scholarly journals Insight on Polyunsaturated Fatty Acids in Endometrial Receptivity

Biomolecules ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 36
Author(s):  
Min Chen ◽  
Zimeng Zheng ◽  
Jialu Shi ◽  
Jun Shao
Keyword(s):  
Fatty Acids ◽  
Cell Proliferation ◽  
Polyunsaturated Fatty Acids ◽  
Growth And Development ◽  
Cell Function ◽  
Essential Fatty Acids ◽  
Supporting Cell ◽  
Endometrial Receptivity ◽  
In Pregnancy

Endometrial receptivity plays a crucial role in fertilization as well as pregnancy outcome in patients faced with fertility challenges. The optimization of endometrial receptivity may help with normal implantation of the embryo, and endometrial receptivity may be affected by numerous factors. Recently, the role of lipids in pregnancy has been increasingly recognized. Fatty acids and their metabolites may be involved in all stages of pregnancy and play a role in supporting cell proliferation and development, participating in cell signaling and regulating cell function. Polyunsaturated fatty acids, in particular, are essential fatty acids for the human body that can affect the receptivity of the endometrium through in a variety of methods, such as producing prostaglandins, estrogen and progesterone, among others. Additionally, polyunsaturated fatty acids are also involved in immunity and the regulation of endometrial decidualization. Fatty acids are essential for fetal placental growth and development. The interrelationship of polyunsaturated fatty acids with these substances and how they may affect endometrial receptivity will be reviewed in this article.

scholarly journals Role of Prostaglandins, Thromboxanes and Leukotrienes as Mediators in Inflammations

2019 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Fatty Acids ◽  
Cell Proliferation ◽  
Polyunsaturated Fatty Acids ◽  
Vascular Permeability ◽  
Inflammatory Responses ◽  
Biological Processes ◽  
Bioactive Lipids ◽  
Fatty Acids Metabolism

Eicosanoids are 20-carbon bioactive lipids derived from the polyunsaturated fatty acids metabolism, which can modify numerous biological processes comprising cell proliferation, migration and adhesion, vascular permeability, angiogenesis and inflammatory responses [1].

scholarly journals The role of long-chain polyunsaturated fatty acids in the treatment of cancer Cachexia and tumour growth in patients with malignant diseases: A review

2008 ◽  
Vol 13 (2) ◽  
pp. 49-60 ◽  
Author(s):  
Elizabeth A Symington ◽  
Gerda J Gericke
Keyword(s):  
Fatty Acids ◽  
Cell Proliferation ◽  
Polyunsaturated Fatty Acids ◽  
Tumour Growth ◽  
Cancer Cachexia ◽  
The Body ◽  
Pufa Supplementation ◽  
Reduce Cell Proliferation

Recent studies show that ω-3 polyunsaturated fatty acids (PUFAs) have the capacity to modulate cancer outcomes. The body responds to cancer in the same way that it responds to inflammation and wound healing. Nutrients with anti-inflammatory effects could therefore be expected to play a role in cancer treatment. This review focuses on the role of ω-3 PUFAs in tumourigenesis and cancer cachexia. Studies indicate that eicosapentaenoic acid (EPA) supplementation may promote arrest of tumour growth and reduce cell proliferation. Patients need to consume at least 2 g of EPA per day for it to have a therapeutic effect. Positive outcomes related to cachexia include diminished weight loss, increased appetite, improved quality of life and prolonged survival, although there is controversy regarding these clinical outcomes. The effects of ω-3 PUFAs on tumourigenesis and cachexia are viewed in the context of altered lipid and protein metabolism. This altered metabolism usually experienced by cancer patients results in increased formation of proinflammatory eicosanoids and cytokines. Cytokines play an indirect role by stimulating the production of arachidonic acid-derived eicosanoids, which support inflammation, cell proliferation and angiogenesis, and inhibit apoptosis. It can be concluded that ω-3 PUFA supplementation offers a means of augmenting cancer therapy, inhibiting tumourigenesis and possibly contributing to cachexia alleviation. Opsomming Onlangse studies toon dat ω-3-poli-onversadigde vetsure (POVSe) oor die vermoë beskik om kankeruitkomste te moduleer. Die liggaam reageer op kanker op dieselfde wyse as wat dit op inflammasie en wondgenesing reageer. Daar kan dus verwag word dat voedingstowwe met ‘n anti-inflammatoriese uitwerking ‘n rol in die behandeling van kanker kan speel. In hierdie oorsig word daar op die rol van ω-3-POVSe in tumorigenese en kankerkageksie gefokus. Studies dui daarop dat eikosapentanoënsuur- (EPS-)aanvulling tumorgroei moontlik kan stuit en selproliferasie verlaag. Pasiënte moet minstens 2 g EPS per dag inneem om ‘n terapeutiese uitwerking te verseker. Positiewe uitkomste verbonde aan kageksie sluit minder gewigsverlies, beter eetlus, beter lewensgehalte en langer oorlewing in, hoewel daar ‘n geskil bestaan oor hierdie kliniese uitkomste. Die uitwerking van ω-3-POVSe op tumorigenese en kageksie word in die konteks van gewysigde lipied- en proteïenmetabolisme beskou. Die metabolisme wat dikwels in kankerpasiënte voorkom, lei tot ‘n verhoogde vorming van pro-inflammatoriese eikosanoïede en sitokiene. Sitokiene speel ook ‘n indirekte rol deur die produksie van aragidoonsuur-afkomstige eikosanoïede te stimuleer. Laasgenoemde ondersteun inflammasie, selproliferasie en angiogenese, en inhibeer apoptose. Die gevolgtrekking kan gemaak word dat ω-3-POVS-aanvulling ‘n manier is om kankerterapie uit te brei, tumorigenese te inhibeer en moontlik tot die verligting van kageksie by te dra.

scholarly journals Necessity of creating the collection of wild relatives of fat-oil crops of Kazakhstan, alternative sources of polyunsaturated fatty acids

2021 ◽  
Vol 102 (2) ◽  
pp. 6-14
Author(s):  
Nurzhamak Berik ◽  
◽  
Aigerim Kurmanaliyeva ◽  
Tansara Murzatayeva ◽  
Karina Makhmudova ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Essential Fatty Acids ◽  
Wild Relatives ◽  
Oil Crops ◽  
Ongoing Work ◽  
Before And After ◽  
Natural Flora ◽  
Alternative Sources

The necessity of creating the collection of wild relatives of fat and oil crops (WRFOC) of Kazakhstan is presented in the article. To achieve this an overview of international experience in studying the role of polyunsaturated fatty acids (PUFA) contained in plants was compiled. These PUFAs are essential fatty acids (EFA) entering the animals’ and humans’ bodies only with food. It is noted that countries possessing the marine wealth use marine fish for production of dietary supplements containing PUFA, but the plant world wealth should be also taken into account. In sufficient quantities EFAs are present in vegetable oils and in small quantities in animal tissues. The participation of EFAs in transcription regulation of certain genes was highlighted. Their role in development of animal and human organisms was noted. The role of the seed bank of Kazakhstan natural flora in ongoing work for creating the various plant species’ collections with great value for the country’s economy, in particular the WRFOC collection of Kazakhstan natural flora was emphasized. The rationale for financing and maintaining works (collecting and preserving seed material, studying seed behavior before and after storage, seed germinating, studying the chemical composition of different plants’ parts) for creating and research this collection is given.

scholarly journals Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1185
Author(s):  
Maud Martinat ◽  
Moïra Rossitto ◽  
Mathieu Di Miceli ◽  
Sophie Layé
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Brain Development ◽  
Essential Fatty Acids ◽  
Developing Brain ◽  
Hyperactivity Disorder ◽  
Brain Functions ◽  
Dietary Polyunsaturated Fatty Acids ◽  
Long Chain

n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for brain functions. They constitute crucial elements of cellular membranes, especially in the brain. They are the precursors of several metabolites with different effects on inflammation and neuron outgrowth. Overall, long-chain PUFAs accumulate in the offspring brain during the embryonic and post-natal periods. In this review, we discuss how they accumulate in the developing brain, considering the maternal dietary supply, the polymorphisms of genes involved in their metabolism, and the differences linked to gender. We also report the mechanisms linking their bioavailability in the developing brain, their transfer from the mother to the embryo through the placenta, and their role in brain development. In addition, data on the potential role of altered bioavailability of long-chain n-3 PUFAs in the etiologies of neurodevelopmental diseases, such as autism, attention deficit and hyperactivity disorder, and schizophrenia, are reviewed.

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