Golden Opportunities in the Synthesis of Natural Products and Biologically Active Compounds

2012 ◽  
pp. 111-154 ◽  
Author(s):  
Fabien Gagosz
Keyword(s):  
Natural Products ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds

Accessing Polycyclic Terpenoids from Zerumbone via Lewis Acid Catalyzed Synthetic Strategies

Synthesis ◽  
2020 ◽  
Vol 52 (14) ◽  
pp. 2045-2064 ◽  
Author(s):  
Puthiyaparambath Sharathna ◽  
Murugan Thulasi Meenu ◽  
Kokkuvayil Vasu Radhakrishnan ◽  
Bhandara Purayil Dhanya ◽  
Greeshma Gopalan ◽  
...  
Keyword(s):  
Natural Products ◽  
Lewis Acid ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Effective Strategy ◽  
Structural Elements ◽  
Nazarov Cyclization ◽  
Active Compounds ◽  
Acid Catalyzed

We herein disclose an effective strategy for the synthesis of [5.3.0] and [6.3.0] fused polycyclic terpenoids, which are important structural elements of natural products and biologically active compounds. The method comprises of Lewis acid catalyzed interrupted Nazarov cyclization of zerumbone derivatives such as zerumbone epoxide, triazole-appended zerumbone, zerumbal, and zerumbenone with a wide substrate scope with different indoles. Zerumbone epoxide furnished [5.3.0] and [6.3.0] fused structurally diverse sesquiterpenoids and all other zerumbone derivatives furnished the [6.3.0] fused motifs.

Developments toward the synthesis and application of 3-hydroxyindanones

2016 ◽  
Vol 14 (38) ◽  
pp. 8895-8910 ◽  
Author(s):  
Tanmoy Chanda ◽  
Maya Shankar Singh
Keyword(s):  
Natural Products ◽  
Functional Materials ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Comprehensive Overview ◽  
Active Compounds ◽  
Drug Candidates

3-Hydroxyindanone is an important scaffold in many natural products, biologically active compounds, and functional materials. This review provides a comprehensive overview of the construction of 3-hydroxyindanone derivatives and their applications towards pharmaceutically promising drug candidates.

scholarly journals Tale of Breslow Intermediate, a Central Player in N-Heterocyclic Carbene Organocatalysis: Then and Now

2021 ◽  
Author(s):  
Raghavan B. Sunoj ◽  
Monika Pareek ◽  
Yernaidu Reddi
Keyword(s):  
Natural Products ◽  
Heterocyclic Carbenes ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Wide Range

N-heterocyclic carbenes (NHCs) belong to the popular family of organocatalysts used in a wide range of reactions, including that for the synthesis of complex natural products and biologically active compounds....

Stereoselective strategies for the construction of polysubstituted piperidinic compounds and their applications in natural products’ synthesis

2017 ◽  
Vol 4 (8) ◽  
pp. 1655-1704 ◽  
Author(s):  
Nishanth Kandepedu ◽  
Isabelle Abrunhosa-Thomas ◽  
Yves Troin
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Natural Products Synthesis

An abridged and far-reaching review communication on the construction of the polysubstituted piperidinic core using diverse methodologies for the benefit of organic chemists interested in the total synthesis of biologically active compounds.

scholarly journals Synthesis of Indoles via Intermolecular and Intramolecular Cyclization by Using Palladium-Based Catalysts

Catalysts ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1018
Author(s):  
Ayesha ◽  
Muhammad Bilal ◽  
Nasir Rasool ◽  
Samreen Gul Khan ◽  
Umer Rashid ◽  
...  
Keyword(s):  
Natural Products ◽  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Palladium Catalysts ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Nitrogen Coupling ◽  
Indole Synthesis

As part of natural products or biologically active compounds, the synthesis of nitrogen-containing heterocycles is becoming incredibly valuable. Palladium is a transition metal that is widely utilized as a catalyst to facilitate carbon-carbon and carbon-heteroatom coupling; it is used in the synthesis of various heterocycles. This review includes the twelve years of successful indole synthesis using various palladium catalysts to establish carbon-carbon or carbon-nitrogen coupling, as well as the conditions that have been optimized.

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