TAT for Enzyme/Protein Delivery to Restore or Destroy Cell Activity in Human Diseases
Keyword(s):
Much effort has been dedicated in the recent decades to find novel protein/enzyme-based therapies for human diseases, the major challenge of such therapies being the intracellular delivery and reaching sub-cellular organelles. One promising approach is the use of cell-penetrating peptides (CPPs) for delivering enzymes/proteins into cells. In this review, we describe the potential therapeutic usages of CPPs (mainly trans-activator of transcription protein, TAT) in enabling the uptake of biologically active proteins/enzymes needed in cases of protein/enzyme deficiency, concentrating on mitochondrial diseases and on the import of enzymes or peptides in order to destroy pathogenic cells, focusing on cancer cells.
2019 ◽
Vol 20
(17)
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pp. 4311
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2000 ◽
Vol 150
(3)
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pp. 689-694
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Keyword(s):
2017 ◽
Vol 3
(1)
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pp. 006-015
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