scholarly journals THE ROLE OF SATELLITE CHANNELS IN FORMING TRAFFIC AWARENESS AND PREVENTING ACCIDENTS - A FIELD STUDY

2021 ◽  
Vol 13 (1) ◽  
pp. 32-42
Author(s):  
Afnan M. Shaban ◽  
Keyword(s):  
Field Study ◽  
Male And Female ◽  
The Public ◽  
General Rules ◽  
Traffic Awareness ◽  
Satellite Channels ◽  
To Receive

The importance of the research comes from dealing with the problem of lack of traffic awareness, which causes accidents and the occurrence of human and material losses, and the research aims to study the role of satellite channels in forming traffic awareness among the public, and a sample was chosen from Baghdad consisting of (280) individuals, male and female, and used the questionnaire tool. To obtain the data, which included several questions, the results were analyzed statistically and several results were reached, the most important of which is that there is an interest among the public in following traffic programs at a rate of one to two hours to receive information through traffic programs and to identify and apply general rules, and it was found that there is a statistically significant correlation between the extent of follow-up. The sample is for traffic programs and the extent to which satellite channels spread traffic awareness among individuals, and there is a significant correlation between the sample's intensity of watching traffic programs and the level of obtaining information about traffic awareness from television, and there are differences between the sample averages towards the role of satellite channels in spreading traffic awareness

scholarly journals Intensified Therapy of Acute Lymphoblastic Leukemia in Adults: Report of the Randomized GRAALL-2005 Clinical Trial

2018 ◽  
Vol 36 (24) ◽  
pp. 2514-2523 ◽  
Author(s):  
Françoise Huguet ◽  
Sylvie Chevret ◽  
Thibaut Leguay ◽  
Xavier Thomas ◽  
Nicolas Boissel ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Standard Dose ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Treatment Phase ◽  
Free Survival ◽  
Treatment Tolerance ◽  
To Receive

Purpose To evaluate randomly the role of hyperfractionated cyclophosphamide (hyper-C) dose intensification in adults with newly diagnosed Philadelphia chromosome–negative acute lymphoblastic leukemia treated with a pediatric-inspired protocol and to determine the upper age limit for treatment tolerability in this context. Patients and Methods A total of 787 evaluable patients (B/T lineage, 525 and 262, respectively; median age, 36.1 years) were randomly assigned to receive a standard dose of cyclophosphamide or hyper-C during first induction and late intensification. Compliance with chemotherapy was assessed by median doses actually received during each treatment phase by patients potentially exposed to the full planned doses. Results Overall complete remission (CR) rate was 91.9%. With a median follow-up of 5.2 years, the 5-year rate of event-free survival (EFS) and overall survival (OS) was 52.2% (95% CI, 48.5% to 55.7%) and 58.5% (95% CI, 54.8% to 61.9%), respectively. Randomization to the hyper-C arm did not increase the CR rate or prolong EFS or OS. As a result of worse treatment tolerance, advanced age continuously affected CR rate, EFS, and OS, with 55 years as the best age cutoff. At 5 years, EFS was 55.7% (95% CI, 51.8% to 59.4%) for patients younger than 55 years of age versus 25.8% (95% CI, 19.9% to 35.6%) in older patients (hazard ratio, 2.16; P < .001). Patients ≥ 55 years of age, in whom a lower compliance to the whole planned chemotherapy was observed, benefited significantly from hyper-C, whereas younger patients did not. Conclusion No significant benefit was associated with the introduction of a hyper-C sequence into a frontline pediatric-like adult acute lymphoblastic leukemia therapy. Overall, tolerability of an intensive pediatric-derived treatment was poor in patients ≥ 55 years of age.

Safety and efficacy of maintenance therapy (MT) with a nonspecific cytochrome-P 17 inhibitor (CYP17i) after response/stabilization to docetaxel in metastatic castratation-resistant prostate cancer (mCRPC) patients.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 145-145
Author(s):  
Ignacio Gil-Bazo ◽  
Ainhoa Castillo ◽  
Maria E. Zudaire ◽  
Estefania Arevalo ◽  
Omar Esteban Carranza ◽  
...  
Keyword(s):  
Progression Free Survival ◽  
Abiraterone Acetate ◽  
Front Line ◽  
Free Survival ◽  
The Usa ◽  
Small Cohort ◽  
Daily Prednisone ◽  
To Receive

145 Background: ACRPC causes >30,000 deaths/year in the USA. The front-line treatment consists of docetaxel-based chemotherapy (D). 50% of patients (pts) show at least a 50% PSA decline during D and >15% show a partial response (R) in measurable disease. However, most of these pts present progression (P) after a median of 6-8 months (m). mCRPC remains driven by ligand-dependent androgen (A) receptor signaling. Ketoconazole (K) is a nonspecific cytochrome-P 17 inhibitor (CYP17i) able to block adrenal A synthesis. Low-dose K (LDK), (200 mg, t.d.s) has shown interesting activity in mCRPC after P to androgen deprivation therapy (ADT). The FDA recently granted approval to Abiraterone acetate, a selective CYP17i showing a survival benefit after P to D. The role of a CYP17i in the maintenance setting after response/stabilization to D has never been studied. Methods: 38 mCRPC pts starting D after P to ADT maintained LHRHa and additionally received a median of 7 cycles (3-12) of front-line three-weekly D (75 mg/m2) plus daily prednisone (10 mg). 20/38 pts showing no progression to D were enrolled. One month after the last D cycle 10 pts were assigned to MT with LDK plus prednisone (10 mg daily) and continued to receive LHRHa while the 10 pts in the control arm continued on LHRHa alone. Progression-free survival (PFS) was the primary endpoint of the study. Results: After a median follow-up of 27 m, all pts in the control arm progressed after D treatment while 8/10 pts progressed to MT. PFS from D initiation was 11.4 m for MT and 8.9 m for control arm (p=0.025). Toxicity profiles showed no significant differences between both arms. No pts discontinued LDK for toxicity reasons. Conclusions: To our knowledge, this is the first study testing a CYP17i for MT after response/stabilization to D in mCRPC. Although this is a small cohort of pts and a longer follow-up is needed, these preliminary data show a significant benefit in PFS of more than 2 months with LDK MT compared to no MT after D with a favorable toxicity profile. Thus, a further analysis in a larger series and the potential impact of this PFS benefit on the overall survival is warranted.

scholarly journals Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004

Blood ◽  
2012 ◽  
Vol 120 (5) ◽  
pp. 978-984 ◽  
Author(s):  
Henrik Hasle ◽  
Jonas Abrahamsson ◽  
Erik Forestier ◽  
Shau-Yin Ha ◽  
Jesper Heldrup ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Gemtuzumab Ozogamicin ◽  
Severe Neutropenia ◽  
Free Survival ◽  
Intention To Treat ◽  
A Minor ◽  
Time To Relapse ◽  
To Receive

Abstract There are no data on the role of postconsolidation therapy with gemtuzumab ozogamicin (GO; Mylotarg) in children with acute myeloid leukemia (AML). The NOPHO-AML 2004 protocol studied postconsolidation randomization to GO or no further therapy. GO was administered at 5 mg/m2 and repeated after 3 weeks. We randomized 120 patients; 59 to receive GO. Survival was analyzed on an intention-to-treat basis. The median follow-up for patients who were alive was 4.2 years. Children who received GO showed modest elevation of transaminase and bilirubin without signs of veno-occlusive disease. Severe neutropenia followed 95% and febrile neutropenia 40% of the GO courses. Only a moderate decline in platelet count and a minor decrease in hemoglobin occurred. Relapse occurred in 24 and 25 of those randomized to GO or no further therapy. The median time to relapse was 16 months versus 10 months (nonsignificant). The 5-year event-free survival and overall survival was 55% versus 51% and 74% versus 80% in those randomized to receive GO or no further therapy, respectively. Results were similar in all subgroups. In conclusion, GO therapy postconsolidation as given in this trial was well tolerated, showed a nonsignificant delay in time to relapse, but did not change the rate of relapse or survival (clinicaltrials.gov identifier NCT00476541).

scholarly journals PERAN KOMISI PENYIARAN INDONESIA DALAM MENGAWASI PENYELENGGARAAN PENYIARAN PADA MASA PANDEMI COVID-19

2021 ◽  
Vol 6 (1) ◽  
pp. 78-100
Author(s):  
Ni Putu Noni Suharyanti ◽  
Kadek Endra Setiawan
Keyword(s):  
Public Service ◽  
The Public ◽  
The Media ◽  
The Government

In order to support the government in overcoming the Covid-19 outbreak, Komisi Penyiaran Indonesia (KPI) has issued several policies related to broadcasting, especially on television. This policy was taken considering that television is still the media with the most audience reach and has a high duplication power in society. Therefore, in every program broadcast to the public, adherence to health protocols is a must. Based on this, it is necessary to examine in depth the role of KPI in overseeing broadcasting and the synergy between Central and Regional KPIs in overseeing broadcasting during the Covid-19 pandemic. The results showed that the KPI in supervising broadcasting during the Covid-19 pandemic played an optimal role in regulating and supervising broadcast content by issuing policies to broadcast the socialization of prevention of the spread of Covid-19 either through Public Service Ads (ILM) or other programs by television and radio. In addition, KPI also issued KPI Decree (KKPI) Number 12 of 2020 concerning Support of Broadcasting Institutions in Efforts to Prevent and Overcome the Spread of Covid-19. Then to follow up on the Circular on news related to the Covid-19 Virus, the Central KPI along with Regional KPI throughout Indonesia conveyed and reminded all Broadcasting Institutions to remain guided by broadcasting rules in broadcasting institutions to convey useful and accountable information.

Updated survival results of the randomized phase II study comparing cisplatin/capecitabine (CX) with epirubicin plus CX (ECX) in advanced gastric cancer (AGC).

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 46-46 ◽  
Author(s):  
T. Lim ◽  
J. Yun ◽  
J. Lee ◽  
S. Park ◽  
J. Park ◽  
...  
Keyword(s):  
Performance Status ◽  
Randomized Study ◽  
Progression Free Survival ◽  
Free Survival ◽  
Randomized Phase Ii ◽  
Grade 3 ◽  
To Receive ◽  
Line Chemotherapy

46 Background: We previously reported results of a randomized study showing that CX is equally active to ECX in terms of progression-free survival (PFS) (Yun et al. Eur J Cancer. 2010). Here we report updated overall survival (OS) results with an additional 12 months' follow-up. Methods: Ninety-one chemotherapy-naïve patients with histologically-confirmed, measurable AGC were randomized to receive CX (cisplatin 75 mg/m2 iv on day 1 and capecitabine 1,000 mg/m2 bid po on days 1-14, n=45) or ECX (epirubicin 50 mg/m2 plus CX, n=44) every 3 weeks. After CX or ECX had failed, second-line chemotherapy (SLC) was recommended for all patients if their performance status was preserved. Results: Treatment duration was similar for both arms (4.4 for CX v 4.2 months for ECX). There was no relevant difference in the occurrence of overall grade 3 or 4 toxicities between the CX and ECX arms (80% v 78%, respectively; p=0.516). However, none in the CX and 12% in the ECX arm discontinued treatment because of toxicity. There were no significant differences in therapeutic efficacy between CX and ECX with respect to the response rate (38% v 37%, respectively), PFS (6.4 v 6.5 months), as well as OS (12.7 v 13.8 months; p=0.51). After failure, 60% of patients (26 CX and 28 ECX patients) received SLC. However, OS was not differed whether a patient was treated with SLC or not (13.1 v 11.2 months; p=0.94). Conclusions: The present analysis confirms previous findings that both CX and ECX appear to be comparatively active as first-line chemotherapy for AGC. Furthermore, the role of SLC in AGC warrants further evaluation. No significant financial relationships to disclose.

Bien agiter avant l’emploi. De l’activation des politiques d’emploi à l’agitation des chômeurs

2019 ◽  
Vol 58 (4) ◽  
pp. 566-588
Author(s):  
Jean-François Orianne ◽  
Laura Beuker
Keyword(s):  
Labor Market ◽  
Reform Process ◽  
Public Employment ◽  
Job Seekers ◽  
Employment Services ◽  
The Public ◽  
Labor Market Intermediaries ◽  
Market Intermediaries

By articulating a pragmatic approach of the labor market intermediaries with a systemic approach of the interactions at the State’s counters, the authors study the follow-up and accompaniment procedure of jobseekers in Belgium, within three public employment services. This procedure appears today as the most successful realization of a reform process, within the employment policies, that is still in progress since the middle of the 1990, under the influence of the European institutions (the European employment strategy). The authors analyze the role of the National Employment Office’s facilitators, the agents who are in charge of the jobseekers’ following-up procedure, that is the control of their effort to find a job. They also focus on the role of the employment counselors of two regional public services by showing that the employability – the official target of the activation policies – operate as a way to speak abstractly of employment and unemployment, as a way to sustain and to intensify the communication at the State’s counters. The action of the labor market intermediaries, qualified by the authors as a moral enterprise, can be characterized by its self-referential nature: to socialize the job seekers, to make them sensitive to the norms and standards of employability that are at stake in the three public employment services. According to the authors, the ‘labor market’ acts as a fiction: a simplified reconstruction of the world of work, within the political system, that serve as a readily available reference for the public action of intermediation.

Clinical Meditation Teacher: A New Role for Health Professionals

2011 ◽  
Vol 16 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Richard Schaub
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Health Professionals ◽  
Public Acceptance ◽  
The Public ◽  
The Right ◽  
The Mind ◽  
To Receive ◽  
Care Costs

The support for integrating meditation into health care and mental health has reached scientific and public acceptance. For the public to receive the benefits of the mind—body medicine of meditation, it is time for health professionals to step into the role of clinical meditation teachers. Clinical meditation refers to the ability to discern the right kinds of meditation for the right person at the right time. With the increased emphasis on preventative medicine and self-care skills to reduce health care costs, the timing is absolutely appropriate for health professionals to gain skills in this new role.

scholarly journals The Role of Media Campaigns in Raising Awareness of Development Issues and Their Relationship to the Level of Anxiety in Adolescents

2021 ◽  
Vol 56 (2) ◽  
pp. 332-349
Author(s):  
Sameh Awadalla El-Sayad Ibrahim
Keyword(s):  
Low Income ◽  
Survey Method ◽  
Health Campaign ◽  
Media Campaigns ◽  
Developmental Issues ◽  
Awareness Campaigns ◽  
The Disabled ◽  
Satellite Channels

The study sought to determine the role of media campaigns in educating university youth about various developmental issues and their relationship to their level of anxiety. The study is descriptive. It relied on the survey method on a sample of 400 adolescents at Ain Shams University. The most important forms of benefiting from the follow-up of media campaigns related to development issues came to provide them with important information about development issues, give a sense of confidence in state institutions, increase the sense of responsibility towards society, follow up on current development issues, awareness and interest in them. The most important media campaigns presented on satellite channels related to development issues are health awareness campaigns (Coronavirus - C virus campaign - 100 million health campaign - breast cancer), slum development campaigns, solidarity and dignity campaign to support the needy, small and micro enterprises support campaign, payment campaigns, electronic, economic campaign (price reduction - price control), low-income support campaign (supply system - bread system), campaigns for the disabled and people with special needs. The positive aspects of media campaigns related to development issues came as follows: The presented development issues are new and consistent with the current needs of society, their goals are clear and specific, their design is innovative, they encourage positive change, they seek to meet the needs of the ordinary citizen, the celebrities involved in media campaigns, the serious development issues that It presents it through its messages, the technical methods used in presenting development issues.

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