“Black Ovaries”: An Uncommon Case of First Systemic Recurrence of Melanoma

Here we describe a rare case of a 48-year-old woman with a previous history of malignant melanoma (pT2a pathological stage, IB clinical stage) occurring about five years previously. She complained of abdominal pain and pelvic discomfort, diagnosed as a consequence of a bilateral ovarian solid masses completely occupying the recto-uterine space. She underwent laparotomy surgery with total hysterectomy and bilateral salpingo-oophorectomy. Gross examination of the excised material revealed an unusual grey-black bilateral ovarian tumor; a histopathological diagnosis of ovarian bilateral metastatic melanoma was made. Imaging study (CT/MRI) did not reveal metastasis in other zones of the body. Melanoma metastasis usually affects the skin, liver, brain and lungs, and rarely gynecological localizations. On the other hand, most bilateral ovarian tumors are comprised of serous carcinoma, mature teratoma and gastrointestinal carcinoma metastasis. Exceptionally, primary ovarian melanoma may arise in mature ovarian cystic teratomas.

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Intramedullary Spinal Capillary Hemangioma: Case Report

Arquivos Brasileiros de Neurocirurgia Brazilian Neurosurgery ◽

10.1055/s-0035-1570100 ◽

2015 ◽

Vol 36 (02) ◽

pp. 125-127

Author(s):

Leonardo Welling ◽

Mariana Welling ◽

Eberval Figueiredo

Keyword(s):

Spinal Cord ◽

Complete Removal ◽

Conus Medullaris ◽

Capillary Hemangioma ◽

The Body ◽

Accurate Information ◽

Histopathological Diagnosis ◽

Intramedullary Lesion ◽

History Of

AbstractCapillary hemangiomas involving the neuraxis are very uncommon. In the spinal cord, they are located mainly intradural and extramedullary. To our knowledge, only four cases in conus medullaris have been previously described. In our case, a 46-year-old man was admitted with back pain, sphincter disturbances, as well as progressive weakness and numbness on the lower extremities. Magnetic resonance imaging revealed an undefined intramedullary lesion on the conus medullaris. The patient underwent microsurgery, which achieved complete removal. Histopathological diagnosis was compatible with capillary hemangioma. His postoperative course was uneventful and all symptoms, including bladder dysfunction clearly regressed. The treatment of intramedullary capillary hemangiomas is very critical in preventing unnecessary morbidity, providing accurate information with respect to prognosis, and establishes a regular outpatient follow-up. The natural history of this lesion involving the spinal cord is not well described, although they are common elsewhere in the body.

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Development of Diabetes Type 3 After SARS-COV-2 Pancreatic B Cell Injury

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.760 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A373-A373

Author(s):

Francisco Jose Zayas ◽

Marianne Hernandez-Negron ◽

Michelle Marie Mangual Garcia

Keyword(s):

Blood Glucose ◽

Previous History ◽

Endocrine System ◽

Diabetes Type ◽

The Body ◽

C Peptide ◽

Organ Systems ◽

History Of ◽

Type 3

Abstract SARS-COV-2 has caused millions of deaths in less than one year, yet little is known about the long-term consequences survivors may suffer. The novel coronavirus uses the ACE2 receptor to infect human cells, allowing it to target organ systems with such receptors including the respiratory, cardiovascular, gastrointestinal and endocrine system. The purpose of this case report is to describe the long-term implications COVID-19 may cause in the endocrine system. A 46-year-old woman was referred to our clinic due to abrupt uncontrolled blood glucose levels ranging from 200-550mg/dL after being infected with COVID-19 for approximately 10 weeks. She has a past medical history of Diabetes Mellitus Type 2 which was diagnosed 3 years ago and was well controlled with diet. Present history reveals polyuria, polydipsia, tiredness and a decreased appetite. Laboratory values show HbA1C 12, negative islet cell antibodies/GAD antibodies, low C-peptide, high TSH, normal FT4 and positive anti-TPO antibodies/thyroglobulin antibodies. The sudden loss of blood glucose control along with low c peptide levels without evidence of autoimmunity support the diagnosis of Pancreatic Diabetes. SARS-COV-2 infection may cause Diabetes Type 3, rendering a patient dependent on insulin use for life. Covid-19 survivors, with or without a previous history of endocrinopathy, should be evaluated for possible long-term sequels of infection as the virus targets tissues throughout the body.

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Helicobacter pylori infection and positive Rome IV criteria for functional dyspepsia in Romanian medical students

Journal of Medicine and Life ◽

10.25122/jml-2021-0163 ◽

2021 ◽

Vol 14 (4) ◽

pp. 492-497

Author(s):

Alexandra Loor ◽

◽

Dan-Lucian Dumitrascu ◽

Teodora Surdea-Blaga ◽

Daniel-Corneliu Leucuta ◽

...

Keyword(s):

Helicobacter Pylori ◽

Medical Students ◽

Functional Dyspepsia ◽

Previous History ◽

The Body ◽

The Status ◽

Lifestyle Questionnaire ◽

History Of ◽

Respiratory Test ◽

Rome Iv

Recent data suggest that the prevalence of Helicobacter pylori (HP) infection in Romania has been declining in the last 30 years. However, there are no studies regarding HP prevalence among medical students. The objectives of this study were to estimate the prevalence of HP infection and assess the prevalence of dyspepsia in medical students and the relationship between dyspepsia and infection. We included 150 students from the Iuliu Hatieganu University of Medicine and Pharmacy of Cluj-Napoca, Romania (102 females and 48 males, mean age 21 years). Each student completed a lifestyle questionnaire, personal history, family history as well as the Rome IV questionnaire for functional dyspepsia. The status of HP infection was determined using the C13-urea respiratory test. The prevalence of HP infection was 25.33%, and 18% met the Rome IV criteria for functional dyspepsia. 37% of students with functional dyspepsia had a positive HP test. Of all students, 8% had a history of HP infection. Those with a history of HP infection had a 4.45% (95% CI 1.6 – 12.37) higher risk of having positive Rome IV criteria for functional dyspepsia than those with no previous history of infection (p=0.008). Thus, the present study adds to the body of evidence regarding HP prevalence among medical students, 25.33% being positive. We found no statistically significant correlation between HP infection and functional dyspepsia. Those with a history of HP infection had a higher risk of functional dyspepsia.

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Serous Cystadenoma of the Pancreas Presenting as a Third Primary Neoplasm

Canadian Journal of Gastroenterology ◽

10.1155/2003/784257 ◽

2003 ◽

Vol 17 (9) ◽

pp. 552-554 ◽

Cited By ~ 1

Author(s):

Aydın Şeref Köksal ◽

Aysel Ülker ◽

Mehmet Asıl ◽

Bilge Tunç ◽

Arda Kemal ◽

...

Keyword(s):

Computed Tomography ◽

Previous History ◽

Serous Cystadenoma ◽

The Body ◽

Pathological Examination ◽

Cystic Neoplasms ◽

Serous Cystadenomas ◽

History Of ◽

Primary Neoplasm ◽

Other Neoplasms

Serous cystadenomas are the most common cystic neoplasms of the pancreas. They may occur solely or coexist with other neoplasms. A 10 cm mass involving the body of the pancreas was observed in the computed tomography of a 61-year-old man with a previous history of bladder and prostate carcinoma. Ultrasonography and computed tomography of the mass demonstrated multiple small cysts associated with a central calcified scar. A distal pancreatectomy was performed. Pathological examination confirmed the diagnosis of serous microcystic adenoma. This is the first report of a serous cystadenoma of the pancreas with two metachronous neoplasms. This feature should be kept in mind during the diagnosis and evaluation of patients with serous cystadenoma.

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Isolated tuberculous epididymal mass mimicking testicular malignancy: an interesting case report and lessons learnt

annals of urologic oncology ◽

10.32948/auo.2021.05.21 ◽

2021 ◽

Author(s):

Tejaswini Manne ◽

Solomon Nazareth ◽

Pavithra Vittalraj ◽

Sandhya Sundaram ◽

Sriram Krishnamoorthy ◽

...

Keyword(s):

Case Report ◽

Pulmonary Tuberculosis ◽

Previous History ◽

Interesting Case ◽

Histopathological Diagnosis ◽

Recent Onset ◽

Appropriate Treatment ◽

History Of ◽

The Right ◽

High Index Of Suspicion

Tuberculous epididymal mass is a condition that presents as a painless scrotal swelling. It resembles a testicular mass and is more often diagnosed after orchidectomy. About 22% of all genitourinary tuberculosis show epididymal involvement and 22% of epididymal tuberculosis are bilateral. This report reiterates the need for an increased awareness amongst the treating urologists that would enable an earlier diagnosis, appropriate treatment and may avert the need for orchidectomy in most cases. A 35-year-old diabetic male presented with rapidly enlarging right testicle associated with recent onset of pain over the testis. He also had fever and chills. At the age of 18, he was treated for pulmonary tuberculosis. The right testicle was enlarged, irregular and mildly tender. The right epididymis was also irregular and nodular, blended with the right testicle and indistinguishable from it. A clinical diagnosis of testicular tumour was made. Tumour markers were normal and he underwent high orchidectomy. Histopathological diagnosis confirmed right epididymal tuberculosis. This case report mainly highlights the need for a high index of suspicion amongst the treating physicians. A previous history of treatment for pulmonary tuberculosis should alert the physician to think in lines of tuberculous pathology in epididymis too. A prompt diagnosis and early, appropriate treatment would largely prevent removal of testicles in most cases.

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Endoscopic Treatment of an Idiopathic Pancreaticopleural Fistula

GE Portuguese Journal of Gastroenterology ◽

10.1159/000518447 ◽

2021 ◽

pp. 1-4

Author(s):

João Correia ◽

Rolando Pinho ◽

Elsa Francisco ◽

Luísa Proença ◽

Carlos Fernandes ◽

...

Keyword(s):

Pleural Effusion ◽

Multidisciplinary Approach ◽

Pancreatic Pseudocyst ◽

Previous History ◽

The Body ◽

Surgical Approaches ◽

Fistula Closure ◽

Endoscopic Retrograde ◽

History Of ◽

Pancreatic Sphincterotomy

A 61-year-old man was diagnosed with an exudative pleural effusion with raised amylase and bilirubin levels. The patient had no previous history of acute pancreatitis or trauma and no clinical or radiological signs of chronic pancreatitis. On thoracoabdominal computed tomography, a pancreatic pseudocyst with a pancreaticopleural fistula was identified. Endoscopic retrograde cholangiopancreatography identified a ductal disruption site in the body of the pancreas. Pancreatic sphincterotomy and stent placement in the duct of Wirsung, combined with medical management, allowed fistula closure, pseudocyst reabsorption, and no relapse of the pleural effusion. The relevance of this case lies not only in its rarity but also as it highlights the importance of a multidisciplinary approach in such uncommon conditions. Optimal management of this condition is debatable due to the absence of prospective studies comparing medical, endoscopic, and surgical approaches.

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IMPROVEMENT METHODS OF DIAGNOSIS THE VISUAL ANALYSER OF PATIENTS WITH MULTIPLE SCLEROSIS

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2013-5-76-86 ◽

2013 ◽

Vol 12 (5) ◽

pp. 76-86

Author(s):

A. V. Kovalenko ◽

G. N. Bisaga ◽

E. V. Boiko ◽

I. Yu. Kovalenko

Keyword(s):

Multiple Sclerosis ◽

Clinical Stage ◽

Previous History ◽

Automated Perimetry ◽

Fiber Layer ◽

Low Contrast ◽

Neurodegenerative Process ◽

Nerve Fiber Layer Thickness ◽

History Of ◽

Multiple Sclerosis Patients

137 (274 eyes) relapsing-remitting multiple sclerosis patients have been given detailed neuroophthalmologic examination. 58 of these patients (74 eyes) had a previous history of optic neuritis. As a result, the most informative methods of examination have been identified. These include the estimation of the frequency characteristics of the vision (vizokontrastoperimetriya, low-contrast tests Sloan), standard static automated perimetry, pattern visual evoked potentials, and optical coherence tomography which is used to measure macular volumes and retinal nerve fiber layer thickness. The above – mentioned methods make it possible to reveal the involvement of the optic analyzer in the inflammatory and neurodegenerative process at the pre-clinical stage. The obtained results allow us to recommend inclusion of the methods in the standard algorithm for the examination of patients with probable multiple sclerosis.

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