Omega-3 Fatty Acids Effect on Major Cardiovascular Events in Patients at High Cardiovascular Risk

JAMA ◽  
2021 ◽  
Vol 325 (13) ◽  
pp. 1332
Author(s):  
Brian Olshansky ◽  
Deepak L. Bhatt ◽  
Mina K. Chung
Keyword(s):  
Fatty Acids ◽  
Cardiovascular Risk ◽  
Cardiovascular Events ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
High Cardiovascular Risk ◽  
Major Cardiovascular Events

scholarly journals Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk

JAMA ◽  
2020 ◽  
Vol 324 (22) ◽  
pp. 2268 ◽  
Author(s):  
Stephen J. Nicholls ◽  
A. Michael Lincoff ◽  
Michelle Garcia ◽  
Dianna Bash ◽  
Christie M. Ballantyne ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cardiovascular Risk ◽  
Cardiovascular Events ◽  
Corn Oil ◽  
Major Adverse Cardiovascular Events ◽  
High Dose ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
High Cardiovascular Risk

scholarly journals Long chain omega-3 fatty acids and cardiovascular disease: a systematic review

2012 ◽  
Vol 107 (S2) ◽  
pp. S201-S213 ◽  
Author(s):  
Javier Delgado-Lista ◽  
Pablo Perez-Martinez ◽  
Jose Lopez-Miranda ◽  
Francisco Perez-Jimenez
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Cardiovascular Risk ◽  
Cardiovascular Event ◽  
Cardiac Death ◽  
Cardiovascular Events ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
High Cardiovascular Risk ◽  
Coronary Events

Introduction: Cardiovascular disease remains the commonest health problem in developed countries, and residual risk after implementing all current therapies is still high. The use of marine omega-3 fatty acids (DHA and EPA) has been recommended to reduce cardiovascular risk by multiple mechanisms. Objectives: To update the current evidence on the influence of omega-3 on the rate of cardiovascular events. Review Methods: We used the MEDLINE and EMBASE databases to identify clinical trials and randomized controlled trials of omega-3 fatty acids (with quantified quantities) either in capsules or in dietary intake, compared to placebo or usual diet, equal to or longer than 6 months, and written in English. The primary outcome was a cardiovascular event of any kind and secondary outcomes were all-cause mortality, cardiac death and coronary events. We used RevMan 5·1 (Mantel-Haenszel method). Heterogeneity was assessed by the I2and Chi2tests. We included 21 of the 452 pre-selected studies. Results: We found an overall decrease of risk of suffering a cardiovascular event of any kind of 10 % (OR 0·90; [0·85–0·96],p = 0·001), a 9 % decrease of risk of cardiac death (OR 0·91; [0·83–0·99];p = 0·03), a decrease of coronary events (fatal and non-fatal) of 18 % (OR 0·82; [0·75–0·90];p < 1 × 10− 4), and a trend to lower total mortality (5 % reduction of risk; OR 0·95; [0·89–1·02];p = 0·15. Most of the studies analyzed included persons with high cardiovascular risk. Conclusions: marine omega-3 fatty acids are effective in preventing cardiovascular events, cardiac death and coronary events, especially in persons with high cardiovascular risk.

Sign in / Sign up

Export Citation Format

Share Document