scholarly journals Effect Of Pomegranate (Punica granatum L.) Fraction In Reducing Total Blood Cholesterol Levels and Triglyceride in Mice (Mus muscullus L.)

2020 ◽  
Vol 4 (1) ◽  
pp. 14-22
Author(s):  
Nurlaily Agustini ◽  
Arum Setiawan ◽  
Salni Salni
Keyword(s):  
Punica Granatum ◽  
Positive Control ◽  
Negative Control ◽  
Blood Cholesterol ◽  
Total Blood ◽  
Methanol Fraction ◽  
Treatment Groups ◽  
Cholesterol Levels ◽  
Punica Granatum L ◽  
Total Blood Cholesterol

Pomegranate (Punica granatum L.) will be examined by looking at the ability between pomegranate extracts or fractions, which are more effective in lowering total blood cholesterol and triglyceride levels in mice. This study aims to determine the active pomegranate fraction that can reduce the total cholesterol levels and triglyceride in mice. The research method used was an experimental method with a Completely Randomized Design (CRD) which was divided into 6 treatment groups, and test animals divided into 6 treatment groups namely negative control given aquades, positive control fed a high-fat diet, given simvastatin, given 25 mg/grBB of pomegranate methanol fraction, given 50 mg/grBB of pomegranate methanol fraction, given 100 mg/grBB of pomegranate methanol fraction, each treatment group will be divided into 4 male mice.Based on the results of this study that the active fraction that has an effect in reducing blood cholesterol levels and mice triglycerides is the treatment given 100mg/grBB of pomegranate water methanol fraction.

scholarly journals Uji efek perasan daging buah labu kuning (Cucurbita moschata D.) terhadap kadar kolesterol total darah tikus wistar (Rattus norvegicus)

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Lisa C. Ratulangi ◽  
Pemsi Wowor ◽  
Christi Mambo
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Negative Control ◽  
Blood Cholesterol ◽  
Control Group ◽  
Cucurbita Moschata ◽  
Fruit Pulp ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Total Blood Cholesterol

Abstract: This study aimed to obtain the effect of pumpkin fruit pulp (Cucurbita moschata D.) juice on total blood cholesterol of wistar rats (Rattus norvegicus). This was an experimental laboratory study conducted in the Laboratory of Pharmacology and Therapy Faculty of Medicine, University of Sam Ratulangi. Samples were 10 rats with an average body weight of 150 g. Samples were divided into 5 groups, each group consisted of 2 rats: negative control group, only used standard food; propylthiouracil (PTU) treatment group; positive control group used simvastatin after PTU induced for 14 days; propylthiouracil (PTU) treatment group continued with standard food; and propylthiouracil (PTU) treatment group continued with pumpkin fruit pulp juice. Doses of the pumpkin fruit pulp juice were 0.93 g/ml/day/rat as many as 2 ml/day. The measurement of total blood cholesterol levels was on days 0, 15, and 22 by using Autocheck. Conclusion: The pumpkin fruit pulp juice had an effect in reducing total blood cholesterol levels in wistar rats.Keywords: juice of pumpkin fruit pulp, total blood cholesterol, propylthiouracil.  Abstrak: Penelitian ini bertujuan untuk mengetahui efek air perasan daging buah labu kuning (Cucurbita moschata D.) terhadap kadar kolesterol darah total pada tikus wistar (Rattus norvegicus). Jenis penelitian ini eksperimental laboratorik di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Sam Ratulangi. Subjek penelitian berupa tikus wistar jantan berjumlah 10 ekor dengan berat rata-rata 150 g yang dibagi kedalam 5 kelompok, masing-masing sebanyak 2 ekor, yaitu: kontrol negatif hanya menggunakan pakan standar; kelompok perlakuan propiltiourasil (PTU); kontrol positif menggunakan simvastatin setelah diinduksi PTU selama 14 hari; kelompok perlakuan pemberian PTU dilanjutkan dengan pakan standar; dan kelompok perlakuan pemberian PTU dilanjutkan dengan perasan daging buah labu kuning (Cucurbita moschata D.). Dosis perasan daging buah labu kuning yang diberikan 0.93 g/ml/hari/ekor sebanyak 2 ml/hari. Pengukuran kadar kolesterol darah total dilakukan pada hari ke 0, 15, dan 22 menggunakan alat pengukur Autocheck. Simpulan: Perasan daging buah labu kuning berefek menurunkan kadar kolesterol total pada tikus wistar.Kata kunci: perasan daging buah labu kuning, kolesterol total darah, propiltiourasil.

scholarly journals Pengaruh Pemberian Ekstrak Buah Kelor (Moringa oleifera) Terhadap Penurunan Kadar Kolestrol Pada Darah Hewan Mencit (Mus musculus)

2017 ◽  
Vol 6 (1) ◽  
pp. 15
Author(s):  
Eva Zulviana ◽  
Nurdin Rahman ◽  
Supriadi Supriadi
Keyword(s):  
Moringa Oleifera ◽  
Positive Control ◽  
Negative Control ◽  
Effective Concentration ◽  
Blood Cholesterol ◽  
Fruit Extract ◽  
Treatment Groups ◽  
Cholesterol Levels ◽  
Lower Blood Cholesterol ◽  
Lower Blood

This study aimed to identify bioactive compounds of moringa (moringa oleifera) extracts and determine the effective concentration on lowering blood cholesterol levels of mice. The animals used were 15 male mice induced by propylthiouracil and fat food diet. The mice were divided randomly into 5 groups with different treatment groups. The first, the second, and the third treatments were given moringa extracts each with a concentration of 10, 20% and 40%. The fourth treatment group was given food fat diet and propiltiorasil as a positive control, and the fifth treatment was given standard food and distilled water as a negative control. Data were analyzed using a statistical analysis of variance (ANOVA) test followed by Duncan test. The results showed that moringa fruit extract contains alkaloids, saponins, flavonoids, and tannins. Moringa fruit extract can lower blood cholesterol levels of mice with the most effective concentration of 10%.

scholarly journals Pengaruh Pemberian Tepung Tempe terhadap Kadar Kolesterol Total Darah Mencit (Mus musculus) Hiperkolesterol

bionature ◽  
2019 ◽  
Vol 20 (2) ◽  
pp. 116
Author(s):  
Heryl Rumtal ◽  
Rosdiana Ngitung ◽  
A. Mu’nisa A. Mu’nisa
Keyword(s):  
Mus Musculus ◽  
Blood Cholesterol ◽  
Cholesterol Concentration ◽  
Total Blood ◽  
Treatment Groups ◽  
Independent Variable ◽  
The Subject ◽  
Imprinting Control Region ◽  
Total Blood Cholesterol ◽  
Research Show

Abstract. This research is experimental which aims to determine the effect of giving Tempe Flour to total blood cholesterol concentration of hypercholesterol mice (Mus musculus). The independent variable of this research Tempe Flour while the dependent variable is the total blood cholesterol concentration of mice (Mus musculus). The subject of this research is 25 male ICR strain (Imprinting Control Region) mice with 3 months age divided 5 treatment groups which are normal group, hypercholesterol group, giving of tempe flour at dose of 10 g / day / BB (P1), 20 g / days / BB (P2) and 25 g / day / BB (P3). Tempe flour is given after the giving of cholesterol feed. All mices blood cholesterol concentration were check after the time of treatment. The result is analyz by using ANOVA with Ducan test. The result of this research show that the giving of Tempe Flour affected the decrease of blood cholesterol concentration of mice (Mus musculus) in dose of 10 g/day/BB,20 g/day/BB and 25 g/day/BB. Dose of 25 g/day/BB showed an effective dose for lowering cholesterol in the research.   Keywords: tempe flour, cholesterol, hypercholesterol, mencit (Mus musculus)

scholarly journals RESPONSE OF BROILER CHICKEN TO INOVO ADMINISTRATION OF DIFFERENT LEVELS OF ROSEMARY OIL(ROSMARINUS OFFICINALIS)

2021 ◽  
Vol 52 (4) ◽  
pp. 896-903
Author(s):  
Sulaiman & Tayeb
Keyword(s):  
Positive Control ◽  
Negative Control ◽  
Blood Cholesterol ◽  
Feed Conversion ◽  
In Ovo ◽  
Treatment Groups ◽  
Rosemary Oil ◽  
In Ovo Injection ◽  
Hatching Eggs ◽  
Positive Effect

This study was conducted to determine the percentage of hatchability, post-hatch growth performance, immune response of broiler  subjected  to in- ovo injection of different doses of rosemary oil. A total of 300  eggs of ross broiler strain were obtained.The experiment distributed into five treatment groups: T1, Negative Control T2, positive control (in ovo injection of 0.05 ml distilled water) T3, in ovo injection of 0.05ml of rosemary oil; T4, in ovo injection of  0.075 ml of rosemary oil; T5, in ovo injection of  0.1 ml of rosemary oil.Highest hatchability  percentage was shown in 0.1ml rosemary oil -injected hatching eggs. The final weight of birds from 0.075 and 0.1 ml of rosemary oil-injected eggs was significantly (P < 0.05) highest through the experiment. Feed intake and feed conversion ratio were improved with in ovo administration of rosemary oil at 0.075 and 0.1 ml doses. In addition, the level of  blood cholesterol and blood glucose  were decreased (p<0.05) in birds from rosemary oil-injected eggs.  The obtained data showed a positive effect of in-ovo injection of rosemary  oil on stimulating bird's immunity.

scholarly journals Pengaruh Pemberian Alpukat Terhadap Kadar Kolesterol Total Darah Pada Mahasiswa/i Obesitas Di Fakultas Kedokteran Universitas HKBP Nommensen Medan Tahun 2019

2021 ◽  
Vol 6 (2) ◽  
pp. 40-43
Author(s):  
Syupiarni Putri Waruwu ◽  
Joseph Partogi Sibarani ◽  
Saharnauli Janna Verawaty Simorangkir
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Density Lipoprotein ◽  
The Body ◽  
Blood Cholesterol ◽  
Ldl Oxidation ◽  
Blood Cholesterol Level ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Total Blood Cholesterol

Background: Cholesterol is a fat that does not dissolve easily in the blood. Most of the cholesterol in the blood is attached to specific protein carriers in the plasma in the form of lipoprotein complexes, which are soluble in water. Lipoprotein which carries cholesterol throughout the body. namely LDL (Low Density Lipoprotein) and HDL (High Density Lipoprotein). An increase in LDL in the body tends to form atherosclerosis. In contrast HDL cholesterol inhibits LDL oxidation so that atherosclerotic plaque formation does not occur. Obesity is one of the risk factors for atherosclerosis with manifestations of coronary heart disease. Handling of obesity has been done by many researchers and implemented. One ingredient from nature that serves as an alternative ingredient to lower blood cholesterol levels is avocado. Objective: To determine the effect of avocado administration on total blood cholesterol levels in the obese college students at the Medical Faculty of Nommensen HKBP University in 2019. Methods :This research is a pre-experimental study with a pre-post test design in one group. The sample was selected by purposive sampling method and obtained 20 obese students. Subjects consumed avocado juice every day for 14 days. Total cholesterol levels were measured before (day 0) and after (day 14) treatment. Results: The mean total cholesterol level of the subject's blood on the pretest examination was 188.10 mg / dL and the posttest examination was 180.05 mg / dL. There was a decrease in the average total blood cholesterol level of 8.05 mg / dl. Paired T-test showed that there was a non-significant decrease in mean total blood cholesterol level with a value of p = 0.068 (p <0.05). Conclusion: In this study there was no effect of avocado administration on total blood cholesterol levels in obese students.

scholarly journals Gambaran Kadar Kolesterol Total Darah pada Mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi dengan Indeks Massa Tubuh ≥23 Kg/M2

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Magdalena Talumewo ◽  
Murniati Tiho ◽  
Michaela E. Paruntu
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Sampling Method ◽  
Descriptive Study ◽  
Blood Cholesterol ◽  
Eating Habit ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Unhealthy Eating ◽  
Total Blood Cholesterol

Abstract: Unhealthy eating habit could lead to obesity. Obesity is always associated with the increase of blood cholesterol level (hypercholesterolemia). Increased cholesterol level is a risk factor of the death in young adult. This study was aimed to obtain the profile of total blood cholesterol levels among students of Faculty of Medicine Sam Ratulang University with body mass index (BMI) ≥23 kg/m2. This was a descriptive study. Samples were obtained by using total sampling method. There were 53 students involved in this study consisted of 22 males and 31 females. The results showed that 23 students (43.4%) had normal total cholesterol levels and 30 students (56.6 %) had low total cholesterol levels. Conclusion: More than half of the students of Faculty of Medicine Sam Ratulangi University with BMI ≥23 kg/m2 had low total cholesterol level.Keywords: total cholesterol, BMI ≥23 kg/m2. Abstrak: Kebiasaan makan yang tidak sesuai dengan kaidah sehat dapat mengakibatkan obesitas. Kondisi obesitas selalu dikaitkan dengan peningkatan kadar kolesterol dalam darah atau hiperkolesterolemia. Peningkatan kadar kolesterol merupakan factor risiko penyebab kematian di usia dewasa muda. Penelitian ini bertujuan untuk mengetahui gambaran kadar kolesterol total darah pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi dengan indeks massa tubuh (IMT) ≥23 kg/m2. Jenis penelitian ialah deskriptif. Sampel diperoleh dengan metode total sampling. Penelitian ini diikuti oleh 53 orang subyek penelitian yang terdiri dari 22 orang laki-laki dan 31 orang perempuan. Hasil penelitian mendapatkan 23 orang (43,4%) memiliki kadar kolesterol total normal dan 30 orang (56,6%) memiliki kadar kolesterol total rendah. Simpulan: Lebih dari setengah mahasiwa Fakultas Kedokteran Universitas Sam Ratulangi dengan IMT ≥23 kg/m2 memiliki kadar kolesterol total rendah.Kata kunci: kolesterol total, IMT ≥23 kg/m2

scholarly journals The Effect of Olive Oil Addition into Oatmeal in Lowering Total Blood Cholesterol and LDL (Low Density Lipoprotein) in Wistar Rat

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Sebastian Hadinata ◽  
Heddy Herdiman ◽  
Fenny Tanuwijaya
Keyword(s):  
Olive Oil ◽  
Ldl Cholesterol ◽  
Unsaturated Fatty Acids ◽  
Negative Control ◽  
Blood Cholesterol ◽  
Combination Group ◽  
Beta Glucan ◽  
Total Blood ◽  
Significant Difference ◽  
Total Blood Cholesterol

Oat contains beta-glucan fiber and olive oil contains unsaturated fatty acids which havebeen proven to decrease blood cholesterol. This research compared the effect between acombination of oatmeal and olive oil and each food as single intake in decreasing total bloodcholesterol and LDL cholesterol. We used 25 rats (Rattus norvegicus L.), divided them into fivegroups; negative control (KN), positive control (KP), olive oil group (KMZ), oatmeal group(KBG), and combination group (KMZ+KBG). The total blood cholesterol and LDL cholesterollevels were measured after 14 days of induction and after 28 days of treatment. Data wereanalyzed using one way ANOVA, continued with LSD test with α = 0.05. The result showedthere were 10.85%, 8.85% and 6.60% lower in total blood cholesterol level using KMZ+KBG,KMZ and KBG respectively and 13.85%, 9.33% ,and 8.80% lower in LDL cholesterol levelusing KMZ+KBG, KMZ and KBG respectively. ANOVA test showed a significant decrease ineach treatment. LSD test showed that there was a significant difference between KMZ+KBGcompared to KBG in total blood cholesterol and LDL lowering, but did not showed significantdifference compared to KMZ.Keywords: oatmeal, olive oil, total blood cholesterol, LDL

scholarly journals The Relationship between Total Blood Cholesterol Levels and All-cause Mortality in Fukui City, and Meta-analysis of This Relationship in Japan

2008 ◽  
Vol 17 (1) ◽  
pp. 67-78 ◽  
Author(s):  
Yuko Kirihara ◽  
Kei Hamazaki ◽  
Tomohito Hamazaki ◽  
Yoichi Ogushi ◽  
Hisako Tsuji ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Blood Cholesterol ◽  
Total Blood ◽  
Cholesterol Levels ◽  
All Cause Mortality ◽  
The Relationship ◽  
Total Blood Cholesterol

scholarly journals A real time non-invasive cholesterol monitoring system

2020 ◽  
Vol 331 ◽  
pp. 06005
Author(s):  
Usman Umar ◽  
Syafruddin Syarif ◽  
Ingrid Nurtanio ◽  
Indrabayu
Keyword(s):  
Digital Data ◽  
Blood Cholesterol ◽  
Infrared Light ◽  
Invasive Technique ◽  
Total Blood ◽  
Blood Samples ◽  
Non Invasive ◽  
Cholesterol Levels ◽  
Body Tissues ◽  
Total Blood Cholesterol

Hypercholesterolemia causes cardiovascular disease which is a disorder of the heart and blood vessels, one of the most significant causes of death in the world, and this needs to be anticipated by monitoring blood cholesterol levels regularly. The current method of monitoring blood cholesterol levels is using invasive technique by collecting blood samples. A simple device is needed to measure blood cholesterol levels that can be done without collecting blood samples. This study aims to develop a non- invasive technique for monitoring blood cholesterol levels using sensors utilizing infrared light absorption in body tissues, in order to simplify measuring blood cholesterol levels regularly for patients with hypercholesterolemia. The application of a non-invasive technique focused on developing a total blood cholesterol monitoring device using an infrared sensor with IR LED - 940nm wavelength as a transmitter. A photodiode was used as a detector with the wavelength range of 400-1100 nm and a microcontroller as the minimum system for controlling the value of the output voltage in the form of digital data and then converted onto total blood cholesterol. The measurement results using non-invasive technique was compared to the results using invasive technique.

scholarly journals Pengaruh Pemberian Berbagai Olahan Telur terhadap Kadar Kolesterol Total Darah Mencit

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Putri Mira Magistri ◽  
Rismawati YaswiR ◽  
Yustini Alioes
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Cholesterol Content ◽  
Blood Cholesterol ◽  
Blood Cholesterol Level ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Randomized Design ◽  
Total Blood Cholesterol

AbstrakMasyarakat menggunakan berbagai cara pengolahan sebelum mengonsumsi telur yang dapat berpengaruh terhadap kadar zat gizi yang terkandung didalamnya, termasuk kadar kolesterol dalam telur yang juga akan mempengaruhi kadar kolesterol dalam darah. Tujuan penelitian ini adalah menentukan pengaruh pemberian berbagai olahan telur terhadap kadar kolesterol total darah mencit. Penelitian menggunakan 24 ekor mencit (Mus musculus) jantan albino umur 3 – 4 bulan dengan berat badan sekitar 30 – 40 gram. Jenis kandang yang digunakan adalah kandang kotak (box) sebanyak 24 unit dengan ukuran 28x30x20 cm. Metode yang digunakan ialah eksperimen dengan Rancangan Acak Lengkap (RAL) terdiri dari 6 unit perlakuan, yaitu unit perlakuan K (Kontrol), unit perlakuan A (telur mentah), unit perlakuan B (telur goreng), unit perlakuan C (telur rebus), unit perlakuan D (telur setengah matang) dan unit perlakuan E (telur asin). Dosis perlakuan adalah 1,56ml/20gram berat badan/mencit dan masing-masing perlakuan diulang 4 kali. Parameter yang diukur adalah kadar kolesterol total darah mencit. Hasil analisis keragaman menunjukan bahwa pemberian berbagai olahan telur memberikan pengaruh berbeda sangat nyata (P<0.01) terhadap kadar kolesterol total darah mencit. Berdasarkan hasil penelitian dapat disimpulkan bahwa rerata kadar kolesterol total darah mencit setelah diberikan berbagai olahan telur adalah telur mentah 106.96 mg/dl, telur goreng 143.53 mg/dl, telur rebus 194.50 mg/dl, telur setengah matang 180.91 mg/dl, dan telur asin 158.27 mg/dl.Kata kunci: olahan telur, kadar kolesterol total darah, mencit AbstractPeople use various methods of processing before consumption eggs which can affect the levels of nutrients contained in, including cholesterol content which can also affect the levels of total cholesterol in blood. The objective of this study was to determine the effect of giving a variety of processed egg on total cholesterol levels of mice. The experiment used 24 male albino mice (Mus nusculus) age 3 – 4 months old with 30 – 40 grams of body weight. The den used was 24 units of box with size of 28x30x20 cm. The experiment used Completely Randomized Design (CRD) consist of 6 treatment units which was K (control), A (raw egg), B (fried egg), C (boiled egg), D (soft-boiled egg), and E (salted egg). The dosage was  1.56 ml/20 grams of body weight/mice and 4 replication for each treatment units. The parameter measured was total blood cholesterol level of mice.  Results of analysis of variance showed that giving of a variety of processed egg gave highly  significant  effect (P <0.01) on total blood cholesterol levels of mice. Based on the results of this study, it can be concluded that the average total blood cholesterol levels of mice after giving of various preparations of eggs is as follows: raw eggs 106.96 mg / dl, fried eggs 143.53 mg / dl, boiled eggs 194.50 mg / dl, soft-boiled eggs 180.91 mg / dl, and salted egg 158.27 mg / dl..Keywords: processed egg, total blood cholesterol level,  mice

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