scholarly journals Prediction of the Survival Outcomes of Patients with Non-Small Cell Cancer Using 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Clinicopathological Factors

2021 ◽  
pp. 548-593
Author(s):  
Elena Locci ◽  
Silvia Raymond

Despite an overall decrease in the incidence of lung cancer, the incidence of the disease is increasing among young people. According to research, this upward trend is due to reduced consumption of vitamin D in foods such as fish, mushrooms, eggs and milk. There is growing evidence of a link between vitamin D and the risk of death from lung cancer, but there is little research on whether vitamin D intake is associated with a risk of lung cancer (before age 50). Because vitamin D deficiency has been on the rise over the past few years, we looked at whether it could increase the risk of lung cancer in young people. The results of this study show that taking 300 units of vitamin D a day or more, roughly equivalent to three glasses of milk, reduces the risk of lung cancer by about 50%. Previous studies have shown that taking more vitamin D is associated with a reduced risk of developing precancerous lung polyps before the age of 50. The findings are based on data from more than 94,000 women, part of a long-running study that began in 1989. They were 25 to 42 years old at the start of the study. It should be noted that the researchers did not find a significant association between vitamin D intake and the risk of lung cancer after age 50. Researchers say more research is needed to determine whether vitamin D actually provides more protection against lung cancer in young people. The researchers say the findings could lead to recommendations for getting more vitamin D as a low-cost supplement for screening tests to prevent lung cancer in adults under 50. Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening; Treatment; Management

2021 ◽  
Author(s):  
Mingxia Qian ◽  
Dina Guo ◽  
Rongrong Fu ◽  
Shuping Qi ◽  
Xiaojun Fu ◽  
...  

Abstract Background: The correlation between vitamin D intake and lung cancer development is controversial. This meta-analysis aims to evaluate the relationship between vitamin D and the prognosis and incidence of lung cancer. Methods: A comprehensive database search on Pubmed, Web of Science, EBSCO, and Cochrane Library was carried out from the beginning to November 2020. Long-term survival and the incidence rate of patients with lung cancer were the primary outcomes of the study. Results: Ten eligible studies were selected for the meta-analysis following specific inclusion and exclusion criteria. Four included studies, covering 5007 patients, compared the overall survival (OS) and relapse-free survival (RFS) of lung cancer patients among total vitamin D users with non-users. Significantly, the estimated pooled hazard ratio (HR) revealed that vitamin D could improve OS and RFS of lung cancer patients [HR=0.83, 95% CI (0.72-0.95); HR=0.79, 95% CI (0.61-0.97), respectively]. Vitamin D intake was inversely associated with lung cancer incidence in six studies [OR=0.90, 95% CI (0.83-0.97)]. Conclusions: The present meta-analysis shows vitamin D not only improves the long-term survival of lung cancer patients but has a beneficial effect on the incidence of lung cancer. Notwithstanding, more studies are needed to confirm the study results.


2013 ◽  
Author(s):  
Ting-Yuan David Cheng ◽  
Andrea Z. LaCroix ◽  
Shirley A.A. Beresford ◽  
Gary E. Goodman ◽  
Mark D. Thornquist ◽  
...  

2013 ◽  
Vol 98 (4) ◽  
pp. 1002-1011 ◽  
Author(s):  
Ting-Yuan David Cheng ◽  
Andrea Z LaCroix ◽  
Shirley AA Beresford ◽  
Gary E Goodman ◽  
Mark D Thornquist ◽  
...  

2007 ◽  
Vol 25 (5) ◽  
pp. 479-485 ◽  
Author(s):  
Wei Zhou ◽  
Rebecca S. Heist ◽  
Geoffrey Liu ◽  
Kofi Asomaning ◽  
Donna S. Neuberg ◽  
...  

PurposeOur previous analyses suggested that surgery in the summertime with higher vitamin D intake is associated with improved survival in patients with early-stage non–small-cell lung cancer (NSCLC). We further investigated the results of circulating 25-hydroxyvitamin D (25[OH]D) levels on overall survival (OS) and recurrence-free survival (RFS) in NSCLC patients.Patients and MethodsAmong 447 patients with early-stage NSCLC, data were analyzed using Cox proportional hazards models, adjusting for age, sex, stage, smoking, and treatment.ResultsThe median follow-up time was 72 months (range, 0.2 to 141), with 161 recurrences and 234 deaths. For OS, the adjusted hazard ratio (AHR) was 0.74 (95% CI, 0.50 to 1.10; Ptrend= .07) for the highest versus lowest quartile of 25(OH)D levels. Stratified by stage, a strong association was observed among stage IB-IIB patients (AHR, 0.45; 95% CI, 0.24 to 0.82; Ptrend= .002), but not among stage IA patients (AHR, 1.10; 95% CI, 0.62 to 1.96; Ptrend= .53). Similar effects of 25(OH)D levels were observed among the 309 patients with dietary information (AHR, 0.74; 95% CI, 0.46 to 1.17; Ptrend= .19). For the joint effects of 25(OH)D level and vitamin D intake, the combined high 25(OH)D levels and high vitamin D intake (by median) were associated with better survival than the combined low 25(OH)D levels and low vitamin D intake (AHR, 0.64; 95% CI, 0.42 to 0.98; Ptrend= .06). Again, stronger associations were observed among stage IB-IIB than IA patients. Similar effects of 25(OH)D levels and vitamin D intake were observed for RFS.ConclusionVitamin D may be associated with improved survival of patients with early-stage NSCLC, particularly among stage IB-IIB patients.


2021 ◽  
Vol 67 (5) ◽  
pp. 273-282
Author(s):  
Mingxia QIAN ◽  
Jun LIN ◽  
Rongrong FU ◽  
Shuping QI ◽  
Xiaojun FU ◽  
...  

Medicine ◽  
2018 ◽  
Vol 97 (37) ◽  
pp. e12282 ◽  
Author(s):  
Hu Wei ◽  
Hu Jing ◽  
Qian Wei ◽  
Guo Wei ◽  
Zhou Heng

2015 ◽  
Vol 36 (1) ◽  
pp. 299-305 ◽  
Author(s):  
Liqun Zhang ◽  
Sihai Wang ◽  
Xiaoyu Che ◽  
Xuehui Li

Background/Aim: Vitamin D has been suggested to have important roles against cancer development. There were several published studies on the association between vitamin D and lung cancer risk, but not conclusive results were available. Methods: To clarify the role of vitamin D in lung carcinogenesis, we performed a comprehensive review of the literature and a meta-analysis to evaluate the association of serum vitamin D levels and dietary vitamin D intake with lung cancer risk. Twelve studies (9 prospective cohort and 3 nested case-control studies) with a total of 288,778 individuals were included. The summary relative risk (RR) with 95% confidence interval (CI) was used to assess lung cancer risk. Results: Meta-analysis of total 12 studies showed that RR for the association of high vitamin D status with lung cancer was 0.84 (95%CI 0.78-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of serum vitamin D levels was 0.83 (95%CI 0.77-0.90, P < 0.001). The RR of lung cancer for the highest versus lowest quintile of vitamin D intake was 0.89 (95%CI 0.74-1.06, P = 0.184). Conclusion: Current data suggest an inverse association between serum vitamin D and lung cancer risk. Further studies are needed to investigate the effect of vitamin D intake on lung cancer risk and to evaluate whether vitamin D supplementation can prevent lung cancer.


2017 ◽  
Vol 2 (1) ◽  
pp. 14-19
Author(s):  
Oscar Rosero Olarte

La vitamina D es un determinante importante de la salud ósea y de la función neuromuscular. Recientemente se ha catalogado el déficit de vitamina D como un problema epidémico de proporción mundial.Evidencia reciente sugiere que el aporte de vitamina D en dosis suficiente disminuye el riesgo de fracturas, así como el riesgo de presentar caídas en pacientes ancianos.Mantener un nivel adecuado de vitamina D es una práctica simple y poco costosa que contribuye a disminuir las consecuencias que su déficit representa para la salud ósea. Abstract Vitamin D is an important determinant of bone health and neuromuscular function. Vitamin D deficiency is now recognized as a worldwide epidemic. Recent evidence suggests that vitamin D intake in a sufficient dose decreases the risk of fractures and falls among elderly patients. It takes a simple and low-cost practice to maintain vitamin D at suitable levels, thus contributing to decrease the consequences that its deficit entails for bone health.


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