An Ethical Discussion of Cardiovascular Disease in Pregnancy

Physiological changes in lipoprotein levels occur in normal pregnancy. Women with hyperlipoproteinemia are advised to discontinue statins, fibrates already when they consider pregnancy up to and including breast-feeding the newborn, because of the fear for teratogenic effects. Hypertriglyceridemia in pregnancy can rarely lead to acute pancreatitis. Management of acute pancreatitis in pregnant women is similar to that used in non-pregnant patients. Further large cohort studies are needed to estimate the consequence of supraphysiologic hyperlipoproteinemia or extreme hyperlipoproteinemia in pregnancy on the risk for cardiovascular disease later in life. Orv. Hetil., 2011, 152, 753–757.

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Drugs during pregnancy and breastfeeding

ESC CardioMed ◽

10.1093/med/9780198784906.003.0696 ◽

2018 ◽

pp. 2876-2882

Author(s):

Stefan Verlohren

Keyword(s):

Cardiovascular Disease ◽

Drug Therapy ◽

Cardiovascular Diseases ◽

Drug Treatment ◽

Treatment Options ◽

Lactation Period ◽

Pregnancy And Lactation ◽

Selection Of ◽

In Pregnancy

Pregnant women with pre-existing cardiovascular disease may require drug therapy during their pregnancy and lactation period. There are no uniform recommendations for selection of medications, dosing, and timing of treatment. Possible adverse or teratogenic effects of the drugs on the fetus must be weighed against the maternal indication of drug treatment. This chapter gives an overview of medical treatment options for cardiovascular diseases in pregnancy. Furthermore, sources of evidence which can be used for risk classification of drugs applied during pregnancy are shown.

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The Importance of Cardiovascular Risk Assessment and Pregnancy Heart Team in the Management of Cardiovascular Disease in Pregnancy

Cardiology Clinics ◽

10.1016/j.ccl.2020.09.002 ◽

2021 ◽

Vol 39 (1) ◽

pp. 7-19

Author(s):

Garima Sharma ◽

Wendy Ying ◽

Candice K. Silversides

Keyword(s):

Cardiovascular Disease ◽

Risk Assessment ◽

Cardiovascular Risk ◽

Heart Team ◽

Cardiovascular Risk Assessment ◽

In Pregnancy

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Hypertension in pregnancy as a risk factor for cardiovascular disease later in life

Journal of Hypertension ◽

10.1097/hjh.0b013e328335c29a ◽

2010 ◽

Vol 28 (4) ◽

pp. 826-833 ◽

Cited By ~ 111

Author(s):

Vesna D Garovic ◽

Kent R Bailey ◽

Eric Boerwinkle ◽

Steven C Hunt ◽

Alan B Weder ◽

...

Keyword(s):

Cardiovascular Disease ◽

Risk Factor ◽

Hypertension In Pregnancy ◽

In Pregnancy

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Cholesterol in pregnancy: a review of knowns and unknowns

Obstetric Medicine ◽

10.1258/om.2011.110003 ◽

2011 ◽

Vol 4 (4) ◽

pp. 147-151 ◽

Cited By ~ 27

Author(s):

Änne Bartels ◽

Keelin O'Donoghue

Keyword(s):

Cardiovascular Disease ◽

Vitamin D ◽

Fetal Development ◽

Plasma Cholesterol ◽

Adult Population ◽

The Body ◽

High Cholesterol ◽

Cholesterol Levels ◽

Growing Body ◽

In Pregnancy

Cholesterol forms part of every cell in the human body, and also helps make and metabolize hormones, bile acids and vitamin D. Human plasma cholesterol levels are determined by production in the liver and by dietary intake. Lipoproteins carry cholesterol around the body, and facilitate it crossing the placenta. Cholesterol is carefully monitored in the non-pregnant adult population, where its association with atherosclerosis and cardiovascular disease is well understood. Although it is known that cholesterol rises in pregnancy, at present it is not routinely measured or treated. The effects of maternal high cholesterol on pregnancy and on fetal development are not yet fully understood. However, a growing body of evidence from animal and human studies suggests adverse consequences of high cholesterol levels in pregnancy.

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