scholarly journals МІКРОСТРУКТУРНА ХАРАКТЕРИСТИКА ПІДНИЖНЬОЩЕЛЕПНОЇ СЛИННОЇ ЗАЛОЗИ ЩУРА В НОРМІ

World Science ◽  
2020 ◽  
Vol 2 (3(55)) ◽  
pp. 13-17
Author(s):  
Mykhalevych Marta ◽  
Paltov Yevgen ◽  
Kryvko Yurii
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Salivary Glands ◽  
Digestive System ◽  
Submandibular Salivary Gland ◽  
Horizontal Position ◽  
Submandibular Salivary Glands ◽  
Cervical Area ◽  
Upper Gastrointestinal ◽  
Functional Purpose

Macroanatomy, topography of the submandibular salivary glands in rats, the size and mechanisms of functioning, are determined by the characteristics of the structure of the skull and cervical area, and the horizontal position of the animal body and features of the functional purpose of the glands. Salivary glands ensure the consistency of homeostasis not only in the oral cavity, but also in the upper gastrointestinal tract, performing the primary enzymatic processing of food, helping the passage of food to the esophagus. Apparently, there are no other organs that perform as many functions (secretory, secretory, excretory, secretory) and have such a significant impact on the condition of the organism, oral cavity and digestive system as a whole.This publication demonstrates microstructures characteristics of submandibular salivary gland of rats.

scholarly journals The determination of specificity, sensitivity and accuracy of core needle biopsy in the diagnosis of parotid and submandibular salivary glands tumors

2019 ◽  
Vol 76 (9) ◽  
pp. 921-928
Author(s):  
Aleksandar Oroz ◽  
Zorana Bokun ◽  
Djordje Antonijevic ◽  
Jasna Jevdjic
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Tumor Tissue ◽  
Submandibular Salivary Gland ◽  
Histopathological Analysis ◽  
Core Needle ◽  
Parotid Salivary Gland ◽  
Submandibular Salivary Glands

Background/Aim. The diagnosis of tumors of salivary glands relies heavily on radiological examination and biopsy of pathological tissue. The aim of this study was to investigate the sensitivity, specificity and accuracy of core needle biopsy in diagnosis of tumors of parotid and submandibular glands. Methods. This study was designed as a crosssectional clinical trial performed between May 2008 and ?ay 2015 at the Department of Otorhinolaryngology and Maxillofacial Surgery, Clinical Center Zemun, Belgrade, Serbia. The examinations included 200 patients among which 100 were diagnosed with tumors of parotid salivary glands and 100 with tumors of submandibular salivary glands. The core needle biopsy was undertaken in all cases where tumor was smaller than 2 cm, far from blood vessels and far from the deep layer of parotid gland. The histopathological analysis was performed to identify histological type of the lesion. Upon performing the surgical procedure and consequently the tumor tissue extirpation, tissue samples obtained were investigated for the definitive diagnosis. Results. The sensitivity of the procedure was 90.9% for parotid salivary gland and 74% for submandibular salivary gland, the specificity was 95.9% for parotid salivary gland and 93% for submandibular salivary gland and the accuracy was 94.7% for parotid salivary gland and 87% for submandibular salivary gland. Based on the histopathological findings of the salivary glands obtained using core needle biopsy of the tumor tissue, it was possible to differentiate between malignant and benign lesions. Conclusion. Current investigation points to the advantages and efficiency of core needle biopsy in diagnosis of tumors of parotid and submandibular salivary glands.

scholarly journals МАКРОАНАТОМІЯ ТА АНГІОАРХІТЕКТОНІКА ВЕЛИКИХ СЛИННИХ ЗАЛОЗ БІЛОГО ЩУРА

2019 ◽  
Vol 1 (11(41)) ◽  
pp. 23-25
Author(s):  
Михалевич М. М. ◽  
Блищак Н. Б. ◽  
Борис Р. Я.
Keyword(s):  
Parotid Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Venous Blood ◽  
Temporal Artery ◽  
Structural Features ◽  
Facial Artery ◽  
Horizontal Position ◽  
Cervical Area ◽  
Functional Purpose

Macroanatomy, topography of a large salivary glands of rats, the size and the functional mechanism are defined by the structural features of the skull and the cervical area, by the horizontal position of the rat’s body and by the features of functional purpose of the salivary glands. The morphological methods of research the large salivary glands of rats, proved that submandibular gland is located together with the large and small sublingual glands in the anterior region of the neck, the parotid gland is localized in the lateral region of the neck. The submandibular gland, the large and small sublingual glands are supplied by the facial artery, when the parotid gland is supplied by the temporal artery. A venous blood from the submandibular gland, the large and small sublingual glands is drained by sublingual vein and from the parotid gland- by the mandibular vein.

scholarly journals Common immunophenotypic features of submandibular salivary glands and thymus in rats

2012 ◽  
Vol 140 (5-6) ◽  
pp. 270-277
Author(s):  
Ivan Dozic ◽  
Tatjana Todorovic ◽  
Miodrag Colic
Keyword(s):  
Salivary Gland ◽  
Epithelial Cells ◽  
Salivary Glands ◽  
Endocrine System ◽  
Immunohistochemical Analysis ◽  
The Body ◽  
Thymic Epithelial Cells ◽  
Submandibular Salivary Gland ◽  
Phenotypic Similarity ◽  
Submandibular Salivary Glands

Introduction. Submandibular salivary gland is a part of the neuro-immune-endocrine system. It contains biological factors which regulate a number of functions in the body including the modulation of thymus function. Objective. The aim of the study was to investigate immunophenotypic characteristics of submandibular salivary glands of rats during ontogenesis, using the panels of monoclonal antibodies and to compare with the phenotypic characteristics of epithelial components of the thymus. Methods. Submandibular salivary glands and thymus were obtained from 1, 30 and 60 days old male AO (Albino, Oxford) rats. Streptavidin-biotin peroxidase method was used for staining. Results. Immunohistochemical analysis of rat submandibular salivary glands showed phenotypic heterogeneity of particular components of this gland during the postnatal development. We demonstrated that rat submandibular salivary glands share common antigens with rat thymic epithelial cells, but the observed phenotypic similarity between the individual regions was considered much more significant. Our data showed that the phenotypic similarity between duct epithelial cells and subcapsular epithelial cells and most medullary cells, whereas cortical epithelial cells are phenotypically similar to acinar cells. Conclusion. This immunohistological study showed phenotypic complexity of the submandibular salivary gland and similarity to the thymus that opens new perspectives in studying phenotypic similarities between this gland and lymphatic organs.

scholarly journals Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Gamilah Al-Qadhi ◽  
Rabab Mubarak
Keyword(s):  
Salivary Glands ◽  
Arabian Peninsula ◽  
Submandibular Salivary Gland ◽  
Catha Edulis ◽  
Ductal Cells ◽  
Cytoplasmic Vacuoles ◽  
Transmission Electron ◽  
Salivary Gland Cells ◽  
Submandibular Salivary Glands

Abstract Objective Khat (Catha edulis Forssk) plant has been widely chewed for its psychostimulatory effects in the African and Arabian Peninsula, particularly in Yemen. Considering the khat leaves are gradually chewed without swallowing, while its active constituents are extracted into saliva, studying the effect of khat on salivary glands is necessary. This work is an extension of the previously published work that studied the effect of khat extract on the rats' submandibular salivary glands in terms of histological and immunohistochemical evaluations. The current research note aimed to better understand this effect on the ultrastructure of submandibular salivary gland cells by using transmission electron microscope. Results Oral administration of khat extract produced degenerative changes in the secretory and ductal cells of rats' submandibular salivary glands. These changes involved irregular boundaries of variable sized-nuclei, dilated RER, cytoplasmic vacuoles as well as swollen and degenerated mitochondria.

scholarly journals Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors

2019 ◽  
Vol 51 (1) ◽  
pp. 3-13
Author(s):  
Araz Ahmed ◽  
Alessandro Gulino ◽  
Simita Amayo ◽  
Walter Arancio ◽  
Ada Maria Florena ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Natriuretic Peptide ◽  
Autonomic Nerves ◽  
Submandibular Salivary Glands ◽  
Peptide System ◽  
Glandular Structures ◽  
Gland Function ◽  
Autocrine Signalling ◽  
Natriuretic Peptide System

Abstract The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.

scholarly journals Sialotripsy as a treatment option for patients with salivary stone disease

2021 ◽  
Author(s):  
A. V. Ivachenco ◽  
A. E. Yablokov ◽  
Е. О. Filatova ◽  
V. A. Monakov
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Stone Disease ◽  
Submandibular Salivary Gland ◽  
Clinical Group ◽  
Preoperative Stage ◽  
Salivary Calculi ◽  
Medical University ◽  
Methods Of Treatment ◽  
Minimally Invasive Methods

Background. The pathologies of the salivary glands are very diverse. Salivary stone disease occupies a special place among diseases of the salivary glands of a non-neoplastic nature. The incidence of salivary stone disease is extremely extensive and accounts for up to 85% of all pathologies of the salivary glands.Objective. Improvement of minimally invasive methods of treatment of salivary stone disease, which does not lead to excision of the gland.Material and methods. On the basis of the Clinics of the Samara State Medical University of the Ministry of Health of Russia, in the period from 2010 to 2020, a clinical group was formed, consisting of 193 patients with salivary stone disease of various localization. The age of the patients ranged from 16 to 84 years. All patients were therapeutically examined at the preoperative stage, voluntary informed consent was signed. Shockwave sialotripsy was performed in 95 patients of the main group (in 64 patients the calculus was located in the submandibular salivary gland, in 31 patients – in the parotid salivary gland). For lithotripsy, we used a lithotripter apparatus "Edap" (France) and "Wolf" (Germany).Results. The analysis of the results obtained as a result of the study made it possible to draw a conclusion about reasonably better results of removal of calculi in the ducts of the salivary glands using the lithotripter "Swiss LithoClast® Master" (Switzerland). At the first visit and the therapeutic effect of the lithotripter, all patients suffering from bouts of salivary colic showed complete cessation.Conclusion. Thus our study, which was devoted to the study of the results of various methods of treating patients with salivary stone disease showed that sialolithotripsy using special narrowly targeted devices for crushing and subsequent excretion of salivary calculi allows to achieve the best results at present.

scholarly journals Morphologic Characteristics of the Submandibular Salivary Gland of the Collared Peccary (Tayassu Tajacu)

2018 ◽  
Vol 35 (02) ◽  
pp. 116-121
Author(s):  
Gabriela de Souza Reginato ◽  
Cristina de Sousa Bolina ◽  
Moacir Franco Oliveira ◽  
Sonia Regina Yokomizo Almeida ◽  
Ii-sei Watanabe ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Secretory Granules ◽  
Morphological Characteristics ◽  
Acinar Cells ◽  
Collagen Fibers ◽  
Submandibular Salivary Gland ◽  
Ductal Cells ◽  
Collared Peccary

Introduction Most salivary glands is located on the inside and around the oral cavity, and are divided into major and minor salivary glands. The aim of the present study was to describe the structural and ultrastructural morphological characteristics of the lingual tissue of the submandibular glands of the collared peccary (Tayassu tajacu). Materials and Methods The submandibular glands (n = 10) of adult male collared peccaries ( T. tajacu) were used for histological and ultrastructural analysis. The techniques used were light microscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Results The submandibular salivary glands of the collared peccary (T. tajacu) showed a capsule formed by a connective tissue containing the acinus and duct cells. Histologically, the nuclei located at the basal region of the cells was observed. The light polarized microscopy clearly showed the presence of type I and type III collagen. In the SEM image, the submandibular salivary gland revealed a round aspect separated in several lobules with bundles of collagen fibers. The vibratome sections showed the groupings of acinar cells, with intermingled secretory ducts containing vessels of different diameters. The secretory granules were noted in the apical portion of the acinar and ductal cells. The thick bundles of collagen fibers formed a glandular capsule and were identified around of the acinar and ductal cells in three-dimensional SEM images. The TEM images showed a number of secretory granules, especially in the apical region of the cytoplasm of the acinar cells and in the basal portion of the nuclei. The granular endoplasmic reticulum area, the euchromatic nuclei and the cytoplasmic projections may be seen. Mucous acinar cells separated by fine collagen fibers were also observed. Conclusion The morphological characteristics of the submandibular gland of the collared peccary is similar to that of other mammals with the same eating habits and habitat.

scholarly journals ПАТОМОРФОЛОГІЧНІ ЗМІНИ СТРУКТУР ПІДНИЖНЬОЩЕЛЕПНОЇ СЛИННОЇ ЗАЛОЗИ НАПРИКІНЦІ 6-го ТИЖНЯ ЕКСПЕРИМЕТАЛЬНОГО ОПІОЇДНОГО ВПЛИВУ

2020 ◽  
pp. 3-6
Author(s):  
Mykhalevych Marta ◽  
Paltov Yevgen ◽  
Kryvko Yurii
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Drug Addiction ◽  
Experimental Research ◽  
Structural Organization ◽  
Morphological Changes ◽  
Submandibular Salivary Gland ◽  
Functional Disorders ◽  
The People ◽  
Salivary Ph

The significant using of drugs and the prevalence of drug addiction in the last decades necessitates the study of the effects of opioids on the structural organization of organs and systems. The people with drug addiction syndrome have functional disorders of the salivary glands earlier than morphological changes in the mucous membrane of oral cavity.Reducing the amount of saliva and changing its composition lead to negative changes in the oral barrier function, salivary pH which is the main natural regulator of oral cavity homeostasis. This publication demonstrates the morphological changes of the submandibular salivary gland under the opioid effect at the 6th week of the experimental research.

The development of the incidence of non-neoplastic diseases of the digestive system in adults evacuated from the 30-kilometer zone of the Chornobyl nuclear power plant during the post-accident observation period (1992–2016)

2021 ◽  
pp. 4-10
Author(s):  
K.Ye. Prykashсhykova ◽  
◽  
Zh.S. Yaroshenko ◽  
O.A. Kapustynska ◽  
V.G. Kostiuk ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Salivary Glands ◽  
Biliary Tract ◽  
Digestive System ◽  
Absolute Risk ◽  
Epidemiological Surveillance ◽  
Educational Work ◽  
Neoplastic Diseases ◽  
Digestive Diseases ◽  
The Absolute

Objective: We analyzed the absolute risk of the development of the incidence of non-neoplastic diseases of the digestive system in adults evacuated from the 30-kilometer zone of the Chornobyl NPP over 1992–2016 epidemiological surveillance. Materials and methods: For the epidemiological study of the incidence of non-neoplastic diseases of the digestive system in the evacuated from the 30-kilometer Chornobyl zone after the Chornobyl accident in 1992–2016 we formed a cohort of 7,143 people aged 18 years and older (2,198 men and 4,945 women). To study the features of the incidence of diseases of the digestive system over the years of observation, we calculated the epidemiological indicator - the absolute risk of development (AR). Results: During 1992–2016, 13,532 cases of the diseases of the digestive system: 3,298 (24.37%) – in men; 10,234 (75.63%) - in women) were revealed for the first time. The absolute risk of the development of digestive diseases makes up 467.64 ± 2.93 cases per 103 man-years of observation (further cases/103 man-years). It was found that 91.05% (12,321 cases) with an absolute risk of 425.32 ± 5.89 93 cas./103 man-years ( 423.22 ± 5.89- in men, 426.19 ± 3, 34 - in women) belonged to the class of the diseases of digestive system (C00-C93). Mostly diseases of oral cavity, salivary glands and jaws (C00 – C14) (200.63 ± 4.77 cases/103 man-years), esophageal diseases, stomach and duodenum (C20 – C31) (146.26 ± 4.21 93) were manifested. Significant loss of health was also caused by the diseases of the gallbladder, biliary tract and pancreas (C83–C87) (50.23 ± 2.60 93), liver disease (C70-C77) – (22.44 ± 1.76 93), non-infectious enteritis and colitis (C50–C52) – (3.93 ± 8.75), other intestinal diseases (C55–C63) – (1.83 ± 0.51) respectively. Irrespective of gender, the development of the incidence of non-neoplastic diseases of the digestive system is characterized by the identity of the diseases and the ratio of their values to the total cohort. However, women suffered more from the diseases of the gallbladder, biliary tract and pancreas, diseases of the oral cavity, men – from the diseases of esophagus, stomach and duodenum. Conclusions: 1. The revealed features of the development of digestive diseases in the evacuated from the 30-kilometer zone of the Chornobyl NPP (high absolute risks of diseases of oral cavity, salivary glands and jaws (C00–C14), diseases of esophagus, stomach and duodenum (C20–C31), biliary diseases bladder, biliary tract and pancreas (C80–C87)) need the improvement of medico-social measures to provide qualitative treatment-and-preventive, rehabilitative care from the primary level of medical care. 2. It is necessary to conduct medico-educational work on radiation hygiene, regimen, food intake and dietary nutrition for the minimization of the development of established prior nosological forms in the evacuees from the 30-kilometer zone of the ChNPP.

Exosomes Derived from Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSC) Protect Submandibular Glands in Diabetic Rats

2021 ◽  
Vol 11 (11) ◽  
pp. 2168-2173
Author(s):  
Cong Zhang ◽  
Xiaohong Zhang ◽  
Min Zhang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Salivary Gland ◽  
Salivary Glands ◽  
Serum Amylase ◽  
Diabetic Rats ◽  
Submandibular Salivary Gland ◽  
Amylase Level ◽  
Group I

Our study assess whether exosomes derived from bone marrow mesenchymal stem cells (BM-MSC) ameliorates diabetic salivary gland complications. 10 SD rats were assigned into diabetes group I and exosome treatment group II. Diabetic rats were induced by streptozotocin (STZ) and injected with DMSO or exosomes through tail vein followed by collection of submandibular salivary gland samples for histological analysis and TGFβ, Smad2 and Smad3 level by PCR, saliva IgA and serum amylase level. Compared with control mice, exosome treatment mice showed less fibrosis of the submandibular salivary glands and duct components with a more complete structure. Exosome treatment inhibited TGFβ, Smad2 and Smad3 level to reduce diabetic salivary gland complications, effectively decreased blood sugar level, improved salivary glands function with significantly reduced serum amylase and salivary IgA levels. In conclusion, BM-MSC-derived exosomes may be a new therapeutic strategy for treating diabetic salivary gland complications.

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