Hepatoprotective Potential of Tecomella undulata Bark on Paracetamol and CCL4 Induced Hepatotoxicity in Rats: Invitro Analysis

In this study the T. undulata bark was tested for its hepatoprotection against paracetamol (PCM) induced hepatic damage and Carbon tetra chloride (CCl4) induced hepatotoxicity. The Invitro study was performed on HepG2 cell line .The Levels of serum marker enzymes i.e. AST, ALT (aminotransferases), ALP (alkaline phosphatase), GSH (reduced glutathione) and MDA (Malondialdehyde) in 70% Ethanol treated rats were monitored, respectively. The 70% Ethanol extract gave promising results as studied in detail. The Present study showed that the 70 % ethanolic extract of bark of T.undulata apparently revive the physiological integrity of hepatocytes. Thus the present study demonstrated the Hepatoprotective property of Tecomella undulate Bark.

Download Full-text

Activation of apoptosis by ethyl acetate fraction of ethanol extract of Dianthus superbus in HepG2 cell line

Cancer Epidemiology ◽

10.1016/j.canep.2011.09.004 ◽

2012 ◽

Vol 36 (1) ◽

pp. e40-e45 ◽

Cited By ~ 10

Author(s):

Jian-Qing Yu ◽

Yan Yin ◽

Jia-Chuan Lei ◽

Xiu-Qiao Zhang ◽

Wei Chen ◽

...

Keyword(s):

Ethyl Acetate ◽

Cell Line ◽

Hepg2 Cell ◽

Ethanol Extract ◽

Ethyl Acetate Fraction ◽

Hepg2 Cell Line

Download Full-text

Cytotoxic activities of Ganoderma lucidum ethanol extract against HepG2 cell line

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v11i3.27906 ◽

2016 ◽

Vol 11 (3) ◽

pp. 632

Author(s):

Kannan Mohan ◽

Muthusamy Padmanaban ◽

Venkatachalam Uthayakumar ◽

Ramachandran Chandrasekhar ◽

Thirunavukkarasu Muralisankar

Keyword(s):

Cell Line ◽

Hepg2 Cell ◽

Ganoderma Lucidum ◽

Ethanol Extract ◽

Cytotoxic Activities ◽

Hepg2 Cell Line

Download Full-text

Laurus nobilis ethanolic extract attenuates hyperglycemia and hyperinsulinemia-induced insulin resistance in HepG2 cell line through the reduction of oxidative stress and improvement of mitochondrial biogenesis - possible implication in pharmacotherapy

Mitochondrion ◽

10.1016/j.mito.2021.06.003 ◽

2021 ◽

Author(s):

Nabila Bourebab ◽

Katarzyna Kornicka-Garbowska ◽

Krzyzstof Marycz ◽

Lynda Bourebaba ◽

Anna Kowalczuk

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Cell Line ◽

Hepg2 Cell ◽

Mitochondrial Biogenesis ◽

Ethanolic Extract ◽

Hepg2 Cell Line ◽

Laurus Nobilis

Download Full-text

Evaluation of Anti-Tumour Potential of Acanthus ilicifolius (Linn.) in HepG2 Cell Line Induced Hepatocellular Carcinoma in Mice

International Journal of Pharmacognosy and Phytochemical Research ◽

10.25258/phyto.v9i6.8196 ◽

2017 ◽

Vol 9 (6) ◽

Cited By ~ 1

Author(s):

R. Vijayaraj ◽

Sri Kumaran ◽

Swarnakala Swarnakala

Keyword(s):

Cell Line ◽

Hepg2 Cell ◽

Ethanolic Extract ◽

Test Sample ◽

Hydroxyl Group ◽

Histopathological Analysis ◽

Phytochemical Analysis ◽

Hepg2 Cell Line ◽

Anticancer Properties ◽

Acanthus Ilicifolius

Acanthus ilicifolius has long history of medicinal plant belong to the family Acanthaceae. In the present study, ethanolic extract of A. ilicifolius showed antitumour potential against HepG2 cell line induced hepatocarcinoma in mice. The phytochemical analysis were studied by using strandard methods. The heptocarcinoma mice were orally treated with extract of A.ilicifolius (500 mg/kg B.W). The result indicates the presence of phytoconstituents such as Protein (2.5%), Carbohydrates (0.16%) , alkaloids (0.42%), flavonoids (0.62%), saponins (4.5%), tannins (1.0%) and terpenoids (0.20%). In FTIR spectrum of test sample, the strong absorbance were showed at peak 678.94 cm-1, 1514.12 cm-1,1741.72 cm-1 ,2304.94 cm-1, 3597.24 cm-1, 3728.40 cm-1 which are associated with presence of functional groups such as Mono substituted benzene, aromatic (c=c), aldehyde (c=o), disubstituted alkynes(c=c), alcohols with free hydroxyl group (OH), alcohols, phenols (O-H). Treatment effectively suppressed HepG2 cells induced mice as revealed by decrease in the levels and extend of Alanine transaminase (84.3±1.86), Aspartate transaminase (41.6±2.15), Alkaline phosphatase (224.9±6.3), Urea (64.3±1.20) and creatinine (1.36±0.155). Histopathological analysis of liver and kidney was also evaluated. This study demonstrates that the A. ilicofolius have a potent anticancer Properties.

Download Full-text