Seroprevalence of Toxoplasma gondii in cats in mainland China 2016–2020: a meta-analysis

Toxoplasma gondii transmitted from blood donors to receiving patients has become a concern as numerous articles about the epidemiology of T. gondii infection in blood donors from different provinces have been published in China. This study aimed to evaluate the seroprevalence of T. gondii infection in Chinese blood donors using a meta-analysis. A total of 40 eligible studies, published from 1986 to 2017 and covering 18 provinces and municipalities were included. Among a total of 49,784 Chinese blood donors, the overall IgG seroprevalence of T. gondii infection was 6.26% (95% CI: 4.62%–8.13%). The highest prevalence was in the Northeast of China and the lowest in Central China. The infection rate increased slowly over the years, but not significantly. A statistically significant correlation was found between the seroprevalence of T. gondii infection and the detection method and educational level (p < 0.01). There was no relationship between age, gender, occupation and blood type and seroprevalence of T. gondii (p > 0.05). The prevalence of antibodies to T. gondii in Chinese blood donors was lower than in other countries, but the risk of transfusion-transmitted toxoplasmosis still exits. More concise methods are still needed to evaluate the possibility of transfusion-transmitted toxoplasmosis from blood donors.

Download Full-text

Prevalence of Toxoplasma gondii in pet dogs in mainland China: A meta-analysis

Veterinary Parasitology ◽

10.1016/j.vetpar.2016.10.009 ◽

2016 ◽

Vol 229 ◽

pp. 126-130 ◽

Cited By ~ 9

Author(s):

Yu-Meng Gao ◽

Huan Ding ◽

Poppy H.L. Lamberton ◽

Da-Bing Lu

Keyword(s):

Toxoplasma Gondii ◽

Meta Analysis ◽

Mainland China ◽

Pet Dogs

Download Full-text

Seroprevalence of Toxoplasma gondii in cats in mainland China 2016–2020: a meta-analysis

Journal of Veterinary Science ◽

10.4142/jvs.2021.22.e83 ◽

2021 ◽

Vol 22 ◽

Author(s):

Siyu Zhou ◽

Ziyin Sang ◽

Lijun Wang ◽

Tangjie Zhang

Keyword(s):

Toxoplasma Gondii ◽

Meta Analysis ◽

Mainland China

Download Full-text

A systematic review and meta-analysis of the seroprevalence of Toxoplasma gondii in cats in mainland China

Parasites & Vectors ◽

10.1186/s13071-017-1970-6 ◽

2017 ◽

Vol 10 (1) ◽

Cited By ~ 27

Author(s):

Huan Ding ◽

Yu-Meng Gao ◽

Yao Deng ◽

Poppy H. L. Lamberton ◽

Da-Bing Lu

Keyword(s):

Systematic Review ◽

Toxoplasma Gondii ◽

Meta Analysis ◽

Mainland China

Download Full-text

The prevalence of sleep problems among children in mainland China: a meta-analysis and systemic-analysis

Sleep Medicine ◽

10.1016/j.sleep.2021.04.014 ◽

2021 ◽

Author(s):

Xianrui Chen ◽

Zhong ling Ke ◽

Yanhui Chen ◽

Xiaoxia Lin

Keyword(s):

Sleep Problems ◽

Meta Analysis ◽

Mainland China ◽

Systemic Analysis

Download Full-text

Influenza-associated disease burden in mainland China: a systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-021-82161-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jing Li ◽

Yinzi Chen ◽

Xiling Wang ◽

Hongjie Yu

Keyword(s):

Systematic Review ◽

Publication Bias ◽

Fixed Effects ◽

Disease Burden ◽

Outpatient Visit ◽

Meta Analysis ◽

Age Groups ◽

Mainland China ◽

Mortality And Morbidity ◽

All Cause Mortality

AbstractInfluenza causes substantial morbidity and mortality. Many original studies have been carried out to estimate disease burden of influenza in mainland China, while the full disease burden has not yet been systematically reviewed. We did a systematic review and meta-analysis to assess the burden of influenza-associated mortality, hospitalization, and outpatient visit in mainland China. We searched 3 English and 4 Chinese databases with studies published from 2005 to 2019. Studies reporting population-based rates of mortality, hospitalization, or outpatient visit attributed to seasonal influenza were included in the analysis. Fixed-effects or random-effects model was used to calculate pooled estimates of influenza-associated mortality depending on the degree of heterogeneity. Meta-regression was applied to explore the sources of heterogeneity. Publication bias was assessed by funnel plots and Egger’s test. We identified 30 studies eligible for inclusion with 17, 8, 5 studies reporting mortality, hospitalization, and outpatient visit associated with influenza, respectively. The pooled influenza-associated all-cause mortality rates were 14.33 and 122.79 per 100,000 persons for all ages and ≥ 65 years age groups, respectively. Studies were highly heterogeneous in aspects of age group, cause of death, statistical model, geographic location, and study period, and these factors could explain 60.14% of the heterogeneity in influenza-associated mortality. No significant publication bias existed in estimates of influenza-associated all-cause mortality. Children aged < 5 years were observed with the highest rates of influenza-associated hospitalizations and ILI outpatient visits. People aged ≥ 65 years and < 5 years contribute mostly to mortality and morbidity burden due to influenza, which calls for targeted vaccination policy for older adults and younger children in mainland China.

Download Full-text

Toxoplasma gondii infection in domestic and wild felids as public health concerns: a systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-021-89031-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Kareem Hatam-Nahavandi ◽

Rafael Calero-Bernal ◽

Mohammad Taghi Rahimi ◽

Abdol Sattar Pagheh ◽

Mehdi Zarean ◽

...

Keyword(s):

Public Health ◽

Toxoplasma Gondii ◽

Meta Analysis ◽

Domestic Cats ◽

Potential Threat ◽

Pooled Prevalence ◽

Wild Felids ◽

Global Status ◽

The One ◽

Toxoplasma Gondii Infection

AbstractFelidae as definitive hosts for Toxoplasma gondii play a major role in transmission to all warm-blooded animals trough oocysts dissemination. Therefore the current comprehensive study was performed to determine the global status of T. gondii infection in domestic and wild felids aiming to provide comprehensive data of interest for further intervention approaching the One Health perspective. Different databases were searched by utilizing particular key words for publications related to T. gondii infecting domestic and wild feline host species, worldwide, from 1970 to 2020. The review of 337 reports showed that the seroprevalence of T. gondii in domestic cats and wild felids was estimated in 37.5% (95% CI 34.7–40.3) (I2 = 98.3%, P < 0.001) and 64% (95% CI 60–67.9) (I2 = 88%, P < 0.0001), respectively. The global pooled prevalence of oocysts in the fecal examined specimens from domestic cats was estimated in 2.6% (95% CI 1.9–3.3) (I2 = 96.1%, P < 0.0001), and that in fecal samples from wild felids was estimated in 2.4% (95% CI 1.1–4.2) (I2 = 86.4%, P < 0.0001). In addition, from 13,252 examined soil samples in 14 reviewed studies, the pooled occurrence of T. gondii oocysts was determined in 16.2% (95% CI 7.66–27.03%). The observed high rates of anti-T. gondii antibodies seroprevalence levels and oocyst excretion frequency in the felids, along with soil (environmental) contamination with oocysts may constitute a potential threat to animal and public health, and data will result of interest in further prophylaxis programs.

Download Full-text

Toxoplasma gondii Infection and Clinical Characteristics of Patients With Schizophrenia: A Systematic Review and Meta-analysis

Schizophrenia Bulletin Open ◽

10.1093/schizbullopen/sgaa042 ◽

2020 ◽

Vol 1 (1) ◽

Author(s):

Arjen L Sutterland ◽

David A Mounir ◽

Juul J Ribbens ◽

Bouke Kuiper ◽

Tom van Gool ◽

...

Keyword(s):

Systematic Review ◽

Toxoplasma Gondii ◽

Publication Bias ◽

Clinical Characteristics ◽

Negative Symptoms ◽

Age Of Onset ◽

Meta Analysis ◽

Random Effects Models ◽

Duration Of Illness ◽

Toxoplasma Gondii Infection

Abstract Schizophrenia is associated with an increased prevalence of IgG antibodies against Toxoplasma gondii (T. gondii seropositivity), whereby the infection seems to precede the disorder. However, it remains unclear whether a T. gondii infection affects clinical characteristics of schizophrenia. Therefore, a systematic review and meta-analysis was conducted following PRISMA guidelines examining the association between T. gondii seropositivity and severity of total, positive, or negative symptoms or age of onset in schizophrenia. PubMed, Embase, and PsycInfo were systematically searched up to June 23, 2019 (PROSPERO #CRD42018087766). Random-effects models were used for analysis. Furthermore, the influence of potential moderators was analyzed. Indications for publication bias were examined. From a total of 934 reports, 13 studies were included. No overall effect on severity of total, positive, or negative symptoms was found. However, in patients with a shorter duration of illness T. gondii seropositivity was associated with more severe positive symptoms (standardized mean difference [SMD] = 0.32; P < .001). Similar but smaller effects were seen for total symptoms, while it was absent for negative symptoms. Additionally, a significantly higher age of onset was found in those with T. gondii seropositivity (1.8 y, P = .015), although this last finding was probably influenced by publication bias and study quality. Taken together, these findings indicate that T. gondii infection has a modest effect on the severity of positive and total symptoms in schizophrenia among those in the early stages of the disorder. This supports the hypothesis that T. gondii infection is causally related to schizophrenia, although more research remains necessary.

Download Full-text