scholarly journals Alanine Aminotransferase Activity in Hypothyroid Patients: A Cross Sectional Study

2013 ◽  
Vol 12 (3) ◽  
pp. 49-51
Author(s):  
Md Aminul Haque Khan ◽  
Md Rezwanur Rahman ◽  
Rawnak Jahan
Keyword(s):  
Alanine Aminotransferase ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Aminotransferase Activity ◽  
Cross Sectional ◽  
Serum Alanine Aminotransferase ◽  
Significant Difference ◽  
Relationship Of ◽  
Hypothyroid Patients ◽  
Alanine Aminotransferase Activity

Background: Hypothyroidism is associated with many biochemical abnormalities including increased serum alanine aminotransferase activity. Very few studies have been done regarding serum alanine aminotransferase activity in hypothyroid patients and, as far we know, no such study has been done in our populations. So, we designed this study in our population for evaluation of serum alanine aminotransferase activity in hypothyroid patients. The objective of this study was to assess serum alanine aminotransferase activity in hypothyroid patients and to find out relationship of alanine aminotransferase activity with severity of hypothyroidism. Methods: It was a retrospective cross sectional study to evaluate the serum alanine aminotransferase activity of hypothyroid patients and to find out relationship of alanine aminotransferase activity with severity of hypothyroidism and the values were compared with that of age and sex matched healthy euthyroid controls. Statistical analyses were performed by using SPSS for Windows version 12.0. Unpaired ‘t’ test was done to find out any significant difference between the cases and controls with respect to age and serum alanine aminotransferase activity. Chisquare test was done to find out any significant difference between the cases and controls with respect to sex. Pearson correlation coefficient test was done to see the correlation of alanine aminotransferase activity with the severity of hypothyroidism. Results: Mean serum alanine aminotransferase activity was found significantly higher in hypothyroid patients compared to that of controls. Conclusion: Results of our study suggest that increased serum alanine aminotransferase activity is associated with hypothyroidism. Therefore, patients presenting with increased ALT activity with normal liver function tests are recommended to be investigated to explore hypothyroidism. Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 49-51

scholarly journals Serum Creatinine and Uric Acid Levels in Hypothyroid Patients: A Cross Sectional Study

2013 ◽  
Vol 3 (2) ◽  
pp. 84-87
Author(s):  
Md. Aminul Haque Khan ◽  
Md. Ishaque Majumder ◽  
Md. Mozammel Hoque ◽  
Md. Fariduddin ◽  
Forhadul Hoque Mollah ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Creatinine ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Medical University ◽  
Relationship Of ◽  
Hypothyroid Patients ◽  
Biochemical Abnormalities

Background: Hypothyroidism is associated with many biochemical abnormalities including increased serum creatinine and uric acid levels. Many studies were done abroad regarding serum creatinine and uric acid levels in hypothyroid patients. We designed this study in our population for evaluation of serum creatinine and uric acid levels in hypothyroid patients. Objective: To assess serum creatinine and uric acid levels in hypothyroid patients and to find out relationship of creatinine and uric acid levels with severity of hypothyroidism. Materials and Methods: This retrospective cross sectional study to evaluate the serum creatinine and uric acid levels of hypothyroid patients and to find out relationship of hyperuricemia and hypercreatininemia with severity of hypothyroidism was done in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka. Results were compared with that of age and sex matched healthy euthyroid controls. Statistical analyses were performed by using SPSS for Windows version 10.0. ANOVA and unpaired ‘t’ tests were done to see the significance among the groups and between groups respectively. Pearson’s correlation coefficient test was done to see the correlation of serum creatinine and uric acid levels with the severity of hypothyroidism. Results: Mean serum creatinine and uric acid levels in cases were 1.38 ± 0.53 and 7.00 ± 2.54 mg/dL respectively compared to 1.01 ± 0.17 and 5.21 ± 1.35 mg/dL in controls. Conclusion: Mean serum creatinine and uric acid levels were found significantly higher in hypothyroid patients compared to controls. These findings suggest that hyperuricemia and hypercreatininemia are associated with hypothyroidism. Therefore, patients presenting with these biochemical abnormalities are recommended to be investigated to explore hypothyroidism. Journal of Enam Medical College; Vol 3 No 2 July 2013; Page 84-87 DOI: http://dx.doi.org/10.3329/jemc.v3i2.16129

scholarly journals Normal levels of inflammatory markers in treated patients with familial hypercholesterolaemia: a cross-sectional study

2012 ◽  
Vol 1 (3) ◽  
pp. 1-9 ◽  
Author(s):  
Mary Seed ◽  
D John Betteridge ◽  
Jackie Cooper ◽  
Muriel Caslake ◽  
Paul N Durrington ◽  
...  
Keyword(s):  
Familial Hypercholesterolaemia ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Risk Markers ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lipoprotein A ◽  
Significant Difference ◽  
Heterozygous Familial Hypercholesterolaemia ◽  
Relationship Of

Objective To assess the relationship of levels of inflammatory risk markers to presence of clinical coronary artery disease (CAD) in patients with treated heterozygous familial hypercholesterolaemia. Design A cross-sectional study of patients on the Simon Broome Familial Hyperlipidaemia Register. Setting Six hospital outpatient clinics in the UK. Participants A total of 211 men and 199 women with heterozygous familial hypercholesterolaemia. Main outcome measures Analysis of conventional risk factors and concentrations of high-sensitivity C-reactive protein (hsCRP), lipoprotein (a), serum intercellular adhesion molecule (sICAM), interIeukin-6 (IL-6) and lipoprotein-associated phospholipase A2 (LpPLA2) mass. Results CAD was present in 104 men and in 55 women; the mean ages of onset were 43.1 and 46.5 years, respectively. On univariate analysis there was a positive relationship of CAD with age, male sex, smoking, IL-6 and sICAM, and an inverse relationship with low-density lipoprotein (LDL) and LpPLA2. On multivariate analysis, age, smoking, low LDL and low LpPLA2 were associated with CAD. When LpPLA2 values were adjusted for apoB and aspirin usage, there was no significant difference between those with and without CAD. Only age and smoking were independently associated with CAD in men, and IL-6 and lipoprotein(a) in women. Conclusions Although on univariate analysis inflammatory marker levels were associated with CAD in these patients, the majority of the associations, including that for hsCRP, disappeared when corrected for smoking and apoB. This may be because atherosclerotic plaques in these statin-treated patients were quiescent or an effect of aspirin usage. In this observational study newer risk markers were not usefully associated with the presence or absence of symptomatic CAD.

scholarly journals Association of body mass index with serum alanine aminotransferase in Chinese adolescents: a school-based cross-sectional study

2019 ◽  
Vol 8 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Zan Ding ◽  
Jing Zhang ◽  
Chang-Yu Deng ◽  
Ying-Bin You ◽  
Hua Zhou
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Alanine Aminotransferase ◽  
Cross Sectional Study ◽  
Chinese Adolescents ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Alanine Aminotransferase ◽  
School Based ◽  
Alt Activity

Abstract Background Numerous studies have consistently demonstrated that high body mass index (BMI) is related to elevated serum alanine aminotransferase (ALT) among adults, but little is known about the association regarding adolescents, especially in China. In this study, we aimed to investigate the association between BMI and ALT activity among Chinese adolescents. Methods A school-based cross-sectional study was performed among nine high schools in Shenzhen, China between February 2017 and June 2018. A generalized linear-regression model adjusting for age and gender was conducted, and bivariate correlation analysis between ALT and BMI was also performed. Results A total of 7,271 adolescents aged from 9 years to 17 years were enrolled. Height, weight, BMI, and ALT were higher among boys than among girls (all P < 0.001). The mean (standard deviation) of serum ALT levels was 14.26 (14.77) U/L. In the entire BMI range, the BMI−ALT correlation was stronger for boys (Spearman's r = 0.396, P < 0.001) and adolescents of 14 years−17 years (r = 0.356, P < 0.001) than for girls (r = 0.203, P < 0.001) and adolescents of 9 years−13 years (r = 0.221, P < 0.001), respectively. Serum ALT increased rapidly and followed a linear pattern from the point of BMI ≥20.5 kg/m2, and each increase of 1 kg/m2 in BMI range above 20.5 kg/m2 was averagely correlated with an increase of 2.71 U/L in ALT levels (P < 0.001). Conclusions We found a significant BMI−ALT relationship. BMI at 20.5 kg/m2 may be a cut-off for evaluating serum ALT. BMIs ≥27.1 kg/m2 for boys and ≥24.9 kg/m2 for girls were linked to an elevated ALT activity for Shenzhen adolescents.

Risk factors for serum alanine aminotransferase elevation: A cross-sectional study of healthy adult males in Tokyo, Japan

2010 ◽  
Vol 42 (12) ◽  
pp. 882-887 ◽  
Author(s):  
Toshiaki Gunji ◽  
Nobuyuki Matsuhashi ◽  
Hajime Sato ◽  
Kimiko Iijima ◽  
Kazutoshi Fujibayashi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alanine Aminotransferase ◽  
Healthy Adult ◽  
Cross Sectional Study ◽  
Adult Males ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Alanine Aminotransferase

scholarly journals Elevated alanine aminotransferase and low aspartate aminotransferase/alanine aminotransferase ratio are associated with chronic kidney disease among middle-aged women: a cross-sectional study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Hirotaka Ochiai ◽  
Takako Shirasawa ◽  
Takahiko Yoshimoto ◽  
Satsue Nagahama ◽  
Akihiro Watanabe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Relationship Of

Abstract Background Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) to ALT ratio (AST/ALT ratio) have been shown to be related to non-alcoholic fatty liver disease or insulin resistance, which was associated with chronic kidney disease (CKD). However, it is unclear whether ALT and AST/ALT ratio are associated with CKD. In this study, we examined the relationship of ALT and AST/ALT ratio to CKD among middle-aged females in Japan. Methods The present study included 29,133 women aged 40 to 64 years who had an annual health checkup in Japan during April 2013 to March 2014. Venous blood samples were collected to measure ALT, AST, gamma-glutamyltransferase (GGT), and creatinine levels. In accordance with previous studies, ALT > 40 U/L and GGT > 50 U/L were determined as elevated, AST/ALT ratio < 1 was regarded as low, and CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 and/or proteinuria. Logistic regression model was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for CKD. Results “Elevated ALT and elevated GGT” and “elevated ALT and non-elevated GGT” significantly increased the OR for CKD when compared with “non-elevated ALT and non-elevated GGT” (OR: 2.56, 95% CI: 2.10–3.12 and OR: 2.24, 95% CI: 1.81–2.77). Compared with “AST/ALT ratio ≥ 1 and non-elevated GGT”, “AST/ALT ratio < 1 and elevated GGT” and “AST/ALT ratio < 1 and non-elevated GGT” significantly increased the OR for CKD (OR: 2.73, 95% CI: 2.36–3.15 and OR: 1.68, 95% CI: 1.52–1.87). These findings still remained after adjustment for confounders. Conclusions Elevated ALT was associated with CKD regardless of GGT elevation. Moreover, low AST/ALT ratio was also associated with CKD independent of GGT elevation.

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