scholarly journals Venous and Arterial Responses to Partial Gravity

2020 ◽  
Vol 11 ◽  
Author(s):  
Stuart M. C. Lee ◽  
David S. Martin ◽  
Christopher A. Miller ◽  
Jessica M. Scott ◽  
Steven S. Laurie ◽  
...  
1997 ◽  
Author(s):  
M. Bahadori ◽  
L. Zhou ◽  
D. Stocker ◽  
M. Bahadori ◽  
L. Zhou ◽  
...  

ASCEND 2020 ◽  
2020 ◽  
Author(s):  
Mahsa Moghimi Esfandabadi ◽  
Olga K. Bannova

2021 ◽  
pp. 0271678X2110103
Author(s):  
Nao Hatakeyama ◽  
Miyuki Unekawa ◽  
Juri Murata ◽  
Yutaka Tomita ◽  
Norihiro Suzuki ◽  
...  

A variety of brain cells participates in neurovascular coupling by transmitting and modulating vasoactive signals. The present study aimed to probe cell type-dependent cerebrovascular (i.e., pial and penetrating arterial) responses with optogenetics in the cortex of anesthetized mice. Two lines of the transgenic mice expressing a step function type of light-gated cation channel (channelrhodopsine-2; ChR2) in either cortical neurons (muscarinic acetylcholine receptors) or astrocytes (Mlc1-positive) were used in the experiments. Photo-activation of ChR2-expressing astrocytes resulted in a widespread increase in cerebral blood flow (CBF), extending to the nonstimulated periphery. In contrast, photo-activation of ChR2-expressing neurons led to a relatively localized increase in CBF. The differences in the spatial extent of the CBF responses are potentially explained by differences in the involvement of the vascular compartments. In vivo imaging of the cerebrovascular responses revealed that ChR2-expressing astrocyte activation led to the dilation of both pial and penetrating arteries, whereas ChR2-expressing neuron activation predominantly caused dilation of the penetrating arterioles. Pharmacological studies showed that cell type-specific signaling mechanisms participate in the optogenetically induced cerebrovascular responses. In conclusion, pial and penetrating arterial vasodilation were differentially evoked by ChR2-expressing astrocytes and neurons.


2007 ◽  
Vol 112 (8) ◽  
pp. 441-447 ◽  
Author(s):  
Tom S. Davies ◽  
Michael P. Frenneaux ◽  
Ross I. Campbell ◽  
Michael J. White

The effects of exercise on the distensibility of large and medium-sized arteries are poorly understood, but can be attributed to a combination of local vasodilator effects of exercise opposed by sympathetic vasoconstrictor tone. We sought to examine this relationship at the conduit artery level, with particular reference to the role of the sympatho-excitatory muscle metaboreflex. The effect of maintained muscle metaboreflex activation on a previously passive or exercised limb femoral artery was investigated. A total of ten healthy volunteers performed 2 min of isometric ankle plantar-flexion at 40% MVC (maximal voluntary force), in conjunction with 2 min of either non-ischaemic isometric HG (handgrip; control condition) or IHG (ischaemic HG) at 40% MVC. IHG was followed by 2 min of PECO (post-exercise circulatory occlusion) to maintain muscle metaboreflex activation. FTPWV [femoral–tibial PWV (pulse wave velocity)] was measured in the exercised or contralateral limb at baseline and immediately following calf exercise. BP (blood pressure) and HR (heart rate) were measured continuously throughout. In the HG condition, BP and HR returned promptly to baseline post-exercise, whereas exercised leg FTPWV was decreased (less stiff) by 0.6 m/s (P<0.05) and the non-exercised leg PWV was not changed from baseline. PECO caused a sustained increase in BP, but not HR, in the IHG condition. Contralateral leg PWV increased (stiffened) during PECO by 0.9 m/s (P<0.05), whereas exercised limb FTPWV was not changed from baseline. In conclusion, muscle metaboreflex activation causes a systemic stiffening of the arterial tree, which can overcome local exercise-induced decreases in arterial PWV.


2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Thomas Davies ◽  
Ross Campbell ◽  
Michael Frenneaux ◽  
Michael White

2017 ◽  
Vol 8 ◽  
Author(s):  
Charlotte Richter ◽  
Bjoern Braunstein ◽  
Andrew Winnard ◽  
Mona Nasser ◽  
Tobias Weber

2011 ◽  
Vol 71 ◽  
pp. e52 ◽  
Author(s):  
Shuji Aou ◽  
Kimiya Narikiyo ◽  
Akira Masuda ◽  
Jorge L. Zeredo ◽  
Katsuya Hasegawa ◽  
...  

PEDIATRICS ◽  
1973 ◽  
Vol 51 (5) ◽  
pp. 956-957
Author(s):  
G. C. Liggins ◽  
R. N. Howie

Dr. Holm's interesting hypothesis has as its core the action of catecholamines on the pulmonary and bronchial vasculature. Our perusal of the reference cited in support of the assertion that norepinephrine causes pulmonary artery vasoconstriction and bronchial artery vasodilation failed to find the expected evidence. In fetal lambs, the response to both methoxamine1 (an α-receptor stimulant) and isoprenaline2 (aβ-receptor stimulant) is pulmonary vasodilation. We are unaware of studies of fetal bronchial arterial responses to catecholamines.


1991 ◽  
Vol 58 (6) ◽  
pp. 462-462
Author(s):  
D. G. Vidt ◽  
A. V. Chobanian
Keyword(s):  

Author(s):  
James Flores ◽  
Farzan Sasangohar

Sending humans to other planets requires an understanding of the effects of the partial gravity on human motion before attempting to design or build buildings or plan mission tasks. Architecture is the most basic example of human-centered design as everything in a building is to “human” scale. While some modern studies (e.g., Capps, et. al, 1989) reference a study which looked at the humans and forces for the Moon landing (Hewes et. al, 1966), this study was never correlated with the actual lunar data and has many erroneous assumptions. Previous work in Biomechanics was reviewed and the elements of physics required to analyze human motion in partial gravity was analyzed and several basic questions were generated. Included in these studies are NASA studies which look at parabolic flight and apparatus to simulate the effects of partial gravity (NASA/TM-2010-216139, 2010). The key part of physics that drives the changes in human motion is the fact that the momentum of a human or object in motion remains the same while gravity reduces the normal forces on the feet which in turn cause a reduction in the friction reaction forces available for maneuvering or stopping. The study investigates design of several building features for space architecture. These include: Ceiling Height, Door Size, Railing Height, Stairs, Ladders, and Ramps. The first of these the ceiling height relates to the question of does a person “bounce” when they walk in partial gravity. Typical ceilings on Earth range from 2.44 m (8 feet) to 3.05 m (10 feet) Studies of walk to run transition speed for partial gravity were reviewed and they measured the vertical displacement of the hip. This measurement varied by less than 1 cm and correlated to a minimal head height change. Door sizes and railing heights related to the height of 99th percentile humans projected to the year of launch to Mars or the Moon and also included spinal growth caused by 0 g transit. These projections do lead to a taller door opening (25 cm) and raised railing (14.3 cm) as compared to earth. Stairs and ladders both ended up being related to joint angles and human preferences such that they remain the same as on Earth. Chair heights which also relate to counter heights were looked at by reviewing studies of the sit-to-stand motion and comparing the foot and buttocks reaction forces to the friction forces available on Mars and the Moon verses Earth standard. This leads to a recommendation to use Pub height chairs and counters. Flooring and ramps required scaling and also calculating equivalency values to make comparisons. It was determined that the required friction when scaled to Mars would be possible with fairly standard flooring materials. The Lunar case however, would require a combination of high friction flooring and training for nominal movement. To analyze ramps independent calculations were used for friction requirements and then correlated to a study of emergency personnel pushing a trolley with a patient up or down a ramp. Both these methods correlated to an extremely shallow 2.86 degrees (slope 1 in 20) ramp being possible on Mars and ramps not being usable on the Moon. Based on these factors it is recommended that many of features follow standards used on earth and that only the required changes be made such that the habitation resemble Earth structures as much as possible. In addition, Astronaut training should incorporate these factors into their procedures.


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