A validated HPLC‐MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor

2021 ◽  
Author(s):  
Jun Zhou ◽  
Yan Zhan ◽  
Dafang Zhong ◽  
Xiaoyan Chen ◽  
Yifan Zhang ◽  
...  
Keyword(s):  
Human Plasma ◽  
Pharmacokinetic Study ◽  
Solid Tumor ◽  
Chinese Patients ◽  
Advanced Solid Tumor

CX1003 quantification by ultra-performance LC–MS/MS in human plasma and its application to a pharmacokinetic study in solid tumor patients

Bioanalysis ◽  
2019 ◽  
Vol 11 (16) ◽  
pp. 1483-1493
Author(s):  
Yu Li ◽  
Qian Zhao ◽  
Pei Hu ◽  
Ji Jiang
Keyword(s):  
Cancer Patients ◽  
Human Plasma ◽  
Solid Tumors ◽  
Pharmacokinetic Study ◽  
Solid Tumor ◽  
Receptor Tyrosine Kinase ◽  
Kinase Inhibitor ◽  
Chinese Patients ◽  
Good Sensitivity ◽  
Tumor Patients

Aim: CX1003 is a novel multitargeted receptor tyrosine kinase inhibitor targeting cancer patients with relapsed or metastatic malignant solid tumors. The study aimed to develop a robust and rapid assay approach to quantify CX1003 in human plasma. Methodology & results: Samples of plasma were purified by SPE where the diluted eluates were then separated by a Waters Acquity CSH C18 column and thereafter detected using positive electrospray ionization via an ultra performance LC–MS/MS. Conclusion: The method to quantify CX1003 in human plasma was first exploited and validated with good sensitivity and specificity, and successfully fulfilled the requirement of the first-in-human clinical pharmacokinetic study of CX1003 in Chinese patients with relapsed or metastatic malignant solid tumors.

Simultaneous determination of ornidazole and its main metabolites in human plasma by LC–MS/MS: application to a pharmacokinetic study

Bioanalysis ◽  
2014 ◽  
Vol 6 (18) ◽  
pp. 2343-2356 ◽  
Author(s):  
Jiangbo Du ◽  
Zhiyu Ma ◽  
Yifan Zhang ◽  
Ting Wang ◽  
Xiaoyan Chen ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Human Plasma ◽  
Pharmacokinetic Study
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