scholarly journals Non-alcoholic Fatty Liver Disease and Longitudinal Cognitive Changes in Middle-Aged and Elderly Adults

2022 ◽  
Vol 8 ◽  
Author(s):  
Qi Liu ◽  
Chang Liu ◽  
Feifei Hu ◽  
Xuan Deng ◽  
Yumei Zhang
Keyword(s):  
Regression Analysis ◽  
Cognitive Impairment ◽  
Liver Disease ◽  
Cognitive Function ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Middle Aged ◽  
Cognitive Changes ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Background and PurposeNon-alcoholic fatty liver disease (NAFLD) and cognitive impairment are common aging-related disorders. This study aims to explore the changes of cognitive function in middle-aged and elderly population with NAFLD from a Jidong impairment cohort.MethodsA total of 1,651 middle-aged and elderly participants (>40 years) without cognitive impairment were recruited into the current study in 2015 and were followed up until to 2019. Abdominal ultrasonography was used for diagnosis of NAFLD. Global cognitive function was assessed with the Mini-Mental State Examination (MMSE). Cognitive impairment was defined as a score <18 for illiterates, a score <21 for primary school graduates, and a score <25 for junior school graduates or above. Multivariable regression analysis was performed to evaluate the association between NAFLD and the four-year cognitive changes.ResultsOut of 1,651 participants, 795 (48.2%) of them had NAFLD in 2015. Cognitive impairment occurred in 241 (14.6%) participants in 2019. Patients with NAFLD had higher 4-year incidence of cognitive impairment than non-NAFLD patients did (17.7 vs. 11.7%, p < 0.001). Multivariable linear regression analysis showed significant association of baseline NAFLD with lower MMSE score in 2019 (β = −0.36, p < 0.05). Multivariable logistic analysis found that the adjusted odds ratio (OR) with 95% confidence interval (CI) of baseline NAFLD was 1.45 (1.00–2.11) for cognitive impairment in 2019 (p = 0.05). We also identified effects of baseline NAFLD on subsequent cognitive impairment as modified by age (interaction p < 0.01) and carotid stenosis (interaction p = 0.05) but not by gender.ConclusionsNAFLD is associated with cognitive decline, especially in middle-aged and with carotid stenosis population.

Menopausal stages and non-alcoholic fatty liver disease in middle-aged women

2015 ◽  
Vol 190 ◽  
pp. 65-70 ◽  
Author(s):  
Seungho Ryu ◽  
Byung-Seong Suh ◽  
Yoosoo Chang ◽  
Min-Jung Kwon ◽  
Kyung Eun Yun ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Middle Aged ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Elena S. George ◽  
Surbhi Sood ◽  
Robin M. Daly ◽  
Sze-Yen Tan
Keyword(s):  
Liver Disease ◽  
Cognitive Function ◽  
Fatty Liver ◽  
Cognitive Performance ◽  
Fatty Liver Disease ◽  
Psychomotor Speed ◽  
Alcoholic Fatty Liver ◽  
Cognitive Domains ◽  
Mental Flexibility ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is represented as the most common liver disease worldwide. NAFLD is associated with metabolic risk factors underpinned by insulin resistance, inflammation and endothelial dysfunction, leading to extrahepatic changes in central nervous diseases such as cognitive impairment, Alzheimer’s disease and dementia. The aim of the review is to explore the association between NAFLD and cognitive function. Methods Using the PRISMA guidelines, a systematic electronic literature search was conducted in four databases: MEDLINE, PsychINFO, Embase and CINAHL from inception until March 2021. Neuropsychological tests utilised within each study were grouped into relevant cognitive domains including ‘general cognition’, ‘reasoning’, ‘mental speed, attention and psychomotor speed’, ‘memory and learning’, ‘language’, ‘visuospatial perception’ and ‘ideas, abstraction, figural creations and mental flexibility’. Results Eleven observational studies that involved 7978 participants with a mean age of 51 years were included. Those with NAFLD had poor cognitive performance in three cognitive domains, including ‘general cognition’, ‘mental speed, attention and psychomotor speed’, and ‘ideas, abstraction, figural creations and mental flexibility’. Conclusion The observed results from the 11 included studies showed that NAFLD was associated with lower cognitive performance across several domains. However, studies conducted to date are limited to observational designs and are heterogeneous with varying diagnostic tools used to assess cognitive function. Trial registration PROSPERO Registration: CRD42020161640.

scholarly journals P2-562: NON-ALCOHOLIC FATTY LIVER DISEASE, LIVER FIBROSIS SCORE AND COGNITIVE FUNCTION IN MIDDLE-AGED ADULTS: THE FRAMINGHAM STUDY

2019 ◽  
Vol 15 ◽  
pp. P837-P838
Author(s):  
Galit Weinstein ◽  
Kendra Davis-Plourde ◽  
Jayandra J. Himali ◽  
Shira Zelber-Sagi ◽  
Alexa S. Beiser ◽  
...  
Keyword(s):  
Liver Disease ◽  
Cognitive Function ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Framingham Study ◽  
Fibrosis Score ◽  
Alcoholic Fatty Liver ◽  
Middle Aged Adults ◽  
Alcoholic Fatty Liver Disease

scholarly journals Effects of sleep quality on non-alcoholic fatty liver disease: a cross-sectional survey

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e039947
Author(s):  
Atsushi Takahashi ◽  
Yukio Anzai ◽  
Masahito Kuroda ◽  
Masae Kokubun ◽  
Yuichiro Kondo ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Liver Disease ◽  
Sleep Quality ◽  
Fatty Liver ◽  
Logistic Regression Analysis ◽  
Fatty Liver Disease ◽  
Medication Use ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

BackgroundThe effects of sleep quality on the risk of developing non-alcoholic fatty liver disease (NAFLD) remain uncertain. The purpose of this study was to clarify the association between sleep quality and NAFLD.MethodsThe data of 4828 participants who underwent health check-ups at four hospitals were analysed. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI), which comprised seven elements scored from 0 to 3. The global PSQI score and the score for each element were compared between NAFLD and non-NAFLD groups separately by sex. Logistic regression analysis was performed to determine the association between NAFLD and each PSQI score.ResultsIn both men and women, the mean PSQI score for sleep medication use was significantly higher in non-NAFLD than in NAFLD. With regard to sleep medication use in men, the OR (95% CI) for NAFLD was lower with a score of 3 (OR 0.60, 95% CI 0.38–0.95) than with a score of 0 on multivariate logistic regression analysis adjusted for age, smoking habits and physical activity. The OR for NAFLD based on daytime dysfunction was also higher with a score of 3 than with a score of 0 in both men (OR 2.82, 95% CI 1.39–5.75) and women (OR 2.08, 95% CI 1.10–3.92). After adjustment for body mass index, the sleep latency scores in men and daytime dysfunction in women were associated with NAFLD.ConclusionSleep quality was associated with NAFLD, and there were sex differences.

scholarly journals A Cohort Study of Serum Bilirubin Levels and Incident Non-Alcoholic Fatty Liver Disease in Middle Aged Korean Workers

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e37241 ◽  
Author(s):  
Yoosoo Chang ◽  
Seungho Ryu ◽  
Yiyi Zhang ◽  
Hee Jung Son ◽  
Jang-Young Kim ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Serum Bilirubin ◽  
Middle Aged ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Associations between nut intake, cognitive function and non‐alcoholic fatty liver disease (NAFLD) in older adults in the United States: NHANES 2011-14

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sze-Yen Tan ◽  
Ekavi N. Georgousopoulou ◽  
Barbara R. Cardoso ◽  
Robin M. Daly ◽  
Elena S. George
Keyword(s):  
Older Adults ◽  
Liver Disease ◽  
Cognitive Function ◽  
Fatty Liver ◽  
Diet Quality ◽  
Fatty Liver Disease ◽  
Healthy Eating Index ◽  
Alcoholic Fatty Liver ◽  
Nut Intake ◽  
Alcoholic Fatty Liver Disease

Abstract Background Nuts are nutrient-rich and reported to provide some cognitive and cardiometabolic health benefits, but limited studies have focused on older adults. This study investigated the cross-sectional relationship between habitual nut intake, dietary pattern and quality, cognition and non-alcoholic fatty liver disease (NAFLD) in older adults. Methods Older adults (≥ 60 years) from the NHANES 2011-12 and 2013-14 cohorts, who had complete data on cognitive function (as CERAD total, delayed recall, animal fluency and digit-symbol substitution test) and variables to calculate the Fatty Liver Index (FLI), an indicator of NAFLD, were included (n = 1848). Nut intake and diet quality (Healthy Eating Index 2015) were determined using two 24-hour diet recalls. Participants were categorised into one of four groups based on their habitual nut intake: non-consumers (0 g/d), low intake (0.1–15.0 g/d), moderate intake (15.1–30.0 g/d) or met recommendation (> 30 g/d), with all outcomes compared between these nut intake groups. Results Cognitive scores of older adults were the lowest in non-consumers and significantly highest in the moderate intake group, with no further increase in those who consumed nuts more than 30 g/d (p < 0.007). FLI was the lowest among older adults with moderate nut intake but the associations disappeared after adjusting for covariates (p = 0.329). Moderate nut intake was also associated with better immediate and delayed memory in older adults with high risk of NAFLD (FLI ≥ 60) (B = 1.84 and 1.11, p < 0.05 respectively). Higher nutrient intake and better diet quality (p < 0.001) were seen with higher nut intake but did not influence energy from saturated fat intake. Factor analysis revealed ‘Nuts and oils’ as one of the four major dietary patterns associated with better cognition and lower FLI scores. Conclusions Moderate nut intake (15.1–30.0 g/d) may be sufficient for better cognitive performance, but not NAFLD risk of older adults in the US.

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