scholarly journals EFFECTS OF LEAD AND CADMIUM INTOXICATION ON ANTIOXIDANT STATUS OF BROILER CHICKENS AND ITS CORRECTION WITH SYNTHETIC PREPARATIONS

2022 ◽  
pp. 7-18
Author(s):  
Yu. I. Koval
Keyword(s):  
Heavy Metals ◽  
Broiler Chickens ◽  
Antioxidant Status ◽  
Live Weight ◽  
The Body ◽  
Cadmium Content ◽  
Oxidation Reactions ◽  
Short Term ◽  
Lead And Cadmium

   The authors present the results of a study of the effects of long-term (1.5 MPa) and short-term (5, 10 and 15 MPa) intoxication with heavy metals on the antioxidant status of broiler chickens. The authors found that the addition of increased concentrations of toxicants to the diet leads to their accumulation in poultry’s muscle, fat tissues, and skin. According to the study, lead content increases by 2.25 times, cadmium content increases by 6.5 times. Lipophilic compounds Tiofan and Tiofan M have the most pronounced detoxifying effect in chronic intoxication. Fantox 11-1 is the most pronounced detoxifying effect among hydrophilic compounds, which are inferior to lipophilic ones. Accumulation of heavy metals in the body led to a decrease in the antioxidant status of poultry. There was an acceleration of oxidative processes in long-term experimental toxicosis up to 3.10, up to 21.00 times in the short-term. The addition of 100 mg of lipophilic antioxidants per 1 kg of live weight to the diet with 7.5 mg of lead and 0.75 mg of cadmium per 1 kg of feed resulted in a decrease in the rate of oxidation reactions. The presence of lead and cadmium ions in the tissues of poultry caused a reduction of induction periods in the temperature-stabilized samples to 90 %. Enrichment of the diet with Thiophan and Fantox 11-1 increased this indicator up to 12.40 times. The hydrophilic antioxidant Fantox 11-1 dosage of 15 mg per 1 kg of live weight had a pronounced effect. Its introduction into the diet will correct the lack of endogenous antioxidants and increase the body’s antioxidant status under the influence of heavy metals.

scholarly journals Use of water-alcohols treatment of medicinal plants under conditions modeling intoxication by lead and cadmium

2021 ◽  
pp. 80-88
Author(s):  
Yu. I. Koval ◽  
T. I. Bokova ◽  
A. F. Petrov
Keyword(s):  
Heavy Metals ◽  
Medicinal Plants ◽  
Blood Serum ◽  
Raw Materials ◽  
Antioxidant Properties ◽  
Live Weight ◽  
The Body ◽  
Laboratory Animals ◽  
Lead And Cadmium ◽  
Water Alcohol

The results of studying the effects of water-alcohol infusions of medicinal plants - rhizomes of thick-leafed incense (Bergenia crasslifolia L. Fritsch), dioica nettle leaves (Urtica dioca L.), burdock roots (Arctium lappa L.), and mother-and-leaf leaves - are presented. ordinary machichi (Tussilago farfara L.) on the organism of laboratory rats under conditions of short-term intoxication with heavy metals in doses of 25 mg of lead and 2.5 mg of cadmium per 1 kg of live weight. In the course of studies it was found that the effect of heavy metals on the body of laboratory animals is selective - the main “depot” of lead was bone tissue, and cadmium - the kidneys and liver. The addition of 1 ml of water-alcohol infusions from medicinal raw materials to the diet of rats as detoxicants caused a decrease in the level of lead in the animal organism to 6.32 times, cadmium to 3.46 times. The greatest detoxification ability was shown by infusions of the roots of burdock and leaves of nettle dioecious. Under the influence of elevated doses of lead and cadmium in laboratory animals there was an increase in heart mass by 40.34 % and spleen by 89.91 %, a decrease in the content of alkaline phosphatase in blood serum by 25.81 %. Water-alcohol infusions normalized the biochemical parameters of rat blood serum. Studies have shown that the infusions of rhizomes of thick-leafed frangipani, burdock roots, dioecious nettles and coltsfoot leaves with antioxidant properties can be the basis for the development of an effective herbal preparation used for the prevention and treatment of animals from intoxication with salts of heavy metals.

scholarly journals MORPHOLOGICAL AND BIOCHEMICAL BLOOD COMPOSITION IN FATTENING STEERS INDUSTRIAL AREA BY THE FEEDING OF THE ADSORBENT AND ENZYME PREPARATION

2019 ◽  
pp. 118-123
Author(s):  
C. R. Chamikoeva ◽  
P. B. Temiraev ◽  
R. S. Godgiev ◽  
V. V. Tedtova ◽  
L. V. Tsalieva ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Biochemical Composition ◽  
Enzyme Preparation ◽  
Live Weight ◽  
Industrial Area ◽  
Zinc Level ◽  
The Body ◽  
Enzyme Preparations ◽  
Lead And Cadmium ◽  
Experimental Group

To reduce the risk of accumulation of heavy metals in the meat of fattened young cattle successfully used adsorbents that bind toxins and removed from the digestive tract. The detoxification effect of adsorbents increases with the skillful selection of enzyme preparations due to the synergy of action. The aim of the research is to study the effect of toxfin adsorbent and the enzyme preparation celloviridin G20x in the diets with high content of heavy metals on the morphological and biochemical composition of the blood of fattened bulls. According to the principle of pairs-analogues (taking into account the origin, sex, age, live weight) were formed 4 groups of 10 heads each. The research material is processed statistically using the software package «Microsoft Excel». In the composition of the winter diet of animals of all groups there was an excess of maximum permissible concentrations (MPC) in zinc level by 67.3-67.5 %, lead -by 63.4-64.6 % and cadmium - by 62.9-63.1 %, in the summer diet - by 66.4-66.6 %, 61.4-61.6 % and 60.6-60.8 %. This article presents experimental material showing that to optimize the morphological and biochemical composition of blood and increase the detoxification effect in the body of bulls on fattening should be in the diet with high levels of heavy metals together to introduce IEC celloviridin G20h at a dose of 70 g/t feed and adsorbent toxfin at a dose of 1 kg/t feed. At the same time, animals of the 3rd experimental group showed improvement of morphological and biochemical composition of blood and optimization of protective properties of their organism. The highest detoxification effect was obtained by co-feeding the tested drugs, so that in the blood of bulls of the 3 experimental group there was a significant (P<0.05) decrease in the concentration of zinc by 2.23 times, lead by 2.43 and cadmium by 3.00 times. At the same time, in no case in animals of the 3 experimental group in the blood there was no excess of MPC in terms of zinc, lead and cadmium.

scholarly journals MORPHOLOGICAL AND BIOCHEMICAL BLOOD COMPOSITION IN FATTENING STEERS INDUSTRIAL AREA BY THE FEEDING OF THE ADSORBENT AND ENZYME PREPARATION

2020 ◽  
pp. 125-130
Author(s):  
S. R. Chamikoeva ◽  
R. B. Temiraev ◽  
R. S. Godgiev ◽  
V. V. Tedtova ◽  
L. V. Tsalieva ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Biochemical Composition ◽  
Enzyme Preparation ◽  
Live Weight ◽  
Industrial Area ◽  
Zinc Level ◽  
The Body ◽  
Enzyme Preparations ◽  
Lead And Cadmium ◽  
Experimental Group

To reduce the risk of accumulation of heavy metals in the meat of fattened young cattle successfully used adsorbents that bind toxins and removed from the digestive tract. The detoxification effect of adsorbents increases with the skillful selection of enzyme preparations due to the synergy of action. The aim of the research is to study the effect of toxfin adsorbent and the enzyme preparation celloviridin G20x in the diets with high content of heavy metals on the morphological and biochemical composition of the blood of fattened bulls. According to the principle of pairs-analogues (taking into account the origin, sex, age, live weight) were formed 4 groups of 10 heads each. The research material is processed statistically using the software package «Microsoft Excel». In the composition of the winter diet of animals of all groups there was an excess of maximum permissible concentrations (MPC) in zinc level by 67.3–67.5 %, lead –by 63.4–64.6 % and cadmium – by 62.9–63.1 %, in the summer diet – by 66.4–66.6 %, 61.4–61.6 % and 60.6–60.8 %. This article presents experimental material showing that to optimize the morphological and biochemical composition of blood and increase the detoxification effect in the body of bulls on fattening should be in the diet with high levels of heavy metals together to introduce IEC celloviridin G20h at a dose of 70 g/t feed and adsorbent toxfin at a dose of 1 kg/t feed. At the same time, animals of the 3rd experimental group showed improvement of morphological and biochemical composition of blood and optimization of protective properties of their organism. The highest detoxification effect was obtained by co-feeding the tested drugs, so that in the blood of bulls of the 3 experimental group there was a significant (P<0.05) decrease in the concentration of zinc by 2.23 times, lead by 2.43 and cadmium by 3.00 times. At the same time, in no case in animals of the 3 experimental group in the blood there was no excess of MPC in terms of zinc, lead and cadmium.

Polymorphism of p-450 cytochrome detoxication genes in adolescents depending on the degree of contamination of the organism by heavy metals

2020 ◽  
Vol 99 (5) ◽  
pp. 478-482
Author(s):  
N. P. Setko ◽  
A. G. Setko ◽  
Ekaterina V. Bulycheva ◽  
A. V. Tyurin ◽  
E. Yu. Kalinina
Keyword(s):  
Heavy Metals ◽  
Environmental Factors ◽  
Heavy Metal Contamination ◽  
Atomic Absorption Spectrophotometry ◽  
The Body ◽  
Lead And Cadmium ◽  
Cyp2b6 Gene ◽  
Cytochrome P 450 ◽  
Gene Cyp1a1 ◽  
Group 1

Introduction. Changes in the body of children and adolescents aimed at adapting to environmental factors are determined by genetic polymorphism in xenobiotic biotransformation genes, determining the degree of susceptibility of the child’s body to pollutants, which is the basis of modern personalized preventive medicine when managing risks to the health of the child population under the influence of environmental factors. Material and methods. Trace elements, including heavy metals, lead and cadmium, were determined in the hair of 256 practically healthy teenagers by atomic absorption spectrophotometry. Depending on the level of content of the latter, two groups of adolescents were formed to determine six genes of the cytochrome P-450 family. Group 1 consisted of adolescents whose cadmium lead content exceeded the average Russian indices. The second group included adolescents whose heavy metals were above the level of average Russian standards. Results. Studies have shown that in adolescents of the 1st group, compared with the data of adolescents of the 2nd group, an increase in the number of carriers of two mutant alleles at the locus rs 1048943 (gene CYP1A1) is 3.08 times, rs 464621 (gene CYP1A1) is 1. 8 times; locus rs 2069522 (CYP1A2 gene) 3.63 times; locus rs 1799853 (CYP2C9 * 2 gene) 4.5 times; locus rs 1057910 (gene CYP2C9 * 3) 3.8 times and locus rs 2279343 (gene CYP2B6) 4.25 times. Moreover, carriers of two normal alleles in adolescents of the first group at the locus rs 1048943 (gene CYP1A1) were 5.14 times; locus rs 2279343 (CYP2B6 gene) was 6.5 fold less than among adolescents of the 2nd group; and at the locus rs 464621 (gene CYP1A1), rs 2069522 (gene CYP1A2), rs 1799853 (gene CYP2C9 * 2), rs 1057910 (gene CYP2C9 * 3) there were no carriers of normal homozygotes. Conclusion. Group 1 adolescents with heavy metal contamination of the body are carriers significantly in a greater number of pathological mutations in the genes of the cytochrome P-450 detoxification system in comparison with data from group 2 adolescents.

Determination of Some Heavy Metals in Milk of Cow Grazing At Selected Areas, of Kaduna Metropolis

2017 ◽  
Vol 7 (7) ◽  
pp. 341 ◽  
Author(s):  
Mahmud Mohammed Imam ◽  
Zahra Muhammad ◽  
Amina Zakari
Keyword(s):  
Heavy Metals ◽  
Cadmium Toxicity ◽  
Research Work ◽  
The Body ◽  
Cow Milk ◽  
Scientific Model ◽  
Potential Health ◽  
Milk Samples ◽  
Lead And Cadmium ◽  
Digestion Technique

In this research work the concentration of zinc, copper, lead, chromium, cadmium, and nickel in cow milk samples obtained from four different grazing areas   (kakuri, kudendan, malali, kawo) of Kaduna metropolis. The samples were digested by wet digestion technique .The trace element were determined using bulk scientific model VPG 210 model  Atomic Absorption Spectrophotometer (AAS).. The concentration of the determined heavy metal were The result revealed that Cr,  Ni and Cd were not detected in milk samples from Kawo, Malali  and Kudendan whereas lead (Pb) is detected in all samples and found to be above  the stipulated limits of recommended dietary allowance (NRC,1989) given as 0.02mg/day. Cu and Zn are essential elements needed by the body for proper metabolism and as such their deficiency or excess is very dangerous for human health. However, they were found in all samples and are within the recommended limits while Cd (2.13 – 3.15 mg/kg) in milk samples from Kakuri was found to be above such limit (0.5mg/day). Cow milk samples analyzed for heavy metals in this research work pose a threat of lead and cadmium toxicity due to their exposure to direct sources of air, water and plants in these grazing areas, thereby, resulting to a potential health risk to the consumers.

Free radical peroxidation and natural antioxidants

2021 ◽  
pp. 36-44
Author(s):  
Oksana Anatolievna Gizinger ◽  
V. A. Dadali
Keyword(s):  
Free Radical ◽  
Antioxidant Status ◽  
Natural Antioxidants ◽  
Food Products ◽  
Nutritional Deficiency ◽  
The Body ◽  
Current State

Modern food products provide no more than 5-6% of the body's need for micronutrients, many of which are antioxidants. The current state of the problem of nutritional deficiency predetermines a chronic long-term deficiency of antioxidants in the diet. Providing the body with balanced polyvalent antioxidant complexes and normalizing its antioxidant status is the basis of health and active longevity.

ANALISA LOGAM BESI (Fe) DI SUNGAI PASAR DAERAH BELANGWETAN KLATEN DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM

2017 ◽  
Vol 2 (1) ◽  
pp. 39
Author(s):  
Rahmi Nurhaini ◽  
Arief Affandi
Keyword(s):  
Heavy Metals ◽  
Sampling Method ◽  
Research Result ◽  
The Body ◽  
Clean Water ◽  
Observational Method ◽  
The Mean ◽  
The Republic

Iron (Fe) is one of many heavy metals that is corrosive resistant, dense, and has a low melting point. If accumulated in the body, the metal can cause some medical conditions, such as irritation to skin and eyes, breathing problems, and in the long term, cancer. This research aims to know generally the spread of metallic iron (Fe) in the river Pasar in Belangwetan, Klaten. This study was conducted using an observational method in which researchers did not examine the effects of interventions. Sampling was done using purposive sampling method taken from three points, namely the upper, middle, lower. Determination of iron levels by Atomic Absorption Spectrophotometer (AAS) obtained a positive result, and the data was processed using SPSS to determine the Mean and Standard Deviation. Of the research result, it could be known the Mean score was 2.33 ppm and SD was 0.0352. The result of this research indicated that the levels of iron in the river Pasar in Belangwetan were 2.33 ppm. It means that the levels violate the regulation of the Minister of Health of the Republic of Indonesia, which is not more than 1mg/L (1ppm) in the clean water

scholarly journals THE USE OF BIOSTIMULANT FOR INCREASING THE BODY WEIGHT GAIN OF CHICKENS

2020 ◽  
Vol 17 (35) ◽  
pp. 800-812
Author(s):  
Ilgiz DOLININ ◽  
George BAZEKIN ◽  
Evgeny SKOVORODIN ◽  
Almaz SHARIPOV ◽  
Ivan CHUDOV
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Live Weight ◽  
The Body ◽  
New Drugs ◽  
Natural Resistance ◽  
Control Group ◽  
Immunological Parameters

Poultry farming holds a special place in ensuring the products that the consumers demand, it provides the population with essential food products,such as eggs and meat,that contain vital micro and macronutrients, proteins, lipids, and vitamins. Therefore, the issues of rational, economically feasible feeding of meat poultry, namely broiler chickens, are an urgent task. It is also essential to find effective methods of their application in order to correct the natural resistance and immune and biological reactivity of birds. The purpose of this research is to study the effect of the biological stimulant-Nucleostim on the growth and development of chickens, hematological, and immunological parameters of the blood of birds.This Biostimulant is a purified bovine spleen extract containing at least 1 mg / ml of low molecular weight peptides (nucleotides and nucleosides) formed as a result of autolysis, using dry whey and diatomite as fillers. Onthe application ofNucleostim, the gain in live weight of chickens was increased by 9.7%. At the end of the experiment, the livability of the chicks of the experimental group treated with Nucleostimcame up to 88%, compared with the 72% of the control group. The use of biostimulant had a stimulating effect on the liver of chickens confirmed by the research results presented in the article, as well as contributed to the development of the thymus in the setting of general dystrophy. Thus, it improved chicklivability and increased body weight gain. The biological stimulant-Nucleostim as an adaptogenic, anabolic, and immunostimulatory agent is promising for finding new drugs that improve the health and productivity of poultry.

scholarly journals Lalabet Financial Analysis: Study of Islamic Economics at Micro Level

2021 ◽  
Vol 4 (1) ◽  
pp. 233-244
Author(s):  
Ainorrofiqie Ainorrofiqie ◽  
Umrotul Khasanah ◽  
Akhmad Djalaluddin
Keyword(s):  
Financial Management ◽  
Financial Analysis ◽  
Financial Statements ◽  
The Body ◽  
Short Term ◽  
The Family ◽  
Micro Level ◽  
The Impact ◽  
The Village

This research aims to explore the model of financial management tradition Lalabet in the village of Babbalan District Batuan Sumenep. This study is based on the fact that occurred in the community about the implementation of traditions carried out by the heirs to family members who died. Interpretative qualitative research is used and an in-depth understanding of a problem that occurs is emphasized more. Based on the results of this study, the financial management tradition Lalabet can be done based on accounting equations. The accounts contained in the accounting equation is not used in its entirety and are reported as are generally financial statements. In this case, the source of funds in carrying out Lalabet tradition is sourced from personal money, money and donations from the family, money from Muslimat, debt, and money or goods from Lalabet's proceeds. The impact is the onset of debt both short-term and long-term. While the expenditure is in the form of costs in taking care of the body, costs for tahlilan (petto'arean), pa'polo, nyatos, nyataon, nyaebu, mangaji, ngin-tangin, nyalenin mayyid, and ajege makam (kep-sekep).

scholarly journals Excretion of Heavy Metals and Glyphosate in Urine and Hair Before and After Long-Term Fasting in Humans

2021 ◽  
Vol 8 ◽  
Author(s):  
Franziska Grundler ◽  
Gilles-Eric Séralini ◽  
Robin Mesnage ◽  
Vincent Peynet ◽  
Françoise Wilhelmi de Toledo
Keyword(s):  
Heavy Metals ◽  
Environmental Pollutants ◽  
Dietary Exposure ◽  
The Body ◽  
Health Concern ◽  
Obese People ◽  
Clinical Trial Registration ◽  
Reduced Body ◽  
Before And After

Background: Dietary exposure to environmental pollutants in humans is an important public health concern. While long-term fasting interrupts the dietary exposure to these substances, fat mobilization as an energy source may also release bioaccumulated substances. This was, to our knowledge, only investigated in obese people decades ago. This study explored the effects of 10-days fasting on the excretion of heavy metals and glyphosate.Methods: Urinary levels of arsenic, chromium, cobalt, lead, nickel, mercury and glyphosate were measured before and after 10 fasting days in 109 healthy subjects. Additionally, hair analysis was done before and ten weeks after fasting in 22 subjects.Results: Fasting caused a decrease in body weight, and in urinary arsenic (by 72%) and nickel (by 15%) concentrations. A decrease in lead hair concentrations (by 30%) was documented. Urinary mercury levels were unchanged for chromium, cobalt and glyphosate, which were undetectable in most of the subjects. Additionally, fatigue, sleep disorders, headache and hunger were reduced. Body discomfort symptoms diminished four weeks after food reintroduction.Conclusions: The results of this study provide the first insights into the changes in heavy metal excretion caused by long-term fasting. Further studies focusing on the kinetics of efflux between different compartments of the body are needed.Clinical Trial Registration:https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&amp;TRIAL_ID=DRKS00016657, identifier: DRKS00016657.

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