scholarly journals A new generation of probiotics — psychobiotics, their purpose and functions

2022 ◽  
Vol 66 (9-10) ◽  
pp. 64-78
Author(s):  
S. D. Dbar ◽  
L. G. Stoyanova
Keyword(s):  
Quality Of Life ◽  
Nervous System ◽  
Developmental Disorders ◽  
Depressive Disorders ◽  
Review Of The Literature ◽  
New Class ◽  
Promising Strategy ◽  
New Generation

A review of the literature on the etiological role of the microbiome in the treatment of depressive disorders is presented based on an analysis of 98 literature sources for 2000–2020, of which 35 are domestic and 63 are foreign. Evidence is substantiated that the gut microbiome may represent a new potential target of antidepressant therapy. The emergence of a new class of probiotics (psychobiotics), as well as possible psychobiotic treatments, could be a promising strategy for improving the quality of life of people suffering from neurodegenerative diseases and developmental disorders of the nervous system.

scholarly journals Quality of Life in Carotid Atherosclerosis: The Role of Co-morbid Mood Disorders

2016 ◽  
Vol 12 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Maria Lecca ◽  
Luca Saba ◽  
Roberto Sanfilippo ◽  
Elisa Pintus ◽  
Michela Cadoni ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Mood Disorders ◽  
Carotid Atherosclerosis ◽  
Short Form ◽  
The Central Nervous System ◽  
Dsm Iv

Introduction/Objective: To study in severe carotid atherosclerosis (CA): the frequency of mood disorders (MD); the impairment of quality of life (QoL); the role of co-morbid MD in such impairment. Methods: Case-control study. Cases: consecutive in-patients with CA (stenosis ≥ 50%). Controls: subjects with no diagnosis of CA randomized from a database of a community survey. Psychiatric diagnosis according to DSM-IV made by clinicians and semi-structured interview, QoL measured by the Short Form Health Survey (SF-12). Results: This is the first study on comorbidity on CA disease and MD in which psychiatric diagnoses are conducted by clinicians according to DSM-IV diagnostic criteria. Major Depressive Disorder (MDD) (17.4% vs 2.72%, P <0.0001) but not Bipolar Disorders (BD) (4.3% vs 0.5%, P = 0.99) was higher in cases (N=46) than in controls (N= 184). SF-12 scores in cases were lower than in controls (30.56±8.12 vs 36.81±6:40; p <0.001) with QoL comparable to serious chronic diseases of the central nervous system. The burden of a concomitant MDD or BD amplifies QoL impairment. Conclusion: Comorbid MD aggravates the impairment of QoL in CA. Unlike autoimmune diseases or degenerative diseases of the Central Nervous System, CA shows a strong risk of MDD than BD.

scholarly journals A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets

2018 ◽  
Author(s):  
Saif Shahriar Rahman Nirzhor ◽  
Rubayat Islam Khan ◽  
Sharmind Neelotpol
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Glial Cells ◽  
Therapeutic Targets ◽  
Concentration Of Ions ◽  
The Central Nervous System

The pathogenesis of Alzheimer&rsquo;s disease (AD) is very complicated and not well-understood. As more and more studies are performed with regards to this disease, new insights are coming to light. Much of the research in AD so far has been very neuron-oriented however, recent studies suggest that certain glial cells i.e. microglia, astrocytes, oligodendrocytes, and NG2 glia are linked to the pathogenesis of AD and may offer several potential therapeutic targets in the long-standing battle against AD. Glial cells are responsible for maintaining homeostasis (i.e. concentration of ions and neurotransmitters) within the neuronal environment of the central nervous system (CNS) and are crucial to the integrity of neurons. This review explores the (1) role of glial cells in AD pathogenesis, (2) complex functionalities of the components involved and (3) potential therapeutic targets that it could eventuate leading to a better quality of life for AD patients.

scholarly journals Untreated Depressive Symptoms Significantly Worsen Quality of Life of the Elderly and may Lead to the Misdiagnosis of Dementia: A Cross-Sectional Study

2020 ◽  
Author(s):  
Viktor Voros ◽  
Sandor Fekete ◽  
Tamas Tenyi ◽  
Zoltan Rihmer ◽  
Ilona Szili ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Depressive Disorders ◽  
Early Recognition ◽  
The Elderly ◽  
Screening Tools ◽  
Adequate Treatment

Abstract Background: Several studies demonstrated the role of depressive mood and cognitive impairment in the background of elevated mortality and decreased Quality of Life (QoL) of the elderly.Methods: In the framework of the ICT4Life project self-administered questionnaires and clinical screening tools were used to assess QoL, depressive symptoms and cognitive functions of 60 elderly over the age of 65.Results: Males found to be depressed and cognitively declined more frequently; and had higher scores on the depression and lower on the QoL scales. Depressed elderly had lower cognitive levels and their QoL was significantly poorer than that of the non-depressed subjects. Depressive disorders were detected in a quarter of the elderly, and the majority of them did not receive adequate antidepressant medication.Conclusions: Close correlation between depression and cognitive impairment was confirmed, as well as the key role of depression in the background of QoL decline. Results also highlighted the problems of recognition and adequate treatment of depression and cognitive decline in elderly, which can be further complicated by the common symptoms of depressive pseudo-dementia. Early recognition of depressive symptoms is important not only to treat the underlying mood disorder, but also to improve QoL of the elderly.

DEPRESSIVE DISORDERS AMONG STUDENTS OF MEDICAL HIGHER EDUCATIONAL INSTITUTIONS

2021 ◽  
Author(s):  
O. L. Moskalenko ◽  
E. V. Derevyannykh ◽  
N. A. Balashova ◽  
R. A. Yaskevich
Keyword(s):  
Quality Of Life ◽  
High Frequency ◽  
Depressive Disorders ◽  
Current Problem ◽  
Negative Impact ◽  
Educational Institutions ◽  
Review Of The Literature ◽  
Higher Educational Institutions ◽  
Higher Educational

The article presents a review of the literature on the current problem of medicine-depressive disorders among medical students. The need to study the problem of depressive disorders among students of medical higher educational institutions is due to their high frequency and negative impact on the quality of life of students.

THE STRUCTURE OF THE PSYCHOLOGICAL DEFENSE MECHANISMS OF PATIENTS WITH SHALLOW PROTRACTED DEPRESSIVE DISORDERS WHO HAVE LOST SOCIAL CONNECTIONS

2020 ◽  
Vol 93 (1) ◽  
pp. 42-45
Author(s):  
Charos Kuchimova ◽  
◽  
N. Xodjaeva
Keyword(s):  
Quality Of Life ◽  
Mental Illness ◽  
Social Functioning ◽  
Defense Mechanisms ◽  
Depressive Disorders ◽  
Social Connections ◽  
Not Given ◽  
Psychological Defense ◽  
New Generation

In recent years, so-called social pathomorphism of mental illness. These factors reduce the quality of life and the level of social functioning of mental patients. A new generation of patients who have lost social connections is being formed. This concept is used quite often in modern psychiatry, but its definition is not given.

Physical Activity in Prevention of Risk and Disability in Some Neurological Diseases

2014 ◽  
Vol 22 (1) ◽  
pp. 21-27
Author(s):  
Józef Opara
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Multiple Sclerosis ◽  
Physical Disability ◽  
Neurological Diseases ◽  
Review Of The Literature ◽  
Disability Progression ◽  
Multiple Sclerosis Patients

Abstract The question of the role of physical activity in preventing disability in neurological diseases is the issue which is not in doubt. There is well known that physical activity in Parkinson`s disease and in Multiple Sclerosis patients is less than is the case in the general population. Numerous scientific studies have confirmed the low physical activity of people with PD and MS. Improving physical activity delays the progress of physical disability and has the effect on increasing the quality of life in those two diseases. In this paper an descriptive review of the literature devoted to the effect of physical activity on risk of PD and its impact on disability progression in PD and MS has been presented. The different recommendations for physical activity and different methods of assessment have been described.

ANXIETY-DEPRESSIVE DISORDERS IN PATIENTS WITH ARTERIAL HYPERTENSION

2021 ◽  
Author(s):  
OLGA MOSKALENKO ◽  
ROMAN YASKEVICH
Keyword(s):  
Quality Of Life ◽  
Depressive Disorders ◽  
Negative Impact ◽  
Modern Medicine ◽  
Economic Consequences ◽  
Social Adaptation ◽  
Review Of The Literature ◽  
Working Age ◽  
Depressive States

Our article presents a review of the literature and considers the most pressing problem of modern medicine - a combination of anxiety-depressive states in patients with cardiovascular diseases, which are more common in people of working age, having a negative impact on the quality of life of patients, contributing to the deterioration of physical, mental and social adaptation, which further leads to negative socio-economic consequences.

scholarly journals New opportunities for treatment of severe bronchial asthma: from clinical studies to portraits of patients

2015 ◽  
Vol 12 (3) ◽  
pp. 51-61
Author(s):  
N M Nenasheva
Keyword(s):  
Quality Of Life ◽  
Severe Asthma ◽  
Bronchial Asthma ◽  
Significant Proportion ◽  
Poor Quality ◽  
New Class ◽  
Definition Of ◽  
First Time

The proportion of patients with controlled asthma has increased over the last 15 years, however, still there is a significant proportion of patients who do not achieve control of the disease, and therefore have a high risk of exacerbations, hospitalizations, and poor quality of life. Patients with severe asthma, for which there were limited additional pharmacotherapy are the major problem. For the first time in recent years in the treatment of asthma a new class of drugs appeared: longacting anticholinergics - tiotropium which had been entered in stepwise therapy of asthma by GINA 2015. The definition of severe asthma, the role of the cholinergic nervous system in bronchial asthma, mechanism of action and clinical efficacy of tiotropium in severe bronchial asthma adults are described in the article.

Psychological and Cognitive Aspects of Borderline Intellectual Functioning

2017 ◽  
Vol 22 (3) ◽  
pp. 159-166 ◽  
Author(s):  
Bastianina Contena ◽  
Stefano Taddei
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Intellectual Functioning ◽  
Clinical Impact ◽  
Review Of The Literature ◽  
Borderline Intellectual Functioning ◽  
General Quality ◽  
Meta Analyses ◽  
Over Time

Abstract. Borderline Intellectual Functioning (BIF) refers to a global IQ ranging from 71 to 84, and it represents a condition of clinical attention for its association with other disorders and its influence on the outcomes of treatments and, in general, quality of life and adaptation. Furthermore, its definition has changed over time causing a relevant clinical impact. For this reason, a systematic review of the literature on this topic can promote an understanding of what has been studied, and can differentiate what is currently attributable to BIF from that which cannot be associated with this kind of intellectual functioning. Using Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) criteria, we have conducted a review of the literature about BIF. The results suggest that this condition is still associated with mental retardation, and only a few studies have focused specifically on this condition.

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