scholarly journals Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5976
Author(s):  
Adriana Aurelia Chis ◽  
Carmen Maximiliana Dobrea ◽  
Luca-Liviu Rus ◽  
Adina Frum ◽  
Claudiu Morgovan ◽  
...  
Keyword(s):  
Viral Vectors ◽  
Active Drug ◽  
Load Capacity ◽  
Comprehensive Overview ◽  
Enzyme Prodrug Therapy ◽  
Site Of Action ◽  
New Strategy ◽  
Delivery Vehicles ◽  
High Load Capacity ◽  
High Bioavailability

Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug. In recent years, numerous therapeutic systems based on GDEPT strategy have entered clinical trials. In order to deliver the desired gene at a specific site of action, this therapeutic approach uses vectors divided in two major categories, viral vectors and non-viral vectors, with the latter being represented by chemical delivery agents. There is considerable interest in the development of non-viral vectors due to their decreased immunogenicity, higher specificity, ease of synthesis and greater flexibility for subsequent modulations. Dendrimers used as delivery vehicles offer many advantages, such as: nanoscale size, precise molecular weight, increased solubility, high load capacity, high bioavailability and low immunogenicity. The aim of the present work was to provide a comprehensive overview of the recent advances regarding the use of dendrimers as non-viral carriers in the GDEPT therapy.

Experimental analysis of the automated process of sanding aircraft surfaces

2014 ◽  
Vol 118 (1199) ◽  
pp. 53-64
Author(s):  
B. Giublin ◽  
J. A. Vieira ◽  
T. G. Vieira ◽  
L. G. Trabasso ◽  
C. A. Martins
Keyword(s):  
Load Capacity ◽  
Manufacturing Processes ◽  
Robotic Cell ◽  
Research Project ◽  
Average Value ◽  
Aluminum Metal ◽  
Structural Assembly ◽  
Riveting Process ◽  
High Load Capacity ◽  
Operating Method

Abstract ITA and EMBRAER are currently executing the research project Automation of Aircraft Structural Assembly (AASA) whose goal is to implement a robotic cell for automating the riveting process of aeronautical structures. The proposal described herein complements the AASA project, adds other manufacturing processes, namely sanding and polishing of aircraft surfaces. To implement the additional processes AASA project resources and facilities were used (robots and metrology systems) and devices designed and /or acquired to allow sharing of these resources. Among these, an Automatic Tooling Support for AERonautics structures (ATS_AER) was designed and built; also, a robot tool changer with high load capacity was acquired. The outcome of this research project is the evaluation of the feasibility of automating the processes of sanding and polishing metal surfaces in the aircraft manufacture using robots. The operating method adopted for surface treatment employed the ‘U’ type trajectory optimised to be run by a KUKA robot KR 500. The sanding process has been applied to aluminum metal sheet specimen sized 2•18ft2 (0•20m2) and used commercial 600 and 800 sandpaper. The automated sanding process yielded an average value of RA 0•48 ± 0•08 which is 25% more efficient when compared to the traditional, manual process whose average value of RA is 0•75 ± 0•51.

Static Performance of a Hydrostatic Thrust Foil Bearing for Large Scale Oil-Free Turbomachines

2020 ◽  
Author(s):  
Nguyen LaTray ◽  
Daejong Kim ◽  
Myongsok Song
Keyword(s):  
Large Scale ◽  
Load Capacity ◽  
Organic Rankine Cycle ◽  
Rankine Cycle ◽  
Outer Diameter ◽  
Frictional Loss ◽  
Foil Bearing ◽  
Foundation Model ◽  
Static Performance ◽  
High Load Capacity

Abstract This work presents a novel design of a hydrostatic thrust foil bearing (HSTFB) with an outer diameter of 154mm along with simulation and test results up to specific load capacity of 223kPa (32.3psi). The HSTFB incorporates a high pressure air/gas injection to the thrust foil bearing with a uniform clearance. This bearing has high load capacity, low power loss, and no friction/wear during startup and shutdown. In addition, the HSTFB allows for bidirectional operation. The paper also presents an advanced simulation model which adopts the exact locations of a tangentially arranged bumps to a cylindrical two-dimensional plate model of the top foil. This method predicts top foil deflection with better accuracy than the traditional independent elastic foundation model which distributes the bump locations over the nodal points in the cylindrical coordinates, and with less computational resource than the finite element method applied to the entire bump/top foils. The presented HSTFB, was designed for Organic Rankine Cycle (ORC) generators, but its performance was predicted and measured using air in this paper. The bearing static performance is compared analytically against the rigid counterpart, and presented at different supply pressures, speeds, and minimum film thicknesses. Experimental verification is conducted at 10, 15 and 20krpm. The measured load capacity and frictional loss agree well with the prediction. The measured film thickness also agrees with the prediction after the structural deflection of the thrust runner disc is compensated. Overall, the novel HSTFB demonstrates an excellent static performance and shows good potential for adoption to the intended ORC generators and other large oil-free turbomachines.

Lastverteilung in Planetenrollengewindetrieben/Description of the load distribution in planetary roller screws

2020 ◽  
Vol 110 (05) ◽  
pp. 322-327
Author(s):  
Christian Brecher ◽  
Thomas Frenken ◽  
Gabriel Axelrad ◽  
Stephan Neus
Keyword(s):  
Load Distribution ◽  
Load Capacity ◽  
Calculation Model ◽  
Axial Stiffness ◽  
Contact Points ◽  
Calculation Results ◽  
Roller Screw ◽  
The Individual ◽  
Individual Contact ◽  
High Load Capacity

Planetenrollengewindetriebe finden aufgrund ihrer hohen Tragfähigkeit Anwendung in Bereichen, in denen Kugelgewindetriebe an ihre Lastgrenzen stoßen. Um ein Berechnungsmodell für Planentenrollengewindetriebe zu entwickeln, wurden Berechnungsmethoden zur Beschreibung der Lastverteilung innerhalb des Planetenrollengewindetriebs entwickelt. Mit diesen lassen sich die in den einzelnen Kontaktpunkten wirkenden Kräfte sowie die Verlagerungen des Gewindetriebs bestimmen. Die Berechnungsergebnisse werden unter anderem für die Berechnung der statischen axialen Steifigkeit und der Ermüdungslebensdauer benötigt.   Due to their high load capacity, planetary roller screws are used in areas where ball screws reach their load limits. To develop a calculation model for planetary roller screws, calculation methods to describe the load distribution within the planetary roller screw were developed in this step. With these methods, the forces acting in the individual contact points as well as the displacements of the screw drive can be determined. The calculation results are required, among other things, for the calculation of static axial stiffness and fatigue life.

An Air Layer Modeling Approach for Air and Air/Vacuum Bearings

1997 ◽  
Vol 119 (3) ◽  
pp. 388-392
Author(s):  
J. M. Pitarresi ◽  
K. A. Haller
Keyword(s):  
Load Capacity ◽  
Load Resistance ◽  
High Load ◽  
Air Bearing ◽  
Air Bearings ◽  
Bearing Surface ◽  
Know How ◽  
Modeling Approach ◽  
Vibrational Characteristics ◽  
High Load Capacity

Air layer supported bearing pads, or “air bearings” as they are commonly called, are popular because of their high load capacity and low in-plane coefficient of friction, making them well suited for supporting moving, high accuracy manufacturing stages. Air/vacuum bearings enhance these capabilities by giving the bearing pad load resistance capacity in both the upward and downward directions. Consequently, it is desirable to know how to model the air layer between the bearing pad and the bearing surface. In this paper, a simple finite element modeling approach is presented for investigating the vibrational characteristics of an air layer supported bearing. It was found that by modeling the air layer as a bed of uniform springs who’s stiffness is determined by load-displacement tests of the bearing, a reasonable representation of the response can be obtained. For a bearing supported by air without vacuum, the dynamic response was very similar to that of a freely supported bearing. The addition of vacuum to an air bearing was found to significantly lower its fundamental frequency which could lead to unwanted resonance problems.

Kinematics Research for a High-Precise Multi-Gratings Mosaic Mechanism

2012 ◽  
Vol 452-453 ◽  
pp. 1496-1500
Author(s):  
Li Hua Lu ◽  
Ying Chun Liang ◽  
Fu Li Yu ◽  
Bao Ku Su
Keyword(s):  
Degrees Of Freedom ◽  
Design Principle ◽  
Load Capacity ◽  
Dual Mode ◽  
Micro Actuator ◽  
Feed Drives ◽  
Parallel Kinematic ◽  
High Load Capacity ◽  
Novel Design ◽  
Kinematic Properties

A novel design of high load capacity multiaxis positioning stages with accuracy in the range of nanometers is presented. For strokes of 2mm with no play and high stiffness a general design principle supporting five Cartesian degrees of freedom has been developed using a new parallel kinematic topology based on Parallelogram arrangements. The five uniform feed drives are improved dual mode mechanism with servomotor and ballscrew as macro-actuator and piezoelectric transducer (PZT) with resolution of 1.2nm as micro-actuator. The performance of the setup and its kinematic properties are described as well as resolution of the five motions and their crosstalk. The setup has been implemented with outstanding characteristics and excellent reliability for alignment of a multigrating mosaic compressor in a PW-class CPA-laser.

Bacterial and viral vectors as vaccine delivery vehicles for breast cancer therapy

Life Sciences ◽  
2020 ◽  
Vol 250 ◽  
pp. 117550 ◽  
Author(s):  
Balamurugan Shanmugaraj ◽  
Lohanathan Bharathi Priya ◽  
B. Mahalakshmi ◽  
Shanmugam Subbiah ◽  
Rouh-Mei Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Viral Vectors ◽  
Vaccine Delivery ◽  
Breast Cancer Therapy ◽  
Delivery Vehicles

scholarly journals Multilayered-Sheet Hot Stamping and Application in Electric-Power-Fitting Products

Metals ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 215 ◽  
Author(s):  
Bin Zhu ◽  
Zhoujie Zhu ◽  
Yongmin Jin ◽  
Kai Wang ◽  
Yilin Wang ◽  
...  
Keyword(s):  
Contact Pressure ◽  
Load Capacity ◽  
Hot Stamping ◽  
High Strength ◽  
Optimal Number ◽  
Electrical Connection ◽  
Number Of Layers ◽  
Stamping Process ◽  
New Type ◽  
High Load Capacity

Traditional electric transmission line fittings, which are always manufactured from thick metal slabs, possess the disadvantage of heavy weight. In this study, a new type of electrical-connection-fitting, clevis-clevis component made of high-strength steel is developed to reduce weight, and a new hot-stamping process for multilayered sheets is proposed to manufacture the component efficiently. First, the structure of the new clevis-clevis component is designed, and the corresponding tool is developed. Second, a flat-tool heat transfer experiment is conducted. The influence of the number of layers and contact pressure on the cooling rate of each sheet is investigated. The optimizing number of layers and contact pressure for the multilayered-sheet, hot-stamping process are obtained. The optimal number of layers is two, and the optimal contact pressure is more than 20 MPa. The final microstructure of each sheet is fully martensitic, and the strength is about 1500 MPa. Finally, U-shaped, double-layer-sheet hot stamping is implemented to produce a typical electrical-connection-fitting, clevis-clevis component. The bearing capacity of a four-layered clevis-clevis is tested through numerical and experimental methods. The new connection-fitting clevis-clevis component exhibits a high load capacity of 280 kN. Compared with that of the traditional component, the weight of the new component is reduced by 60%.

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