scholarly journals Effect of diterpene alkaloids on lipid peroxidation in mitochondria

2021 ◽  
Vol 20 (2) ◽  
pp. e850
Author(s):  
Dilnoza Kh. Muratova ◽  
Nurali A. Ergashev ◽  
Jobir J. Sobirov ◽  
Utkir Kh. Kurbanov ◽  
Muzaffar I. Asrarov
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Protective Effect ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Diterpenoid Alkaloids ◽  
Secondary Products ◽  
Diterpene Alkaloids

In this article, the antioxidant activity of some alkaloids lipid peroxidation (LPO) in rat liver mitochondria has been studied. It has been established that diterpenoid alkaloids: 1-О-benzoylnapelline, napelline and songorine have a protective effect on mitochondria, reducing the damaging effect of Fe2+/ascorbate and the release of malondialdehyde (MDA) into the secondary products of peroxidation. The effect of alkaloids napelline, 1-O-benzoylnapelline and songorine on the processes of MDA formation in rat liver mitochondria in vitro has been studied.Where in at 200 мM concentrations, 1-О-benzoylnapelline inhibited the formation of MDA by 95 %, and the alkaloids napelline and songorine at this concentration inhibited the formation of MDA by 54 and 44 %. From the data obtained, it can be shown that 1-О-benzoylnapelline strongly inhibits the formation of MDA compared to songorine and napelline.

Antioxidant activity of Peumus boldus extract and alkaloid boldine against damage induced by Fe(II)–citrate in rat liver mitochondria in vitro

2014 ◽  
Vol 54 ◽  
pp. 240-247 ◽  
Author(s):  
Cláudia Vargas Klimaczewski ◽  
Rogério de Aquino Saraiva ◽  
Daniel Henrique Roos ◽  
Aline Boligon ◽  
Margareth Linde Athayde ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria

IN VITRO LIPID PEROXIDATION INHIBITORY AND ANTI-ARTHRITIC ACTIVITIES OF SOME INDIAN MEDICINAL PLANTS

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (06) ◽  
pp. 31-35
Author(s):  
A. A Rege ◽  
◽  
P. R. Juvekar ◽  
A. R. Juvekar
Keyword(s):  
Lipid Peroxidation ◽  
Liver Mitochondria ◽  
Tinospora Cordifolia ◽  
Ocimum Sanctum ◽  
Rat Liver Mitochondria ◽  
Total Phenolic ◽  
Lipid Peroxidation Inhibitory Activity ◽  
Gallic Acid Equivalent ◽  
Indian Medicinal Plants

Anti-lipid peroxidation effect of aqueous extracts of Ocimum sanctum, Tinospora cordifolia and Withania somnifera was evaluated against Fe2+-ascorbic acid-induced lipid peroxidation using rat liver mitochondria as model system, whereas, anti-arthritic activity was evaluated by proteinase inhibitory assay. O. sanctum showed potent anti-lipid peroxidation and anti-arthritic activities. T. cordifolia exhibited moderate anti-lipid peroxidation activity, but considerable anti-arthritic activity, whereas, W. somnifera revealed least lipid peroxidation inhibitory activity and considerable anti-arthritic activity. Besides, Folin-Ciocalteu reagent in terms of gallic acid equivalent achieved the total phenolic content and the trend was found to be O. sanctum > T. cordifolia > W. somnifera.

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