scholarly journals Autonomic Nervous System Dysfunction Is Associated With Re-hospitalization in Pediatric Septic Shock Survivors

2022 ◽  
Vol 9 ◽  
Author(s):  
Colleen M. Badke ◽  
Lindsey Swigart ◽  
Michael S. Carroll ◽  
Debra E. Weese-Mayer ◽  
L. Nelson Sanchez-Pinto
Keyword(s):  
Quality Of Life ◽  
Heart Rate ◽  
Septic Shock ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Sensitivity Analyses ◽  
Autonomic Nervous System Dysfunction ◽  
Targeted Interventions ◽  
Autonomic Nervous

Objective: Re-hospitalization after sepsis can lead to impaired quality of life. Predictors of re-hospitalization could help identify sepsis survivors who may benefit from targeted interventions. Our goal was to determine whether low heart rate variability (HRV), a measure of autonomic nervous system dysfunction, is associated with re-hospitalization in pediatric septic shock survivors.Materials and Methods: This was a retrospective, observational cohort study of patients admitted between 6/2012 and 10/2020 at a single institution. Patients admitted to the pediatric intensive care unit with septic shock who had continuous heart rate data available from the bedside monitors and survived their hospitalization were included. HRV was measured using age-normalized z-scores of the integer HRV (HRVi), which is the standard deviation of the heart rate sampled every 1 s over 5 consecutive minutes. The 24-h median HRVi was assessed on two different days: the last 24 h of PICU admission (“last HRVi”) and the 24-h period with the lowest median HRVi (“lowest HRVi”). The change between the lowest and last HRVi was termed “delta HRVi.” The primary outcome was re-hospitalization within 1 year of discharge, including both emergency department encounters and hospital readmission, with sensitivity analyses at 30 and 90 days. Kruskal-Wallis, logistic regression, and Poisson regression evaluated the association between HRVi and re-hospitalizations and adjusted for potential confounders.Results: Of the 463 patients who met inclusion criteria, 306 (66%) were re-hospitalized, including 270 readmissions (58%). The last HRVi was significantly lower among re-hospitalized patients compared to those who were not (p = 0.02). There was no difference in the lowest HRVi, but patients who were re-hospitalized showed a smaller recovery in their delta HRVi compared to those who were not re-hospitalized (p = 0.02). This association remained significant after adjusting for potential confounders. In the sensitivity analysis, a smaller recovery in delta HRVi was consistently associated with a higher likelihood of re-hospitalization.Conclusion: In pediatric septic shock survivors, a smaller recovery in HRV during the index admission is significantly associated with re-hospitalization. This continuous physiologic measure could potentially be used as a predictor of patients at risk for re-hospitalization and lower health-related quality of life.

Autonomic Nervous System Dysfunction in Lifelong Premature Ejaculation: Analysis of Heart Rate Variability

Urology ◽  
2012 ◽  
Vol 80 (6) ◽  
pp. 1283-1286 ◽  
Author(s):  
Orhan Unal Zorba ◽  
Yuksel Cicek ◽  
Hakkı Uzun ◽  
Mehmet Çetinkaya ◽  
Kadir Önem ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Premature Ejaculation ◽  
Autonomic Nervous System Dysfunction ◽  
Autonomic Nervous ◽  
Lifelong Premature Ejaculation

scholarly journals Сlinical features of changes in the microcirculation system among children with allergic rhinitis, depending on the severity of dysfunction of the autonomic nervous system

2021 ◽  
Vol 23 (1) ◽  
pp. 169-172
Author(s):  
N. S. Tataurschikova ◽  
P. V. Berezhansky
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Adaptive Systems ◽  
Allergic Diseases ◽  
The Body ◽  
Individual Treatment ◽  
Autonomic Nervous

In recent years, there has been an increase in the prevalence of allergic diseases in children. Allergic rhinitis (AR) ranks first among other allergic diseases in terms of prevalence and impact on the health and quality of life patients. In various countries of the world, according to various sources, from 10 to 40% of the population suffers. Allergic rhinitis is a serious medical, social and economic problem. In addition, allergic rhinitis, especially with multiple sensitization and insufficiently controlled course, is an independent risk factor for recurrence of respiratory infections and the development of bronchial asthma, and also significantly reduces the quality of life patients.AR is a multifactorial disease in the development of which many factors play a role. The basis of the pathological process in AR is IgE--dependent mucosal inflammation, which is realized under the influence of specific and nonspecific mechanisms and has a Th2 character. The tissues and organs involved in the process determine the formation of complex mechanisms of interaction between the immune, microcirculatory and autonomic nervous systems.The inflammatory process in AR is characterized by a number of features, for example, the presence of minimal persistent inflammation and the priming effect, which in turn is a predisposing factor for the clinical onset and progression of AR. Microcirculatory mechanisms are of great pathogenetic significance in the development of allergic inflammation, including in AR.Depending on the leading pathognomonic trait, it is now customary to distinguish individual phenotypes and endotypes of AR.The phenotype covers the clinically significant properties of AR, but does not reveal the detailed mechanisms of its development, on the basis of which a personalized algorithm for prevention, treatment and prognosis can be created.And the autonomic nervous system is responsible for setting links between the body, ambient and internal environment through the regulation of metabolism, functioning of organs and tissues based on changes in this environment; it also provides the integration of all organs into a single whole acting as one of the main body’s adaptive systems.Since the autonomic nervous system governs the body and homeostasis uniting separate pathogenetic links of disease progression and sets the basis for structural and functional unity. In light of this, the failure of neuroregulatory mechanisms takes the lead among the causes of systemic changes in the microvasculature, which, in turn, reflects general pathogenetic processes in the body. The regulatory mechanism is implemented through nerves and reflexes by different neurohumoral factors, their nature has been studied under experimental conditions and is beyond doubt to date.The study of the main indicators of microcirculation and the autonomic nervous system among children with allergic rhinitis in various combinations with concomitant pathology will highlight new AR phenotypes and select an individual treatment and rehabilitation plan for these children.

scholarly journals Heart rate variability as an indicator of autonomic nervous system disturbance in tetanus

2019 ◽  
Author(s):  
Ha Thi Hai Duong ◽  
Girmaw Abebe Tadesse ◽  
Phung Tran Huy Nhat ◽  
Nguyen Van Hao ◽  
John Prince ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Clinical Signs ◽  
Autonomic Nervous System Dysfunction ◽  
Autonomic Nervous ◽  
Non Invasive ◽  
Nervous System Activity ◽  
Grade 3

AbstractAutonomic nervous system dysfunction (ANSD) is a significant cause of mortality in tetanus. Currently diagnosis relies on non-specific clinical signs. Heart rate variability (HRV) may indicate underlying autonomic nervous system activity and represents a potentially valuable non-invasive tool for ANSD diagnosis in tetanus. HRV was measured from 3 5-minute ECG recordings during a 24-hour period in a cohort patients with severe tetanus, all receiving mechanical ventilation. HRV measurements from all subjects - 5 with ANSD (Ablett Grade 4) and 4 patients without ANSD (Ablett Grade 3) - showed HRV was lower than reported ranges for healthy individuals. Comparing different severities of tetanus, raw data for both time and frequency measurements of HRV were reduced in those with ANSD compared to those without. Differences were statistically significant in all except root mean square standard deviation RMSSD (p=0.07) indicating HRV may be a valuable tool in ANSD diagnosis.

scholarly journals The Heart of an Endurance Athlete: Impact of and Recovery After an Ultra-Endurance Event.

2021 ◽  
Author(s):  
Anton Swart ◽  
Demitri Constantinou
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
The Body ◽  
Mountain Biking ◽  
Vagal Activity ◽  
Autonomic Nervous System Dysfunction ◽  
Autonomic Nervous ◽  
Ultra Endurance

Abstract Background: Acute bouts of ultra-endurance exercise may cause an acute reduction in cardiac function, causing a physiological cascade which releases cardiac biomarkers. This study set out to determine the cardiac stress and recovery of participation in a three-day ultra-endurance mountain biking event of athletes using heart rate variability (HRV) as an outcome measure. Sixteen healthy participants (male and female) participating in a three-day ultra-endurance mountain biking event underwent a five-minute resting electrocardiography (ECG) recording in a supine position. Heart rate variability measurements were recorded two days before the race (baseline testing), after each race day, and at 24-hour post-event (recovery). Results: Time-domain and frequency domain measures showed significant (p≤0.05) changes from baseline in HRV parameters after each race day. The significant changes in HRV parameters reflected an increase in sympathetic activity after each day of the event. Our data revealed that the mean HR and RR variability variables did not return to baseline value after 24-hours of recovery, reflecting autonomic nervous system dysfunction, and that changes persisted for at least 24-hours post-event.Conclusion: Our study shows that competing in an ultra-endurance mountain bike event led to diminished vagal activity and a decrease in HRV throughout the event and persisted for at least 24-hours post-event. The body was under continuous sympathetic dominance during rest as well as during each day of racing, implying each race day can be considered a physiological stress. This may, in turn, cause a disturbance in homeostasis and an increase in autonomic nervous system dysfunction. This has implications for further research, including dysrhythmia risk, and monitoring of athletes in advising a return to strenuous activity.

scholarly journals The heart of an endurance athlete: impact of and recovery after an ultra-endurance event.

2020 ◽  
Author(s):  
Anton Swart ◽  
Demitri Constantinou
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
The Body ◽  
Mountain Biking ◽  
Vagal Activity ◽  
Autonomic Nervous System Dysfunction ◽  
Autonomic Nervous ◽  
Ultra Endurance

Objectives Our study set out to determine the cardiac stress and recovery of participation in a three-day ultra-endurance mountain biking event of athletes using heart rate variability (HRV) as an outcome measure. Methods Sixteen healthy participants (male and female) participating in a three-day ultra-endurance mountain biking event underwent a five-minute resting ECG recording in a supine position. Heart rate variability measurements were recorded two days before the race (baseline testing), after each race day, and at 24-hour post-event (recovery). Results Time-domain and frequency domain measures showed significant (p≤0.05) changes from baseline in HRV parameters after each race day. Our study found significant changes in HRV parameters, all of which reflected an increase in sympathetic activity after each day of the event. These data also revealed that the mean HR and RR variability variables did not return to baseline value after 24-hours of recovery, reflecting autonomic nervous system dysfunction, and that changes persisted for at least 24-hours post-event. Conclusion Our study shows that competing in an ultra-endurance mountain bike event led to diminished vagal activity and a decrease in HRV throughout the event and persisted for at least 24 hours post-event. The body was under continuous sympathetic dominance during rest as well as during each day of racing, implying each race day can be considered a physiological stress. This may, in turn, cause a disturbance in homeostasis and an increase in autonomic nervous system dysfunction. This has implications for further research, including dysrhythmia risk, and monitoring of athletes in advising a return to strenuous activity.

scholarly journals Features of autonomic regulation in cholelithiasis before and after cholecystectomy

2018 ◽  
pp. 60-64
Author(s):  
A. D. Bagmet ◽  
A. P. Ruban ◽  
V. N. Egorov ◽  
T. V. Tayutina
Keyword(s):  
Quality Of Life ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Mathematical Analysis ◽  
Sympathetic Activity ◽  
Heart Rhythm ◽  
Autonomic Regulation ◽  
Autonomic Nervous ◽  
Before And After

It is appropriate and necessary to examine the functional state of the autonomic nervous system and the quality of life in patients with cholelithiasis using the mathematical analysis of the heart rhythm at the present-day level. Materials and methods: 136 patients (115 women and 21 men) were examined, of which 70 patients after cholecystectomy with cholelithiasis and 66 patients with cholelithiasis. Fractional chromatic minute-type duodenal intubation with an analysis of the biochemical and microscopic composition of the bile was used to assess the biliary system condition. The examination of the autonomic nervous system was carried out by determining the heart rhythm using the cardiointervalography method with further mathematical analysis of the structure and variational pulsometry. Changes in the autonomic status in patients with cholelithiasis before and after cholecystectomy differ in general patterns: adaptive possibilities decrease and sympathetic activity of the autonomic regulation increases. An increase in the lithogenicity of bile, which positively correlates with the level of sympathicotonia, is characteristic for patients with cholelithiasis before and after cholecystectomy. The autonomic regulation in patients with cholelithiasis after cholecystectomy improves, however, the high bile lithogenicity persists. 

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