scholarly journals Cardiovascular involvement in patients with 2019 novel coronavirus disease

2021 ◽  
Vol 9 (3) ◽  
pp. 152-160
Author(s):  
Chenze Li ◽  
Dao Wen Wang ◽  
Chunxia Zhao
Keyword(s):  
Cardiovascular Diseases ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Symptoms ◽  
Clinical Characteristics ◽  
First Line ◽  
High Quality ◽  
Cardiovascular Involvement ◽  
Underlying Mechanisms ◽  
Novel Coronavirus ◽  
Quality Reports

Abstract 2019 novel coronavirus disease (COVID-19) is caused by the infection of severe acute respiratory syndrome novel coronavirus (SARS-CoV-2). It is characterized by substantial respiratory symptoms and complicated with widespread other organ injuries. Cardiovascular impairment is one of the notable extrapulmonary manifestations, in terms of the deterioration of pre-existing cardiovascular diseases and newly onset acute events. We hereby review the high-quality reports about cardiovascular involvement in COVID-19 and summarize the main clinical characteristics of cardiac relevance for the all the first line clinical physicians. Additionally, the possible underlying mechanisms and the rationale for the application of specific medications, such as renin-angiotensin-aldosterone system inhibitors and hydroxychloroquine are also discussed.

scholarly journals COVID-19-Induced Hyperleucocytosis in Chronic Lymphocytic Leukaemia

2021 ◽  
Author(s):  
Balraj Singh ◽  
Sarah Ayad ◽  
Parminder Kaur ◽  
Ro-Jay Reid ◽  
Sachin Gupta ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Chronic Lymphocytic Leukaemia ◽  
Respiratory Symptoms ◽  
Lymphocytic Leukaemia ◽  
Wide Spectrum ◽  
Multiple Organ ◽  
Global Pandemic ◽  
Organ Systems ◽  
Wbc Count ◽  
Novel Coronavirus

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus responsible for the current global pandemic, coronavirus disease 2019 (COVID-19). COVID-19 usually presents with respiratory symptoms but can affect multiple organ systems. A wide spectrum of complications can occur depending upon the comorbidities of patients. There is limited literature available regarding the presentation and outcome of COVID-19 in chronic lymphocytic leukaemia (CLL) patients. We report 2 cases of COVID-19-induced hyperleucocytosis (WBC count >100,000/?l) in CLL patients.

scholarly journals Guillain-Barré Syndrome associated with the coronavirus disease 2019 (COVID-19)

2020 ◽  
pp. 10.1212/CPJ.0000000000000879 ◽  
Author(s):  
Seyed Amir Ebrahimzadeh ◽  
Abdoreza Ghoreishi ◽  
Nasrin Rahimian
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Symptoms ◽  
Guillain Barre Syndrome ◽  
Unknown Etiology ◽  
Neurologic Complications ◽  
Wuhan City ◽  
First Case ◽  
Guillain Barré Syndrome ◽  
Novel Coronavirus ◽  
Guillain Barré

In December 2019, the first case of pneumonia with unknown etiology was reported in Wuhan city, China. The identified pathogen was a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).1 Since then, the virus has spread rapidly worldwide. Although Coronavirus disease 2019 (COVID-19) typically presents with upper or lower respiratory symptoms, there have been rare reports of significant neurologic complications.2,3 Recently, a few reports presented cases of Guillain-Barré syndrome (GBS) after COVID-19.4,5 In this report, we describe 2 cases of GBS that occurred following COVID-19.

scholarly journals Severe Acute Respiratory Syndrome Coronavirus 2-Induced Neurological Complications

2020 ◽  
Vol 8 ◽  
Author(s):  
Shijia Yu ◽  
Mingjun Yu
Keyword(s):  
Multiple Sclerosis ◽  
Nervous System ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Symptoms ◽  
Neurological Complications ◽  
Supportive Treatment ◽  
Cytokine Storm ◽  
Neurological Signs ◽  
Underlying Mechanisms ◽  
Immunomodulatory Therapies

Our review aims to highlight the neurological complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the available treatments according to the existing literature, discussing the underlying mechanisms. Since the end of 2019, SARS-CoV-2 has induced a worldwide pandemic that has threatened numerous lives. Fever, dry cough, and respiratory symptoms are typical manifestations of COVID-19. Recently, several neurological complications of the central and peripheral nervous systems following SARS-CoV-2 infection have gained clinicians' attention. Encephalopathy, stroke, encephalitis/meningitis, Guillain–Barré syndrome, and multiple sclerosis are considered probable neurological signs of COVID-19. The virus may invade the nervous system directly or induce a massive immune inflammatory response via a “cytokine storm.” Specific antiviral drugs are still under study. To date, immunomodulatory therapies and supportive treatment are the predominant strategies. In order to improve the management of COVID-19 patients, it is crucial to monitor the onset of new neurological complications and to explore drugs/vaccines targeted against SARS-CoV-2 infection.

scholarly journals Focus on the 2019 novel coronavirus (SARS-CoV-2)

2020 ◽  
Vol 15 (10) ◽  
pp. 905-918 ◽  
Author(s):  
Ling-Pu Zhang ◽  
Meixian Wang ◽  
Yanping Wang ◽  
Jun Zhu ◽  
Nannan Zhang
Keyword(s):  
Risk Assessment ◽  
Severe Acute Respiratory Syndrome ◽  
Laboratory Testing ◽  
Clinical Characteristics ◽  
Viral Infections ◽  
Targeted Drugs ◽  
Entire World ◽  
Academic Information ◽  
Novel Coronavirus ◽  
And Control

A new coronavirus, severe acute respiratory syndrome coronavirus 2, was first discovered in Wuhan, China, in December 2019. As of 7 April 2020, the new coronavirus has spread quickly to 184 countries and aroused the attention of the entire world. No targeted drugs have yet been available for intervention and treatment of this virus. The sharing of academic information is crucial to risk assessment and control activities in outbreak countries. In this review, we summarize the epidemiological, genetic and clinical characteristics of the virus as well as laboratory testing and treatments to understand the nature of the virus. We hope this review will be helpful to prevent viral infections in outbreak countries and regions.

scholarly journals Clinical characteristics of 4490 COVID-19 patients in Africa: A meta-analysis

2020 ◽  
Author(s):  
Testimony Jesupamilerin Olumade ◽  
Leonard Ighodalo Uzairue
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Characteristics ◽  
Meta Analysis ◽  
The Novel ◽  
Fatality Rate ◽  
African Continent ◽  
Novel Coronavirus

ABSTRACTIntroductionThe novel coronavirus disease-2019 (COVID-19) pandemic that started in December 2019 has affected over 39 million people and killed over 1.1 million people. While more studies are published to help us understand the virus, there is a dearth of studies on the clinical characteristics and associated outcomes of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on the African continent.MethodsWe evaluated evidence from previous studies in Africa available in six databases between January 1 and October 6, 2020. Meta-analysis was then performed using Open-Meta Analyst software.ResultsA total of seven studies including 4490 COVID-19 patients were included. The result of the meta-analysis showed 68.8% of infected patients were male. Common symptoms presented (with their incidences) were fever (42.8%), cough (33.3%), headache (11.3%), breathing problems (16.8%). Other minor occurring symptoms included diarrhea (7.5%), and rhinorrhea (9.4%). Fatality rate was 5.6%.ConclusionThis study presents the first description and analysis of the clinical characteristics of COVID-19 patients in Africa. The most common symptoms are fever, cough and breathing problems.

scholarly journals Clinical characteristics of COVID-19 and personal protective equipment for trauma surgeons

2020 ◽  
pp. 81-83
Keyword(s):  
Infectious Disease ◽  
Phylogenetic Analysis ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Characteristics ◽  
Rna Viruses ◽  
Protective Equipment ◽  
Whole Genome ◽  
Positive Sense ◽  
Novel Coronavirus ◽  
Trauma Surgeons

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a new virus from the coronavirus family (1) regarded as enveloped, positive-sense, single-stranded ribonucleic acid (RNA) viruses with helical symmetric nucleocapsid (2). According to the whole genome sequencing and phylogenetic analysis of coronavirus strains, a distinct clade of betacoronavirus is shown to be associated with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (3). This novel clade is called the 2019 novel coronavirus (2019-nCoV) and due to more similarity to the SARS virus is also called severe acute respiratory syndrome coronavirus 2. The disease is known as COVID-19.

Novel Coronavirus Disease (COVID-19): A Narrative Review Based on Current Status

2020 ◽  
Vol 18 ◽  
Author(s):  
Rina Das ◽  
Dinesh Kumar Mehta ◽  
Meenakshi Dhanawat
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Symptoms ◽  
Virus Disease ◽  
Relevant Literature ◽  
World Health ◽  
Current Status ◽  
Future Research ◽  
Treatment And Prevention ◽  
First Case ◽  
Novel Coronavirus

Abstract:: A novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared and expanded globally by the end of year in 2019 from Wuhan, China, causing severe acute respiratory syndrome. During its initial stage, the disease was called the novel coronavirus (2019-nCoV). It was named COVID-19 by the World Health Organization (WHO) on 11 February 2020. The WHO declared worldwide the SARS-CoV-2 virus a pandemic on March 2020. On 30 January 2020 the first case of Corona Virus Disease 2019 (COVID-19) was reported in India. Now in current situation the virus is floating in almost every part of the province and rest of the globe. -: On the basis of novel published evidences, we efficiently summarized the reported work with reference to COVID-19 epidemiology, pathogen, clinical symptoms, treatment and prevention. Using several worldwide electronic scientific databases such as Pubmed, Medline, Embase, Science direct, Scopus, etc were utilized for extensive investigation of relevant literature. -: This review is written in the hope of encouraging the people successfully with the key learning points from the underway efforts to perceive and manage SARS-CoV-2, suggesting sailent points for expanding future research.

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