Oxidative Stability and in vitro Release Properties of Encapsulated Wheat Germ Oil in Saccharomyces Cerevisiae Cell‐Based Microcapsules

SummaryDuring the collection of samples for plasma β-thromboglobulin (β-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single β-TG measurement, blood samples were collected simultaneously from both arms on two separate occasions in 56 diabetic patients selected for a clinical trial. From each arm, blood was taken into two tubes containing an anticoagulant mixture with (tube A) and without (tube B) PGE!. The overall mean value of B-TG in tube B was 1.14 times higher than in tube A (p <0.01). The markedly large between-arms variation accounted for the most part of within-subject variation in both tubes and was significantly greater in tube B than in tube A. Based on the difference between B-TG values from both arms, the number of subjects with artifically high B-TG values was significantly higher in tube B than in tube A on each occasion (overall rate: 28% and 14% respectively). Estimate of between-occasions variation showed that B-TG levels were relatively stable for each subject between two occasions in each tube. It is concluded that the use of PGEi decreases falsely high B-TG levels, but a single measurement of B-TG does not provide a reliable estimate of the true B-TG value in vivo.

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In vitro release of GnRH from superfused hypothalami of male rats during pubertal development

Acta Endocrinologica ◽

10.1530/acta.0.107s067 ◽

1984 ◽

Vol 104 (4_Supplb) ◽

pp. S67

Author(s):

G. BRABANT ◽

A. K. RAY ◽

R. GRECH

Keyword(s):

Pubertal Development ◽

In Vitro Release ◽

Male Rats ◽

Vitro Release

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Preparation and In-vitro Evaluation of Fe3O4 Encapsulated by Chitosan Loaded Capecitabine Nanoparticles for the Treatment of Breast Cancer

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v6i3.8888 ◽

2016 ◽

Vol 6 (3) ◽

Author(s):

Shanmuganathan S. ◽

Nigma S. ◽

Anbarasan B. ◽

Harika B.

Keyword(s):

Fe3o4 Nanoparticles ◽

Polymer Concentration ◽

In Vitro Release ◽

Entrapment Efficiency ◽

In Vitro Evaluation ◽

Sem Image ◽

Therapeutic Molecules ◽

Dialysis Method ◽

Vitro Release

Nanoparticulate Carriers which is biodegradable, biocompatible and bio adhesive have significant feasible applications for administration of therapeutic molecules. The present study was aimed to formulate and optimise Capecitabine loaded Chitosan-Fe3O4 Nanoparticles and to study the in-vitro evaluation by sigma dialysis method. Capecitabine loaded chitosan – Fe3O4 nanoparticles batches with different ratios of drug: polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6) were prepared by ionic gelation method. Increase in polymer concentration increases the nanoparticle drug content. Entrapment efficiency was 60.12% with drug to polymer ratio F3 (1:3). In-vitro release was found to be 65.20% for 12 hrs. Capecitabine from chitosanFe3O4 nanoparticles SEM image reveals discrete spherical structure and particles with size range of 100-500nm. FTIR studies represent the functional groups present with no characteristics change in formulations. Samples stored at refrigerator conditions showed better stability compared with samples kept at other conditions during 8 weeks of storage.

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Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v5i3.8876 ◽

2015 ◽

Vol 5 (3) ◽

Author(s):

Laxman Devkota ◽

Bhupendra Poudel ◽

Junu Silwal

Keyword(s):

In Vitro Release ◽

Magnesium Stearate ◽

Physical Parameters ◽

Artificial Sweetener ◽

Leukotriene Receptor Antagonist ◽

Montelukast Sodium ◽

Chewable Tablets ◽

Leukotriene Receptor ◽

Vitro Release

The objective of the present study is to develop chewable tablets containing different pharmaceutical compositions with simple manufacturing procedures using different excipients. Mannitols, L-HPC 11, Aspartame, Crospovidone, Crospovidone, Aerosil, and Magnesium Stearate are used as excipients for effective formulation of anti-asthmatic drug Montelukast. Montelukast is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. Montelukast chewable tablets were prepared by Direct Compression methods using suitable excipients. The chewable tablets were better presented using artificial sweetener Aspartame as flavouring agent. A total of forteen formulations were prepared and the granules were evaluated for pre-compression parameters. The formulated tablets were evaluated for post-compression parameters .The results showed that all the physical parameters were within the acceptable limits. The in vitro release study of all the formulations showed good release. The study concludes that aforementioned excipients can be used to design chewable montelukast sodium tablets.

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