scholarly journals Proton MRS detects metabolic changes in hormone sensitive and resistant human prostate cancer models CWR22 and CWR22r

2009 ◽  
Vol 62 (5) ◽  
pp. 1112-1119 ◽  
Author(s):  
H. Carl Le ◽  
Mihaela Lupu ◽  
Khushali Kotedia ◽  
Neal Rosen ◽  
David Solit ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Metabolic Changes ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Proton Mrs ◽  
Cancer Models ◽  
Hormone Sensitive

scholarly journals Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models

2021 ◽  
Author(s):  
Arjanneke F. van de Merbel ◽  
Geertje van der Horst ◽  
Maaike H. van der Mark ◽  
Selas T. F. Bots ◽  
Diana J. M. van den Wollenberg ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ex Vivo ◽  
Human Cancer ◽  
Lytic Replication ◽  
Oncolytic Viruses ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Castration Resistant Prostate Cancer ◽  
Human Tumour ◽  
Cancer Models

AbstractTreatment of castration-resistant prostate cancer remains a challenging clinical problem. Despite the promising effects of immunotherapy in other solid cancers, prostate cancer has remained largely unresponsive. Oncolytic viruses represent a promising therapeutic avenue, as oncolytic virus treatment combines tumour cell lysis with activation of the immune system and mounting of effective anti-tumour responses. Mammalian Orthoreoviruses are non-pathogenic human viruses with a preference of lytic replication in human tumour cells. In this study, we evaluated the oncolytic efficacy of the bioselected oncolytic reovirus mutant jin-3 in multiple human prostate cancer models. The jin-3 reovirus displayed efficient infection, replication, and anti-cancer responses in 2D and 3D prostate cancer models, as well as in ex vivo cultured human tumour slices. In addition, the jin-3 reovirus markedly reduced the viability and growth of human cancer cell lines and patient-derived xenografts. The infection induced the expression of mediators of immunogenic cell death, interferon-stimulated genes, and inflammatory cytokines. Taken together, our data demonstrate that the reovirus mutant jin-3 displays tumour tropism, and induces potent oncolytic and immunomodulatory responses in human prostate cancer models. Therefore, jin-3 reovirus represents an attractive candidate for further development as oncolytic agent for treatment of patients with aggressive localised or advanced prostate cancer.

Establishment and characterization of osseous prostate cancer models: Intra-tibial injection of human prostate cancer cells

The Prostate ◽  
2002 ◽  
Vol 52 (1) ◽  
pp. 20-33 ◽  
Author(s):  
Eva Corey ◽  
Janna E. Quinn ◽  
Franck Bladou ◽  
Lisha G. Brown ◽  
Martine P. Roudier ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Cancer Models

Antitumor activity of irofulven monotherapy and in combination with mitoxantrone or docetaxel against human prostate cancer models

The Prostate ◽  
2004 ◽  
Vol 59 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Emily S. Van Laar ◽  
Steven Weitman ◽  
John R. MacDonald ◽  
Stephen J. Waters
Keyword(s):  
Prostate Cancer ◽  
Antitumor Activity ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Models

scholarly journals Valproic Acid Alters Angiogenic and Trophic Gene Expression in Human Prostate Cancer Models

2016 ◽  
Vol 36 (10) ◽  
pp. 5079-5086 ◽  
Author(s):  
RAJU CHELLURI ◽  
TIFFANY CAZA ◽  
MARK R WOODFORD ◽  
JAY E REEDER ◽  
GENNADY BRATSLAVSKY ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Valproic Acid ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Models

scholarly journals Effect of Small Molecules Modulating Androgen Receptor (SARMs) in Human Prostate Cancer Models

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62657 ◽  
Author(s):  
Anna Tesei ◽  
Carlo Leonetti ◽  
Marzia Di Donato ◽  
Elisa Gabucci ◽  
Manuela Porru ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Small Molecules ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Models

scholarly journals Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models

2009 ◽  
Vol 125 (11) ◽  
pp. 2711-2720 ◽  
Author(s):  
Gongjie Liu ◽  
Stacey A. Taylor ◽  
Cindy H. Marrinan ◽  
Yunsheng Hsieh ◽  
W. Robert Bishop ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Efficacy ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Cancer Models
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