scholarly journals Validated UV spectrophotometric method for quantitative determination of agomelatine coated tablets dosage form

2022 ◽  
Vol 10 (01) ◽  
pp. 98-103
Author(s):  
V. Koti Reddy ◽  
K. Venkata Ramana
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Method ◽  
Dosage Form

scholarly journals Spectrophotometric quantitative analysis of metronidazole and itraconazole in a combined preparation made on the basis of Tizol gel

2020 ◽  
Vol 20 (5-6) ◽  
pp. 157-163
Author(s):  
Anna I. Zamaraeva ◽  
Natalya S. Bessonova ◽  
Tatyana A. Kobeleva ◽  
Alik I. Sichko
Keyword(s):  
Quantitative Analysis ◽  
Quantitative Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Dosage Form ◽  
Statistical Processing ◽  
Ultraviolet Region ◽  
System Of Equations ◽  
Base Materials

Actuality. Nowadays, the problems of effectiveness and accessibility of dermatoprotective therapy and prevention of dermatological diseases are urgent. The complex use of metronidazole in combination with drugs of other pharmacological groups is particularly relevant and promising. The dosage form consisting of 0.1 g of Itraconazole, 0.1 g of metronidazole and Tizol gel up to 10 g, termed by us Metroitraconazole, can be used in dermatology, ophthalmology and gynecology as a bactericidal and antifungal agent. The aim of the study is to develop the method for the quantitative spectrophotometric determination of metronidazole and itraconazole in a soft dosage form on a titanium-containing base. Materials and methods. For the analysis, we used substances, ethanol solutions of Metronidazole and Itraconazole, an ointment with the conditional name Metroitraconazole, containing 1.0% of the preparations in the Tizol gel. The study was carried out by spectrophotometry in the ultraviolet region, using spectrophotometer SF-2000 (Russia). Results. The study of the absorption spectra and statistical processing of the finding demontstrated that spectrophotometric determination of Itraconazole and metronidazole demanded the wavelengths of 262 and 312 nm, with a relative error of 1.52% and 1.67%, respectively. As a result of the analysis of the soft dosage form, it was determined that the content of metronidazole calculated with the use of Firordt method and a simplified system of equations ranged 0.0987-0.1057 g, and Itraconazole ranged 0.0925-0.1055 g. These data conformed the acceptance criteria. Conclusion. The conducted research allowed us to develop and propose a method for the quantitative determination of itraconazole and metronidazole in Metroitraconazole ointment by means of spectrophotometric method. It allowed us to determine the content of drugs in the dosage form with an error not exceeding the standard deviations.

Spectrophotometric Determination of Alendronate Sodium by using Sodium-1,2-Naphthoquinone-4-Sulphonate

2012 ◽  
Vol 4 (4) ◽  
pp. 1563-1568
Author(s):  
Sagar Suman Panda ◽  
Ravi Kumar B V V ◽  
D Patanaik
Keyword(s):  
Spectrophotometric Method ◽  
Absorption Maximum ◽  
Dosage Form ◽  
Dosage Forms ◽  
Alendronate Sodium ◽  
Colored Complex ◽  
Pharmaceutical Dosage Forms ◽  
Recovery Study ◽  
Assay Conditions

A simple, precise and accurate spectrophotometric method was developed for analysis of the osteoporesis drug alendronate sodium (ALS). The method is based on reaction of the drug with sodium-1,2-naphthoquinone-4-sulphonate (NQS) in presence of alkali to form a brown colored complex giving absorption maximum at 525 nm. The drug obeyed Beer’s law in the range of 5-70 µg/ml with a correlation coefficient of 0.999. The LOD and LOQ values are 1.7 µg/ml and 5.0 µg/ml, respectively. The average recoveries for recovery study were found to be in the range of 99.37%-100.46%. The R.S.D. values for intraday and inter-day precision were found to be 0.48 and 0.62, respectively. The optimized assay conditions were applied successfully for determination of ALS in pharmaceutical dosage forms. No interference was observed from the excipients present in the dosage form. The method is statistically validated as per the ICH requirements.  

scholarly journals Spectrophotometric method for determination of atazanavir sulfate in capsule dosage form

Química Nova ◽  
2011 ◽  
Vol 34 (8) ◽  
pp. 1349-1353
Author(s):  
Anindita Behera ◽  
Swapan Kumar Moitra ◽  
Sudam Chandra Si ◽  
Dannana Gowri Sankar
Keyword(s):  
Spectrophotometric Method ◽  
Dosage Form ◽  
Atazanavir Sulfate

scholarly journals Difference spectrophotometric method for the determination of Fluphenazine hydrochloride in tablets using peroxomonosulfate

2021 ◽  
Vol 9 (2) ◽  
pp. 64-71
Author(s):  
Mykola Blazheyevskiy ◽  
◽  
Valeriy Moroz ◽  
Olena Mozgova ◽  
◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Present Method ◽  
Molar Absorptivity ◽  
Limit Of Quantification ◽  
Derivatizing Agent ◽  
Sensitive Method

The oxidative derivatization method using potassium hydrogenperoxomonosulfate for the indirect spectrophotometric determination of Fluphenazine hydrochloride is presented. Potassium hydrogenperoxomonosulfate is introduced as a derivatizing agent for Fluphenazine hydrochloride, yielding the sulfoxide. This reaction product was successfully used for the spectrophotometric determination of the Fluphenazine hydrochloride. The UV spectroscopic detection of the sulfoxide proved to be a more robust and sensitive method. The elaborated method allowed the determination of Fluphenazine hydrochloride in the concentration range of 0.2-30 µg mL-1. The molar absorptivity at 349 nm is 5.6×103 (dm3cm-1mol-1). The limit of quantification, LOQ (10S) is 0.24 µg/mL. A new spectrophotometric technique was developed and the possibility of quantitative determination of Fluphenazine hydrochloride in tablets 5.0 mg was demonstrated. The present method is precise, accurate and excipients did not interfere. RSD for Fluphenazine Hydrochloride 5.0 mg tablets was 1.37 %.

Quantitative Determination of Benzaldehyde in Flavors and Cordials by Ultraviolet Spectrophotometry and 2,4-Dinitrophenylhydrazine Precipitation

1967 ◽  
Vol 50 (2) ◽  
pp. 319-322
Author(s):  
Richard L Brunelle
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Method ◽  
Alternative Methods ◽  
Ultraviolet Spectrophotometry ◽  
Precipitation Procedure ◽  
Gravimetric Procedure

Abstract Three sets of samples were collaboratively analyzed by the official, first action ultraviolet spectrophotometric and 2,4-dinitrophenylhydrazine precipitation methods for determining benzaldehyde in flavors and cordials. The spectrophotometric method was unchanged, except for clarification, and collaborators reported recoveries averaging nearly 100%. The gravimetric procedure using 2,4-dinitrophenylhydrazine gave unsatisfactory recoveries on the first two sets of collaborative samples. However, collaborators reported approximately 96% recovery of benzaldehyde with a modified precipitation procedure on a third set of samples. The ultraviolet spectrophotometric method and the modified 2,4-dinitrophenylhydrazine precipitation procedure are recommended for adoption as official, final action as alternative methods.

scholarly journals Determination of vitamin A content from selected Nigerian fruits using spectrophotometric method

2017 ◽  
Vol 52 (2) ◽  
pp. 153-158 ◽  
Author(s):  
SO Aremu ◽  
CC Nweze
Keyword(s):  
Vitamin A ◽  
Quantitative Determination ◽  
Spectrophotometric Method ◽  
Fruits And Vegetables ◽  
Significant Difference ◽  
Conversion Formula ◽  
Major Nutrients

The vitamin A content of the fresh fruits was determined by the extraction and quantitative determination of the pro-vitamin A carotenoid-?-carotene. The Retinol Equivalent (RE) was then obtained using standard conversion formula. The result indicated that the fruit with the minimum vitamin A content and percentage among the six samples was found in mango 301.61 ± 1.03 (7%), which was followed closely by watermelon 350.12 ± 19.01 (8%), guava 504.1 ± 0.75 (11%), tomato 542.86 ± 20.20 (12%), pawpaw 683.93 ± 5.15 (16%) and the highest content was found in carrot 2054.10 ± 1.28 (46%) in (RE/100 g). Statistical calculations and analysis showed that there was significant difference in vitamin A content among the fruits (p<0.05). Thus, besides major nutrients fruits and vegetables contribute very good amount of micro nutrient-vitamin A from ?-carotene.Bangladesh J. Sci. Ind. Res. 52(2), 153-158, 2017

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