scholarly journals DIAGNOSTIC CRITERIA OF COGNITIVE IMPAIRMENTS IN PATIENTS WITH MIXED DEMENTIA COMPLICATED BY HALLUCINATORY-PARANOID DISORDERS

2019 ◽  
Vol 6 (4) ◽  
pp. 248-252
Author(s):  
K. Shevchenko-Bitensky
Keyword(s):  
Diagnostic Criteria ◽  
Psychotic Disorders ◽  
Cognitive Impairments ◽  
Main Group ◽  
Control Group ◽  
Mixed Dementia ◽  
Dementia Diagnosis ◽  
Cognitive Dysfunctions ◽  
Process Thinking ◽  
Attention Process

DIAGNOSTIC CRITERIA OF COGNITIVE IMPAIRMENTS IN PATIENTS WITH MIXED DEMENTIA COMPLICATED BY HALLUCINATORY-PARANOID DISORDERS Shevchenko-Bitensky K. The study involved 72 patients with mixed dementia complicated by hallucinatory-paranoid disorders (main group) and 61 patients with mixed dementia not complicated by psychotic disorders (control group). It was established and proved that patients with mixed dementia complicated by psychotic disorders were characterized by more expressed cognitive impairments, which were manifested in impairments of praxis, gnosis, memory, skills of counting, attention process, thinking and orientation. Keywords: mixed dementia, diagnosis, hallucinatory-paranoid disorders, cognitive dysfunctions.     Анотація. ДІАГНОСТИЧНІ КРИТЕРІЇ КОГНІТИВНИХ ПОРУШЕНЬ У ПАЦІЄНТІВ З ЗМІШАНОЮ ДЕМЕНЦІЄЮ, УСКЛАДНЕННОЮ ГАЛЮЦИНАТОРНО-ПАРАНОЇДНИМИ РОЗЛАДАМИ Шевченко-Бітенський К. У дослідженні прийняло участь 72 пацієнтів зі змішаною деменцією, ускладненою галюцинаторно-параноїдними розладами (основна група) та 61 пацієнт зі змішаною деменцією, не ускладненою психотичними розладами (контрольна група). Встановлено та доведено, що пацієнти зі змішаною деменцією, ускладнених психотичними розладами, характеризувались більш вираженими когнітивними порушеннями, що проявлялось в порушеннях праксису, гнозису, пам’яті, навичок рахування, процесу уваги, мислення та орієнтації. Ключові слова: змішана деменція, діагностика, галюцинаторно-параноїдні розлади, когнітивні дисфункції   Аннотация. ДИАГНОСТИЧЕСКИЕ КРИТЕРИИ КОГНИТИВНЫХ НАРУШЕНИЙ У ПАЦИЕНТОВ СО СМЕШАННОЙ ДЕМЕНЦИЕЙ, ОСЛОЖНЕННОЙ ГАЛЛЮЦИНАТОРНО-ПАРАНОИДНЫМИ РАССТРОЙСТВАМИ Шевченко-Битенський К. В исследовании приняло участие 72 пациентов со смешанной деменцией, осложненной галлюцинаторно-параноидными расстройствами (основная группа) и 61 пациент со смешанной деменцией, не осложненной психотическими расстройствами (контрольная группа). Установлено и доказано, что пациенты со смешанной деменцией, осложненной психотическими расстройствами, характеризовались более выраженными когнитивными нарушениями, проявляющимися в нарушениях праксиса, гнозиса, памяти, навыков счета, процесса внимания, мышления и ориентации. Ключевые слова: смешанная деменция, диагностика, галлюцинаторно-параноидные расстройства, когнитивные дисфункции

scholarly journals Clinical-psychopathological structure of hallucinatory-paranoid disorders during vascular dementia of moderate degrees of severity

2019 ◽  
Vol 27 (2 (99)) ◽  
pp. 63-67
Author(s):  
Kostiantyn Shevchenko-Bitensky
Keyword(s):  
Vascular Dementia ◽  
Diagnostic Criteria ◽  
Main Group ◽  
Control Group ◽  
Stage Of Development ◽  
Keywords Dementia ◽  
Paranoid Symptoms ◽  
Degrees Of Severity

41 patients with vascular dementia in the medium stage of development with mixed cortical and subcortical dysfunction with hallucinatory-paranoid symptoms (main group) were examined. The control group consisted of 34 patients with vascular dementia in the medium stage of development without hallucinatoryparanoid disorders. The patterns of clinical and psychopathological manifestations of hallucinatory-paranoid disorders in patients with vascular dementia in the medium stage of development were established, which can be considered as diagnostic criteria for assessing the clinical and psychopathological structure of hallucinatory-paranoid disorders in this pathology. Keywords: dementia, hallucinatoryparanoid symptoms, clinical and psychopathological manifestations

scholarly journals Rehabilitation of patients with hallucinatory-paranoid disorders in mixed dementia

2019 ◽  
Author(s):  
Kostiantyn Shevchenko-Bitsensky
Keyword(s):  
Cognitive Impairment ◽  
Psychotic Disorders ◽  
Neurological Diseases ◽  
Psychosocial Rehabilitation ◽  
Cognitive Disorders ◽  
Control Group ◽  
Mixed Dementia ◽  
Psychosocial Effects ◽  
Psychopathological Disorders ◽  
Developing System

The study involved 72 patients with hallucinatory-paranoid disorders (HPD) in mixed dementia, who were included in the main group. 61 patients with mixed dementia without psychotic disorders participated in control group. The study of the clinical and psychopathological manifestations of HPD and the cha rac teris tics of cognitive impairment in mixed dementia allowed the development of the program of comprehensive personified psychosocial rehabilitation based on the principles of a comprehensive, diff erentiated and personality-oriented approach, and includes a combination of biological and psychosocial effects on all etiopathogenetic links in the development and progression of mixed dementia. The main targets in the developing system of therapy and rehabilitation were: non-cognitive psychopathological disorders, cognitive disorders, psychosocial defi ciency, concomitant somatic and neurological diseases. Effectiveness has been proven of the developed program of therapy and rehabilitation of patients with HPD in mixed dementia. Keywords: mixed dementia, hallucinatory-paranoid disorders, psychopathological manifestations, cognitive impairment, therapy, psychosocial rehabilitation

scholarly journals Social functioning of patients with hallucinator-paranoid disorders in mixed dementia of heavy direction of expression

2019 ◽  
Vol 27 (3) ◽  
pp. 61
Author(s):  
Kostiantyn Shevchenko-Bitensky
Keyword(s):  
Key Words ◽  
Social Functioning ◽  
Psychotic Disorders ◽  
Control Group ◽  
Parental Role ◽  
Mixed Dementia ◽  
Household Chores ◽  
The Social ◽  
Group A ◽  
Per Se

In the study of the features of the social functioning of patients with mixed dementia of heavy direction of expression, complicated by hallucinatoryparanoid disorders, 56 patients took part. 27 patients with mixed dementia of heavy direction of expression, which comprised the main group and 29 patients with mixed dementia without psychotic disorders entered the control group. A more pronounced eff ect on the overall level of social functioning of a cognitive defect is brought up than the eff ect of psychotic disorders per se. A pronounced negative eff ect of psychotic disorders on the functions of selfcare, communication, on the eff ectiveness and level of participation in household chores and the fulfi llment of the parental role has been established. Key words: mixed dementia, hallucinatory disorders, paranoid disorders, social functioning, heavy direction of expression

Cognitive Dysfunctions in Chronic Schizophrenia Patients in Relationship with Clinical and Functional Capacity

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
C. Tintila ◽  
I.V. Miclutia ◽  
C. Popescu ◽  
I. Barsan
Keyword(s):  
Functional Capacity ◽  
Spatial Working Memory ◽  
Psychiatric Symptoms ◽  
Cognitive Impairments ◽  
Chronic Schizophrenia ◽  
Control Group ◽  
Central Feature ◽  
List Type ◽  
Global Functioning ◽  
Cognitive Dysfunctions

Aims:The aims of the current study are:•To examine the clinical symptoms and functional capacity of the patients.•To evaluate the cognitive dysfunctions and to see how they develop in 6 month.•To examine the relationship between clinical and functional capacity and the cognitive dysfunctions of the chronic schizophrenia patients.Method:24 people with chronic schizophrenia were followed up 6 month along with a control group of 50 individuals free from schizophrenia. Patients were diagnosed using DSM-IV criteria, assessed with the PANSS, GAF, to evaluate psychiatric symptoms, respectively functionality. Rey Memory Test, Trail Making, Spatial Recognition Memory (SRM),Spatial Working Memory (SWM), Paired Associated Learning (PAL), Spatial Spam (SSP) and Stoking of Cambridge (SOC) from the CANTAB were applied to all patients at the start point of the study and after 6 month, in order to evaluate the cognitive functions.Results:The overall performance of chronic schizophrenia patients was significantly lower compared to healthy individuals on all cognitive tasks. the cognitive dysfunction is independent of age and intellectual level, but does correlate with global functioning and remain stable. CANTAB is a useful tool to detect and estimate the cognitive impairments.Conclusions:The current study reveals that cognitive impairments are a central feature of schizophrenia and a major cause of poor functioning of the patients. the chronic schizophrenia patients perform worse on all investigated cognitive domains (memory, attention and executive function). the reviewed studies show different opinions about the development of these impairments. Further longitudinal studies are required in order to settle if they remain stable or progress in time.

scholarly journals The structure of cognitive and non-cognitive impairment in patients with hallucinatory-paranoid disorders in mixed dementia

2020 ◽  
Keyword(s):  
Cognitive Impairment ◽  
Mental State ◽  
Psychotic Disorders ◽  
Rating Scale ◽  
Structured Interview ◽  
Assessment Scale ◽  
Control Group ◽  
Mixed Dementia ◽  
Sequence Of Events ◽  
Disease Rating

The aim of the study was to determine the specifics of cognitive impairment and clinic-psychopathological characteristics in patients with hallucinatory-paranoid disorders in mixed dementia. In study involved 72 patients with hallucinatory-paranoid disorders in mixed dementia (main group) and 61 patients with mixed dementia without psychotic disorders (control group). To achieve the goals and objectives of the study a comprehensive approach was used, which was implemented using the following research methods: the clinic-psychopathological method (a structured interview conducted as part of the clinical, phenomenological and psychopathological approaches in psychiatry), elementary neuropsychological studies of the main cognitive functions of patients (compilation of pictures, understanding of stories and plot pictures, establishing a sequence of events, classification, elimination of excess, highlight significant features, search for analogies, definition and comparison of concepts, formation of artificial concepts, selection antonyms words), held in a structured interview; Mini-Mental State Examination (MMSE) short mental state assessment scale; Montreal Cognitive Assessment Scale (MoCa); Behavioral Disorders Scale (BEHAVE-AD) and non-cognitive sections of the Alzheimer's Disease Rating Scale (ADAS-Non Cog). As a result of the study, features of cognitive impairment in mixed dementia with hallucinatory-paranoid disorders, which included: decreased concentration, impaired praxis, gnosis, delayed reproduction, counting skills, thinking (motivational, operational components of thinking and criticality) and orientation in one's own personality. The psychopathological features of hallucinatory-paranoid disorders in the structure of mixed dementia were determined, which included: delusions about dishonesty of others, hallucinations, disorders of the depressive spectrum, vagrancy, aimless activity (cognitive bulimia), inappropriate behavior, circadian rhythm disturbance, fear of being left alone. The distinguished features must be taken into account in the process of diagnosis and treatment of patients with hallucinatory-paranoid disorders in mixed dementia.

Suicidal behavior in patients with dementia

2020 ◽  
pp. 4-12
Author(s):  
Nataliya Maruta ◽  
Iryna Mudrenko ◽  
Galyna Kalenska ◽  
Mykhailo Denysenko
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Suicidal Behavior ◽  
High Efficiency ◽  
Main Group ◽  
Control Group ◽  
Formation Mechanisms ◽  
Mixed Dementia ◽  
Complex Approach

203 patients were examined, including 75 with dementia at Alzheimer’s disease (AD), 73 with vascular dementia (VD) and 60 patients with mixed dementia (MD). Patients were divided into main and control group by the factor of presence/absence of signs of suicidal behavior (intentions, attempts, thoughts, anti-vital mood, statements). Among patients with AD, 36 patients were the main group, 39 were the control group; at VD 39 patients were main group, 34 were control group; in mixed dementia, 30 patients were included in the main group, 30 patients were in the control group. It has been found that in 56 % of cases with dementia due to Alzheimer’s disease, in 65 % with vascular dementia and 56 % with mixed dementia of the clinical picture, suicidal behavior (SB) is observed. The complex of factors of SB risk/anti- risk and suicide-genesis mechanisms in dementia, that became the targets for development of differentiated program for medical and psychological rehabilitation and prevention (MPRP) patients with SB in dementia were distinguished. The suicide-genesis concept in dementia which determines the mechanisms of the formation of suicidal behavior under the influence of clinical and intra-personal indexes, was worked out. Accounting the formation mechanisms and SB predictors, special features of clinical and psychopathological, clinical and phenomenological SB demonstration in various types of dementia the complex and differentiated MPRP program and SB prevention, realized on the basis of complex approach including usage of psychopharmacological, psychotherapeutic, psychoeducational psychosocial actions was worked out and tested. The result of the developed system testing proved its high efficiency, which is supported by the positive dynamics of clinical and psychopathological indexes of suicide status and level of independence in the everyday life of patients with SB in dementia.

scholarly journals The structure of cognitive and non-cognitive impairment in patients with hallucinatory-paranoid disorders in vascular dementia

2020 ◽  
pp. 75-78
Author(s):  
Kostiantyn Shevchenko-Bitensky
Keyword(s):  
Cognitive Impairment ◽  
Vascular Dementia ◽  
Psychotic Disorders ◽  
Verbal Aggression ◽  
Control Group ◽  
Material Damage ◽  
Dementia Diagnosis ◽  
Persecutory Delusions ◽  
Severe Anxiety ◽  
Key Words Vascular Dementia

The study involved 75 patients with hallucinatory-paranoid disorders in the structure of vascular dementia (main group) and 63 patients with vascular dementia not complicated by psychotic disorders (control group). As a result of the study, the cognitive features of hallucinatory-paranoid disorders in vascular dementia were identified, which include: operating (DC = –1,55), motivational (DC = –2.32) and dynamic (DC = –1.19) disorders components of thinking and its criticality (DK = –2,06), decrease in stability of attention (DK = –1,93) and memory (DK = –1,27), violation of praxis (DK = –1,46), gnosis (DK = –1.42), costing (DK = –1.08), and orientation (DK = –1.50). Psychopathological features of hallucinatory-paranoid disorders in the structure of vascular dementia were identified, which included: persecutory delusions of material damage, robbery, robbery (p < 0.05), hallucinations (p < 0.0001), verbal aggression (DK = 3.04), severe anxiety (DC = 1.67), rhythm disorders day / night (DC = 2.25), decreased mood (mainly in the form of dysphoria) (DC = 1.42), disorders of the depressive spectrum (p < 0.05); marked distraction (DC = 1.54). The findings should be considered in the diagnosis, treatment and rehabilitation of patients with hallucinatory-paranoid disorders in the structure of vascular dementia. Key words: vascular dementia, diagnosis, hallucinatory-paranoid disorders, cognitive dysfunction, psychopathological features

scholarly journals The role of neurotrophic proteins as prognostic markers of neurological, functional and cognitive impairments in the acute period of cerebral infarction in patients with sleep apnea

2021 ◽  
Vol 24 (3) ◽  
pp. 14-21
Author(s):  
Ekaterina V. Serebrova ◽  
Natalia N. Usova
Keyword(s):  
Sleep Apnea ◽  
Cerebral Infarction ◽  
Functional Outcome ◽  
Neurological Deficit ◽  
Prognostic Markers ◽  
Comparison Group ◽  
Cognitive Impairments ◽  
Main Group ◽  
Control Group ◽  
Acute Period

The objective: to evaluate the diagnostic efficacy of neurotrophic proteins BDNF, NGF, NT3 as prognostic markers of neurological, functional and cognitive impairments in the acute period of cerebral infarction in patients with and without sleep apnea. Materials and methods. 52 patients were examined in the first 72 hours from the onset of cerebral infarction (CI). The survey included an assessment on the NIHSS, mRs and MOSA scales (in the first 72 hours and after a month); study of the concentration of proteins BDNF, NGF, NT3 in plasma by enzyme immunoassay and respiratory polygraphy. The patients were divided into the main group (32 patients with sleep apnea (SA)) and the comparison group (20 patients without SA). The control group consisted of 32 patients without CI and SA. Results. In patients of main group at the end of the acute period of CI threshold concentrations of BDNF ≤1605.2 pg/ml (AUC - 80%), NGF ≤697.37 pg/ml (AUC - 78%) and NT3 ≤400.7 pg/ml (AUC - 70%) were established as effective prognostic markers of an unfavorable functional outcome (MRs≥3); BDNF ≤1994.8 pg/ml (AUC - 75%) - of severe neurological deficit (NIHSS> 4); BDNF ≤1724.7 pg/ml (AUC - 76%) and NGF ≤858.55 pg/ml (AUC - 73%) - of the presence of cognitive impairments (MOCA <26). In patients of the comparison group the threshold concentration of BDNF protein ≤1189.6 pg/ml was established as an effective prognostic marker of unfavorable functional outcome (AUC - 85%) and severe neurological deficit (AUC - 80%). Conclusion. Neurotrophic proteins have good indicators of diagnostic accuracy as prognostic markers of neurological, functional, and cognitive impairments at the end of the acute period of CI in patients with and without SA.

Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

2020 ◽  
pp. 97-105
Author(s):  
E. N. Simakova ◽  
O. V. Stenkova
Keyword(s):  
Intraocular Pressure ◽  
Drug Therapy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Open Angle ◽  
Complex Treatment ◽  
Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

Experience of using time-lapse microscopy in IVF and ICSI programs

2020 ◽  
pp. 47-50
Author(s):  
N. V. Saraeva ◽  
N. V. Spiridonova ◽  
M. T. Tugushev ◽  
O. V. Shurygina ◽  
A. I. Sinitsyna
Keyword(s):  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Selection Procedure ◽  
Time Lapse ◽  
Single Embryo Transfer ◽  
Main Group ◽  
Clinical Pregnancy ◽  
Control Group ◽  
Time Lapse Microscopy

In order to increase the pregnancy rate in the assisted reproductive technology, the selection of one embryo with the highest implantation potential it is very important. Time-lapse microscopy (TLM) is a tool for selecting quality embryos for transfer. This study aimed to assess the benefits of single-embryo transfer of autologous oocytes performed on day 5 of embryo incubation in a TLM-equipped system in IVF and ICSI programs. Single-embryo transfer following incubation in a TLM-equipped incubator was performed in 282 patients, who formed the main group; the control group consisted of 461 patients undergoing single-embryo transfer following a traditional culture and embryo selection procedure. We assessed the quality of transferred embryos, the rates of clinical pregnancy and delivery. The groups did not differ in the ratio of IVF and ICSI cycles, average age, and infertility factor. The proportion of excellent quality embryos for transfer was 77.0% in the main group and 65.1% in the control group (p = 0.001). In the subgroup with receiving eight and less oocytes we noted the tendency of receiving more quality embryos in the main group (р = 0.052). In the subgroup of nine and more oocytes the quality of the transferred embryos did not differ between two groups. The clinical pregnancy rate was 60.2% in the main group and 52.9% in the control group (p = 0.057). The delivery rate was 45.0% in the main group and 39.9% in the control group (p > 0.050).

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