scholarly journals Monoprophylaxis With Cephalosporins for Transrectal Prostate Biopsy After the Fluoroquinolone-Era: A Multi-Institutional Comparison of Severe Infectious Complications

2021 ◽  
Vol 11 ◽  
Author(s):  
Mike Wenzel ◽  
Jost von Hardenberg ◽  
Maria N. Welte ◽  
Samuel Doryumu ◽  
Benedikt Hoeh ◽  
...  
Keyword(s):  
Single Dose ◽  
Prostate Biopsy ◽  
Infectious Complications ◽  
Complication Rates ◽  
Logistic Regression Models ◽  
Prostate Biopsies ◽  
Multiple Doses ◽  
Related Risk ◽  
Transrectal Prostate Biopsy ◽  
Low Incidence

BackgroundTo compare severe infectious complication rates after transrectal prostate biopsies between cephalosporins and fluoroquinolones for antibiotic monoprophylaxis.Material and MethodsIn the multi-institutional cohort, between November 2014 and July 2020 patients received either cefotaxime (single dose intravenously), cefpodoxime (multiple doses orally) or fluoroquinolones (multiple-doses orally or single dose intravenously) for transrectal prostate biopsy prophylaxis. Data were prospectively acquired and retrospectively analyzed. Severe infectious complications were evaluated within 30 days after biopsy. Logistic regression models predicted biopsy-related infectious complications according to antibiotic prophylaxis, application type and patient- and procedure-related risk factors.ResultsOf 793 patients, 132 (16.6%) received a single dose of intravenous cefotaxime and were compared to 119 (15%) who received multiple doses of oral cefpodoxime and 542 (68.3%) who received fluoroquinolones as monoprophylaxis. The overall incidence of severe infectious complications was 1.0% (n=8). No significant differences were observed between the three compared groups (0.8% vs. 0.8% vs. 1.1%, p=0.9). The overall rate of urosepsis was 0.3% and did not significantly differ between the three compared groups as well.ConclusionMonoprophylaxis with third generation cephalosporins was efficient in preventing severe infectious complications after prostate biopsy. Single intravenous dose of cefotaxime and multiday regimen of oral cefpodoxime showed a low incidence of infectious complications <1%. No differences were observed in comparison to fluoroquinolones.

Time of administration of a single dose of oral levofloxacin and its effect in infectious complications from transrectal prostate biopsy

2007 ◽  
Vol 39 (3) ◽  
pp. 897-903 ◽  
Author(s):  
Athanasios N. Argyropoulos ◽  
Konstantinos Doumas ◽  
Antonios Farmakis ◽  
Ioannis Liakatas ◽  
Ioannis Gkialas ◽  
...  
Keyword(s):  
Single Dose ◽  
Prostate Biopsy ◽  
Infectious Complications ◽  
Transrectal Prostate Biopsy ◽  
Time Of Administration

scholarly journals Impact of Rectal Swabs on Infectious Complications after Transrectal Prostate Biopsy

2016 ◽  
Vol 97 (3) ◽  
pp. 340-346 ◽  
Author(s):  
Carlos Gustavo Trujillo ◽  
Mauricio Plata ◽  
Juan Ignacio Caicedo ◽  
Juan Guillermo Cataño Cataño ◽  
Angela Marcela Mariño Alvarez ◽  
...  
Keyword(s):  
Prostate Biopsy ◽  
Infectious Complications ◽  
Rectal Swabs ◽  
Transrectal Prostate Biopsy

scholarly journals Complications of Prostate Biopsy: A Prospective, Single-institution Study

2020 ◽  
pp. 271-279
Author(s):  
Colette M. Antoine ◽  
Belinda F. Morrison ◽  
Michael E. Brooks
Keyword(s):  
Urinary Tract ◽  
Urinary Retention ◽  
Prostate Biopsy ◽  
Public Hospital ◽  
Retention Rate ◽  
Tertiary Care ◽  
Transrectal Ultrasound ◽  
Final Analysis ◽  
Infectious Complications ◽  
Prostate Biopsies

Aims:  This study aimed to determine the prevalence rates of transrectal ultrasound-guided prostate biopsy-related complications among patients receiving treatment at the large tertiary-care urology clinic of Kingston Public Hospital (KPH), Jamaica. Study Design: Prospective cohort study. Place and Duration of Study: Kingston Public Hospital (KPH), Jamaica from July 2018 to April 2019. Methodology: Our study population included men who underwent prostate biopsy at KPH. Data on demographics and clinical characteristics were collected using purpose-designed questionnaires from consenting patients who underwent prostate biopsy during the stated period. Patients were then followed up for complications 30 days post biopsy. Details regarding hospitalization due to biopsy-related complications were obtained from the medical records. Results: Data from 185 men were included in the final analysis. Among the patients biopsied, 49% were diagnosed with prostate cancer, while 72% experienced at least one complication, mainly non-infectious complications such as hematuria (46%), lower urinary tract symptoms (24%), rectal bleeding (23%), hematospermia (9%), and urinary retention (16%). Overall, a 15% risk of developing infectious complications was observed, with 9% experiencing fever and 3% experiencing both urinary tract infection and epididymo-orchitis. Our data showed a 6% hospitalization rate within 30 days, with all available records suggesting infectious complications. One death from a prostatic abscess was noted. The present study showed that most prostate biopsy complications were minor. Moreover, although bleeding and infectious complications as well as hospitalization rates were consistent with those reported in larger series, our population experienced a slightly higher mortality and urinary retention rate. Conclusion: Overall, our results showed that prostate biopsies performed within our institution are generally safe and well tolerated. Nonetheless, further studies are needed to determine whether morbidity of the procedure remains acceptable.

scholarly journals Single dose quinolone prophylaxis for out-patient transrectal prostate biopsy: The first experience in Taiwan

2017 ◽  
Vol 28 (4) ◽  
pp. 232-234
Author(s):  
Chun-Kai Hsu ◽  
Chia-Da Lin ◽  
Cheng-Hsing Heish ◽  
Shei-Dei Yang
Keyword(s):  
Single Dose ◽  
Prostate Biopsy ◽  
Transrectal Prostate Biopsy

Single-dose oral ciprofloxacin versus placebo for prophylaxis during transrectal prostate biopsy

Urology ◽  
1998 ◽  
Vol 52 (4) ◽  
pp. 552-558 ◽  
Author(s):  
Deepak A Kapoor ◽  
Ira W Klimberg ◽  
Gholam H Malek ◽  
John D Wegenke ◽  
Clair E Cox ◽  
...  
Keyword(s):  
Single Dose ◽  
Prostate Biopsy ◽  
Transrectal Prostate Biopsy ◽  
Dose Oral ◽  
Oral Ciprofloxacin

scholarly journals Cutting to the Core of the Issue: Emerging Strategies To Reduce Prostate Biopsy-Related Infections

2016 ◽  
Vol 54 (10) ◽  
pp. 2431-2435 ◽  
Author(s):  
Robin R. Chamberland
Keyword(s):  
Prostate Cancer ◽  
United States ◽  
Prostate Biopsy ◽  
Current Trend ◽  
The United States ◽  
Infectious Complications ◽  
Published Data ◽  
The Core ◽  
Link Type ◽  
Transrectal Prostate Biopsy

Over 1 million men undergo biopsy in the United States each year to evaluate for prostate cancer (S. Loeb, H. B. Carter, S. I. Berndt, W. Ricker, and E. M. Schaeffer, J Urol 186:1830–1834, 2011,http://dx.doi.org/10.1016/j.juro.2011.06.057). In recent years, there has been a rise in infectious complications related to these procedures. This review aims to provide an overview of the guidelines that direct transrectal prostate biopsy, to describe associated infection, and to evaluate the published data driving the current trend toward prebiopsy screening for resistant organisms.

scholarly journals Acute Aortic Valve Rupture from Infective Endocarditis after Transrectal Prostate Biopsy: A Call to Revise the AHA Guidelines for Prevention of Infective Endocarditis

2013 ◽  
Vol 6 ◽  
pp. CCRep.S10503 ◽  
Author(s):  
Julia Ansari ◽  
Gurkaran Singh Garcha ◽  
Henry Huang ◽  
Faisal G. Bakaeen ◽  
Salim S. Virani ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Aortic Valve ◽  
Prostate Biopsy ◽  
Transrectal Ultrasound ◽  
Febrile Illness ◽  
Heart Association ◽  
Infectious Complications ◽  
Medical Work ◽  
Intermittent Fever ◽  
Transrectal Prostate Biopsy

We describe the case of a 63-year-old man with a known murmur who presented with a 4-month history of intermittent fever and a progressive reduction in energy level after a transrectal prostate biopsy (TRPB). He subsequently presented with acute heart failure secondary to aortic valve cusp rupture caused by endocarditis and underwent urgent aortic valve surgery. The 2008 American College of Cardiology/American Heart Association Guideline update on infective endocarditis has narrowed the use of antibiotic prophylaxis before most accepted dental procedures and continues to recommend against prophylaxis before genitourinary or gastrointestinal procedures. In contrast, the American Urological Association recommends the use of fluoroquinolones for the prevention of transrectal ultrasound–derived infectious complications. Notably, TRPB is associated with a high frequency of bacteremia and bacteriuria. In our case, an antibiotic course before the procedure and a more meticulous medical work-up after febrile illness might have mitigated the patient's catastrophic medical presentation.

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