scholarly journals Ethnopharmacology, Phytochemistry and Pharmacological Properties of Cortex Phellodendri Chinensis: A Comprehensive Review

2020 ◽  
pp. 1-24
Author(s):  
Xi-jun Wang ◽  
Jun-ling Ren ◽  
Aihua Zhang ◽  
Ling Kong ◽  
Xi-jun Wang
Keyword(s):  
Scientific Basis ◽  
Future Research ◽  
Traditional Chinese Medicines ◽  
Bioactive Constituents ◽  
Medicinal Uses ◽  
Chinese Medicines ◽  
Additional Information ◽  
Quality Markers ◽  
Bioactive Ingredients ◽  
Cortex Phellodendri

Ethnopharmacological Relevance: Cortex Phellodendri Chinensis (CPC), a traditional Chinese medicine known as “HuangBai” in China, are being widely employed as its health benefits. CPC has the function of clearing heat and expelling dampness, purging fire and removing toxin, detumescencing and removing necrotic tissue, which have the treatment for a variety of diseases. Aim of The Study: The present review is intended to summarize the current researches on the phytochemistry, pharmacological significances and medicinal uses of CPC, hoping to provide reference and scientific basis for the research of bioactive ingredients, quality markers of CPC, as well as further development and utilization in treatment of human diseases with CPC. Materials and Methods: Extensive search of various documents and electronic databases such as Pubmed, Royal Society of Chemistry, Science Direct, Springer, Web of Science, and Wiley, etc., were done to obtain data. Other online academic libraries, e.g. Google Scholars, Scopus and national pharmacology literature were also been employed to learn more information about CPC. Additional information was derived from herbal classic books, Chinese pharmacopoeia, Postgraduate theses, China national knowledge internet, etc. Results: The comprehensive analysis of the electronic database and literatures demonstrated that CPC is a valuable herbal medicine with multiple pharmacological effects. Phytochemical and pharmacological analysis indicated alkaloids are the major bioactive ingredients in CPC. However, there are no reports on the research of quality markers of CPC, which means in a short time, there will emerge many studies to fill this gap. Under the guidance of traditional Chinese medicines theory, CPC is usually combined with other traditional Chinese medicines into prescriptions for various clinical use. Conclusions: This review summarized the results from current researches about the basic characteristics of CPC, such as bioactive constituents, pharmacological effect and mechanism of action, which are still being studied and explored in order to realize the optimal medical practice. Meanwhile, it points out the existed problems of the current researches of CPC and puts forward some suggestions for the future research of CPC.

Amruthapala (Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter): A Comprehensive Review on Diversity, Therapeutic Uses, and Valorization of Bioactive Constituents

2019 ◽  
Vol 20 (5) ◽  
pp. 376-389 ◽  
Author(s):  
Sonali Mishra ◽  
Nupur Srivastava ◽  
Velusamy Sundaresan ◽  
Karuna Shanker
Keyword(s):  
Secondary Metabolite ◽  
Current Knowledge ◽  
Experimental Studies ◽  
Critical Discussion ◽  
Future Research ◽  
Bioactive Constituents ◽  
Medicinal Uses ◽  
Comprehensive Review ◽  
Therapeutic Uses ◽  
Decalepis Arayalpathra

Background: Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter is used primarily for nutrition besides its therapeutic values. Traditional preparations/formulations from its tuber are used as a vitalizer and blood purifier drink. The folklore medicinal uses cover inflammation, cough, wound healing, antipyretic, and digestive system management. A comprehensive review of the current understanding of the plant is required due to emerging concerns over its safety and efficacy. Objective: The systematic collection of the authentic information from different sources with the critical discussion is summarised in order to address various issues related to botanical identity, therapeutic medicine, nutritional usage, phytochemical, and pharmacological potentials of the D. arayalpathra. Current use of traditional systems of medicine can be used to expand future research opportunities. Materials and Methods: Available scripted information was collected manually, from peered review research papers and international databases viz. Science Direct, Google Scholar, SciFinder, Scopus, etc. The unpublished resources which were not available in database were collected through the classical books of ‘Ayurveda’ and ‘Siddha’ published in regional languages. The information from books, Ph.D. and MSc dissertations, conference papers and government reports were also collected. We thoroughly screened the scripted information of classical books, titles, abstracts, reports, and full-texts of the journals to establish the reliability of the content. Results: Tuber bearing vanilla like signature flavor is due to the presence of 2-hydroxy-4-methoxybenzaldehyde (HMB). Among five other species, Decalepis arayalpathra (DA) has come under the ‘critically endangered’ category, due to over-exploitation for traditional, therapeutic and cool drink use. The experimental studies proved that it possesses gastro-protective, anti-tumor, and antiinflammatory activities. Some efforts were also made to develop better therapeutics by logical modifications in 2-Hydroxy-4-methoxy-benzaldehyde, which is a major secondary metabolite of D. arayalpathra. ‘Amruthapala’ offers the enormous opportunity to develop herbal drink with health benefits like gastro-protective, anti-oxidant and anti-inflammatory actions. Results: The plant has the potential to generate the investigational new lead (IND) based on its major secondary metabolite i.e. 2-Hydroxy-4-methoxy-benzaldehyde. The present mini-review summarizes the current knowledge on Decalepis arayalpathra, covering its phytochemical diversity, biological potentials, strategies for its conservation, and intellectual property rights (IPR) status. Chemical Compounds: 2-hydroxy-4-methoxybenzaldehyde (Pubchem CID: 69600), α-amyrin acetate (Pubchem CID: 293754), Magnificol (Pubchem CID: 44575983), β-sitosterol (Pubchem CID: 222284), 3-hydroxy-p-anisaldehyde (Pubchem CID: 12127), Naringenin (Pubchem CID: 932), Kaempferol (Pubchem CID: 5280863), Aromadendrin (Pubchem CID: 122850), 3-methoxy-1,2-cyclopentanedione (Pubchem CID: 61209), p-anisaldehyde (Pubchem CID: 31244), Menthyl acetate (Pubchem CID: 27867), Benzaldehyde (Pubchem CID: 240), p-cymene (Pubchem CID: 7463), Salicylaldehyde (Pubchem CID: 6998), 10-epi-γ-eudesmol (Pubchem CID: 6430754), α -amyrin (Pubchem CID: 225688), 3-hydroxy-4-methoxy benzaldehyde (Pubchem CID: 12127).

The interactions between gut microbiota and bioactive ingredients of traditional Chinese medicines: A review

2020 ◽  
Vol 157 ◽  
pp. 104824 ◽  
Author(s):  
Xue Gong ◽  
Xue Li ◽  
Agula Bo ◽  
Ru-Yu Shi ◽  
Qin-Yu Li ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Bioactive Ingredients

Prediction of quality markers of traditional Chinese medicines based on network pharmacology

2019 ◽  
Vol 11 (4) ◽  
pp. 349-356 ◽  
Author(s):  
Yu-li Wang ◽  
Tao Cui ◽  
Ya-zhuo Li ◽  
Mao-liang Liao ◽  
Hong-bing Zhang ◽  
...  
Keyword(s):  
Network Pharmacology ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Quality Markers

scholarly journals Gardenia ternifolia Schum. & Thonn. (Rubiaceae): Review of medicinal uses, phytochemistry and biological activities

2020 ◽  
Vol 11 (4) ◽  
pp. 5876-5885
Author(s):  
Alfred Maroyi
Keyword(s):  
Traditional Medicine ◽  
Democratic Republic Of Congo ◽  
Respiratory Infections ◽  
Biological Activities ◽  
Future Research ◽  
Tropical Africa ◽  
Scientific Publications ◽  
Medicinal Uses ◽  
Additional Information

Gardenia ternifolia Schum. & Thonn. is a shrub or small tree widely used as a traditional medicine throughout its distributional range in tropical Africa. Gardenia ternifolia is widespread in tropical Africa, extending from Senegal eastwards to Ethiopia and Kenya, through the Democratic Republic of Congo (DRC) southwards to Namibia, South Africa and Mozambique. This study was aimed at providing a critical review of the medicinal uses, phytochemistry and biological activities of G. ternifolia. Documented information on the medicinal uses, phytochemistry and biological activities of G. ternifolia was collected from several online sources which included Scopus, Google Scholar, PubMed and Science Direct. Additional information was gathered from pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. This study showed that the species is widely used as an aphrodisiac and protective charm, and traditional medicine for headache, migraine, respiratory infections, sore eyes, hypertension, diabetes, gastro-intestinal problems, erectile dysfunction, malaria, convulsions and epilepsy. Phytochemical compounds identified from the species include alkaloids, anthocyanins, coumarins, flavonoids, phenols, quinones, saponins, steroids, stereoisomeric neolignans, tannins and terpenoids. Pharmacological research revealed that G. ternifolia extracts and compounds isolated from the species have antibacterial, antiviral, anti-inflammatory, antileishmanial, antioxidant, antiplasmodial, antisickling, antitheilerial, hepatotoxicity, larvicidal and cytotoxicity activities. Future research on G. ternifolia should focus on detailed phytochemical evaluations, including toxicological, in vivo and clinical studies to corroborate the traditional medical applications of the species.

scholarly journals Screening for the bioactive constituents of traditional Chinese medicines—progress and challenges

RSC Advances ◽  
2017 ◽  
Vol 7 (6) ◽  
pp. 3089-3100 ◽  
Author(s):  
Xing-Xin Yang ◽  
Wen Gu ◽  
Li Liang ◽  
Hong-Li Yan ◽  
Yan-Fang Wang ◽  
...  
Keyword(s):  
Drug Development ◽  
Traditional Chinese Medicines ◽  
Bioactive Constituents ◽  
Chinese Medicines ◽  
Lead Compounds ◽  
New Drug ◽  
New Drug Development

The search for lead compounds from traditional Chinese medicines (TCMs) may be promising for new drug development.

Evaluation of Medicinal uses, Phytochemistry and Biological Activities of Adenia gummifera (Harv.) Harms -

2020 ◽  
Vol 10 (5) ◽  
pp. 280-286
Author(s):  
Alfred Maroyi
Keyword(s):  
Traditional Medicine ◽  
Democratic Republic Of Congo ◽  
Respiratory Infections ◽  
Biological Activities ◽  
Future Research ◽  
Scientific Publications ◽  
Medicinal Uses ◽  
Additional Information ◽  
Cytotoxicity Activities

Adenia gummifera (Harv.) Harms is a climber or liane widely used as traditional medicine throughout its distributional range in tropical Africa. Adenia gummifera occurs naturally in the Democratic Republic of Congo (DRC), Eswatini, Ethiopia, Kenya, Malawi, Mozambique, Seychelles, Somalia, South Africa, Tanzania, Uganda, Zambia and Zimbabwe. This study is aimed at providing a critical review of the medicinal uses, phytochemistry and biological activities of A. gummifera. Documented information on the medicinal uses, phytochemistry and biological activities of A. gummifera was collected from several online sources, which included Scopus, Google Scholar, PubMed and Science Direct. Additional information was gathered from pre-electronic sources such as book chapters, books, journal articles and scientific publications sourced from the university library. This study showed that the species is widely used as an emetic and a protective charm, and, as traditional medicine for infertility, sexually transmitted infections, gastro-intestinal infections, leprosy, respiratory infections, malaria and menstrual problems. Phytochemical compounds identified from the species include polyacetylenic diepoxide, alkaloids, flavonoids, flavonol, modeccin, proanthocyanidins, tetraphyllin, phenolics, polyphenol and tannins. Pharmacological research revealed that A. gummifera extracts and compounds isolated from the species have antibacterial, antifungal, acetylcholinesterase inhibitory (AChEI), anaesthetic, antioxidant, antiplasmodial and cytotoxicity activities. Future research on A. gummifera should focus on detailed phytochemical evaluations including toxicological, in vivo and clinical studies to corroborate the traditional medical applications of the species.

scholarly journals HELICHRYSUM CYMOSUM (L.) D.DON (ASTERACEAE): MEDICINAL USES, CHEMISTRY, AND BIOLOGICAL ACTIVITIES

2019 ◽  
pp. 19-26
Author(s):  
ALFRED MAROYI
Keyword(s):  
Biological Activities ◽  
Future Research ◽  
Pharmacological Properties ◽  
Journal Articles ◽  
Tropical Africa ◽  
Medicinal Uses ◽  
Additional Information ◽  
Cytotoxicity Activities ◽  
The University ◽  
Anti Hiv

Helichrysum cymosum is a valuable and well-known medicinal plant in tropical Africa. The current study critically reviewed the medicinal uses, phytochemistry and biological activities of H. cymosum. Information on medicinal uses, phytochemistry and biological activities of H. cymosum, was collected from multiple internet sources which included Scopus, Google Scholar, Elsevier, Science Direct, Web of Science, PubMed, SciFinder, and BMC. Additional information was gathered from pre-electronic sources such as journal articles, scientific reports, theses, books, and book chapters obtained from the University library. This study showed that H. cymosum is traditionally used as a purgative, ritual incense, and magical purposes and as herbal medicine for colds, cough, fever, headache, and wounds. Ethnopharmacological research revealed that H. cymosum extracts and compounds isolated from the species have antibacterial, antioxidant, antifungal, antiviral, anti-HIV, anti-inflammatory, antimalarial, and cytotoxicity activities. This research showed that H. cymosum is an integral part of indigenous pharmacopeia in tropical Africa, but there is lack of correlation between medicinal uses and existing pharmacological properties of the species. Therefore, future research should focus on evaluating the chemical and pharmacological properties of H. cymosum extracts and compounds isolated from the species.

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