Determination of morphine and its metabolites in the biological samples: an updated review

Bioanalysis ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 1161-1194
Author(s):  
Roghayeh Amini ◽  
Elaheh Rahimpour ◽  
Abolghasem Jouyban
Keyword(s):  
Analytical Method ◽  
Biological Samples ◽  
Opioid Analgesic ◽  
Individual Variability ◽  
Active Metabolites ◽  
Analytical Research ◽  
Reliable Analytical Method ◽  
Selection Of

Morphine (MO) as an opioid analgesic is used for the treatment of moderate-to-severe pains, particularly cancer-related pains. Pharmacologic studies on MO are complicated due to drugs binding to the protein or metabolization to active metabolites, and even inter-individual variability. This necessitates the selection of a reliable analytical method for monitoring MO and the concentrations of its metabolites in the biological samples for the pharmacokinetic or pharmacodynamic investigations. Therefore, this study was conducted to review all the analytical research carried out on MO and its metabolites in the biological samples during 2007–2019 as an update to the study by Bosch et al. (2007).

scholarly journals Determination of the optimal curvature of the turnout diverging track for HSR using dynamic analysis

2017 ◽  
Vol 2017 (10) ◽  
pp. 1-11
Author(s):  
Władysław Koc ◽  
Katarzyna Palikowska
Keyword(s):  
Dynamic Analysis ◽  
Analytical Method ◽  
High Speed ◽  
Extreme Points ◽  
Point Of View ◽  
High Speed Railway ◽  
Zero Values ◽  
Linear And Nonlinear ◽  
Selection Of

The paper presents an analytical method of identifying the curvature of the turnout diverging track consisting of sections of varying curvature. Such turnout is mainly applied on High Speed Railway. Both linear and nonlinear (polynomial) curvatures of the turnout diverging track are considered in the paper. Obtained solutions enable to assume curvature values at the beginning and end point of the geometrical layout of the turnout.The paper focus on a fundamental and unexplained so far issue connected with selection of the most favourable curvature section from the operational requirements point of view. In order to determine the optimal curvature a dynamic analysis has been carried out on the several representative cases. It has been indicated that, used in railway practice, clothoid sections with nonzero curvatures at the beginning and end points of the turnout should be verified. It has been proved that the turnout with nonlinear curvature reaching zero values at the extreme points of the geometrical layout is the most favourable.

Determination of triclocarban in aquatic plants by using SPE combined with HPLC-ESI-MS/MS

2014 ◽  
Vol 6 (7) ◽  
pp. 2227-2232 ◽  
Author(s):  
Hong-Hao Miao ◽  
Yi-Nan Wang ◽  
Ru-Song Zhao ◽  
Wei-Lin Guo ◽  
Xia Wang ◽  
...  
Keyword(s):  
Aquatic Plants ◽  
Analytical Method ◽  
Esi Ms ◽  
Homogenate Extraction ◽  
Reliable Analytical Method

A convenient and reliable analytical method was developed for determination of antibacterial triclocarban in aquatic plants based on homogenate extraction, SPE clean-up, and HPLC-ESI-MS/MS determination.

scholarly journals Analytical method development for the determination of polycyclic aromatic hydrocarbons in biological samples

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
P.-L. Cloutier ◽  
F. Fortin ◽  
M. Fournier ◽  
P. Brousseau ◽  
P.-É. Groleau ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Analytical Method ◽  
Biological Samples ◽  
Method Development ◽  
Polycyclic Aromatic

Not available

Determination of a selection of anti-epileptic drugs and two active metabolites in whole blood by reversed phase UPLC-MS/MS and some examples of application of the method in forensic toxicology cases

2014 ◽  
Vol 7 (7) ◽  
pp. 634-644 ◽  
Author(s):  
Ritva Karinen ◽  
Vigdis Vindenes ◽  
Inger Hasvold ◽  
Kirsten Midtbøen Olsen ◽  
Asbjørg S. Christophersen ◽  
...  
Keyword(s):  
Whole Blood ◽  
Forensic Toxicology ◽  
Reversed Phase ◽  
Active Metabolites ◽  
Selection Of

An optimized method based on MAE-SPE-GC-MS for the analysis of thirteen PBDEs in airborne particles

2014 ◽  
Vol 6 (24) ◽  
pp. 9658-9666 ◽  
Author(s):  
X. Li ◽  
X. M. Li ◽  
X. X. Yang ◽  
Q. Li ◽  
B. Huang ◽  
...  
Keyword(s):  
Glass Fibre ◽  
Analytical Method ◽  
Polybrominated Diphenyl Ethers ◽  
Airborne Particles ◽  
Atmospheric Particulates ◽  
Diphenyl Ethers ◽  
Fine Glass ◽  
Reliable Analytical Method

An efficient and reliable analytical method has been developed for the determination of polybrominated diphenyl ethers (PBDEs) in atmospheric particulates collected by ultra-fine glass fibre filters.

Simultaneous determination of chlorite, chlorate, perchlorate and bromate in ozonated saline by using IC-MS

2020 ◽  
Vol 12 (48) ◽  
pp. 5916-5921
Author(s):  
Xiuzhen Yin ◽  
He Cui ◽  
Sa Li ◽  
Shuyan Niu
Keyword(s):  
Mass Spectrometry ◽  
Simultaneous Determination ◽  
Ion Chromatography ◽  
Analytical Method ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometry ◽  
Quadrupole Mass Spectrometry ◽  
Reliable Analytical Method

A simple, accurate and reliable analytical method for simultaneous determination of chlorite, chlorate, perchlorate and bromate in ozonated saline by using ion chromatography coupled with triple quadrupole mass spectrometry (IC-MS) has been developed.

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