scholarly journals Perceptual reality monitoring: Neural mechanisms dissociating imagination from reality

2021 ◽  
Author(s):  
Nadine Dijkstra ◽  
Peter Kok ◽  
Stephen M Fleming
Keyword(s):  
Clinical Symptoms ◽  
Neural Mechanisms ◽  
Reality Monitoring ◽  
Cognitive Factors ◽  
Future Research ◽  
Cortical Circuits ◽  
First Order ◽  
Source Confusion ◽  
Multi Level ◽  
The Brain

There is increasing evidence that imagination relies on similar neural mechanisms as externally triggered perception. This overlap presents a challenge for perceptual reality monitoring: deciding what is real and what is imagined. Here, we explore how perceptual reality monitoring might be implemented in the brain. We first describe sensory and cognitive factors that could dissociate imagery and perception and conclude that no single factor unambiguously signals whether an experience is internally or externally generated. We suggest that reality monitoring is implemented by higher-level cortical circuits that evaluate first-order sensory and cognitive factors to determine the source of sensory signals. According to this interpretation, perceptual reality monitoring shares core computations with metacognition. This multi-level architecture might explain several types of source confusion as well as dissociations between simply knowing whether something is real and actually experiencing it as real. We discuss avenues for future research to further our understanding of perceptual reality monitoring, an endeavor that has important implications for our understanding of clinical symptoms as well as general cognitive function.

scholarly journals Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome

2013 ◽  
Vol 305 (8) ◽  
pp. G529-G541 ◽  
Author(s):  
Yehuda Ringel ◽  
Nitsan Maharshak
Keyword(s):  
Irritable Bowel Syndrome ◽  
Immune Function ◽  
Intestinal Microbiota ◽  
Clinical Symptoms ◽  
Current Evidence ◽  
Future Research ◽  
Gastrointestinal Microbiota ◽  
Plausible Model ◽  
Irritable Bowel ◽  
The Brain

The pathophysiology of irritable bowel syndrome (IBS) is believed to involve alterations in the brain-gut axis; however, the etiological triggers and mechanisms by which these changes lead to symptoms of IBS remain poorly understood. Although IBS is often considered a condition without an identified “organic” etiology, emerging evidence suggests that alterations in the gastrointestinal microbiota and altered immune function may play a role in the pathogenesis of the disorder. These recent data suggest a plausible model in which changes in the intestinal microbiota and activation of the enteric immune system may impinge upon the brain-gut axis, causing the alterations in gastrointestinal function and the clinical symptoms observed in patients with IBS. This review summarizes the current evidence for altered intestinal microbiota and immune function in IBS. It discusses the potential etiological role of these factors, suggests an updated conceptual model for the pathogenesis of the disorder, and identifies areas for future research.

scholarly journals The case of CAUSE: neurobiological mechanisms for grounding an abstract concept

2018 ◽  
Vol 373 (1752) ◽  
pp. 20170129 ◽  
Author(s):  
Friedemann Pulvermüller
Keyword(s):  
Real Life ◽  
Family Resemblance ◽  
Future Research ◽  
Semantic Features ◽  
Abstract Concept ◽  
Abstract Concepts ◽  
Cortical Circuits ◽  
Theme Issue ◽  
The Brain

How can we understand causal relationships and how can we understand words such as ‘cause’? Some theorists assume that the underlying abstract concept is given to us, and that perceptual correlation provides the relevant hints towards inferring causation from perceived real-life events. A different approach emphasizes the role of actions and their typical consequences for the emergence of the concept of causation and the application of the related term. A model of causation is proposed that highlights thefamily resemblancebetween causal actions and postulates that symbols are necessary forbinding together the different partially shared semantic features of subsetsof causal actions and their goals. Linguistic symbols are proposed to play a key role in binding the different subsets of semantic features of the abstract concept. The model is spelt out at the neuromechanistic level of distributed cortical circuits and the cognitive functions they carry. The model is discussed in light of behavioural and neuroscience evidence, and questions for future research are highlighted. In sum, taking causation as a concrete example, I argue that abstract concepts and words can be learnt and grounded in real-life interaction, and that the neurobiological mechanisms realizing such abstract semantic grounding are within our grasp.This article is part of the theme issue ‘Varieties of abstract concepts: development, use and representation in the brain'.

Aging and Neuroeconomics: Insights from Research on Neuromodulation of Reward-based Decision Making

2007 ◽  
Vol 29 (1) ◽  
Author(s):  
Shu-Chen Li ◽  
Guido Biele ◽  
Peter N. C. Mohr ◽  
Hauke R. Heekeren
Keyword(s):  
Decision Making ◽  
Empirical Evidence ◽  
Dopaminergic System ◽  
Neural Mechanisms ◽  
Future Research ◽  
Neurotransmitter Systems ◽  
Reward Prediction ◽  
Dopaminergic Modulation ◽  
The Brain ◽  
Expected Outcomes

Abstract‘Neuroeconomics’ can be broadly defined as the research of how the brain interacts with the environment to make decisions that are functional given individual and contextual constraints. Deciphering such brain-environment transactions requires mechanistic understandings of the neurobiological processes that implement value-dependent decision making. To this end, a common empirical approach is to investigate neural mechanisms of reward-based decision making. Flexible updating of choices and associated expected outcomes in ways that are adaptive for a given task (or a given set of tasks) at hand relies on dynamic neurochemical tuning of the brain’s functional circuitries involved in the representation of tasks, goals and reward prediction. Empirical evidence as well as computational theories indicate that various neurotransmitter systems (e.g., dopamine, norepinephrine, and serotonin) play important roles in reward-based decision making. In light of the apparent aging-related decline in various aspects of the dopaminergic system as well as the effects of neuromodulation on reward-related processes, this article focuses selectively on the literature that highlights the triadic relations between dopaminergic modulation, reward-based decision making, and aging. Directions for future research on aging and neuroeconomoics are discussed.

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis

2011 ◽  
Vol 11 (1) ◽  
pp. 130-133
Author(s):  
Astra Zviedre ◽  
Arnis Engelis ◽  
Mohit Kakar ◽  
Aigars Pētersons
Keyword(s):  
Early Detection ◽  
Acute Appendicitis ◽  
Inflammatory Mediators ◽  
Potential Role ◽  
Clinical Symptoms ◽  
Future Research ◽  
Mesenteric Lymphadenitis ◽  
Proper Diagnosis ◽  
Near Future

Potential Role of Cytokines in Children with Acute Appendicitis and Acute Mesenteric Lymphadenitis Although, AAP and AML have different etiological factors, clinical symptoms are very much similar but treatment tactics in both the disease differ a lot. In case of AML, treatment is more conservative and does not require hospitalization while in case of AAP immediate hospitalization and maybe further surgery can be mandatory. With the identification of group of cytokines serum inflammatory mediators IL-8, IL-10, IL-12[p70], IL-17, TNF-a and MCP-1, it is believed early and proper diagnosis of AAP in the near future. Research of cytokines-serum inflammatory mediators has opened new opportunities for an early detection and differentiation of these two diseases in children.

Novel Coronavirus Disease (COVID-19): A Narrative Review Based on Current Status

2020 ◽  
Vol 18 ◽  
Author(s):  
Rina Das ◽  
Dinesh Kumar Mehta ◽  
Meenakshi Dhanawat
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Symptoms ◽  
Virus Disease ◽  
Relevant Literature ◽  
World Health ◽  
Current Status ◽  
Future Research ◽  
Treatment And Prevention ◽  
First Case ◽  
Novel Coronavirus

Abstract:: A novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared and expanded globally by the end of year in 2019 from Wuhan, China, causing severe acute respiratory syndrome. During its initial stage, the disease was called the novel coronavirus (2019-nCoV). It was named COVID-19 by the World Health Organization (WHO) on 11 February 2020. The WHO declared worldwide the SARS-CoV-2 virus a pandemic on March 2020. On 30 January 2020 the first case of Corona Virus Disease 2019 (COVID-19) was reported in India. Now in current situation the virus is floating in almost every part of the province and rest of the globe. -: On the basis of novel published evidences, we efficiently summarized the reported work with reference to COVID-19 epidemiology, pathogen, clinical symptoms, treatment and prevention. Using several worldwide electronic scientific databases such as Pubmed, Medline, Embase, Science direct, Scopus, etc were utilized for extensive investigation of relevant literature. -: This review is written in the hope of encouraging the people successfully with the key learning points from the underway efforts to perceive and manage SARS-CoV-2, suggesting sailent points for expanding future research.

scholarly journals Learning from and Leveraging Multi-Level Changes in Responses to the COVID 19 Pandemic to Facilitate Breast Cancer Prevention Efforts

2021 ◽  
Vol 18 (13) ◽  
pp. 6999
Author(s):  
Deborah J. Bowen ◽  
Kelly E. Rentscher ◽  
Amy Wu ◽  
Gwen Darien ◽  
Helen Ghirmai Haile ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Health Care ◽  
Cancer Prevention ◽  
Care Delivery ◽  
Breast Cancer Prevention ◽  
Health Care Use ◽  
Economic Life ◽  
Future Research ◽  
Multi Level ◽  
And Shifts

The coronavirus pandemic (COVID-19) has had multilevel effects on non-COVID-19 health and health care, including deferral of routine cancer prevention and screening and delays in surgical and other procedures. Health and health care use has also been affected by pandemic-related loss of employer-based health insurance, food and housing disruptions, and heightened stress, sleep disruptions and social isolation. These disruptions are projected to contribute to excess non-COVID-19 deaths over the coming decades. At the same time municipalities, health systems and individuals are making changes in response to the pandemic, including modifications in the environmental to promote health, implementation of telehealth platforms, and shifts towards greater self-care and using remote platforms to maintain social connections. We used a multi-level biopsychosocial model to examine the available literature on the relationship between COVID-19-related changes and breast cancer prevention to identify current gaps in knowledge and identify potential opportunities for future research. We found that COVID-19 has impacted several aspects of social and economic life, through a variety of mechanisms, including unemployment, changes in health care delivery, changes in eating and activity, and changes in mental health. Some of these changes should be reduced, while others should be explored and enhanced.

scholarly journals Multi-Level Perspective on Sustainability Transition towards Nature-Based Solutions and Co-Creation in Urban Planning of Belgrade, Serbia

2021 ◽  
Vol 13 (14) ◽  
pp. 7576
Author(s):  
Ana Mitić-Radulović ◽  
Ksenija Lalović
Keyword(s):  
Urban Planning ◽  
Urban Forest ◽  
Case Study Research ◽  
Eu Enlargement ◽  
Planning System ◽  
Future Research ◽  
Horizon 2020 ◽  
Research On Evaluation ◽  
Private Interests ◽  
Multi Level

In recent years, nature-based solutions have been increasingly promoted as a climate change adaptation instrument, strongly advocated to be co-created. Achieving clear, coherent, and ambitious urban greening strategies, embedded in urban planning and developed in a co-creative, participatory and inclusive manner, is highly challenging within the EU enlargement context. In this article, such challenges are studied through two recent urban development initiatives in Belgrade, the Capital of Serbia: the first initiative focuses on planning the new Linear Park, within the framework of the CLEVER Cities Horizon 2020 project; the second initiative envisages the transformation of the privatised Avala Film Complex in the Košutnjak Urban Forest, primarily led by private interests but supported by the local authorities. The multiple-case study research method is applied, with an exploratory purpose and as a basis for potential future research on evaluation of co-creation processes for NBS implementation. The theoretical basis of this article is founded in the research on sustainability transitions, focusing on multi-level perspective (MLP) framework. The urban planning system in Belgrade and Serbia is observed as a socio-technical regime of the MLP. In such framework, we recognize co-creative planning of the Linear Park as a niche innovation. We interpret opposition towards planning of the Avala Film Complex as escalation, or an extreme element of the socio-technical landscape, comprised of civic unrests and political tensions on one side, combined with the climate crisis and excessive pollution on the other side. Moreover, the article examines informal urban planning instruments that can be implemented by the practitioners of niche innovations, that could support urban planners and NBS advocates in the Serbian and EU enlargement contexts to face the challenges of motivating all stakeholders to proactively, constructively and appropriately engage in co-creation.

scholarly journals Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Florian Bitsch ◽  
Philipp Berger ◽  
Andreas Fink ◽  
Arne Nagels ◽  
Benjamin Straube ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Positive Emotions ◽  
Emotional Memory ◽  
Brain Regions ◽  
Neural Mechanisms ◽  
Functional Magnetic Resonance ◽  
Frontal Brain ◽  
Successful Resolution ◽  
Neural Underpinnings ◽  
The Brain

AbstractThe ability to generate humor gives rise to positive emotions and thus facilitate the successful resolution of adversity. Although there is consensus that inhibitory processes might be related to broaden the way of thinking, the neural underpinnings of these mechanisms are largely unknown. Here, we use functional Magnetic Resonance Imaging, a humorous alternative uses task and a stroop task, to investigate the brain mechanisms underlying the emergence of humorous ideas in 24 subjects. Neuroimaging results indicate that greater cognitive control abilities are associated with increased activation in the amygdala, the hippocampus and the superior and medial frontal gyrus during the generation of humorous ideas. Examining the neural mechanisms more closely shows that the hypoactivation of frontal brain regions is associated with an hyperactivation in the amygdala and vice versa. This antagonistic connectivity is concurrently linked with an increased number of humorous ideas and enhanced amygdala responses during the task. Our data therefore suggests that a neural antagonism previously related to the emergence and regulation of negative affective responses, is linked with the generation of emotionally positive ideas and may represent an important neural pathway supporting mental health.

scholarly journals Exploring the Social Networks’ Use in the Health-Care Industry: A Multi-Level Analysis

2021 ◽  
Vol 18 (14) ◽  
pp. 7295
Author(s):  
Tommasina Pianese ◽  
Patrizia Belfiore
Keyword(s):  
Health Care ◽  
Social Networks ◽  
Health Care Providers ◽  
Health Care Industry ◽  
Future Research ◽  
Great Level ◽  
Care Providers ◽  
Care Industry ◽  
Multi Level ◽  
Video And Audio

The application of social networks in the health domain has become increasingly prevalent. They are web-based technologies which bring together a group of people and health-care providers having in common health-related interests, who share text, image, video and audio contents and interact with each other. This explains the increasing amount of attention paid to this topic by researchers who have investigated a variety of issues dealing with the specific applications in the health-care industry. The aim of this study is to systematize this fragmented body of literature, and provide a comprehensive and multi-level overview of the studies that has been carried out to date on social network uses in healthcare, taking into account the great level of diversity that characterizes this industry. To this end, we conduct a scoping review enabling to identify the major research streams, whose aggregate knowledge are discussed according to three levels of analysis that reflect the viewpoints of the major actors using social networks for health-care purposes, i.e., governments, health-care providers (including health-care organizations and professionals) and social networks’ users (including ill patients and general public). We conclude by proposing directions for future research.

scholarly journals Involvement of Microglia in the Pathophysiology of Intracranial Aneurysms and Vascular Malformations—A Short Overview

2021 ◽  
Vol 22 (11) ◽  
pp. 6141
Author(s):  
Teodora Larisa Timis ◽  
Ioan Alexandru Florian ◽  
Sergiu Susman ◽  
Ioan Stefan Florian
Keyword(s):  
Immune Cells ◽  
Arteriovenous Malformations ◽  
Intracranial Aneurysms ◽  
Immune Cell ◽  
Vascular Malformations ◽  
Cerebral Injury ◽  
Future Research ◽  
Mortality And Morbidity ◽  
The Central Nervous System ◽  
The Brain

Aneurysms and vascular malformations of the brain represent an important source of intracranial hemorrhage and subsequent mortality and morbidity. We are only beginning to discern the involvement of microglia, the resident immune cell of the central nervous system, in these pathologies and their outcomes. Recent evidence suggests that activated proinflammatory microglia are implicated in the expansion of brain injury following subarachnoid hemorrhage (SAH) in both the acute and chronic phases, being also a main actor in vasospasm, considerably the most severe complication of SAH. On the other hand, anti-inflammatory microglia may be involved in the resolution of cerebral injury and hemorrhage. These immune cells have also been observed in high numbers in brain arteriovenous malformations (bAVM) and cerebral cavernomas (CCM), although their roles in these lesions are currently incompletely ascertained. The following review aims to shed a light on the most significant findings related to microglia and their roles in intracranial aneurysms and vascular malformations, as well as possibly establish the course for future research.

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