scholarly journals Effect of omega-3 polyunsaturated fatty acids on blood lipid profile, leptin level and endothelial function in patients with ischemic heart disease in combination with non-alcoholic steatosis of the liver

2018 ◽  
Vol 0 (3) ◽  
pp. 19-24
Author(s):  
О. В. Курята ◽  
М. М. Гречаник
Keyword(s):  
Fatty Acids ◽  
Heart Disease ◽  
Endothelial Function ◽  
Polyunsaturated Fatty Acids ◽  
Ischemic Heart Disease ◽  
Lipid Profile ◽  
Blood Lipid ◽  
Ischemic Heart ◽  
Omega 3 ◽  
Blood Lipid Profile

scholarly journals LONG-TERM EFFECTS OF OMEGA-3 POLYUNSATURATED FATTY ACIDS ON THE COURSE OF ISCHEMIC HEART DISEASE IN PATIENTS AFTER ST-ELEVATION MYOCARDIAL INFARCTION AT THE BACKGROUND OF MULTIPLE-VESSEL LESION CORONARY ATHEROSCLEROSIS

2014 ◽  
Vol 13 (6) ◽  
pp. 32-37
Author(s):  
M. N. Sin’kova ◽  
T. V. Pepelyaeva ◽  
L. K. Isakov ◽  
N. I. Tarasov ◽  
A. T. Teplyakov
Keyword(s):  
Myocardial Infarction ◽  
Fatty Acids ◽  
Heart Disease ◽  
Polyunsaturated Fatty Acids ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Primary Pci ◽  
Omega 3 ◽  
St Elevation

Currently there is enough evidence for that the use of omega-3-faty acids compounds in ischemic heart disease is followed by the decrease of mortality, and the efficacy of this usage in multivessel coronary lesions after primary percutaneous intervention (PCI) has not been studied.Aim.To evaluate the efficacy of long-term intake of the omega-3-polyunsaturated fatty acids compounds on the course of ischemic heart disease at the background of multiple coronary lesion after primary PCI.Material and methods.Totally 101 patient included at the age of 35-70 y.o., who had underwent primary PCI for the myocardial infarction with ST elevation and multiple vessel lesion of coronary arteries. The patients were selected into 2 groups: 1 group (n=68) — conservative tactics with the standard pharmacotherapy; 2nd group (n=33) — Omacor was added to the standard therapy.Results.In 36 months of follow-up in the Omacor group there was significant decrease of repeated myocardial infarctions, decompensating heart failure, angina progression and rhythm disorders. In 2nd group patients during the 36-month follow-up a better antiischemic effect achieved with 80,9% decrease of angina from the baseline (p<0,047) and by 27,6% of the heart failure severity. The increase of exercise tolerance by the 6-minute walking test during 36 months was the highest in the 2nd group — by 65%.Conclusion.Long-term prescription of omega-3-polyunsaturated fatty acids in ST elevation myocardial infarction with multiple vessel coronary lesions after primary PCI leads to the improvement of clinical condition, which then leads to the increase of exercise tolerance and better life quality. 

Krill oil to improve blood lipids status in advanced cancer patient with cachexia.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e19634-e19634
Author(s):  
Roberto Serpe ◽  
Clelia Madeddu ◽  
Filomena Panzone ◽  
Giorgia Antoni ◽  
Maria Chiara Cau ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cancer Cachexia ◽  
Blood Lipid ◽  
Blood Levels ◽  
Krill Oil ◽  
Omega 3 ◽  
Blood Lipid Profile ◽  
Cholesterol Levels

e19634 Background: Cancer patients with cachexia symptoms often show a lipid profile disorder, consisting in severe hypertriglyceridemia due to increased circulating free fatty acids and variable total cholesterol levels, decreased activity of lipoprotein lipase and increased lipolysis, which is correlated with proinflammatory cytokines levels, particularly IL-6 and TNFα. Recent evidence further confirms impairment of adipose tissue metabolism in inflammatory condition like cancer cachexia. The aim of this study was to assess the effect of nutritional supplementation with Omega 3 fatty acids (EPA and DHA) in the form of Krill Oil, on main parameters of blood lipid profile and on IL-6 and TNFα blood levels. Methods: In 2011, 34 IV stage cachectic patients (M/F 20/14; age range 55-85 y) with cancer at different sites were enrolled. 21 healthy subjects were studied as controls. All patients had high blood tryglicerides, low total cholesterol levels , high levels of blood IL-6 and TNFα compared to controls. Patients received 3 capsules (3 g/day) of krill oil (Superba™ Krill Oil, Aker Biomarine, Norway), which is an oil extract from the crustacean krill (Euphausia Superba) which contains Omega-3 series unsaturated fatty acids in phospholipidic form, of which 98 % are EPA and DHA mainly in phospholipid form. Treatment duration was 2 months. Results: A significant reduction of tryglicerides blood levels (148.23 ± 88.06 vs 114 ± 55.8 mg/dl) and a significant improvement of HDL cholesterol (42.5 ± 15.6 vs 60.9 ± 12.3 mg/dl) and Total Cholesterol (135.6 ± 46.3 vs 159 ± 41.1 mg/dl) was observed after treatment. Cytokines Il-6 and TNFα blood levels did not change significantly after treatment Conclusions: Nutritional supplementation with krill oil showed a positive activity in the regulation of blood lipid profile, involving different metabolic and inflammatory pathways, probably mainly affecting hormone-sensitive lipase activity. Our data suggest that krill oil could be useful in multi-targeted combined pharmaco-nutritional approaches to treat cancer-cachexia. Additional phase III clinical studies are warranted.

Plasma levels of free polyunsaturated fatty acids in patients with ischemic heart disease

Metabolism ◽  
1973 ◽  
Vol 22 (11) ◽  
pp. 1349-1356 ◽  
Author(s):  
Lars Hagenfeldt ◽  
Juhani Paasikivi ◽  
Andreas Sjögren
Keyword(s):  
Fatty Acids ◽  
Heart Disease ◽  
Polyunsaturated Fatty Acids ◽  
Ischemic Heart Disease ◽  
Plasma Levels ◽  
Ischemic Heart

PP200-MON REGULAR CONSUMPTION OF FUNCTIONAL OIL ENRICHED WITH OMEGA 3 FATTY ACIDS FROM FISH OIL IMPROVES THE BLOOD LIPID PROFILE IN OBESE PEOPLE

2012 ◽  
Vol 7 (1) ◽  
pp. 217
Author(s):  
B. López Plaza ◽  
L.M. Bermejo ◽  
L. Zurita Rosa ◽  
D. Rodríguez Duran ◽  
S. Palma Milla ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Lipid Profile ◽  
Blood Lipid ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Obese People ◽  
Blood Lipid Profile ◽  
Regular Consumption

Abstract 12033: Impact of n-3 Polyunsaturated Fatty Acids on Mortality of Patients With Hospitalized Heart Failure Patients

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Shunsuke Watanabe ◽  
Akiomi Yoshihisa ◽  
Yuki Kanno ◽  
Mai Takiguchi ◽  
Shunsuke Miura ◽  
...  
Keyword(s):  
Heart Failure ◽  
Fatty Acids ◽  
Heart Disease ◽  
Polyunsaturated Fatty Acids ◽  
Ischemic Heart Disease ◽  
Linolenic Acid ◽  
Independent Predictor ◽  
Ischemic Heart ◽  
Cardiac Mortality ◽  
All Cause Mortality

Background: Intake of n-3 polyunsaturated fatty acids (n-3 PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lowers risk of atherosclerotic cardiovascular events, particularly ischemic heart disease. In addition, a ratio of EPA/arachidonic acid (AA) is recently recognized as a risk marker of ischemic heart disease. In contrast, prognostic impact of the EPA, DHA and EPA/AA ratio on patients with heart failure (HF) still remains unclear. Methods and Results: Consecutive 577 patients admitted for HF were divided into 2 groups based on median levels of EPA/AA ratio: low EPA/AA (EPA/AA ≤ 0.32 mg/dl, n=291) and high EPA/AA (0.32 < EPA/AA, n=286) groups. We compared laboratory data, echocardiographic findings and cardio-pulmonary exercise test results, and prospectively followed cardiac and all-cause mortality. The low EPA/AA group, as compared to the high EPA/AA group, had lower levels of EPA and DHA (EPA: 33.9 vs. 86.8 μg/ml, P<0.003; DHA: 107.0 vs. 150.5 μg/ml, P<0.001), and higher levels of AA and dihomosexual linolenic acid (AA: 174.0 vs. 156.5 μg/ml, P<0.001; dihomosexual linolenic acid: 32.4 vs. 29.5 μg/ml, P=0.010). In contrast, body mass index, blood pressure, B-type natriuretic peptide, hemoglobin, estimated GFR, total protein, albumin, sodium, C-reactive protein, left ventricular ejection fraction, peak VO 2 and VE/VCO 2 slope were similar between the two groups. Cardiac mortality (log-rank P=0.004) and all-cause mortality (P<0.001) were higher in the low EPA/AA group than in the high EPA/AA group. In the multivariable Cox proportional hazard analyses, the EPA/AA ratio was an independent predictor of cardiac mortality (HR 0.087, P=0.003) and all-cause mortality (HR 0.233, P=0.009) in HF patients. Conclusions: The EPA/AA ratio was an independent predictor of cardiac and all-cause mortality in HF patients. Thus, taking appropriate management to control EPA/AA balance may improve the prognosis of HF patients.

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