Diagnostic and prognostic value of serum Chitinase 3‐like protein 1 in hepatocellular carcinoma

Poor Prognosis ◽

Prognostic Value ◽

Clinical Characteristics ◽

Cox Regression ◽

Normal Liver ◽

Diagnostic Value ◽

The Relationship ◽

Abstract Background: The potential correlation between H2AFY (also known as MacroH2A1) and the clinical characteristics of hepatocellular carcinoma (HCC) patients was analysed through gene expression profiles and clinical data in The Cancer Genome Atlas (TCGA) database, and the diagnostic and prognostic value of H2AFY in HCC was discussed. Methods: The gene expression data of HCC and the corresponding clinical characteristics of HCC patients were downloaded from the TCGA database. The differences in H2AFY in normal liver tissues and HCC were analysed. The relationship between H2AFY and clinical characteristics was analysed by Wilcoxon signed-rank test, logistic regression and Kruskal-Wallis test. The Kaplan-Meier method and the Cox regression method were used to analyse the relationship between overall survival and clinical characteristics of the patients. An ROC curve was used to predict the diagnostic value of H2AFY in HCC. Gene set enrichment analysis (GSEA) was used to analyse the pathway enrichment of H2AFY. Result: Compared with normal liver tissues, H2AFY was significantly highly expressed in HCC. H2AFY was positively correlated with the age, clinical stage, G stage (grade) and T stage (tumor stage) of liver cancer patients. Higher H2AFY expression predicted a poor prognosis in HCC patients. Cox regression analysis suggested that H2AFY was an independent risk factor for the prognosis of HCC patients. The ROC curve suggested that H2AFY had certain diagnostic value in HCC. GSEA suggested that H2AFY was correlated with lipid metabolism and a variety of tumour pathways. Conclusion: Our study showed that H2AFY was significantly overexpressed in HCC. H2AFY may be a potential diagnostic and prognostic marker for HCC, and high expression of H2AFY predicts a poor prognosis in patients with HCC.

Role of BCYRN1 in hepatocellular carcinoma pathogenesis by lncRNA–miRNA–mRNA network analysis and its diagnostic and prognostic value

Epigenomics ◽

10.2217/epi-2018-0218 ◽

2019 ◽

Vol 11 (10) ◽

pp. 1209-1231 ◽

Cited By ~ 2

Author(s):

Xin-Liang Ming ◽

Yan-Lin Feng ◽

Ding-Dong He ◽

Chang-Liang Luo ◽

Jia-Ling Rong ◽

...

Keyword(s):

Data Mining ◽

Microarray Data ◽

Prognostic Value ◽

Prognostic Biomarker ◽

Tumor Node Metastasis ◽

Comprehensive Strategy ◽

Node Metastasis ◽

Aim: This study aimed to excavate the roles of BCYRN1 in hepatocellular carcinoma (HCC). Methods: A comprehensive strategy of microarray data mining, computational biology and experimental verification were adopted to assess the clinical significance of BCYRN1 and identify related pathways. Results: BCYRN1 was upregulated in HCC and its expression was positively associated with both tumor, node, metastasis and worse survival rate in patients with HCC. Through combing plasma BCYRN1 with alpha fetoprotein, the diagnosis of HCC was remarkably improved. BCYRN1 may regulate some cancer-related pathways to promote HCC initiation via an lncRNA–miRNA–mRNA network. Conclusion: Our results propose BCYRN1 as a potential diagnostic and prognostic biomarker and offer a novel perspective to explore the etiopathogenesis of HCC.

Diagnostic and prognostic value of serum golgi protein 73 in hepatocellular carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.e15096 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. e15096-e15096

Author(s):

Min Dong ◽

Zhan-Hong Chen ◽

Xiao-Yun Li ◽

Jing-yun Wen ◽

Xing Li ◽

...

Keyword(s):

Prognostic Value ◽

Golgi Protein ◽

Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma

Oncology Reports ◽

10.3892/or.2019.7224 ◽

2019 ◽

Author(s):

Quanfa Han ◽

Xiangkun Wang ◽

Xiwen Liao ◽

Chuangye Han ◽

Tingdong Yu ◽

...

Keyword(s):

Gene Expression ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Prognostic Value ◽

B Virus ◽

Family Gene ◽

Diagnostic and prognostic value of lncRNA cancer susceptibility candidate 9 in hepatocellular carcinoma

World Journal of Gastroenterology ◽

10.3748/wjg.v25.i48.6902 ◽

2019 ◽

Vol 25 (48) ◽

pp. 6902-6915 ◽

Cited By ~ 3

Author(s):

Yong-Lian Zeng ◽

Zhen-Ya Guo ◽

Hui-Zhao Su ◽

Fu-Di Zhong ◽

Ke-Qing Jiang ◽

...

Keyword(s):

Prognostic Value ◽

Cancer Susceptibility ◽

Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma

Oncology Letters ◽

10.3892/ol.2020.12171 ◽

2020 ◽

Vol 20 (6) ◽

pp. 1-1

Author(s):

Hong-Tao Li ◽

Bing Wei ◽

Zhou-Quan Li ◽

Xiao Wang ◽

Wen-Xian Jia ◽

...

Keyword(s):

Prognostic Value ◽

Interacting Proteins ◽

Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value

World Journal of Gastroenterology ◽

10.3748/wjg.v25.i15.1890 ◽

2019 ◽

Vol 25 (15) ◽

pp. 1890-1898 ◽

Cited By ~ 11

Author(s):

Yao Cui ◽

Hai-Feng Xu ◽

Ming-Yue Liu ◽

Yu-Jie Xu ◽

Jun-Chuang He ◽

...

Keyword(s):

Prognostic Value ◽

Exosomal Microrna ◽

Role of FBXL19-AS1 in hepatocellular carcinoma by lncRNA–miRNA–mRNA network analysis and its diagnostic and prognostic value

10.21203/rs.3.rs-44069/v1 ◽

2020 ◽

Cited By ~ 1

Author(s):

Dingdong He ◽

Xiaokang Zhang ◽

Xinyu Zhu ◽

Narayani Maharjan ◽

Yingchao Wang ◽

...

Keyword(s):

Prognostic Value ◽

Clinical Value ◽

Cerna Network ◽

Diagnosis And Prognosis ◽

Potential Biomarker ◽

Viral Carcinogenesis ◽

New Biomarkers ◽

Abstract Background: Hepatocellular carcinoma (HCC) is one of the most common neoplastic diseases worldwide. Available biomarkers are not sensitive enough for the diagnosis of HCC, seeking new biomarkers of HCC is urgent and challenging. The purpose of this study was to investigate the role of F-box and leucine-rich repeat protein 19-antisense RNA 1 (FBXL19-AS1) through competing endogenous RNA (ceRNA) network and its diagnostic and prognostic value in HCC.Methods: A comprehensive strategy of genomic data mining, bioinformatics and experimental validation was used to evaluate the clinical value of FBXL19-AS1 in the diagnosis and prognosis of HCC and to identify the pathways that FBXL19-AS1 may be involved in.Results: FBXL19-AS1 was up-regulated in HCC, and its high expression was associated with TNM stage and poor prognosis of HCC patients. The combined use of plasma FBXL19-AS1 and alpha-fetoprotein (AFP) could prominently improve the diagnostic validity for HCC. FBXL19-AS1 might participate in regulating HCC related pathways, including hepatitis C, hepatitis B, microRNAs in cancer, cell cycle, viral carcinogenesis, and proteoglycans in cancer through ceRNA network.Conclusions: Our findings indicated that FBXL19-AS1 not only serves as a potential biomarker for HCC diagnosis and prognosis, but it may be functionally carcinogenic.

Overexpression of chaperonin containing TCP1 subunit 7 has diagnostic and prognostic value for hepatocellular carcinoma.

10.21203/rs.3.rs-848403/v1 ◽

2021 ◽

Author(s):

Huaxiang Wang ◽

Fengfeng Feng Xu ◽

Lizhi Lv ◽

Ruling Wang ◽

Bin Jiang ◽

...

Keyword(s):

Dna Methylation ◽

Mrna Expression ◽

Prognostic Value ◽

Methylation Status ◽

Alpha Fetoprotein ◽

Gene Set Enrichment Analysis ◽

Cox Regression Analysis ◽

Tumor Stages ◽

Abstract Background Chaperonin containing TCP1 subunit 7 (CCT7), a member of the chaperonin containing TCP1 complex (CCT), has been reported regulating the expression of many tumor-related proteins. In this study, we investigated the diagnostic and prognostic value of CCT7 expression for hepatocellular carcinoma (HCC). Methods We investigated the CCT7 expression in HCC in The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and our cohort. The diagnostic and prognostic value were verified by receiver operating characteristic curve (ROC) analysis and Kaplan-Meier analysis, respectively. The association between CCT7 expression with DNA methylation status was investigated in the TCGA database. Gene ontology (GO), The Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA) analysis were employed to identify the potential pathway in which CCT7 is involved in tumorigenesis and progression. Results CCT7 expression in HCC was significantly higher than adjacent normal tissues, and elevated CCT7 expression correlated with tumor stages and tumor grade. Furthermore, the ROC curve showed CCT mRNA expression has a better diagnostic value for HCC with early-stage and low alpha-fetoprotein expression. Positive predictive value (PPV) of CCT7 was higher than alpha-fetoprotein both in the GEO and TCGA database. The Multivariate Cox Regression analysis of clinicopathologic characteristics revealed that both high mRNA and protein expression of CCT7 were independent risk factors for overall survival (OS) and recurrence-free survival (RFS). High DNA methylation of CpG site(cg19515186) was associated with low CCT7 expression and better OS in HCC. The GO, KEGG and GSEA analysis demonstrated that CCT7 mRNA expression was associated with Spliceosome signaling pathway. Conclusions The findings of this study demonstrated that CCT7 has diagnostic and prognostic value for HCC.