Outcome of atypia of undetermined significance/follicular lesion of undetermined significance in thyroid fine‐needle aspirations: A six‐year institutional experience

Introduction: The fine-needle aspiration has a significant role in assessing the malignancy risk of thyroid nodules. There is uncertainty regarding the value of repeat fine-needle aspiration in benign nodules. This study aims to evaluate the concordance of results in consecutive fine-needle aspiration and to study the relevance of repetition in benign results.Material and Methods: Retrospective study of the 4800 thyroid nodules fine-needle aspiration held in Instituto de Patologia e Imunologia Molecular da Universidade do Porto between January 1, 2014 and May 2, 2016. Of the initial sample, we selected the repeated fine-needle aspiration on the same nodule.Results: The first fine-needle aspiration result of the 309 nodules underwent revaluation was non-diagnostic in 103 (33.3%), benign in 120 (38.8%) and atypia/follicular lesion of undetermined significance in 86 (27.8%). The agreement between the first and second fine-needle aspiration was significantly higher in cases with an initial benign result (benign: 85.8%, non-diagnostic: 27.2% and atypia/ follicular lesion of undetermined significance: 17.4%, p < 0.005). The fine-needle aspiration repeating motifs in initially benign nodules (n = 78) were repetition suggestion in 58, nodule growth in 17 and suspicious ultrasonographic features in 3.Discussion: The fine-needle aspiration repetition in nodules with initial non-diagnostic and atypia/follicular lesion of undetermined significance result changed the initial diagnosis in a significant proportion of patients, modifying their therapeutic approach. The high concordance of results in initially benign nodules makes fine-needle aspiration repetition not cost-effective in most cases.Conclusion: The fine-needle aspiration should be repeated when the initial cytology result is non-diagnostic or atypia/follicular lesion of undetermined significance.

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The impact of rapid on‐site evaluation on thyroid fine‐needle aspiration biopsy: A 2‐year cancer center institutional experience

Cancer Cytopathology ◽

10.1002/cncy.22051 ◽

2018 ◽

Vol 126 (10) ◽

pp. 846-852 ◽

Cited By ~ 4

Author(s):

Ricardo G. Pastorello ◽

Camila Destefani ◽

Pedro H. Pinto ◽

Caroline H. Credidio ◽

Rafael X. Reis ◽

...

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Biopsy ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Cancer Center ◽

Fine Needle ◽

Thyroid Fine Needle Aspiration ◽

Institutional Experience ◽

Site Evaluation ◽

The Impact

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Cost-effectiveness analysis of repeat fine-needle aspiration for thyroid biopsies read as atypia of undetermined significance

Surgery ◽

10.1016/j.surg.2012.05.038 ◽

2012 ◽

Vol 152 (3) ◽

pp. 423-430 ◽

Cited By ~ 29

Author(s):

Michael Heller ◽

Kyle Zanocco ◽

Sara Zydowicz ◽

Dina Elaraj ◽

Ritu Nayar ◽

...

Keyword(s):

Cost Effectiveness ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Cost Effectiveness Analysis ◽

Fine Needle ◽

Effectiveness Analysis ◽

Undetermined Significance

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The Impact of the Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Classification on Cytologic Diagnosis in Thyroid Fine Needle Aspirations (FNA): An Institutional Experience

Journal of the American Society of Cytopathology ◽

10.1016/j.jasc.2018.06.050 ◽

2018 ◽

Vol 7 (5) ◽

pp. S18-S19

Author(s):

Negin Shafizadeh ◽

Sana Tabbara

Keyword(s):

Thyroid Neoplasm ◽

Cytologic Diagnosis ◽

Fine Needle ◽

Institutional Experience ◽

The Impact ◽

Nuclear Features

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Surgical Outcome of Thyroid Nodules with Atypia of Undetermined Significance and Follicular Lesion of Undetermined Significance in Fine Needle Aspiration Biopsy

World Journal of Endocrine Surgery ◽

10.5005/jp-journals-10002-1220 ◽

2017 ◽

Vol 9 (3) ◽

pp. 100-103

Author(s):

Saad Alqahtani ◽

Saif Alsobhi ◽

Riyadh I Alsalloum ◽

Saleh N Najjar ◽

Hindi N Al-Hindi

Keyword(s):

Fine Needle Aspiration ◽

Surgical Outcome ◽

Thyroid Nodules ◽

Fine Needle Aspiration Biopsy ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Fine Needle ◽

Risk Of Malignancy ◽

Needle Aspiration Biopsy ◽

Undetermined Significance

ABSTRACT Aim To correlate selected clinical and ultrasonographic (US) characteristics with the final histopathological diagnosis in patients with atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS), and whether this information can be used in planning the surgical approach. Materials and methods It is a retrospective study including the operated cases of AUS/FLUS from 2011 to 2014 treated at one center. Results This cohort included 87 women and 28 men. To test for independence between categorical variables, the chi-square test was used. There was no significant correlation between age or US variables and final pathological diagnosis. However, final diagnosis of malignancy was higher in men compared with women (64.3 and 41.4% respectively; p = 0.035). Furthermore, a significant association between the diagnosis of repeated fine needle aspiration biopsy (FNAB) and the final pathological diagnosis was noted (benign vs malignant, p = 0.005). Conclusion The FNAB has a significant role in the assessment of thyroid nodules. Our results showed no correlation between age, US variables, and the risk of malignancy. Male gender is associated with higher risk of malignancy. Clinical significance Determining the risk of malignancy and prediction of surgical outcome may help triaging cases for repeat FNA or proceeding to surgery. How to cite this article Alqahtani S, Alsobhi S, Alsalloum RI, Najjar SN, Al-Hindi HN. Surgical Outcome of Thyroid Nodules with Atypia of Undetermined Significance and Follicular Lesion of Undetermined Significance in Fine Needle Aspiration Biopsy. World J Endoc Surg 2017;9(3):100-103.

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