Natural marine sponges for bone tissue engineering: The state of art and future perspectives

2016 ◽  
Vol 105 (6) ◽  
pp. 1717-1727 ◽  
Author(s):  
Renata Neves Granito ◽  
Márcio Reis Custódio ◽  
Ana Claudia Muniz Rennó
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Marine Sponges ◽  
The State ◽  
Future Perspectives ◽  
State Of Art

In vitro and in vivo evaluation of the marine sponge skeleton as a bone mimicking biomaterial

2015 ◽  
Vol 7 (2) ◽  
pp. 250-262 ◽  
Author(s):  
Samit K. Nandi ◽  
Biswanath Kundu ◽  
Arnab Mahato ◽  
Narsinh L. Thakur ◽  
Siddhartha N. Joardar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Marine Sponge ◽  
Marine Sponges ◽  
In Vivo Evaluation

This investigation was carried out to identify and characterize marine sponges as potential bioscaffolds in bone tissue engineering.

scholarly journals Electrospun Nanofibers Containing Strontium for Bone Tissue Engineering

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Qi Zhang ◽  
Yanjing Ji ◽  
Weiping Zheng ◽  
Mingzhe Yan ◽  
Danyang Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Repair ◽  
Composite Nanofibers ◽  
Electrospun Nanofibers ◽  
Biological Properties ◽  
Metal Composite ◽  
Future Perspectives ◽  
Polymer Metal

Electrospun polymer/metal composite nanofibers have received much attention in the field of bone tissue engineering and regenerative medicine (BTERM) owing to their extracellular matrix- (ECM-) like structure, sufficient mechanical strength, favorable biological properties, and bone induction. In particular, electrospun nanofibers containing strontium (Sr) can significantly promote bone repair and regeneration by mediating osteolysis and osteogenesis, which offers a promising bioactive material for BTERM. In this review, we summarized the effects of electrospun nanofibers containing Sr on stem cells, osteoblasts, and osteoclasts in BTERM. Also, current challenges and future perspectives for electrospun nanofibers containing Sr in BTERM are briefly outlined. It is hoped that the systematic overview will inspire the readers to further study Sr-containing nanofibers for BTERM and accelerate their translation from the bench to the clinic.

scholarly journals Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhuowen Hao ◽  
Zhenhua Xu ◽  
Xuan Wang ◽  
Yi Wang ◽  
Hanke Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Defects ◽  
Bioactive Molecules ◽  
Mechanical Stimuli ◽  
Future Perspectives ◽  
Biomaterial Scaffolds ◽  
Critical Bone Defects

The repair of critical bone defects remains challenging worldwide. Three canonical pillars (biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have been widely used for bone regeneration in separate or combined strategies, but the delivery of bioactive molecules has several obvious drawbacks. Biophysical stimuli have great potential to become the fourth pillar of bone tissue engineering, which can be categorized into three groups depending on their physical properties: internal structural stimuli, external mechanical stimuli, and electromagnetic stimuli. In this review, distinctive biophysical stimuli coupled with their osteoinductive windows or parameters are initially presented to induce the osteogenesis of mesenchymal stem cells (MSCs). Then, osteoinductive mechanisms of biophysical transduction (a combination of mechanotransduction and electrocoupling) are reviewed to direct the osteogenic differentiation of MSCs. These mechanisms include biophysical sensing, transmission, and regulation. Furthermore, distinctive application strategies of biophysical stimuli are presented for bone tissue engineering, including predesigned biomaterials, tissue-engineered bone grafts, and postoperative biophysical stimuli loading strategies. Finally, ongoing challenges and future perspectives are discussed.

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

PLGA+HA/βTCP scaffold incorporating simvastatin: a promising biomaterial for bone tissue engineering

2020 ◽  
Author(s):  
Mariane Beatriz Sordi ◽  
Ariadne Cristiane Cabral da Cruz ◽  
Águedo Aragones ◽  
Mabel Mariela Rodríguez Cordeiro ◽  
Ricardo de Souza Magini
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Thermal Analyses ◽  
Chemical Properties ◽  
Biological Properties ◽  
Scanning Calorimetry ◽  
Evaporation Technique ◽  
Porosity Analysis ◽  
Biphasic Ceramic

The aim of this study was to synthesize, characterize, and evaluate degradation and biocompatibility of poly(lactic-co-glycolic acid) + hydroxyapatite / β-tricalcium phosphate (PLGA+HA/βTCP) scaffolds incorporating simvastatin (SIM) to verify if this biomaterial might be promising for bone tissue engineering. Samples were obtained by the solvent evaporation technique. Biphasic ceramic particles (70% HA, 30% βTCP) were added to PLGA in a ratio of 1:1. Samples with SIM received 1% (m:m) of this medication. Scaffolds were synthesized in a cylindric-shape and sterilized by ethylene oxide. For degradation analysis, samples were immersed in PBS at 37 °C under constant stirring for 7, 14, 21, and 28 days. Non-degraded samples were taken as reference. Mass variation, scanning electron microscopy, porosity analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetry were performed to evaluate physico-chemical properties. Wettability and cytotoxicity tests were conducted to evaluate the biocompatibility. Microscopic images revealed the presence of macro, meso, and micropores in the polymer structure with HA/βTCP particles homogeneously dispersed. Chemical and thermal analyses presented very similar results for both PLGA+HA/βTCP and PLGA+HA/βTCP+SIM. The incorporation of simvastatin improved the hydrophilicity of scaffolds. Additionally, PLGA+HA/βTCP and PLGA+HA/βTCP+SIM scaffolds were biocompatible for osteoblasts and mesenchymal stem cells. In summary, PLGA+HA/βTCP scaffolds incorporating simvastatin presented adequate structural, chemical, thermal, and biological properties for bone tissue engineering.

Sign in / Sign up

Export Citation Format

Share Document