Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis

JAMA ◽  
2021 ◽  
Vol 326 (20) ◽  
pp. 2021
Author(s):  
Kim L. Bennell ◽  
Kade L. Paterson ◽  
Ben R. Metcalf ◽  
Vicky Duong ◽  
Jillian Eyles ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Cartilage Volume ◽  
Tibial Cartilage

Higher dynamic medial knee load predicts greater cartilage loss over 12 months in medial knee osteoarthritis

2011 ◽  
Vol 70 (10) ◽  
pp. 1770-1774 ◽  
Author(s):  
Kim L Bennell ◽  
Kelly-Ann Bowles ◽  
Yuanyuan Wang ◽  
Flavia Cicuttini ◽  
Miranda Davies-Tuck ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Disease Progression ◽  
Cartilage Volume ◽  
Cartilage Defects ◽  
Medial Knee ◽  
Tibial Cartilage ◽  
Medial Knee Osteoarthritis ◽  
Structural Progression ◽  
The Relationship ◽  
Knee Load

ObjectiveMechanical factors, in particular increased medial knee joint load, are believed to be important in the structural progression of knee osteoarthritis. This study evaluated the relationship of medial knee load during walking to indices of structural disease progression, measured on MRI, in people with medial knee osteoarthritis.MethodsA longitudinal cohort design utilising a subset of participants (n=144, 72%) enrolled in a randomised controlled trial of lateral wedge insoles was employed. Medial knee load parameters including the peak knee adduction moment (KAM) and the KAM impulse were measured at baseline using three-dimensional gait analysis during walking. MRI at baseline and at 12 months was used to assess structural indices. Multiple regression with adjustment for covariates assessed the relationship between medial knee load parameters and the annual change in medial tibial cartilage volume. Binary logistic regression was used for the dichotomous variables of progression of medial tibiofemoral cartilage defects and bone marrow lesions (BML).ResultsA higher KAM impulse, but not peak KAM, at baseline was independently associated with greater loss of medial tibial cartilage volume over 12 months (β=29.9, 95% CI 6.3 to 53.5, p=0.01). No significant relationships were seen between medial knee load parameters and the progression of medial tibiofemoral cartilage defects or BML.ConclusionThis study suggests knee loading, in particular the KAM impulse, may be a risk factor for loss of medial tibial cartilage volume. As knee load is modifiable, load-modifying treatments may potentially slow disease progression.

scholarly journals The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study

2010 ◽  
Vol 12 (2) ◽  
pp. R58 ◽  
Author(s):  
Stephanie K Tanamas ◽  
Anita E Wluka ◽  
Jean-Pierre Pelletier ◽  
Johanne Martel-Pelletier ◽  
François Abram ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Knee Osteoarthritis ◽  
Subchondral Bone ◽  
Joint Replacement ◽  
Cartilage Volume ◽  
Bone Cysts ◽  
Tibial Cartilage ◽  
Subchondral Bone Cysts

scholarly journals Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis

JAMA ◽  
2016 ◽  
Vol 315 (10) ◽  
pp. 1005 ◽  
Author(s):  
Xingzhong Jin ◽  
Graeme Jones ◽  
Flavia Cicuttini ◽  
Anita Wluka ◽  
Zhaohua Zhu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Vitamin D Supplementation ◽  
Cartilage Volume ◽  
Tibial Cartilage ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

scholarly journals Change in knee angle influences the rate of medial tibial cartilage volume loss in knee osteoarthritis

2009 ◽  
Vol 17 (1) ◽  
pp. 8-11 ◽  
Author(s):  
A.J. Teichtahl ◽  
M.L. Davies-Tuck ◽  
A.E. Wluka ◽  
G. Jones ◽  
F.M. Cicuttini
Keyword(s):  
Knee Osteoarthritis ◽  
Cartilage Volume ◽  
Volume Loss ◽  
Knee Angle ◽  
Tibial Cartilage ◽  
Cartilage Volume Loss

scholarly journals Baseline knee adduction moment interacts with body mass index to predict loss of medial tibial cartilage volume over 2.5 years in knee Osteoarthritis

2017 ◽  
Vol 35 (11) ◽  
pp. 2476-2483 ◽  
Author(s):  
Nicholas M. Brisson ◽  
Emily G. Wiebenga ◽  
Paul W. Stratford ◽  
Karen A. Beattie ◽  
Saara Totterman ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Body Mass ◽  
Cartilage Volume ◽  
Knee Adduction Moment ◽  
Tibial Cartilage
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