scholarly journals In vivo histomorphologically evaluate of the initial bone healing in geopolymer-carbonated apatite nanocomposites as a potential dental implant material

2021 ◽  
Vol 33 (1) ◽  
pp. 63
Author(s):  
Dahlia Sutanto ◽  
Mieke Hemiawati Satari ◽  
Bethy Suryawathy Hernowo ◽  
Bambang Pontjo Priosoeryanto ◽  
Rifki Septawendar ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Dental Implant ◽  
Bone Healing ◽  
Biologically Active ◽  
Wilcoxon Test ◽  
Carbonate Apatite ◽  
Carbonated Apatite ◽  
Woven Bone ◽  
Implant Material ◽  
Bone Response

Introduction: Dental implants have become more common treatment for replacing missing teeth. Titanium and zirconia have been widely applied as dental implant material because of their excellent biocompatibility and biomechanics properties. However, they are lack of biologically active surface that encourages osseointegration and their mechanical properties significant different from enamel and dentin value. Carbonate apatite Ca10(PO4)x(CO3)y(OH)z  comprises a chemical composition closer to bone and enamel. Calcium phosphate are widely used as biomaterials, their osteoconductive and osteoinductive properties have shown beneficial effect on bone osteogenesis. Geopolymers are ceramic-like inorganic polymers, they have excellent mechanical properties, bioactivity, biocompatibility, suitable for hard tissue prostheses, and environmentally friendly. The aim of the study was to evaluate the initial bone healing in geopolymer-carbonated apatite (CHA) nanocomposites. Methods: Geopolymer-CHA nanocomposites samples were prepared in cylinder of 3 mm diameter and 6 mm thickness and placed in the tibia of eight healthy male breeding New Zealand white rabbits weighing 3.0 to 3.5 kg and 6 month aged. Experimental subjects were randomly assigned to 2 groups for evaluating initial bone healing capability around samples to 14 and 28 days histomorphologically. Wilcoxon test was performed and p<0.05 was considered statistically significant, Minitab software version 13 was used. Result:Granulation tissue, woven, and lamellar bone were analyzed. Day 14 revealed a reactive bone formation, which was characterized by granulation tissue, fibroblasts were in an organized extracellular collagen matrix, osteoblast that directly laid out woven bone contained of immature osteoids, and immature osteocytes were observed. The formation of dense fibrocollagen connective tissue that would be the cartilage, osteoblasts, osteoids, and osteocytes showed more mature while woven bone became denser at day 28.Conclusion: Geopolymer-CHA nanocomposites was a potential dental implant material from mechanical and biological properties point of view.Keywords: Histomorphologically, initial bone response, geopolimer-carbonated apatite nanocomposites, dental implant material

Microstructure and mechanical properties of Ti–15Zr alloy used as dental implant material

2016 ◽  
Vol 62 ◽  
pp. 384-398 ◽  
Author(s):  
Alexander E. Medvedev ◽  
Andrey Molotnikov ◽  
Rimma Lapovok ◽  
Rolf Zeller ◽  
Simon Berner ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Dental Implant ◽  
Implant Material ◽  
Microstructure And Mechanical Properties

scholarly journals Bone Response in vivo of Ti-45Zr Alloy as Dental Implant Material

2021 ◽  
Keyword(s):  
Dental Implant ◽  
Full Text ◽  
Implant Material ◽  
Bone Response

Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.

The Flexural Strength of Y-TZP Coated with Carbonate Apatite for Dental Implant Material

2019 ◽  
Vol 829 ◽  
pp. 131-137
Author(s):  
Wenny A. Awalia ◽  
Taufik Sumarsongko ◽  
Rasmi Rikmasari ◽  
Andrie Harmaji ◽  
Arief Cahyanto
Keyword(s):  
Flexural Strength ◽  
Dental Implant ◽  
Control Group ◽  
Carbonate Apatite ◽  
Inorganic Elements ◽  
Implant Placement ◽  
Implant Material ◽  
Before And After ◽  
The Mean ◽  
And Control

In order to gain acceleration of the osseointegration process after implant placement, micro retention using inorganic elements such as Hydroxyapatite (HA) were commonly used as a coating material in dental implant. Meanwhile, another inorganic material such as Carbonate Apatite (CO3Ap) has been known as bone substitute for decades. The purpose of this study is to investigate the flexural strength of Yttria-Stabilized Zirconia (Y-TZP) as dental implant material after being coated with CO3Ap. Ten specimens of Y-TZP were divided into two groups. The first group was coated with CO3Ap while other groups without coatings were used as the control. Biaxial flexural strength was determined using piston on three balls-technique and data were evaluated by statistical analysis. The specimens surface were analyzed through images taken by Scanning Electron Microscope (SEM). As the result, this study showed that there was no statistically significant found between the group with coating and the control group (p>0.05). The biaxial flexural strength’s mean of the group with coating and control were 212.80 MPa and 209.35 MPa; while micro Vickers hardness’ means were 229.56 HV and 245.40 HV. It can be concluded that there was no difference in the mean flexural strength between Y-TZP before and after coating.

scholarly journals Bone Response in vivo of Ti-45Zr Alloy as Dental Implant Material

2021 ◽  
Author(s):  
Pinghua Ou ◽  
Taomei Zhang ◽  
Jianying Wang ◽  
Cui Li ◽  
Chunsheng Shao ◽  
...  
Keyword(s):  
Immune Response ◽  
Dental Implant ◽  
Blood Compatibility ◽  
Interleukin 10 ◽  
Sprague Dawley ◽  
Hard Tissue ◽  
Implant Material ◽  
Bone Response

Abstract BackgroundTi-Zr alloys have gain more attention as a new metallic biomaterial. using as implants both for orthopedics and dentistry. More recently, our group found promising results for Ti-45Zr alloy, while presenting a low elastic modulusand, a pronounced excellent mechanic character and excellent cell compatibility in vitro. However, the biocompatibility and the potential to promote osteogenesis remains unclear.Methods In this study, the biocompatibility, osteointegration ability, and immune response effects of Ti-45Zr alloy were systematicly investigated in vivo. The biocompatibility of Ti-45Zr alloy was evaluated by hemolysis test and in vivo implantation test in New Zealand white rabbits. The bone integration ability of Ti-45Zr alloy with tissue interface was also investigated by hard tissue section staining and biomechanical experiments. At the same time, the effects of Ti-45Zr alloy on the immune response of Sprague Dawley rats were studied through serum biochemical detection and immunohistochemistry (IHC) staining of hard tissue sections. Interleukin-6 (IL-6) and Interleukin-10 (IL-10) was detected by ELISA. ResultsResults showed that the alloy had good blood compatibility and no body side effects. After implantation in vivo, The serum concentrations of anti-inflammatory and proinflammatory factors reached the highest values at the 9th day, and the inflammation level around the implant hole returned well with the prolongation of the implantation time. On the 14th day, new bone formation was observed around the three materials. The Ti-45Zr alloy was conducive to the polarisation balance of the macrophages.ConclusionThe Ti-45Zr alloy showed exccelent biocompatibility and good osteointegration ability, and it is beneficial to the polarization balance of macrophages.It confirmed that the Ti-45Zr alloy can be used as a dental implant material.

scholarly journals Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1797
Author(s):  
Manuel Toledano ◽  
Marta Vallecillo-Rivas ◽  
María T. Osorio ◽  
Esther Muñoz-Soto ◽  
Manuel Toledano-Osorio ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Bone Repair ◽  
Complex Modulus ◽  
Bacterial Colonization ◽  
Guided Bone Regeneration ◽  
M2 Macrophage

Barrier membranes are employed in guided bone regeneration (GBR) to facilitate bone in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in bone healing and regeneration is necessary. The aim of the present study is to state the effect of doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. A narrative exploratory review was undertaken, focusing on the antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity, bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility, strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis, angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with SiO2 nanoparticles have performed as bioactive modulators provoking an M2 macrophage increase and are a potential biomaterial for promoting bone repair. Zn-doped membranes have promoted pro-healing phenotypes.

Mechanical Property Assessment of Bone Healing around a Titanium-Zirconium Alloy Dental Implant

2013 ◽  
Vol 16 (6) ◽  
pp. 913-919 ◽  
Author(s):  
Rodolfo B. Anchieta ◽  
Marta Baldassarri ◽  
Fernando Guastaldi ◽  
Nick Tovar ◽  
Malvin N. Janal ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Dental Implant ◽  
Bone Healing ◽  
Zirconium Alloy ◽  
Titanium Zirconium ◽  
Property Assessment

scholarly journals Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Bone Healing ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Left Femur ◽  
Bone Response ◽  
First Choice ◽  
Significant Difference

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

scholarly journals Experimental Investigation into the Effect of Surface Roughness and Mechanical Properties of 3D-Printed Titanium Ti-64 ELI after Heat Treatment

2021 ◽  
Author(s):  
Lebogang Lebea ◽  
Harry M Ngwangwa ◽  
Dawood Desai ◽  
Fuluphelo Nemavhola
Keyword(s):  
Mechanical Properties ◽  
Surface Roughness ◽  
Dental Implants ◽  
Dental Implant ◽  
Complex Geometry ◽  
Poor Performance ◽  
Vital Role ◽  
Ultimate Tensile Stress ◽  
3D Printed ◽  
Effect Of Surface

The initial stability after implantology is paramount to the survival of the dental implant and the surface roughness of the implant plays a vital role in this regard. The characterisation of surface topography is a complicated branch of metrology, with a huge range of parameters available. Each parameter contributes significantly towards the survival and mechanical properties of 3D-printed specimens. The purpose of this paper is to experimentally investigate the effect of surface roughness of 3D-printed dental implants and 3D-printed dogbone tensile samples under areal height (Ra) parameters, amplitude parameters (average of ordinates), skewness (Rsk) parameters and mechanical properties. During the experiment, roughness values were analysed and the results showed that the skewness parameter demonstrated a minimum value of 0.596%. The 3D-printed dental implant recorded Ra with a 3.4 mm diameter at 43.23% and the 3D-printed dental implant with a 4.3 mm diameter at 26.18%. Samples with a complex geometry exhibited a higher roughness surface, which was the greatest difficulty of additive manufacturing when evaluating surface finish. The results show that when the ultimate tensile stress (UTS) decreases from 968.35 MPa to 955.25 MPa, Ra increases by 1.4% and when UTS increases to 961.18 MPa, Ra increases by 0.6%. When the cycle decreases from 262142 to 137433, Ra shows that less than a 90.74% increase in cycle is obtained. For 3D-printed dental implants, the higher the surface roughness, the lower the mechanical properties, ultimately leading to decreased implant life and poor performance.

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