A novel approach to production of Chlorella protothecoides oil‐loaded nanoparticles via electrospraying method: Modeling of critical parameters for particle sizing

Investigation on the critical parameters affecting the working design dynamics of a torque motor employed in an electro-hydraulic servovalve

SIMULATION ◽

10.1177/0037549718759187 ◽

2018 ◽

Vol 95 (1) ◽

pp. 31-49 ◽

Cited By ~ 1

Author(s):

Sharan A S ◽

Somashekhar S Hiremath ◽

C S Venkatesha ◽

S Karunanidhi

Keyword(s):

Electrical Signal ◽

Critical Parameters ◽

Fe Model ◽

Test Set ◽

Effective Dynamics ◽

Novel Approach ◽

Set Up ◽

Experimental Values ◽

Simulation Parameters ◽

Good Agreement

The torque motor is an intricate assembly in electro-hydraulic technology and plays a crucial role in converting the electrical signal into controlled mechanical output signal. It involves many precise components, such as the feedback spring, armature and its coil, permanent magnet, feed pipe, flexure shaft, jetpipe, and flexure support. The components are embedded together as a single operating component. Each component contributes to the effective dynamics of the system. The present paper proposes a novel approach to investigate the effect of critical parameters on the working design dynamics of the torque motor employed in the jetpipe electro-hydraulic servovalve. Based on the principles of mechatronics, a mathematical model is developed. The model-based design approach is employed to investigate the dynamics of the system. The required simulation parameters of the critical and precision components were obtained from solid and finite element (FE) models. The solid and FE models of the critical and precision components were first analyzed with suitable boundary and loading conditions to establish the stiffness. To validate the obtained FE results, experiments were carried out with a specially designed and fabricated test set-up. Based on the basic principle of electromagnetics, a nonlinear FE model of torque motor is analyzed for magnetic field distribution, the torque developed, and armature and jetpipe deflection for varied input current. From the results obtained, good agreement was observed between FE, simulated, and experimental values. The present novel approach enables one to improve the working design dynamics of the torque motor.

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Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

Biochemical Journal ◽

10.1042/bcj20190591 ◽

2019 ◽

Vol 476 (24) ◽

pp. 3705-3719 ◽

Cited By ~ 2

Author(s):

Avani Vyas ◽

Umamaheswar Duvvuri ◽

Kirill Kiselyov

Keyword(s):

Oxidative Stress ◽

Head And Neck ◽

Transcriptional Activation ◽

Platinum Resistance ◽

Mrna Levels ◽

Strong Positive Correlation ◽

Platinum Compounds ◽

Copper Chelation ◽

Novel Approach ◽

Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

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Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

Language Speech and Hearing Services in Schools ◽

10.1044/2020_lshss-19-00050 ◽

2020 ◽

Vol 51 (3) ◽

pp. 544-560 ◽

Cited By ~ 3

Author(s):

Kimberly A. Murphy ◽

Emily A. Diehm

Keyword(s):

Written Language ◽

Morphological Knowledge ◽

English Orthography ◽

Word Level ◽

Novel Approach ◽

Language Pathology ◽

The One ◽

Critical Intervention ◽

Reading And Spelling ◽

Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

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