coronavirus disease (COVID-19) if the capacity for diagnostic PCR test is limited. The point-of-care test to detect SARS-CoV-2 specific IgG antibody in peripheral blood (n =202) was performed in two community clinics in Tokyo, Japan. The overall positive rate of SRAS-CoV-2 IgG antibody was 5.9% (95% confidence interval[CI]: 3.1-10.1). Higher rate was observed for healthcare workers (n =55, 9.1 [3.0-20.0]). The limitation on antibody tests includes low sensitivity and potent cross-reactivity with the previous coronavirus. Robust healthcare policy to efficiently monitor COVID-19 spread is warranted in Tokyo.

scholarly journals Development of an immunochromatographic point-of-care test for detection of IgG antibody in serodiagnosis of human trichinellosis

2021 ◽  
Author(s):  
Tongjit Thanchomnang ◽  
Lakkhana Sadaow ◽  
Oranuch Sanpool ◽  
Pewpan M. Intapan ◽  
Rutchanee Rodpai ◽  
...  
Keyword(s):  
Point Of Care ◽  
Igg Antibody ◽  
Point Of Care Test ◽  
Human Trichinellosis

scholarly journals Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243025 ◽  
Author(s):  
Mina Psichogiou ◽  
Andreas Karabinis ◽  
Ioanna D. Pavlopoulou ◽  
Dimitrios Basoulis ◽  
Konstantinos Petsios ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Attack Rate ◽  
Point Of Care ◽  
Igg Antibody ◽  
Comparative Performance ◽  
Point Of Care Test ◽  
Care Workers ◽  
Potential Risk Factors ◽  
Second Wave

Introduction Greece is a country with limited spread of SARS-CoV-2 and cumulative infection attack rate of 0.12% (95% CI 0.06–0.26). Health care workers (HCWs) are a well-recognized risk group for COVID-19. The study aimed to estimate the seroprevalence of antibodies to SARS-CoV-2 in a nosocomial setting and assess potential risk factors. Methods HCWs from two hospitals participated in the study. Hospital-1 was a tertiary university affiliated center, involved in the care of COVID-19 patients while hospital-2 was a tertiary specialized cardiac surgery center not involved in the care of these patients. A validated, CE, rapid, IgM/IgG antibody point-of-care test was used. Comparative performance with a reference globally available assay was assessed. Results 1,495 individuals consented to participate (response rate 77%). The anti-SARS-CoV-2 weighted prevalence was 1.26% (95% CI 0.43, 3.26) overall and 0.53% (95% CI 0.06, 2.78) and 2.70% (95% CI 0.57, 9.19) in hospital-1 and hospital-2, respectively although the study was underpowered to detect statistically significant differences. The overall, hospital-1, and hospital-2 seroprevalence was 10, 4 and 22 times higher than the estimated infection attack rate in general population, respectively. Suboptimal use of personal protective equipment was noted in both hospitals. Conclusions These data have implications for the preparedness of a second wave of COVID-19 epidemic, given the low burden of SARS-CoV-2 infection rate, in concordance with national projections.

scholarly journals Kinetics and performance of the Abbott architect SARS-CoV-2 IgG antibody assay

2020 ◽  
Vol 81 (6) ◽  
pp. e7-e9 ◽  
Author(s):  
Fergus Hamilton ◽  
Peter Muir ◽  
Marie Attwood ◽  
Alan Noela Barry Vipond ◽  
Richard Hopes ◽  
...  
Keyword(s):  
Antibody Assay ◽  
Igg Antibody ◽  
And Performance ◽  
Abbott Architect

Testing for resistance: Point-of-care testing as a communicational tool in antibiotic prescribing

2018 ◽  
Vol 14 (3) ◽  
pp. 229-240
Author(s):  
Johanna Lindell
Keyword(s):  
Point Of Care ◽  
Rapid Test ◽  
Antibiotic Use ◽  
Treatment Recommendation ◽  
Antibiotic Prescribing ◽  
Communicative Practices ◽  
Effective Strategies ◽  
Reactive Protein ◽  
Point Of Care Test ◽  
Test Result

As antibiotic resistance becomes a growing health emergency, effective strategies are needed to reduce inappropriate antibiotic use. In this article, one such strategy – communicative practices associated with the C-reactive protein point-of care test – is investigated. Building on a collection of 31 videorecorded consultations from Danish primary care, and using conversation analysis, this study finds that the rapid test can be used throughout the consultation to incrementally build the case for a nonantibiotic treatment recommendation, both when the test result is forecast and reported. The study also finds that the format of reports of elevated results differs from that of ‘normal’ results, resulting in a subtle shift of authority from doctor to test.

Novel High Sensitivity Tuberculosis Point-of-Care Test for People Living with HIV

2018 ◽  
Author(s):  
Tobias Broger ◽  
Bianca Sossen ◽  
Elloise du Toit ◽  
Andrew D. Kerkhoff ◽  
Charlotte Schutz ◽  
...  
Keyword(s):  
Point Of Care ◽  
High Sensitivity ◽  
People Living With Hiv ◽  
Point Of Care Test ◽  
Living With Hiv

scholarly journals Longitudinal analysis of antibody decay in convalescent COVID-19 patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Weiming Xia ◽  
Mingfei Li ◽  
Ying Wang ◽  
Lewis E. Kazis ◽  
Kim Berlo ◽  
...  
Keyword(s):  
Immune Response ◽  
Reduction Rate ◽  
Mixed Linear Model ◽  
Decay Rates ◽  
Primary Study ◽  
Igg Antibody ◽  
Blood Samples ◽  
Response Capacity ◽  
Index Level ◽  
Abbott Architect

AbstractDetermining the sustainability of antibodies targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for predicting immune response against the Coronavirus disease 2019 (COVID-19). To quantify the antibody decay rates among the varying levels of anti-nucleocapsid (anti-N) Immunoglobulin G (IgG) in convalescent COVID-19 patients and estimate the length of time they maintained SARS-CoV-2 specific antibodies, we have collected longitudinal blood samples from 943 patients over the course of seven months after their initial detection of SARS-CoV-2 virus by RT-PCR. Anti-N IgG levels were then quantified in these blood samples. The primary study outcome was the comparison of antibody decay rates from convalescent patients with high or low initial levels of antibodies using a mixed linear model. Additional measures include the length of time that patients maintain sustainable levels of anti-N IgG. Antibody quantification of blood samples donated by the same subject multiple times shows a gradual decrease of IgG levels to the cutoff index level of 1.4 signal/cut-off (S/C) on the Abbott Architect SARS-CoV-2 IgG test. In addition, this study shows that antibody reduction rate is dependent on initial IgG levels, and patients with initial IgG levels above 3 S/C show a significant 1.68-fold faster reduction rate compared to those with initial IgG levels below 3 S/C. For a majority of the donors naturally occurring anti-N antibodies were detected above the threshold for only four months after infection with SARS-CoV-2. This study is clinically important for the prediction of immune response capacity in COVID-19 patients.

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