scholarly journals Encrusted Uropathy: A Comprehensive Overview—To the Bottom of the Crust

2021 ◽  
Vol 7 ◽  
Author(s):  
Els Van de Perre ◽  
Gina Reichman ◽  
Deborah De Geyter ◽  
Caroline Geers ◽  
Karl M. Wissing ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Diagnosis And Treatment ◽  
Inflammatory Disorder ◽  
Urinary Ph ◽  
Comprehensive Overview ◽  
Chronic Inflammatory Disorder ◽  
Carbonated Apatite ◽  
Corynebacterium Urealyticum ◽  
Predisposing Conditions

Encrusted uropathy is a rare subacute to chronic inflammatory disorder caused by infection with urease-producing bacteria, mainly Corynebacterium urealyticum. The disorder is characterized by urothelial deposition of struvite and carbonated apatite, resulting in encrustations and ulceronecrotic inflammation of the urothelium and surrounding tissues. Most commonly, encrusted uropathy is encountered in patients with predisposing conditions. The disease remains underdiagnosed. High urinary pH and negative conventional urine cultures should raise suspicion of the diagnosis. Prognosis is dependent on timely diagnosis and treatment installment, which consists of urological removal of encrustations in combination with urinary acidification and long-term antibiotic therapy.

Treatment of scar endometriosis with elagolix

2020 ◽  
Vol 12 (1) ◽  
pp. 56-58
Author(s):  
Timothy A D’Amico ◽  
Lisa Bystry ◽  
Sean M Kandel
Keyword(s):  
Rare Complication ◽  
High Rate ◽  
Attractive Potential ◽  
Inflammatory Disorder ◽  
Invasive Treatment ◽  
Scar Endometriosis ◽  
Chronic Inflammatory Disorder ◽  
Non Invasive ◽  
Long Term Follow Up

Endometriosis is a chronic inflammatory disorder that affects approximately 5%–10% of women and is a major contributor to chronic pelvic pain. It can result in a significant impact on a woman’s quality of life with a high rate of reoccurrence throughout the woman’s reproductive years. Medical treatment is available but often surgical intervention is required. Scar endometriosis is a rare complication of this disease, mostly involving cesarean section scars. Our case demonstrates a possible new, non-invasive treatment for scar endometriosis with elagolix. The ability to avoid the potential morbidity of surgical scar revision makes this a very attractive potential option. Further studies with larger cohorts and long-term follow up are needed to confirm efficacy.

scholarly journals A Rare Localization of Actinomycosis Mimicking Ulcerative Malignancy

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Luca Volpi ◽  
Fabio Ferreli ◽  
Maurizio Bignami ◽  
Andrea Pistochini ◽  
Francesco Meloni ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Antibiotic Therapy ◽  
Rare Case ◽  
Diagnosis And Treatment ◽  
Pathological Features ◽  
Cervical Disease ◽  
Clinical And Pathological Features

Actinomycosis is a chronic, suppurative, and granulomatous process caused by Actinomycetes, saprophytic bacteria normally residing in the oral cavity. It can involve any organ, but the cervicofacial disease is the most frequent. Pharyngolayngeal involvement is rare and usually occurs secondary to the oral or cervical disease. There are few cases of primary pharyngolaringeal actinomycosis described in the literature. A rare case of pharyngeal actinomycosis mimicking an ulcerative malignancy in a 63-year-old man is reported. The patient was treated successfully with long-term antibiotic therapy. The clinical and pathological features and the aspects of diagnosis and treatment of cervicofacial actinomycosis are discussed.

CLIPPERS and the need for long-term immunosuppression

2017 ◽  
Vol 62 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Tarig M Abkur ◽  
Hugh Kearney ◽  
Michael J Hennessy
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Inflammatory Disorder ◽  
Sustained Remission ◽  
Gait Ataxia ◽  
Immunomodulatory Treatment ◽  
Chronic Inflammatory Disorder ◽  
Cerebellar Peduncles ◽  
The Central Nervous System

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) is a rare chronic inflammatory disorder of the central nervous system. Herein, we describe the case of a 62-year-old female who presented with right sided facial tingling, gait ataxia and diplopia. Neuroimaging revealed pontine curvilinear enhancing lesions with extension into cerebellar peduncles, characteristic of CLIPPERS. This report discusses the differential diagnosis and the importance of prolonged immunomodulatory treatment for this rare neuro-inflammatory disorder. Long-term immunosuppression appears to be mandatory in order to achieve sustained remission and prevent disability related to atrophy of the structures involved in repeated attacks.

scholarly journals Mesenchymal Stromal Cell Therapy in the Management of Perianal Fistulas in Crohn’s Disease: An Up-To-Date Review

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 563
Author(s):  
Gaetano Gallo ◽  
Vincenzo Tiesi ◽  
Serena Fulginiti ◽  
Gilda De Paola ◽  
Giuseppina Vescio ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Stromal Cells ◽  
Tissue Repair ◽  
Negative Impact ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Entire Gastrointestinal Tract

Crohn’s Disease (CD) is a chronic inflammatory disorder that potentially involves the entire gastrointestinal tract. Perianal fistulizing CD (pCD) is a serious and frequent complication associated with significant morbidities and a heavy negative impact on quality of life. The aim of CD treatment is to induce and maintain disease remission and to promote mucosal repair. Unfortunately, even the best therapeutic regimens in pCD do not have long-term efficacy and cause a significant number of side effects. Therefore, it is mandatory to study new therapeutical options such as the use of mesenchymal stromal cells (MSCs). These cells promote tissue repair via the induction of immunomodulation. The present review aims to analyze the existing updated scientific literature on MSCs adoption in the treatment of pCD to evaluate its efficacy and safety and to compare the use of bone marrow and adipose tissue derived MSCs, type of administration, and dose required for recovery.

scholarly journals Efficacy and Safety of Mesenchymal Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An Up-to-Date Systematic Review

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 82
Author(s):  
Jeffrey Zheng-Hsien Ko ◽  
Sheeva Johnson ◽  
Maneesh Dave
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Symptoms ◽  
Inflammatory Disorder ◽  
Novel Therapy ◽  
Chronic Inflammatory Disorder ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Detailed Search ◽  
Favorable Safety

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gut that can lead to severe gastrointestinal symptoms, malnutrition, and complications such as fistulas and cancer. Mesenchymal stem/stromal cells (MSCs) are being investigated as a novel therapy for IBD and have been demonstrated to be safe and effective for perianal fistulizing Crohn’s disease (PFCD). This systematic review aims to present the most recent studies on the safety and efficacy of MSC therapy in IBD. A detailed search strategy of clinical trials on MSCs and IBD was performed on PubMed, with 32 studies selected for inclusion in this review. The newest studies on local MSC injection for PFCD continue to support long-term efficacy while maintaining a favorable safety profile. The evidence for systemic MSC infusion in luminal IBD remains mixed due to marked methodological heterogeneity and unclear safety profiles. Although further studies are needed to better establish the role of this novel treatment modality, MSCs are proving to be a very exciting addition to the limited therapies available for IBD.

Lichen sclerosus

2005 ◽  
Vol 16 (7) ◽  
pp. 465-474 ◽  
Author(s):  
P D Yesudian ◽  
H Sugunendran ◽  
C M Bates ◽  
C O'Mahony
Keyword(s):  
Age Groups ◽  
Lichen Sclerosus ◽  
Inflammatory Disorder ◽  
Cell Degeneration ◽  
Balanitis Xerotica Obliterans ◽  
Chronic Inflammatory Disorder ◽  
Anogenital Region ◽  
Short Courses ◽  
Term Monitoring

Lichen sclerosus (LS) is a chronic inflammatory disorder of the skin and mucosa, presenting to genitourinary physicians and dermatologists. It affects both sexes and all age groups. Although the exact aetiology is uncertain, genetic predisposition, infections and autoimmune factors have been implicated in its pathogenesis. Symptoms include pruritis and soreness, but asymptomatic presentations are not uncommon. The classical clinical picture is of atrophic white plaques in the anogenital region. Histopathology is specific with basal cell degeneration, upper dermal oedema, homogenization of collagen and a chronic inflammatory infiltrate. Short courses of potent topical corticosteroids form the mainstay of treatment. The condition tends to be remitting and relapsing, with spontaneous regressions reported in a few. In men, the term balanitis xerotica obliterans is sometimes used to describe late and severe LS of the penis. Scarring and progression to squamous cell carcinomas can occur in chronic LS, resulting in significant morbidity. A multi-disciplinary approach to care and the need for long-term monitoring cannot be over-emphasized.

scholarly journals Terapi Controller pada Asma

2021 ◽  
Vol 1 (3) ◽  
pp. 438-444
Author(s):  
Alexander Kam ◽  
Fauzar Fauzar ◽  
Roza Kurniati ◽  
Zulkarnain Arsyad
Keyword(s):  
Symptom Control ◽  
Asthma Management ◽  
Inflammatory Disorder ◽  
Clinical Effects ◽  
Chronic Inflammatory Disorder ◽  
Blood Institute ◽  
Advantages And Disadvantages ◽  
National Heart Lung ◽  
The Right

Asthma, according to the National Heart Lung and Blood Institute (NHBLI) in 2002, is a chronic inflammatory disorder of the airways that involves the role of many cells and cellular components. The long-term goals of asthma management are to achieve good symptom control and maintain normal living activities and to minimize the risk of exacerbations, airway obstruction, and side effects. The drugs available for asthma therapy are divided into long-term control or controller medication and rapid-acting or reliever medication based on their pharmacodynamics and clinical effects. Controller is a therapy given to reduce chronic airway inflammation, control symptoms, and reduce the risk of exacerbations and decreased lung function. There are several asthma controller drug options that have their respective advantages and disadvantages. Selection of the right controller will provide good asthma control. Keyword: Ashtma, therapy, controller

Encrusted Cystitis with Suspected Ureteral Obstruction Following Cystoscopic-Guided Laser Ablation of Ectopic Ureters in a Dog

2018 ◽  
Vol 54 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Maura Duffy ◽  
Alex Gallagher
Keyword(s):  
Laser Ablation ◽  
Antibiotic Therapy ◽  
Ureteral Obstruction ◽  
Complete Recovery ◽  
Labrador Retriever ◽  
Left Ureter ◽  
Unilateral Hydronephrosis ◽  
Ectopic Ureters ◽  
Corynebacterium Urealyticum

ABSTRACT A 1 yr old 30 kg spayed female Labrador retriever presented for stranguria and hematuria 3 wk after cystoscopic laser ablation for ectopic ureters. Encrusted cystitis was diagnosed based on ultrasonography, cystoscopy, urinalysis, and culture of Corynebacterium urealyticum from the urine. Unilateral hydronephrosis and hydroureter were suspected to be secondary to obstruction at the trigone. The dog was treated with focal debridement of plaques at the left ureter, urinary acidification, and long-term antibiotic therapy with complete recovery. This is the first report of encrusted cystitis as a complication of cystoscopic-guided laser ablation for ectopic ureters, and suggests cystoscopic debridement may be useful if ureteral obstruction occurs.

scholarly journals Autoimmune Hepatitis: A Review of Current Diagnosis and Treatment

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Ashima Makol ◽  
Kymberly D. Watt ◽  
Vaidehi R. Chowdhary
Keyword(s):  
Autoimmune Hepatitis ◽  
Immunosuppressive Agents ◽  
Clinical Manifestations ◽  
Normal Liver ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Initiation Of Therapy ◽  
Long Term Prognosis ◽  
Indolent Disease

Autoimmune hepatitis (AIH) is a chronic inflammatory disorder characterized by periportal inflammation, elevated immunoglobulins, autoantibodies, and a dramatic response to immunosuppression. An environmental agent is hypothesized to trigger an immune-mediated attack directed against liver antigens in genetically predisposed individuals. A plethora of clinical presentations can be seen ranging from chronic indolent disease to fulminant hepatic failure, and diagnosis requires exclusion of other causes of liver disease. Corticosteroid therapy must be instituted early and modified in an individualized fashion. Treatment decisions are often complicated by the diverse clinical manifestations, uncertainty about natural history, evolving ideas about treatment end points, and a multitude of alternative immunosuppressive agents. Achieving normal liver tests and tissue is the ideal treatment end point, but needs to be weighed against the risk of side effects. Decompensated patients may benefit from early liver transplantation. Long-term prognosis is excellent with early and aggressive initiation of therapy. Our paper discusses AIH, giving a detailed overview of its clinical presentation, risk factors, immunopathogenesis, up-to-date diagnostic criteria, current updates in therapy with a brief discussion of AIH in pregnancy, and long-term implications for cirrhosis and hepatocellular carcinoma in AIH patients.

Steroid-responsive, cervical, pyogranulomatous pachymeningitis in a dog

1997 ◽  
Vol 33 (5) ◽  
pp. 461-468 ◽  
Author(s):  
PR Hess ◽  
RK Sellon
Keyword(s):  
Spinal Cord ◽  
Cerebrospinal Fluid ◽  
Immunosuppressive Therapy ◽  
Dura Mater ◽  
Protein Concentration ◽  
Cord Compression ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Elevated Protein

Syndromes of steroid-responsive meningitis have been described in the dog and typically are characterized by neutrophilic pleocytosis and an elevated protein concentration of the cerebrospinal fluid. In a minority of cases, histopathology has demonstrated suppurative leptomeningeal (i.e., arachnoid and pia) inflammation. A case of compressive, cervical, pyogranulomatous inflammation of undetermined cause affecting the dura mater (i.e., pachymeningitis), accompanied by fever and hyperpathia, is presented. The pachymeningitis ultimately regressed with long-term immunosuppressive therapy. This case shares features with hypertrophic spinal pachymeningitis of humans, an uncommon, frequently idiopathic, chronic inflammatory disorder causing dural hypertrophy, radiculopathy, and spinal cord compression.

Sign in / Sign up

Export Citation Format

Share Document