Formulation and Evaluation of Lercanidipine Loaded Solid Lipid Nanoparticles By Design Of Experiment

2021 ◽  
Vol 13 (03) ◽  
Keyword(s):  
Design Of Experiment ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Optimizing the Size of Drug-Loaded Nanoparticles Using Design of Experiments

2020 ◽  
pp. 131-157
Author(s):  
Paola Cervantes-Covarrubias ◽  
Ayla Vea-Barragan ◽  
Aracely Serrano-Medina ◽  
Eugenia Gabriela Carrillo-Cedillo ◽  
José Manuel Cornejo-Bravo
Keyword(s):  
Particle Size ◽  
Design Of Experiments ◽  
Design Of Experiment ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Fractional Factorial ◽  
Solid Lipid ◽  
Two Factors ◽  
Nanoparticle System ◽  
Selection Of

Nanoparticles formed from lipids are currently applied successfully to deliver drugs. The particle size of the nanoparticle system is an essential characteristic to enhance the entrance of the drugs inside tissues and cells. Using design of experiment is appealing to find the specific conditions to optimize particle size of drug-loaded nanoparticles. Authors of this chapter applied a fractional factorial design of half fraction 24-1 with levels between continue factors, finding statistically significant differences for two factors such as concentrations of drugs and type of solvent where the organic phase is dissolved. This design shows the optimization of a formulation of capsaicin in solid lipid nanoparticles. The chapter also includes information on methods to prepare solid lipid nanoparticles (SLN), the variables involved, and a selection of studies about optimization of SLN formulations.

Formulation and Optimization of Topical Solid Lipid Nanoparticles based Gel of Dapsone Using Design of Experiment

2019 ◽  
Vol 6 (4) ◽  
pp. 264-275 ◽  
Author(s):  
Sanjeevani Shekhar Deshkar ◽  
Shyam Gangadhar Bhalerao ◽  
Monali Shivaji Jadhav ◽  
Satish Vasudeo Shirolkar
Keyword(s):  
Design Of Experiment ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Optimizing the Size of Drug-Loaded Nanoparticles Using Design of Experiments

2021 ◽  
pp. 330-356
Author(s):  
Paola Cervantes-Covarrubias ◽  
Ayla Vea-Barragan ◽  
Aracely Serrano-Medina ◽  
Eugenia Gabriela Carrillo-Cedillo ◽  
José Manuel Cornejo-Bravo
Keyword(s):  
Particle Size ◽  
Design Of Experiments ◽  
Design Of Experiment ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Fractional Factorial ◽  
Solid Lipid ◽  
Two Factors ◽  
Nanoparticle System ◽  
Selection Of

Nanoparticles formed from lipids are currently applied successfully to deliver drugs. The particle size of the nanoparticle system is an essential characteristic to enhance the entrance of the drugs inside tissues and cells. Using design of experiment is appealing to find the specific conditions to optimize particle size of drug-loaded nanoparticles. Authors of this chapter applied a fractional factorial design of half fraction 24-1 with levels between continue factors, finding statistically significant differences for two factors such as concentrations of drugs and type of solvent where the organic phase is dissolved. This design shows the optimization of a formulation of capsaicin in solid lipid nanoparticles. The chapter also includes information on methods to prepare solid lipid nanoparticles (SLN), the variables involved, and a selection of studies about optimization of SLN formulations.

Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

2009 ◽  
Vol 00 (00) ◽  
pp. 090820062440031-9 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Mohsen Minayian ◽  
Elaheh Moazen
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development and optimization of solid lipid nanoparticles of amikacin by central composite design

2009 ◽  
Vol 00 (00) ◽  
pp. 090721051030036-8
Author(s):  
Jaleh Varshosaz ◽  
Solmaz Ghaffari ◽  
Mohammad Reza Khoshayand ◽  
Fatemeh Atyabi ◽  
Shirzad Azarmi ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Central Composite

Solid lipid nanoparticles for oral delivery of curcumin

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
C Righeschi ◽  
M Bergonzi ◽  
B Isacchi ◽  
A Bilia
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Pravin Patil ◽  
Anil Sharma ◽  
Subhash Dadarwal ◽  
Vijay Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Rotation Speed ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Brain Penetration ◽  
Solid Lipid ◽  
Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

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