Low Serum Vitamin D is Independently Associated with Acute Ischemic Stroke

Low serum vitamin D levels have been associated with various vascular diseases. Very little is known its association with acute stroke in Bangladeshi population. We therefore sought to assess whether low serum 25- hydroxyvitamin D, a marker of vitamin D status is associated with acute stroke. We performed a prospective study in Comilla Medical Collage, Comilla, from November 2016 to November 2017. All the patients diagnosed as acute ischemic stroke on the basis of CT scan or MRI of brain. Patients were eligible for inclusion if they were admitted with onset of symptoms within 24 hours. Estimation of 25(OH)D level was done at presentation. The patients were stratified by vitamin D status, >30 as vitamin D sufficient, vitamin D 20-20.9 as insufficient and finally vitamin D<20 as deficient. Multivariate logistic regression analysis revealed that out of the desired 7 variables, smoking, hypertension and low serum vitamin D were found independent predictors for acute stroke with ORs being 1.44, 4.23 and 2.39 respectively. Vitamin D deficiency represents an important risk factor for acute stroke and it might play a causal role in the development adverse events associated with stroke.Medicine Today 2018 Vol.30(1): 34-37

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Estimation of Vitamin D Levels in Acute Ischaemic Stroke - A Study from Amritsar, Punjab

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/593 ◽

2021 ◽

Vol 8 (35) ◽

pp. 3264-3268

Author(s):

Pooja Parteek ◽

Manish Chandey ◽

Satya Nayyar ◽

Poonam Verma ◽

Raminder Singh

Keyword(s):

Vitamin D ◽

Ischemic Stroke ◽

Ischaemic Stroke ◽

Acute Ischemic Stroke ◽

Acute Ischaemic Stroke ◽

Serum Vitamin ◽

Mean Value ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Low Serum

BACKGROUND World Health Organization (WHO) defines stroke as “rapidly developing clinical signs of focal (or global) disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than that of vascular origin.” Low serum 25 hydroxy vitamin D is associated with large infarct volume, which worsens the outcome in ischemic stroke patients. In this study, we wanted to evaluate serum vitamin D levels in acute ischaemic stroke (AIS) patients and correlate the severity of stroke with lipid profile & central nervous system (CNS). METHODS It was a cross sectional comparative study, conducted in Department of Medicine in SGRDIMSR, Sri Amritsar from December 2018 to June 2020. A total of 100 subjects, 50 cases of AIS, diagnosed by history, clinical examination and supported by magnetic resonance imaging (MRI) of brain and 50 age and sex matched healthy controls were enrolled for the present study to estimate serum vitamin D level in AIS. Detailed clinical history and clinical examination were done on all participating subjects and relevant investigations were done. Diagnosis was confirmed by MRI brain in acute ischemic stroke cases. The severity of neurological impairment was evaluated as per Canadian neurological stroke scale within 24 hours of admission of the cases. RESULTS Mean age of cases was 62.06 ± 10.52 years and mean age of control was 59.14 ± 11.36 with maximum number of subjects were in age group of 61 - 70 years. The mean value of vitamin D in study group was 19.31 ± 9.24 while in control group, mean value was 36.42 ± 8.33, showing more serum vitamin D deficiency in cases having AIS than controls. (P value 0.021). CONCLUSIONS The present study suggests that the low serum vitamin D levels in the body is associated with more severe neurological deficit. KEYWORDS Stroke, Serum Vitamin D, Acute Ischemic Stroke, Canadian Neurological Scale

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Evaluation of vitamin D status, parathyroid hormone, and calcium among Iranian pregnant women with preeclampsia: A case-control study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v17i10.5494 ◽

2019 ◽

Cited By ~ 1

Author(s):

Laaya Hamedanian ◽

Bita Badehnoosh ◽

Niloofar Razavi-Khorasani ◽

Zinat Mohammadpour ◽

Hassan Mozaffari-Khosravi

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Serum Vitamin ◽

Multivariate Logistic Regression Analysis ◽

Control Group ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Mean ◽

And Control

Background: Preeclampsia is considered as a serious life-threatening condition that could affect both maternal and fetal outcome. Many studies have examined the association of nutritional factors with the incidence of preeclampsia. However, little is known about the possible role of vitamin D in the development of preeclampsia among the Iranian population. Objective: The aim of the present study was to evaluate the association between vitamin D status and preeclampsia. Materials and Methods: A total of 120 pregnant women who were referred to Kamali and Alborz General Hospital located in the Karaj City were enrolled in this study and categorized into preeclamptic and control groups (n = 60/each). The clinical details of patients such as demographic characteristics and laboratory findings were obtained from the patients. The serum levels of vitamin D, calcium, phosphorus, and parathormone were also measured. Multivariate logistic regression analysis was used to assess for independent predictors of preeclampsia. Results: The mean age among pregnant women with preeclampsia and control group were 31.48 ± 5.25 and 29.01 ± 5.28, respectively. The mean body mass index among the preeclamptic group was 27.92 ± 4.98, which was significantly higher compared to the control group (p < 0.001). The serum vitamin D levels were significantly lower in women with preeclampsia compared to the control subjects (p = 0.007). Moreover, no correlation between vitamin D deficiency and predisposing factors of preeclampsia was observed after adjusting for confounding factors. Conclusion: Our study revealed that serum vitamin D level is significantly lower in among the pregnant women diagnosed with preeclampsia compared to the healthy subjects. However, no correlation was observed between the vitamin D status and the risk of preeclampsia development. Key words: Preeclampsia, Vitamin D, 25-Hydroxyvitamin D, Pregnancy.

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Influence of serum vitamin D status on severe sarcopenia among female patients with rheumatoid arthritis: the KURAMA database

10.21203/rs.3.rs-697981/v1 ◽

2021 ◽

Author(s):

Hiroto Minamino ◽

Masao Katsushima ◽

Mie Torii ◽

Wataru Yamamoto ◽

Yoshihito Fujita ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Muscle Mass ◽

Gait Speed ◽

Serum Vitamin ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

High Prevalence

Abstract Sarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum vitamin D (25(OH)D) affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 Patients (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait-speed. Furthermore, multiple regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08). In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH) status. In conclusion, vitamin D levels are associated with severe sarcopenia and its components, and modification of vitamin D status including vitamin D supplementation may play a role in improving sarcopenia in RA.

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Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women

Nutrients ◽

10.3390/nu12103176 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3176

Author(s):

Sharon M. Anderson ◽

Andrea R. Thurman ◽

Neelima Chandra ◽

Suzanne S. Jackson ◽

Susana Asin ◽

...

Keyword(s):

Vitamin D ◽

Reproductive Tract ◽

Serum Vitamin ◽

Female Reproductive Tract ◽

High Dose ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Hiv 1

While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediators, immune cell populations, gene expression, and ex vivo HIV-1 infection, were assessed. While systemic vitamin D levels showed a significant increase following supplementation, these changes translated into modest effects on the cervicovaginal factors studied. Paradoxically, post-supplementation vitamin D levels were decreased in cervicovaginal fluids. Given the strong correlation between vitamin D status and HIV-1 infection and the widespread nature of vitamin D deficiency, further understanding of the role of vitamin D immunoregulation in the female reproductive tract is important.

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A170 VITAMIN D IN IBD PATIENTS – A RETROSPECTIVE REVIEW

Journal of the Canadian Association of Gastroenterology ◽

10.1093/jcag/gwz047.169 ◽

2020 ◽

Vol 3 (Supplement_1) ◽

pp. 35-36

Author(s):

R A MacMillan ◽

T Ponich

Keyword(s):

Vitamin D ◽

Bone Density ◽

Disease Severity ◽

Regression Coefficient ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Serum Vitamin D ◽

Mayo Score ◽

Vitamin D Levels ◽

Low Serum

Abstract Background Vitamin D is a critical factor in bone remodelling, calcium absorption and may promote anti-inflammatory cytokines in the gut. Inflammatory bowel disease (IBD) is associated with a reduction in serum Vitamin D levels and a chronic inflammatory state, both of which are strong risk factors for bone density loss affecting IBD patients. Despite European and North American IBD maintenance guidelines for Vitamin D monitoring and bone density scans, there are limited North American investigations into factors influencing serum Vitamin D levels in the IBD patient population specifically. Aims We investigated whether patient demographics, disease severity indexes and/or inflammatory markers were linked to low serum Vitamin D levels in our IBD patients. We also established the extent of Vitamin D serum deficiencies and supplementation rates in our IBD patients. Methods A retrospective chart review of a single clinician’s practice at London Health Science Centre, Victoria Hospital, over the past 20 months, was performed to: 1) assess the frequency of low serum 25-OH Vitamin D (25-OH D) in the IBD patient population and 2) determine whether patient disease severity was linked to lower 25-OH D levels. A multivariate regression analysis was performed assessing Crohn’s Disease (CD) or Ulcerative Colitis (UC) patient factors: age, sex, disease duration, seasonality, current pharmacologic treatments, past surgeries, CD Activity Index, UC Mayo score, C-reactive protein, and fecal calprotectin (Fcal) level. Results 175 IBD patients had at least one 25-OH D measurement with 71 patients actively on Vitamin D therapy. Of UC and CD patients who were not on Vitamin D therapy, 63% (17/27) and 79% (61/77) were 25-OH D deficient, respectively. 25-OH D levels in the CD population was associated with Vitamin D supplementation (regression coefficient [RC] 23.99, 95% confidence interval [CI] 14.54 to 33.45), summer season ([RC] 9.90, [CI] 0.56 to 19.24), and past bowel resection ([RC] -10.61, [CI] -20.48 to -0.76). 25-OH D levels in the UC population was associated with Vitamin D supplementation (regression coefficient [RC] 47.23, 95% confidence interval [CI] 27.62 to 66.83), and Mayo severity scores ([RC] -23.01, [CI] -41.82 to -4.20). Fcal (78 patients) was inversely associated with 25-OH D levels but the trend was not significant. Conclusions Overall, 25-OH D levels were lower in both the UC and CD patient populations relative to the already deficient Canadian population. However, IBD patients are responsive to Vitamin D supplementation. Tools with more objective evidence of disease severity such as UC Mayo score and fcal should be prioritized for identifying the IBD population requiring supplementation. Funding Agencies None

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Decreased Neuromuscular Function in Crohn’s Disease Patients Is Not Associated with Low Serum Vitamin D Levels

Digestive Diseases and Sciences ◽

10.1007/s10620-012-2372-4 ◽

2012 ◽

Vol 58 (2) ◽

pp. 526-533 ◽

Cited By ~ 7

Author(s):

Amanda J. Salacinski ◽

Miguel D. Regueiro ◽

Craig E. Broeder ◽

Jean L. McCrory

Keyword(s):

Vitamin D ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Serum Vitamin ◽

Neuromuscular Function ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Low Serum

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Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

Brain and Behavior ◽

10.1002/brb3.885 ◽

2018 ◽

Vol 8 (2) ◽

pp. e00885 ◽

Cited By ~ 11

Author(s):

Qiongzhang Wang ◽

Zhuoying Zhu ◽

Yuntao Liu ◽

Xinjie Tu ◽

Jincai He

Keyword(s):

Vitamin D ◽

Acute Stroke ◽

Inflammatory Markers ◽

Serum Vitamin ◽

Stroke Patients ◽

Serum Vitamin D ◽

Vitamin D Levels

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Variations in serum vitamin D status during cancer chemotherapy.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e19550 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e19550-e19550

Author(s):

Bogda Koczwara ◽

Richard John Woodman ◽

Laisa Vicki Teleni ◽

Michael Kimlin ◽

Euan Thomas Walpole ◽

...

Keyword(s):

Vitamin D ◽

Demographic Data ◽

Serum Vitamin ◽

Sun Exposure ◽

Unknown Primary ◽

Curative Intent ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Impact ◽

Low Serum

e19550 Background: Low serum vitamin D in cancer patients has been associated with inferior cancer outcomes and bone loss. The impact of chemotherapy on vitamin D levels is not known. We examined serum vitamin D levels during chemotherapy to identify magnitude and predictors of change. Methods: A prospective study of chemotherapy naïve patients commencing chemotherapy in two different sun exposure areas. Vitamin D (25(OH)D) deficiency was defined as ≤25 nmol/L and insufficiency 26-50 nmol/L. Demographic data, nutrition, sun exposure, season and biochemical parameters were collected at baseline 6 weeks (6W) and 12 weeks (12W) since commencement of treatment. The effects were assessed using a multivariate multilevel linear regression model that also included age, gender and BMI. Results: 82 Caucasian and 3 indigenous patients were enrolled. Median age was 57 (21-85) years. Forty-nine (58%) were female; 54 (65%) were treated with curative intent. Tumours included 29 (34%) breast,12 (14%) colorectal, 9 (11%) lymphomas, 7 (8%) leukemias, 7 (8%) lung, 5 (6%) ovarian, 3 (4%) testis, 3 (4%) unknown primary and 10 (11%) others. Median weight was 75 kg (50-151) and median BMI was 26.9 kg/m2 (17.7- 44.5). Seventy-six (89%) and 55 (65%) patients were receiving chemotherapy treatment at 6W and 12W respectively. Mean (±SD) serum 25(OH)D at baseline was 49.2±22.3 nmol/L. Ten (12%) patients were vitamin D deficient at baseline and a further 33 (41%) had insufficient levels. Mean serum 25(OH)D status was higher in higher sun exposure locations (61.9±22.1 nmol/L vs 42.2±19.2 nmol/L, p<0.001), varied according to season (spring=46.9±20.3 nmol/L, summer=50.8±18.2 nmol/L, fall=76.4±25.2 nmol/L, winter=36.5±15.7 nmol/L, p<0.001) and changed with treatment period (baseline=49.2±22.3 nmol/L, 6W=40.9±19.0 nmol/L, 12W=45.9±19.7 nmol/L, p=0.002). There was no association between 25(OH)D status and age, gender, BMI or nutritional status. Conclusions: Chemotherapy is associated with a fall in serum 25(OH)D. Further research is needed to determine the underlying mechanism, the impact of low serum 25(OH)D on patient outcomes and the potential role for screening and vitamin D supplementation in this group.

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